Clinical trials: Lens Disease
Cataract, Lens Opacities
Multicentric Clinical Study on Isatis TF Trifocal Intraocular Lens
The study will be a multicentric, prospective open-label ethics committee approved clinical study to investigate safety, visual outcomes, contrast sensitivity and rotational stability after bilateral implantation of Isatis TF IOL…
- Trial name
- NCT04465344
- Testing
- Implantation of trifocal IOL, Isatis TF (device under investigation), Implantation of monofocal IOL, Isatis (control device)
- Where
- 7 sites in Czechia, Spain
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Cutting Edge SAS
Ametropia
Performance of Toric Hydrogel Lenses Following A Refit With Toric Silicone Hydrogel Lenses for 1 Month
The aim of this prospective study is to evaluate the clinical performance of habitual wearers of methafilcon A toric lenses after a refit with fanfilcon A toric lenses for 1-month of daily wear.
- Trial name
- NCT03835221
- Testing
- methafilcon A toric contact lenses, fanfilcon A toric contact lenses
- Where
- Mexico
- Volunteers
- 43 people
- Sponsor
- CooperVision, Inc.
Post-Surgical Ocular Pain, Post-Surgical Ocular Inflammation
Dextenza Within Upper Lid Canaliculus Compared With Lower Lid Canaliculus Following Bilateral Cataract Extraction Surgery With PCIOL.
Assessing DEXTENZA efficacy when placed within the upper eyelid canaliculus as opposed to the lower eyelid canaliculus.
- Trial name
- NCT04592081
- Testing
- Dextenza 0.4Mg Ophthalmic Insert
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kerry Assil, MD
Cataract, Epiretinal Membrane
Combined 25-gauge Vitrectomy and Cataract Surgery With Toric Intraocular Lens With Idiopathic Epiretinal Membrane.
Toric intraocular lens (IOL) is now widely used for the cataract surgery with preoperative corneal astigmatism. Symptomatic epiretinal membrane (ERM) is often treated with 25-gauge transconjunctival sutureless vitrectomy…
- Conditions
- Cataract, Epiretinal Membrane, Corneal Astigmatism
- Trial name
- NCT02328157
- Testing
- Vitrectomy with cataract surgery and toric IOL, Vitrectomy with cataract surgery and common IOL
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Kagawa University
Pain
Intravitreal Injection Site and Perceived Pain
The objective of this study is to explore the perception of pain during intravitreal injection related to the distance of the entry site from the limbus.
- Trial name
- NCT05640895
- Testing
- Intravitreal injection site
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Unilateral Cataract Extraction, Congenital Cataract
A Randomized Study in Children Ages Birth Through Three Years Undergoing Unilateral Cataract Extraction With or Without Lens Replacement
The purpose of this study is to evaluate the effect of OMS302 compared to phenylephrine when administered in irrigation solution during cataract extraction on intraoperative pupil diameter, acute postoperative pain, and safety in…
- Trial name
- ILR7 (NCT02132312)
- Testing
- OMS302, Phenylephrine HCl
- Where
- 11 sites in United States
- Volunteers
- 78 people
- Sponsor
- Omeros Corporation
Myopia, Hypermetropia
Comparison Between Myopia Versus Hypermetropia With Progressive Addition Lenses in Computer Users
This study examines how myopia (nearsightedness) and hyperopia (farsightedness) affect the use of progressive addition lenses (PALs) for computer users.
- Trial name
- NCT06484257
- Testing
- Myopia, Hypermetropia
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Superior University
Cataract
Association Between Matrix Metalloproteinase-2 Gene Polymorphism rs243865 and Susceptibility to Cataract Development
The primary aim of this study is to investigate the potential association between MMP-2 gene polymorphism and susceptibility to cataract development in Egyptian patients.
- Trial name
- NCT05670834
- Testing
- genotyping assay by real-time PCR, ELISA
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Sohag University
Cataract, Pseudophakia
Effect of Optic Edge Design in a Silicone Intraocular Lens on Posterior Capsule Opacification
Purpose: To compare the posterior capsule opacification (PCO) inhibiting effect of the sharp posterior optic edge design of the Clariflex silicone intraocular lens (IOL) with that of the double-round edge design of the SI40…
- Trial name
- NCT00428363
- Testing
- Cataract surgery with implantation of an intraocular lens
- Where
- Austria
- Volunteers
- 52 people
- Sponsor
- Medical University of Vienna
Myopia
Evaluation of the Feasibility a New Silicone Hydrogel Contact Lens
The objective of this study is to determine the clinical feasibility and to evaluate the product performance of an investigational contact lens.
- Trial name
- NCT01309906
- Testing
- Investigational lens, Air Optix Aqua lens
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Presbyopia Correction, Presbyopia
Clinical Evaluation of Visual Performance, Spectacle Independence, and Patient Satisfaction With TECNIS PureSee Mini-Monovision and TECNIS PureSee-TECNIS Odyssey Mix-Match
The purpose of the study is to evaluate the binocular clinical endpoints of distance, intermediate, and near vision and patient reported outcomes utilizing mini-monovision versus mix-match approaches for the correction of…
- Conditions
- Presbyopia Correction, Presbyopia, Dysphotopsia, Visual Acuity
- Trial name
- NCT07860567
- Testing
- TECNIS PureSee IOL (Model DEN00V/DET150), TECNIS Odyssey IOL (Model DRN00V/DRT150)
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Dr. Daniel H. Chang, MD
Eye Disease, Cataract
Trying a New Device for Performing Capsulorhexis in Cataract Surgery Surgery
During cataract operations a capsulorhexis is being performed. This is done in order to enable the removal of lens material while keeping the capsule intact in order to put inside the lens capsule an artificial intra ocular lens.
- Trial name
- NCT01396967
- Testing
- surgery
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Myopia
Dual Focus Soft Contact Lens Wear Cessation Study
The purpose of this study is to investigate the effect of ceasing treatment with dual focus soft contact lenses.
- Trial name
- NCT05779072
- Testing
- Single Vision Soft Contact Lens
- Where
- 4 sites in Canada, Portugal and 2 more
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Vision Disorders, Refractive Errors
Rapid Computerized Visual Acuity Test
A novel computerized visual acuity test was developed and tested on both healthy persons and patients with ocular conditions. Visual acuity outcomes of the computerized test will be compared to the Early Treatment Diabetic…
- Conditions
- Vision Disorders, Refractive Errors, Retinal Disease, Cataract
- Trial name
- NCT05447845
- Testing
- Computerized visual acuity assessment program
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Cataract
Long-term (3 Months) Safety of Femtosecond-laser Assisted Cataract Surgery
This clinical study is a prospective, post-market-clinical-follow-up study to investigate the long-term (3 months) safety of femtosecond laser assisted cataract surgery as a study follow-up extension to the Study #1304 titled as…
- Trial name
- NCT02023437
- Testing
- Femtosecond laser cataract surgery, Manual cataract surgery
- Where
- 2 sites in Czechia, India
- Volunteers
- 132 people
- Sponsor
- Technolas Perfect Vision GmbH
ICL, Vault
Predictive Performance of a Generative Model for Corneal Tomography After ICL Implantation
To evaluate the efficacy of a corneal tomography Imaging model in predicting postoperative vault based on preoperative corneal topography in Implantable Collamer Lens (ICL) surgery.
- Conditions
- ICL, Vault, Deep Learning, AI (Artificial Intelligence)
- Trial name
- NCT07146737
- Testing
- Corneal tomography generation model after ICL surgery
- Where
- China
- Volunteers
- 818 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Cataract, Vitreous Hemorrhage
Study on Eye-Brain Cross-Organ Mapping and Systemic Disease Association Based on Multimodal Big Data
This project integrates multimodal eye data (CFP, OCT, OCTA) from 50,000 cases, brain MR data from 150,000 cases, and ICD diagnoses, medical orders, and test results from an eye-brain paired cohort of 8,000 cases to construct an…
- Conditions
- Cataract, Vitreous Hemorrhage, Diabetic Eye Diseases, Cerebral Small Vessel Disease
- Trial name
- NCT07541651
- Testing
- No interventions were involved in this study.
- Volunteers
- 208,000 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Presbyopia
Comparison of Two Soft Bifocal Contact Lenses
The purpose of the study is to compare the visual performance of two soft bifocal contact lenses.
- Trial name
- NCT00724945
- Testing
- balafilcon A, senofilcon A
- Where
- 6 sites in United States
- Volunteers
- 113 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Refractive Error, Myopia
A Comparison of Two Daily Disposable Contact Lenses.
This study seeks to evaluate the clinical fitting performance of a new daily disposable contact lens to an existing daily disposable contact lens.
- Trial name
- NCT00721500
- Testing
- etafilcon A, narafilcon A
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Cataract
Influence of DisCoVisc Ophthalmic Viscosurgical Device (OVD) on Intraoperative Aberrometry Readings
The purpose of the study is to develop a nomogram that correlates intraoperative, aphakic refraction measurements when the anterior chamber is pressurized with either balanced salt solution (BSS) or DisCoVisc; and to understand…
- Trial name
- NCT03751033
- Testing
- BSS, DiscoVisc
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Clinical Research Consultants, Inc.
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