Clinical trials: Lens Disease
Cataract
A Comparison of Visual Function After Bilateral Implantation of Presbyopia Correcting Intraocular Lenses
To prospectively evaluate postoperative visual and refractive parameters in a series of subjects bilaterally implanted with AcrySof ReSTOR +3 vs. those bilaterally implanted with LENTIS MPlus Intraocular Lens (IOL).
- Trial name
- NCT01299155
- Testing
- ReSTOR +3, LENTIS MPlus
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Alcon Research
Retina; Change, Intraocular Pressure
Changes After Suprachoroidal Injection.
Changes after suprachoroidal injection are analyzed for statistical analysis.
- Conditions
- Retina; Change, Intraocular Pressure, Cataract, Macular Edema
- Trial name
- NCT05288192
- Testing
- Suprachoroidal triamcinolone acetonide (SCTA) injection
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Mitigating Chronic Respiratory Disease Through the Lens of Multimorbidity (MARES3)
The investigators aim to investigate how individuals attending primary healthcare (PHC) services in Brazil for treatment of non-communicable diseases (NCDs), identified there as having abnormal spirometry or as being at high risk…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Preserved Ratio Impaired Spirometry (PRISM)
- Trial name
- NCT07134855
- Where
- 2 sites in Brazil
- Volunteers
- 473 people
- Sponsor
- University College, London
Cataract, Presbyopia
Clinical Investigation of the Visual Outcomes and Safety of a Trifocal Intraocular Lens (IOL) in a Korean Population
The purpose of this study is to confirm the effectiveness of the investigational lens in a Korean population, especially for visual performance, quality of vision, and subject satisfaction with the visual outcome, as well as the…
- Trial name
- NCT03268746
- Testing
- AcrySof IQ PanOptix Multifocal IOL
- Where
- 4 sites in South Korea
- Volunteers
- 52 people
- Sponsor
- Alcon Research
Dry Eye, Visual Acuity
Treating Lid Wiper Epitheliopathy
Lid wiper epitheliopathy (LWE) is a relatively new entry into the abundance of clinical ocular surface health signs. LWE was first reported in 2002 as a potential cause for dry eye disease (DED) (Korb et al., 2002).
- Trial name
- TLWE (NCT06671041)
- Testing
- Preservative Free eye drop
- Where
- 4 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Southern College of Optometry
Cataract, Corneal Astigmatism
Comparison of Toric IOL Implantation and Opposite Clear Corneal Incision During Cataract Surgery to Correct Corneal Astigmatism
With increasing demands of patients concerning refractive outcome after cataract surgery, toric intraocular lenses (IOLs) that correct corneal astigmatism have been introduced more widely to cataract surgery.
- Trial name
- NCT01763151
- Testing
- toric IOL, IOL combined with opposite clear corneal incision (OCCI)
- Where
- Austria
- Volunteers
- 55 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Cataract, Lens Opacities
Clinical Investigation of a Monofocal Toric Intra Ocular Lens (IOL) in Cataractous Eyes
This is a Multi-center, single-arm and non-masked study whereby patients undergoing routine cataract surgery be implanted with a hydrophobic acrylic monofocal toric intraocular lens PODEYE TORIC (model POD T 49P).
- Conditions
- Cataract, Lens Opacities, Astigmatism
- Trial name
- PHY2107 (NCT05255029)
- Testing
- POD T 49P implantation experimental
- Where
- 4 sites in Japan
- Volunteers
- 42 people
- Sponsor
- Beaver-Visitec International, Inc.
Cataract, Presbyopia
Single-center, Double-arm, Prospective Clinical Trial to Compare Visual Performance of Non-diffractive Extended Vision and Neutral Aspheric Monofocal Intraocular Lenses
The purpose of this study is to compare the binocular distance, intermediate, and near visual acuity of the Alcon Vivity and Bausch \& Lomb enVista IOLs.
- Trial name
- NCT04591054
- Testing
- Extended Vision IOL, Neutral Aspheric Monofocal IOL
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Milton S. Hershey Medical Center
Myopia, Refractive Error
A Comparison of Two Color Contact Lenses in Habitual Clear Contact Lens Wearers
The purpose of this study was to evaluate overall satisfaction with AIR OPTIX® COLORS as compared to FRESHLOOK® COLORBLENDS contact lenses.
- Trial name
- NCT01782482
- Testing
- Lotrafilcon B contact lens with color, Phemfilcon A contact lens with color
- Volunteers
- 574 people
- Sponsor
- Alcon Research
Cataract
Evaluation of the Aspheric ReSTOR IOL After Routine Cataract Extraction
The purpose of this study is to evaluate the visual outcomes and patient satisfaction after bilateral implantation of the aspheric ReSTOR multifocal intraocular lens (IOL) and compare it to a historical control group of patients…
- Trial name
- NCT00720005
- Testing
- Aspheric Acrysof ReSTOR intraocular lens
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Cataract, Shallow Anterior Chamber
Assessment Of Anterior Chamber Configuration Changes After Phacoemulsification
To investigate changes in anterior chamber angle configuration after phacoemulsification and intraocular lens (IOL) implantation with Swept-Source Optical Coherence Tomography (SS-OCT).
- Conditions
- Cataract, Shallow Anterior Chamber, Narrow Angle
- Trial name
- AOACCCAP (NCT02238002)
- Testing
- cataract surgery
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Zheng Qian
Myopia
LSH Silicone Hydrogel Soft Hydrophilic Contact Lens for Daily Wear
This study is to evaluate the performance of the LSH (mangofilcon A) silicone hydrogel soft contact lenses when used as a daily wear contact lens for the correction of myopia.
- Trial name
- NCT01735045
- Testing
- Lagado LSH (mangofilcon A) Soft (hydrophilic) Contact Lens, Benz 3GX (hioxifilcon B) Soft (hydrophilic) Contact Lens
- Where
- 5 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Szabocsik and Associates, Inc.
Cataract
Vision Performance Evaluation of TECNIS EYHANCE™ With TECNIS SIMPLICITY™ Compared to TECNIS® 1-piece Intraocular Lenses
This study is a 6-month, prospective, multicenter, bilateral, randomized subject- and evaluator-masked, clinical investigation of the TECNIS Eyhance IOL versus the TECNIS 1-piece IOL.
- Trial name
- NCT05025345
- Testing
- Tecnis Eyhance, Tecnis 1 piece IOL
- Where
- 15 sites in United States
- Volunteers
- 228 people
- Sponsor
- Johnson & Johnson Surgical Vision, Inc.
Cataract
The Influence of Vision on Balance, Gait and Falls
Falls are the most serious and frequent home accident amongst elderly. Most falls occur during walking. Vision is reduced with ageing and visual impairments affect balance.
- Trial name
- NCT00218894
- Testing
- Cataract surgery
- Where
- Norway
- Volunteers
- 148 people
- Sponsor
- Norwegian University of Science and Technology
Dry Eye Syndromes
Evaluation Of Vision Recovery And Comfort Index In Patients With Borderline/Mild Dry Eyes Undergoing FLACS With Premium IOL
This is a prospective, open-label, single-center, randomized, head-to-head, investigator-sponsored clinical study. It aims to investigate the vision recovery and patient comfort in borderline/mild dry eye disease patients…
- Trial name
- ENHANCE (NCT04863742)
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sight Medical Doctors PLLC
Cataract, Diabetes Mellitus
Corneal Endothelial Cell Changes After Phacoemulsification in Patients With Type 2 Diabetes Mellitus
This study investigate the change of the corneal endothelial cells in patients with type 2 diabetes after phacoemulsification with intraocular lens implantation.
- Trial name
- NCT03260673
- Testing
- specular microscope
- Volunteers
- 30 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Myopia
Comparison of Two Daily Disposable Contact Lenses Over 1-week of Wear
This is a one week 2x2 crossover study comparing delefilcon A with etafilcon A, with a primary hypothesis of comparing the handling of each lens.
- Trial name
- NCT01669629
- Testing
- delefilcon A, etafilcon A
- Where
- 10 sites in United States
- Volunteers
- 183 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Cataract, Cataract Surgery
Outcomes of High vs Physiological Intraocular Pressure During Cataract Surgery Using ACTIVE SENTRY
Cataract surgery is a widely performed procedure across the world that helps restore vision in many patients suffering from cataracts. Irrigation is an essential component of the surgery.
- Conditions
- Cataract, Cataract Surgery, Cataract Bilateral
- Trial name
- ACTIVESENTRY (NCT06611670)
- Testing
- Cataract surgery with Active Sentry, Traditional cataract surgery
- Where
- Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cataract
Combined EDOF / Trifocal
The purpose of this study is to obtain postoperative visual performance data of patients with bilateral implantation of the AT LARA IOL or the AT LARA implanted in the dominant eye and AT LISA tri implanted in the other eye.
- Trial name
- NCT05462067
- Testing
- AT LARA IOL, AT LISA Tri IOL
- Where
- 4 sites in Denmark, Germany and 1 more
- Volunteers
- 72 people
- Sponsor
- Carl Zeiss Meditec AG
Contact Lens and Punctal Plug in Preventing Corneal Injuries
A Comparison Between Bandage Contact Lens, Punctal Plugs and Standard Measures in Preventing Corneal Injuries
Study Rationale: The insertion of a bandage contact lens or punctal plug in a defined group of patients admitted to the ICU may be more effective than standard care in decreasing the incidence of corneal injuries.
- Trial name
- COMLENPLSTAN (NCT01961193)
- Testing
- contact lens, punctal plug
- Where
- Israel
- Volunteers
- 105 people
- Sponsor
- Rabin Medical Center
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