Clinical trials: Lens Disease
Cataracts
Comparison of Centurion® Vision System With Balanced Tip and the Infiniti® Vision System With the Mini Flared Kelman (MFK) Tip During Cataract Extraction Surgery of Hard Lenses
The purpose of this study is to demonstrate that the Centurion® Vision System (CVS) used with the 45° Balanced Tip will result in less Cumulative Dissipated Energy (CDE) than the lnfiniti® Vision System (IVS) used with the 45°…
- Trial name
- NCT02502526
- Testing
- Centurion® Vision System, 45° Balanced Tip, Centurion® Vision System, 45° MFK Tip, lnfiniti® Vision System, 45° MFK Tip
- Volunteers
- 231 people
- Sponsor
- Alcon Research
Aphakia, Presbyopia
Real-World Study of Vivity Intraocular Lenses (IOLs)
The primary objective of this clinical study is to assess the clinical performance of the AcrySof IQ Vivity Extended Vision IOL in a Chinese population.
- Trial name
- NCT04800016
- Testing
- AcrySof IQ Vivity Extended Vision IOL, Cataract surgery
- Where
- China
- Sponsor
- Alcon Research
Cataract, Presbyopia
Retrospective / Prospective Clinical Study of AcrySof® IQ ReSTOR® +2.5 D Multifocal Toric Intraocular Lenses
The purpose of this study is to characterize the safety and effectiveness of the ACRYSOF IQ ReSTOR +2.5 diopter (D) Multifocal Toric Intraocular Lens (IOL) in subjects at least 3 months and no more than 14 months after IOL…
- Conditions
- Cataract, Presbyopia, Corneal Astigmatism
- Trial name
- NCT02176343
- Testing
- AcrySof® IQ ReSTOR® +2.5 D Multifocal Toric IOL
- Volunteers
- 37 people
- Sponsor
- Alcon Research
Open Angle Glaucoma (OAG)
Efficacy and Safety of Gonioscopy Assisted Transluminal Trabeculotomy in Patients with Primary Open-angle Glaucoma and Cataract.
Prospective, randomized, , double-blind, clinical trial, comparing the variation of intraocular pressure (IOP) of patients with mild or moderate primary open-angle glaucoma (OAG) and cataract divided into three groups.
- Trial name
- NCT06865235
- Testing
- 360º goniotomy assisted transluminal trabeculotomy, Phacoemulsification, 180º gonioscopy assisted transluminal trabeculotomy
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Faculdade de Ciências Médicas de Minas Gerais
Cataract
Evaluating Patient Satisfaction After Cataract Surgery With Multifocal Intraocular Lens
Multifocal lens allow most patients to be spectacle-free after cataract surgery. Most studies published up-to-date have focused on visual acuity, but not on patient-reported outcomes.
- Trial name
- NCT03787576
- Testing
- Cataract surgery
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Clínica Rementería
Contact Lens Complication, Astigmatism
Total30 for Astigmatism Contact Lenses
Determine if Total30 for Astigmatism contact lenses (CLs) provide a comfortable wearing experience all day. CL discomfort affects most CL wearers with discomfort consistently topping the reasons why established CL wearers drop…
- Conditions
- Contact Lens Complication, Astigmatism, Refractive Errors
- Trial name
- NCT06052046
- Testing
- TOTAL30 for Astigmatism Contact Lenses
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Southern College of Optometry
Cataract
Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients: Trough Drug Effects
The purpose of this study is to compare the ability of two different topical NSAIDs (non-steroidal anti-inflammatory medications used for pain relief) to reach the back of the eye and to stop inflammation.
- Trial name
- NCT00469690
- Testing
- Acular, Xibrom
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Innovative Medical
Myopia
Evaluating Contact Lens Optics
This study will evaluate changes in refractive error and visual performance between a single vision soft contact lens and multifocal soft contact lens
- Trial name
- NCT05028790
- Testing
- Single vision contact lens, Multifocal contact lens
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- David A Berntsen, OD PhD
VR-based Informed Consent, Cataract and Intraocular Lens Surgery
VR for Cataract Anxiety Lowering Management
Cataract is currently the leading cause of blindness globally, and surgery is the only effective treatment. With the advancement of medical technology, cataract surgery is usually performed under topical anesthesia, which means…
- Trial name
- VR-CALM (NCT07586280)
- Testing
- Virtual reality simulation of intraoperative audiovisual experience
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Lens Diseases
Full 3D Eye Modeling in the Diagnosis and Treatment of Lens Diseases With Eye Structures Disorders
In patients with complex cataracts, spatial abnormalities in the lens and its surrounding tissues-including both the anterior and posterior ocular segments-are often present.
- Trial name
- NCT07321769
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Macular Edema, Cystoid, Vision Disorders
Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema
This study is undertaken to determine the effect of intravitreal long acting dexamethasone implant, (Ozurdex®) in improving outcome of cataract surgery in patients with diabetic macular edema.
- Conditions
- Macular Edema, Cystoid, Vision Disorders, Diabetic Macular Edema, Cystoid Macular Edema Following Cataract Surgery
- Trial name
- NCT01546402
- Testing
- Dexamethasone Drug delivery system (Ozurdex), Cataract surgery
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Glaucoma, Suspect, Diabetic Retinopathy
Eye Health Intervention Study in Upper Manhattan
Individuals living in Upper Manhattan have limited access to eye care, high vision impairment rates, and poor ocular health outcomes.
- Conditions
- Glaucoma, Suspect, Diabetic Retinopathy, Cataract, Refractive Errors
- Trial name
- EYES-UM (NCT06112431)
- Testing
- Intervention, Usual Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Myopia
Evaluation of The Comfort of Orthokeratology Lenses Fit Using A New Software
As new orthokeratology fitting software emerges onto the market, it is of interest to assess their usefulness in guiding eye practitioners with lens fit.
- Trial name
- NCT05389072
- Testing
- control contact lens
- Where
- 4 sites in United States, Spain
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- CooperVision International Limited (CVIL)
Marfan Syndrome, Lens Subluxation or Dislocation
Surgical Treatment of Marfan Syndrome With Subluxation Lens
To analyze the postoperative visual effects, and to compare the safety and efficacy of different surgical treatment with of Marfan Syndrome with subluxation lens.
- Trial name
- NCT05578469
- Testing
- surgical treatment of Marfan Syndrome with subluxation lens
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cataract
Pseudophakic Accommodation
Purpose: The aim of this study was to compare the effect of ciliary body training as proposed by manufacturers of accommodating IOLs and patient motivation on the pseudoaccommodative ability with a standard intraocular lens…
- Trial name
- NCT00716339
- Testing
- motivation
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Myopia
Evaluation of The Clinical Acceptance of Soft Contact Lenses for Myopia Control
The main objective of the study was to evaluate the clinical acceptance of soft contact lenses for Myopia control.
- Trial name
- NCT04709237
- Testing
- omafilcon A control lens, omafilcon A test lens 1, omafilcon A test lens 2
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Myopia
Comparative Performance of PureVision, Acuvue Oasys and O2Optix
The objective of this study is to evaluate the performance of the PureVision Contact Lens compared to Acuvue Oasys Contact lens and O2Optix Contact lens when worn on a daily wear basis.
- Trial name
- NCT00640341
- Testing
- PureVision Contact Lens, Acuvue Oasys Contact Lens, O2Optix Contact lens
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Bausch & Lomb Incorporated
Cataract, Corneal Astigmatism
Evaluation of the Impact of Corneal Width on Surgically Induced Astigmatism (SIA) and Functional Results After Bimanual 1.4 mm Microincision Cataract Surgery (B-MICS), Coaxial 1.8 mm MICS (C-MICS) and 2.4 mm Small Incision Cataract Surgery (C-SICS).
The aim of the study is to compare functional results and complications of 3 methods of cataract phacoemulsification: bimanual 1.4 mm cataract surgery (B-MICS), coaxial 1.8 mm cataract surgery (C-MICS) and coaxial 2.4 mm small…
- Conditions
- Cataract, Corneal Astigmatism, Corneal Incision Contracture
- Trial name
- MICS (NCT05510869)
- Testing
- Bimanual 1.4 mm microincision cataract surgery (B-MICS) with IOL implantation in a "wound-assisted" technique. In bimanual MICS group a self-sealing 1.4 mm wide incision was created supratemporally, Coaxial 1.8 mm microincision cataract surgery (C-MICS) with IOL implantation with an injector through the 1.8 mm wide incision created temporally., Coaxial 2.4 mm small incision cataract surgery (C-SICS) with IOL implantation with an injector through the 2.4 mm wide incision located temporally.
- Volunteers
- 90 people
- Sponsor
- Medical University of Lodz
Aphakia, Cataract
Visual Quality Following Aspheric Intraocular Lens (IOL) Implantation - a Comparative Clinical Study
To evaluate visual acuity and quality of vision in participants undergoing cataract surgery with a Hoya model 751 intra-ocular lens and to compare the visual results to the common monofocal lens in use.
- Trial name
- 751 (NCT01544777)
- Testing
- Study IOL, Hoya iSert 751, Negatively aspheric IOL
- Where
- Australia
- Volunteers
- 42 people
- Sponsor
- Hoya Surgical Optics, Inc.
Myopia
Safety and Effectiveness of CARE1.02 Spectacle Lens in Myopia Control
China is a major country in myopia, with the highest number of teenagers suffering from myopia. Controlling the progression of myopia and the related complications caused by axial elongation have clinical significance and social…
- Trial name
- NCT05818033
- Testing
- CARE1.02, Single-vision spectacle lens
- Where
- China
- Volunteers
- 796 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
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