Clinical trials: Lenses
Open Angle Glaucoma and Cataract
RCT to Investigate if Prostaglandin Analogue Drops Increase the Risk of Cystoid Macular Oedema After Cataract Surgery.
Post-operative cystoid macular oedema (CMO) is a common complication causing visual loss following routine cataract surgery. This complication is more prevalent in eyes with excessive inflammation as they heal from surgery.
- Trial name
- CMO (NCT03292796)
- Testing
- Prostaglandins
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- Julie Dawson
Cataract
Effect of Minimising Ultrasound Power to 1% During Cataract Surgery on Corneal Endothelium.
Coaxial microincision cataract surgery using 1% ultrasound is not inferior to standard coaxial microincision cataract surgery in patients of grade 0.1-6.0 immature senile cataract in terms of corneal endothelial safety.
- Trial name
- OCTOPUS (NCT01259349)
- Testing
- one percent ultrasound power in CMICS, 40 percent ultrasound power in CMICS
- Where
- India
- Volunteers
- 72 people
- Sponsor
- Dr. Ram Manohar Lohia Hospital
Cataract, Endophthalmitis
The Effect of Intracameral Cefuroxime on Post-op Fibrin in Pediatric Cataract Surgery
The study investigates whether placing an antibiotic inside the eye at the end of cataract surgery in children will reduce the amount of fibrin formation (fibrin formation can block the pupil and reduce vision).
- Trial name
- NCT00730938
- Testing
- cefuroxime
- Where
- Kenya
- Volunteers
- 45 people
- Sponsor
- Presbyterian Church East Africa Kikuyu Hospital
Cataract
Evaluation of the EpiGlare Tester for the Measurement of Glare-Induced Changes in BSCVA in Subjects With and Without Cataracts
The EpiGlare Tester will identify visual disability resulting from the glare experienced by subjects with cataracts in the glare-induced change in best spectacle corrected visual acuity (BSCVA).
- Trial name
- NCT04739397
- Testing
- Glare Testing
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Epico, LLC
Myopia, Myopia Progression
Evaluation of Performance of MiYOSMART Photochromic and Clear Spectacle Lenses in Myopic Children
This clinical study aims to evaluate the non-inferiority of the photochromic DIMS spectacles lenses performance (PDIMS) compared to clear DIMS spectacles lenses (DIMS) in myopia management.
- Trial name
- PDIMS (NCT06717035)
- Testing
- EYE001
- Where
- Singapore
- Volunteers
- 202 people
- Sponsor
- Singapore National Eye Centre
Anxiety, Intraoperative Hypertension
The Effects of Music and Television on Intraoperative Hypertensive Events in Cataract Surgery
This study investigates whether television viewing or music listening can reduce pre-operative anxiety and improve surgical outcomes for patients undergoing cataract surgery.
- Conditions
- Anxiety, Intraoperative Hypertension, Cataract
- Trial name
- NCT06356324
- Testing
- Music Intervention, Television Intervention
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Refractive Error, Presbyopia
Clinical Evaluation of DAILIES TOTAL 1® Multifocal Compared to 1-Day Acuvue® Moist® Multifocal in a Japanese Population
The purpose of this clinical study is to evaluate DAILIES TOTAL1® Multifocal (DT1MF) contact lenses compared to 1-DAY ACUVUE® Moist® Multifocal (AMMF) contact lenses for investigator-graded lens centration in a Japanese…
- Trial name
- NCT03341923
- Testing
- Delefilcon A multifocal contact lenses, Etafilcon A multifocal contact lenses
- Where
- 4 sites in Japan
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Myopia
Effects of Contact Lens Care Regimens on the Corneal Epithelium
The purpose of this study is to compare the performance of two different contact lens care solutions, specifically their affects on the front surface of the eye.
- Trial name
- NCT00349882
- Testing
- soft contact lens, Marketed multipurpose disinfection regimen
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Waterloo
Aphakia
A Real-World Evidence (RWE) Long-Term Follow-Up Study to Assess Outcomes of Alcon Monofocal Intraocular Lenses
The purpose of this post-market clinical follow-up (PMCF) study is to describe the long-term safety and performance of AcrySof Single-Piece and AcrySof Multi-Piece monofocal intraocular lenses (IOLs).
- Trial name
- NCT05799950
- Testing
- AcrySof single-piece IOL, AcrySof multi-piece IOL
- Where
- 7 sites in United States, Puerto Rico
- Volunteers
- 138 people
- Sponsor
- Alcon Research
Cataract
Comparison of the Accuracy of Different Intraocular Lens Power Calculation Formulas in Cataract Patients With Prior Radial Keratotomy
The Web-based Barret True K formula with no history formula has been proven to be a good choice for cataract patients after RK in several studies.
- Trial name
- NCT06354296
- Volunteers
- 50 people
- Sponsor
- He Eye Hospital
Contact Lens Solution
Evaluation of Tangible Boost Replenishing System
This study will evaluate Tangible Boost, a new contact lens care product which is designed to replenish the hydrogel layer on fluorosilicone acrylate lenses with Hydra-PEG.
- Trial name
- NCT03073148
- Testing
- Tangible Boost
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Tangible Science
Cataract
Galilei Lens Professional vs. Predicate Devices: a Comparison Study
Study question: How does the new GALILEI Lens Professional compare to predicate devices? Study hypothesis: The GALILEI Lens Professional achieves a better precision in the postoperative, calculated target refraction with cataract…
- Trial name
- NCT01961089
- Testing
- Galilei Lens Professional, IOLMaster, Lenstar
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ziemer Ophthalmic Systems AG
Dry Eye Disease (DED), Cataract
Rebamipide Versus Diquafosol for Perioperative Dry Eye in Cataract Surgery
This clinical trial is designed to compare two commonly used eye drop treatments for dry eye disease in patients undergoing cataract surgery.
- Trial name
- NCT07397949
- Testing
- Rebamipide 2% ophthalmic solution, Diquafosol 3% ophthalmic solution
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Inflammation, Pain
Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation Following Cataract Surgery
The objective of this study is to compare the safety and efficacy of Mapracorat Ophthalmic Suspension, 3% to vehicle for the treatment of postoperative inflammation and pain following cataract surgery.
- Conditions
- Inflammation, Pain, Cataract
- Trial name
- NCT01298752
- Testing
- Mapracorat, Vehicle
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Bausch & Lomb Incorporated
Open Angle Glaucoma
Trabectome Versus Trabeculectomy With Mitomycin C in Patients With Open Angle Glaucoma
The purpose of this study is to compare the efficacy and safety of Trabectome versus Trabeculectomy with adjunctive Mitomycin C, combined with cataract surgery, in patients with open angle glaucoma.
- Trial name
- NCT00901108
- Testing
- Trabectome-IOL, Trab-IOL
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- University of Alberta
Dry Eyes
Effect of Contact Lens With Alginic Acid in Dry Eye Patients
Contact lens induced dry eyes leads to lens intolerance and discontinuation. Incidence of dry eye in contact lens wearer is significantly higher in Asian population compared to other ethnic group considering Asian has lower tear…
- Trial name
- NCT01918410
- Testing
- Contact Lens with alginic acid, Contact Lens without alginic acid
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Louis Tong
Glaucoma, Angle-Closure, Cataract
Comparison of Phacotrabeculectomy and Trabeculectomy in the Treatment of Primary Angle-closure Glaucoma (PACG)
Primary angle closure glaucoma (PACG) is caused by contact between the iris and trabecular meshwork, which in turn obstructs outflow of the aqueous humor from the eye.
- Trial name
- NCT01298635
- Testing
- combined phacotrabeculectomy, trabeculectomy
- Volunteers
- 31 people
- Sponsor
- Sun Yat-sen University
Presbyopia, Astigmatism
Clinical Evaluation of Investigational Multifocal Toric Contact Lenses
This non-dispensing study is to evaluate the clinical performance of a test multifocal toric silicone hydrogel contact lens compared to a marketed multifocal toric contact lens (control).
- Trial name
- NCT03519282
- Testing
- comfilcon A multifocal toric lens, omafilcon A Multifocal Toric Lens
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- CooperVision, Inc.
Hyperopia, Myopia
Clinical Study of Clariti Monthly Contact Lens
A clinical study report follows; this clinical study evaluated the safety and efficacy of SAUFLON CLARITI Soft Silicone Hydrogel Contact Lens with UV Blocker by comparison with Air Optix Aqua silicone hydrogel contact lenses…
- Trial name
- NCT01392950
- Testing
- Air Optix Aqua, Clariti
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sauflon Pharmaceuticals Ltd
Cataract
Clinical Investigation of the Next-Generation Intraocular Lens
This study is a 6-month, prospective, multicenter, bilateral, randomized clinical investigation of the TECNIS Model ZHR00 and Model ZQR00 IOLs versus the TECNIS Symfony control IOL.
- Trial name
- NCT03111550
- Testing
- Investigational Intraocular Lens Device #1: TECNIS Model ZHR00, Investigational Intraocular Lens Device #2: TECNIS Model ZQR00, TECNIS Symfony® Extended Range of Vision Intraocular Lens: Model ZXR00
- Where
- 12 sites in United States
- Volunteers
- 242 people
- Sponsor
- Abbott Medical Optics
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