Clinical trials: Leptomeningeal Carcinomatosis
Solid Tumor, High-grade Glioma
Concurrent Azeliragon With Craniospinal Irradiation
Single institution study to assess the safety of concurrent Azeliragon with craniospinal irradiation (CSI) in patients with leptomeningeal metastasis from solid tumor malignancies and high-grade gliomas.
- Conditions
- Solid Tumor, High-grade Glioma, Leptomeningeal Metastasis
- Trial name
- NCT06724926
- Testing
- Azeliragon, CSI
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- NYU Langone Health
Leptomeningeal Metastases
Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease
This pilot clinical trial studies continuous intraventricular methotrexate in treating patients with leptomeningeal disease. Drugs used in chemotherapy, such as methotrexate, work in different ways to stop the growth of cancer…
- Trial name
- NCT01438021
- Testing
- pharmacological study, methotrexate
- Sponsor
- City of Hope Medical Center
Leptomeningeal Metastasis
Study of Craniospinal Irradiation With Linac Based Volumetric Modulated Arc Therapy (VMAT) for Patients With Leptomeningeal Metastasis
The purpose of this study is to confirm the safety and efficacy of linac based Volumetric Modulated Arc Therapy (VMAT) for craniospinal irradiation (CSI) in solid tumor cancer patients with leptomeningeal metastasis.
- Trial name
- NCT06984523
- Testing
- Varian Eclipse
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Breast Cancer Female, Leptomeningeal Metastases
BATs in Patients With Breast Cancer and Leptomeningeal Metastases
This study uses bi-specific antibody (HER2Bi) armed activated T-cells (HER2 BATs) to target breast cancer cells that have metastasized to the membranes surrounding the brain and spinal cord.
- Trial name
- NCT03661424
- Testing
- HER2 BATs
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Virginia
Leptomeningeal Carcinomatosis
A Safety Study of RTA 744 in Recurrent, Progressive or Refractory Neoplastic Meningitis
This study assesses the tolerability, safety, efficacy and pharmacokinetics of RTA 744 in recurrent neoplastic meningitis.
- Trial name
- LMD (NCT00527410)
- Testing
- RTA 744
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Biogen
Non-small Cell Lung Cancer
Aumolertinib Combined Intrathecal Chemotherapy for Leptomeningeal Metastasis From EGFR-Mutated NSCLC and Prognostic Value of Dynamic Changes in cfDNA Profiles
This is a prospective, open-label, single-arm clinical trial. The aim of this study is to evaluate the efficacy and safety of almonertinib and intrathecal chemotherapy in patients with advanced EGFR mutation positive (EGFRm+)…
- Trial name
- NCT05810350
- Testing
- Aumonertinib 165mg orally once daily and intrathecal chemotherapy with pemetrexed
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Three Gorges Hospital of Chongqing University
Malignant Peritoneal Effusion, Malignant Ascites
Dual-targeting VEGFR1 and PD-L1 CAR-T for Pleural, Peritoneal, or Leptomeningeal Metastases
This is a Phase I, open-label, single-arm, dose-escalation and expansion study designed to evaluate the safety, tolerability, and preliminary antitumor activity of dual-targeting VEGFR1/PD-L1 chimeric antigen receptor (CAR)…
- Conditions
- Malignant Peritoneal Effusion, Malignant Ascites, Serous Cavity Metastatises, Leptomeningeal Metastases
- Trial name
- NCT05477927
- Testing
- Dual-targeting VEGFR1/PD-L1 CAR-T cells
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sichuan University
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Pemetrexed Disodium in the Cerebrospinal Fluid of Patients With Leptomeningeal Metastases
RATIONALE: Pemetrexed disodium may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Studying samples of cerebrospinal fluid and blood from patients with cancer in the laboratory may help…
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00424242
- Testing
- Pemetrexed
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Northwestern University
Leptomeningeal Metastasis
Tomotherapy for Leptomeningeal Metastases
This clinical trial was designed to investigate the efficiency and toxicity of tomotherapy for leptomeningeal metastases.
- Trial name
- NCT04178343
- Testing
- tomotherapy
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Chinese Academy of Medical Sciences
Leptomeningeal Metastasis
Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors
Intrathecal chemotherapy is one of the most important treatment modalities for leptomeningeal metastasis of solid tumors. In the previous retrospective study, it has been proved that concurrent radiotherapy and intrathecal…
- Trial name
- NCT03507244
- Testing
- Pemetrexed, Dexamethasone, Radiotherapy
- Where
- China
- Volunteers
- 34 people
- Sponsor
- The First Hospital of Jilin University
Non Small Cell Lung Cancer Metastatic, Leptomeningeal Metastasis
Study of Osimertinib in Patients with a Lung Cancer with Brain or Leptomeningeal Metastases with EGFR Mutation
Treatment of non-small cell lung cancer (NSCLC) with Epidermal Growth Factor Receptor (EGFR) mutation is mainly based on tyrosine kinase inhibitors (TKIs) targeting EGFR.
- Conditions
- Non Small Cell Lung Cancer Metastatic, Leptomeningeal Metastasis, Brain Metastases, EGFR Activating Mutation
- Trial name
- ORBITAL (NCT04233021)
- Testing
- Osimertinib
- Where
- 36 sites in France
- Volunteers
- 57 people
- Sponsor
- Intergroupe Francophone de Cancerologie Thoracique
Leptomeningeal Metastasis
A Study of the Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal Metastases
The goal of this clinical trial is to learn if the intraventricular injection of Pemetrexed and Nivolumab works to treat refractory non-squamous non-small cell lung cancer with leptomeningeal metastases.
- Trial name
- NCT06901817
- Testing
- Intraventricular Pemetrexed, Intraventricular Nivolumab, Intraventricular Dexamethasone
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Shanghai Cancer Hospital, China
Non-small Cell Lung Cancer, Leptomeningeal Metastasis
A Multi-center Prospective Observational Biomarker Study on EGFRm+ Non-small Cell Lung Cancer Patients With Leptomeningeal Metastasis
Leptomeningeal metastasis (LM) is one of the disastrous events when managing advanced Non-small cell lung cancer (NSCLC) due to a grave prognosis.
- Trial name
- NCT02803619
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Brain Metastases, Adult
Prospective Double Arm Randomized Trial: WBRT Alone and WBRT Plus Silibinin
The occurrence of brain metastases (BMs) is increasing given the availability of a more accurate radiological imaging such as MRI for detecting also small brain lesions and the most effective systemic therapy able to control…
- Trial name
- NCT05793489
- Testing
- Silibinin
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Istituto Clinico Humanitas
Patients With Advanced Non-small Cell Lung Cancer With Meningeal Progression After Osimertinib Treatment
Zorifertinib With Osimertinib for NSCLC With Meningeal Progression
This is a clinical trial that aims to test Zorifertinib when used together with a known drug, Osimertinib. The goal is to learn if this combination is safe and works for people with advanced Non-Small Cell Lung Cancer (NSCLC)…
- Trial name
- NCT07361705
- Testing
- Zorifertinib and Osimertinib Combination Therapy
- Where
- 5 sites in China
- Volunteers
- 42 people
- Sponsor
- Alpha Biopharma (Jiangsu) Co., Ltd.
Leptomeningeal Metastases, Solid Tumors
Combined Intrathecal and Systemic Therapy With Trastuzumab Rezetecan for Leptomeningeal Metastases
This phase II clinical study enrolls patients with leptomeningeal metastases from solid tumors. Participants will receive intrathecal and systemic administration of Trastuzumab Rezetecan.
- Trial name
- ITST-ADC-LM (NCT07833657)
- Testing
- Intrathecal and systemic administration of Trastuzumab Rezetecan
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Jiuda Zhao
Leptomeningeal Metastasis, Pemetrexed
Intrathecal Dual Checkpoint Inhibitor (PD-1 and CTLA-4) in Combination With Pemetrexed for Leptomeningeal Metastasis
This phase I/II study is to evaluate the recommended dose, safety, feasibility, and therapeutic response of intrathecal dual checkpoint inhibitor (targeting PD-1 and CTLA-4 with QL1706) in combination with pemetrexed in patients…
- Conditions
- Leptomeningeal Metastasis, Pemetrexed, PD-1 Inhibitor, CTLA4
- Trial name
- NCT06809530
- Testing
- QL1706 (bispecific antibody targeting PD-1 and CLTA-4), Pemetrexed (Alimta)
- Where
- 5 sites in China
- Volunteers
- 39 people
- Sponsor
- Guangzhou Medical University
Leptomeningeal Metastasis, Lung Neoplasms, Non-Small Cell Lung Cancer
Double-Dose Third-Generation EGFR-TKI Plus Bevacizumab and Intrathecal Chemotherapy for Refractory Leptomeningeal Metastatic NSCLC: A Phase II Study
The goal of this clinical trial is to explore the efficacy and safety of double-dose third-generation EGFR-TKI combined with bevacizumab and intrathecal chemotherapy in treating advanced non-small cell lung cancer (NSCLC)…
- Trial name
- NCT07398599
- Testing
- a combined regimen consisting of double-dose third-generation EGFR-TKI, bevacizumab, and intrathecal chemotherapy in patients
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Meningeal Carcinomatosis
Circulating Tumor Cells and Cytology in Cerebrospinal Fluid of Patients Clinically Suspected for Leptomeningeal Metastases
The purpose of this study is to determine whether the quantitative detection of circulating tumor cells (CTCs) in patients with Epcam expressing tumors can be used compared to standard qualitative method - cytology both in the…
- Trial name
- NCT01713699
- Testing
- lumbar puncture
- Where
- 2 sites in Netherlands
- Volunteers
- 146 people
- Sponsor
- The Netherlands Cancer Institute
Leptomeningeal Metastases
Phase 1 Study of WBRT or PCSI With REYOBIQ for Leptomeningeal Metastases
This Phase 1 study is designed to assess the safety, tolerability, and schedule feasibility of administering Rhenium-186 NanoLiposome (REYOBIQ) at different dosing intervals following whole brain radiotherapy (WBRT) or proton…
- Trial name
- NCT07674693
- Testing
- 186RNL
- Volunteers
- 29 people
- Sponsor
- NYU Langone Health