Clinical trials: Lesion
Ischemic Heart Failure, CABG-patients
hiPSC-CMs-loaded Chitosan Patch to Treat Severe Chronic Ischemic Heart Disease
This is an exploratory study. A total of 16 patients meeting the inclusion and exclusion criteria and awaiting coronary artery bypass grafting (CABG) surgery will be enrolled.
- Trial name
- NCT07471698
- Testing
- HiCM-188 Chitosan Patch, Blank Chitosan Patch
- Where
- China
- Volunteers
- 16 people
- Sponsor
- HELP Therapeutics Co., Ltd.
Desaturation of Blood
Clinical Study of Peripheral Capillary Oxygen Saturation (SpO2): Vital Signs Patch (VSP)
A clinical study designed to determine the accuracy of the peripheral capillary oxygen saturation (SpO2) function of the Vital Signs Patch (VSP) device for measuring blood saturation level.
- Trial name
- NCT01899911
- Testing
- Vital Signs Patch (VSP)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- LifeWatch Services, Inc.
Coronary Artery Disease
Study of the 2.25mm Sirolimus-Eluting Stent in the Treatment of Patients With Coronary Artery Lesions
The main objective of this study is to assess the safety and effectiveness of the sirolimus-eluting Bx VELOCITYTM stent in reducing in-lesion restenosis in patients with de novo native coronary artery lesions.
- Trial name
- NCT00232739
- Testing
- CYPHER Sirolimus-eluting Coronary Stent
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cordis US Corp.
Idiopathic Parkinson Disease
Transdermal Rotigotine User Surveillance Study
This study will be conducted in an observational multiple-cohort design aimed at acquiring clinical, treatment, health status, and economic data. Patients with Parkinson's disease (PD) will be enrolled.
- Trial name
- TRUST (NCT00599339)
- Where
- 211 sites in Czechia, Denmark and 8 more
- Volunteers
- 2,195 people
- Sponsor
- UCB Pharma
Defect of Articular Cartilage
HyaloFAST Trial for Repair of Articular Cartilage in the Knee
The purpose of this study is to evaluate the safety and efficacy of Hyalofast® scaffold with bone marrow aspirate concentrate (BMAC) compared to microfracture in the treatment of symptomatic cartilage defects of the knee.
- Trial name
- FastTRACK (NCT02659215)
- Testing
- Hyalofast, Microfracture
- Where
- 48 sites in United States, Austria and 7 more
- Volunteers
- 200 people
- Sponsor
- Anika Therapeutics, Inc.
Psoriasis
Combining Topical Corticosteroid and LCD Treatment for Localized Plaque Psoriasis
This is a 12 week bilateral study, consisting of 6 weeks of treatment and 6 weeks of follow-up. The purpose of the study is to compare the safety and effectiveness of combining and then following a high potency topical…
- Trial name
- NCT00769184
- Testing
- Corticosteroid, LCD
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NeoStrata Company, Inc.
General Menstrual Discomfort
A Study of the Jovi Patch, Powered by Signal Relief, for the Improvement of General Menstrual Discomfort
This pilot study is testing whether a thin, flexible, drug-free patch called the Jovi Patch (powered by Signal Relief) can help reduce general menstrual discomfort (pain and related symptoms during periods).
- Trial name
- NCT07825558
- Testing
- Jovi Patch
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Signal Relief
Moderate to Severe Plaque-type Psoriasis
Secukinumab Dosage Optimisation in Partial Responders With Moderate to Severe Plaque-type Psoriasis
This study is designed to support the optimal use of secukinumab by providing data to refine guidance on dosing flexibility in patients with psoriasis.
- Trial name
- GAIN (NCT02474069)
- Testing
- Secukinumab
- Where
- 89 sites in Germany
- Volunteers
- 772 people
- Sponsor
- Novartis Pharmaceuticals
Atherosclerosis, Heart Diseases, Coronary
A Clinical Trial to Confirm Safety & Effectiveness of the SYNERGY 4.50 mm and 5.00 mm Stent for Treatment of Atherosclerotic Lesion(s)
EVOLVE 4.5/5.0 is a prospective, single-arm, multi-center observational (standard of care) trial intended to confirm the safety and effectiveness of the SYNERGY 4.50 mm and 5.00 mm Coronary Stent System for the treatment of…
- Conditions
- Atherosclerosis, Heart Diseases, Coronary, Coronary Artery Disease, Cardiovascular Diseases
- Trial name
- NCT03875651
- Testing
- SYNERGY 4.50 mm and 5.0 mm Coronary Stent System
- Where
- 9 sites in United States
- Volunteers
- 100 people
- Sponsor
- Boston Scientific Corporation
Coronary Artery Disease
NeoVas Bioresorbable Coronary Scaffold Registry Study
The NeoVas Bioresorbable Coronary Scaffold Registry Trial is a prospective, multi-center, single arm registry trial based on the NeoVas FIM study which verified the safety and effectiveness of NeoVas initially.
- Trial name
- NCT02305472
- Testing
- NeoVas BCS
- Where
- 27 sites in China
- Volunteers
- 825 people
- Sponsor
- Lepu Medical Technology (Beijing) Co., Ltd.
Lung Lesion(s) Requiring Evaluation
Transbronchial Lung Biopsy Guided by ENB
The purpose of this study is to evaluate the performance and safety of electromagnetic navigation bronchoscopy (ENB) system and system kit (iLungTM SuperNavigator) .
- Trial name
- NCT03628222
- Testing
- ENB-TBLB, X-ray-TBLB
- Where
- 8 sites in China
- Volunteers
- 226 people
- Sponsor
- Changzhou LungHealth Medtech Company Limited
Rosacea
CGB-400 Topical Gel for the Treatment of Inflammatory Lesions of Rosacea
This is a multicenter, randomized, double-blind, vehicle-controlled, parallel design study evaluating the efficacy and safety of CGB-400 Topical Gel for the treatment of inflammatory lesions of rosacea.
- Trial name
- NCT04886739
- Testing
- CGB-400, Vehicle Gel
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- CAGE Bio Inc.
Healthy Volunteers
A Study to Evaluate the Skin Irritation Potential of PBI-100 Topical Cream in Healthy Participants
This is an open-label, single-arm, randomized, evaluator-blinded repeat insult patch testing (RIPT) study wherein test product is applied under an occlusive dressing to the upper back or arm continuously and repeatedly to the…
- Trial name
- NCT04882631
- Testing
- PBI-100 Topical Cream, Positive Control - Sodium laurel sulfate (SLS), PBI-100 Topical Cream, Vehicle
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pyramid Biosciences
Vital Signs
Vital Signs Patch Early Feasibility and Usability Study v1.0
To assess the feasibility and usability of the Vital Signs Patch (VSP) System in the in-patient hospital setting to monitor vital signs using a patch, brain, gateway, and console.
- Trial name
- VSP (NCT02524470)
- Testing
- VSP System - NEHB Configuration, VSP System - PAL Configuration
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- LifeWatch Services, Inc.
Head and Neck Cancer, Squamous Cell Carcinoma of the Oral Cavity or Oropharynx
Phase II Trial of Allovectin-7® for Head and Neck Cancer
The purpose of this clinical trial is to determine if Allovectin-7®, an experimental gene-based immunotherapy, can shrink head and neck tumors.
- Conditions
- Head and Neck Cancer, Squamous Cell Carcinoma of the Oral Cavity or Oropharynx, Head and Neck Neoplasms, Carcinoma of the Head and Neck
- Trial name
- NCT00050388
- Testing
- Allovectin-7®
- Where
- 10 sites in United States
- Sponsor
- Vical
Skin Lesion, Skin Abnormalities
Comparative Study Between CellFX and Electrodessication in Sebaceous Hyperplasia (SH) Lesions
This study is designed as a multi-center, single-blinded, prospective, randomized, study to compare the safety and effectiveness of the CellFX System to the comparator group, Electrodessication for the treatment of SH lesions in…
- Conditions
- Skin Lesion, Skin Abnormalities, Sebaceous Hyperplasia
- Trial name
- NCT04539886
- Testing
- CellFX System, Intralesional Electrodesiccation
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Pulse Biosciences, Inc.
Gram-positive, Skin Infections, Mild Eczema/Dermatoses
A Study to Evaluate Safety, Tolerability and Efficacy of Lytixar™ (LTX-109) on Uncomplicated, Gram-positive, Skin Infection
The purpose of this study is to evaluate the safety and tolerability of Lytixar™ applied topically to uncomplicated skin infections. Three dose levels of Lytixar™ (1%, 2% and 5%) versus placebo will be tested.
- Conditions
- Gram-positive, Skin Infections, Mild Eczema/Dermatoses, Atopic Dermatitis
- Trial name
- NCT01223222
- Testing
- LTX-109
- Where
- 4 sites in Hungary
- Volunteers
- 24 people
- Sponsor
- Lytix Biopharma AS
Coronary Occlusion
Supplemental Study to Evaluate the Safety and Effectiveness of the NovaCross™ Micro-catheter
This study will include up to 60 eligible male and female subjects. The purpose of this trial is to evaluate the safety and effectiveness of the NovaCross™ micro-catheter when used to facilitate crossing of Chronic Total…
- Trial name
- NCT03717675
- Testing
- NovaCross™ Chronic Total Occlusion micro-catheter
- Where
- 3 sites in Israel, Poland and 1 more
- Volunteers
- 40 people
- Sponsor
- Nitiloop Ltd.
High-grade Squamous Intraepithelial Lesion (HSIL)
Evaluation of NWRD09 for HPV-16 Related Cervical HSIL
This is a randomized, double-blind, placebo controlled Phase 2 study to determine the efficacy and safety of NWRD09 administered by intramuscular (IM) injection in adult women with histologically confirmed cervical high grade…
- Trial name
- NCT07712692
- Testing
- NWRD09 Injection
- Where
- 15 sites in China
- Volunteers
- 156 people
- Sponsor
- Newish Biotech (Wuxi) Co., Ltd.
Dental Caries
Effect of Curodont Repair or Placebo on the Remineralisation in Patients With Class 5 Carious Lesions
The purpose of this study is to evaluate the therapeutic benefit of Curodont Repair for the treatment of early buccal carious lesions compared to placebo.
- Trial name
- NCT02020681
- Testing
- Curodont Repair, Fluoride
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Credentis AG
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