Clinical trials: Lesion
Biliary Stricture, Pancreas Cancer
Volumetric Laser Endomicroscopy's (VLE) Diagnostic Accuracy Validation Study: Impact on Clinical Management Study
The purpose of this study is to assess the interobserver agreement (IOV) for pancreatico-biliary Volumetric Laser Endomicroscopy (VLE) de-identified clips using the new VLE criteria.
- Conditions
- Biliary Stricture, Pancreas Cancer, Cholangiocarcinoma, Bile Duct Cancer
- Trial name
- VLE-IOV (NCT03951324)
- Testing
- Interobserver agreement or Interrater agreement
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Innovative Digestive Health Education and Research Inc
White Spot Lesion
Effect of Different Remineralization Gels
The aim of the study is to treat white spot lesions that occur after orthodontic treatment. Different gels will be used for remineralization. The study will consist of 45 people between the ages of 15-18.
- Trial name
- NCT05868603
- Testing
- Remineralization gel
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Marmara University
Ventricular Septal Defects, Persistent Common Atrioventricular Canal
Optimal Timing for Repair of Left to Right Shunt Lesions
The purpose of this study is to determine the optimal timing for repair of left-to-right shunt lesions such as ventricular septal defects and atrioventricular canals.
- Trial name
- NCT00229827
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Healthcare of Atlanta
Atopic Dermatitis
Efficacy and Safety Study of the Use of Benralizumab for Patients With Moderate to Severe Atopic Dermatitis
The purpose of the study is to compare the efficacy and safety of benralizumab versus placebo and to compare benralizumab dosing regimens during extension period.
- Trial name
- NCT04605094
- Testing
- Benralizumab
- Where
- 51 sites in United States, Australia and 6 more
- Volunteers
- 194 people
- Sponsor
- AstraZeneca
Coronary Artery Disease, Myocardial Ischemia
EXCEL-II Stent Vesus EXCEL Stent to Treat the Patients With de Novo Coronary Artery Lesions.
The purpose of this Randomized Study to evaluate the safety and efficacy of the Excel-II DES compared to the EXCEL DES in the treatment of patients with de novo coronary artery lesions.
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Coronary Disease, Heart Diseases
- Trial name
- CREDIT-II (NCT02057978)
- Testing
- EXCEL DES implatation, EXCEL-II DES implantation
- Where
- China
- Volunteers
- 419 people
- Sponsor
- JW Medical Systems Ltd
Cerebrospinal Fluid Leak
Evaluate the Safety and Efficacy of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery
The objective of the study is to clinically assess the safety and effectiveness of LIQOSEAL® as a means of reducing intra- as well as post-operative CSF leakage in patients undergoing elective cranial intradural surgery with a…
- Trial name
- ENCASE-II (NCT04086550)
- Testing
- LIQOSEAL, DuraSeal, Adherus
- Where
- 17 sites in United States, Austria and 5 more
- Volunteers
- 228 people
- Sponsor
- Polyganics BV
Post-Lumbar Puncture Headache
Epidural Blood Patch on the Resolution of Postdural Puncture Headache (PDPH)
The purpose of this study is to address the question, "What is the volume of blood for injection at epidural blood patch that most effectively relieves post-dural puncture headache?"
- Trial name
- NCT00373074
- Testing
- Epidural Blood Patch
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Coronary Artery Calcification, Angioplasty
CAlcified Lesion Intervention Planning Steered by OCT.
Calcified lesions are very frequent among coronary artery disease stenotic lesions. The prevalence of calcifications ranges from 30 to 40% (by angiography evaluation) but is higher when analyzed by intra coronary imaging.
- Trial name
- CALIPSO (NCT05301218)
- Testing
- angioplasty
- Where
- 14 sites in France
- Volunteers
- 140 people
- Sponsor
- Institut Mutualiste Montsouris
Kawasaki Disease
Efficacy of Immunoglobulin Plus Infliximab for the Early Regression of Coronary Artery Lesion in Kawasaki Disease
This study evaluates the efficacy of the addition of infliximab to conventional initial treatment (intravenous immunoglobulin [IVIG] plus aspirin) in early regression of coronary artery lesion in patients with Kawasaki disease…
- Trial name
- NCT04535518
- Testing
- IVIG, Aspirin, Infliximab
- Where
- 5 sites in China
- Sponsor
- Children's Hospital of Fudan University
Prostate Cancer Adenocarcinoma
Hypofractionated Focal Lesion Ablative Microboost in prostatE Cancer
The hypo-FLAME study is a multicenter phase II study (n=100) to investigate whether a focal SBRT boost to the MRI-defined macroscopic tumor volume is feasible and associated with acceptable toxicity in addition to whole gland…
- Trial name
- Hypo-FLAME (NCT02853110)
- Testing
- Hypo-FLAME study
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 100 people
- Sponsor
- UMC Utrecht
Chronic Granulomatous Diseases (CGD) and Liver Lesions
Radiofrequency Ablation for Liver Abscesses From Chronic Granulomatous Disease
Background: Abscesses are a pocket of infection in an organ or tissue. Patients with a disease called chronic granulomatous disease (CGD) often develop these abscesses.
- Trial name
- NCT01851460
- Testing
- Cool-tip RF Ablation System
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chemotherapy-induced Peripheral Neuropathy
Capsaicin 179 mg Patch Versus Oral Duloxetine in Patients With Chemotherapy-induced Peripheral Neuropathy
Chemotherapy induced peripheral neuropathy (CIPN) is a frequent and disabling complication of systemic chemotherapy, particularly with oxaliplatin or taxanes.
- Trial name
- CAPNEUCHIM (NCT05840562)
- Testing
- Capsaicin, Duloxetine
- Where
- 11 sites in France
- Volunteers
- 274 people
- Sponsor
- Institut Cancerologie de l'Ouest
Diabetic Foot Ulcers
Wound Dressing Patch with Kelulut Honey-Infused Alginate (Tri-Gnate Alginate) for Effective Wound Care Management
The main aim of this study to effectiveness of dressing patch with Kelulut honey (Tri-Gnate Alginate) in promoting wound healing compared to conventional treatments (standard wound dressing + bactigras) and other types of…
- Trial name
- NCT06873646
- Testing
- Tri-Gnate Alginate Dressing, Dressing product from Manuka honey, Bactigras + Dermacyn
- Where
- Malaysia
- Volunteers
- 110 people
- Sponsor
- Mohd Khairul Zul Hasymi Firdaus
Cartilage Injury, Knee Injuries
7T MRI to Evaluate Cartilage Defects in the Knee
The investigators propose to prospectively evaluate the accuracy of a novel 7-Tesla (7T) knee MRI protocol for the detection and grading of cartilage lesions in the knee, which is a significant limitation of current MRI…
- Conditions
- Cartilage Injury, Knee Injuries, Arthropathy of Knee, Cartilage Damage
- Trial name
- NCT04118023
- Testing
- 7 Tesla Magnetic Resonance Imaging Test
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- The Methodist Hospital Research Institute
Dental Restoration Failure of Marginal Integrity
Outcomes of Restoring Untreated and SDF-treated Dentine Caries Lesions in Primary Teeth of Preschool Children
The primary objective of this proposed clinical study is to compare the success rates of ART restorations placed in untreated and SDF-treated dentine caries lesions in primary teeth.
- Trial name
- NCT03657862
- Testing
- application of 38% silver diamine fluoride solution
- Where
- China
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dental Cervical Non-carious Lesion
Glass Hybrid Versus Composite Restorations of Non-carious Cervical Lesions
A glass hybrid restorative system (EQUIA forte) clinically compared to a composite resin based material (Clearfil SE Bond, Filtek Supreme XT) for the treatment of dental non-carious cervical lesions.
- Trial name
- NCT02631161
- Testing
- Equia Forte, Filtek Supreme XT/Clearfil SE Bond
- Where
- Germany
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Oral Squamous Cell Carcinoma
Developing an In-vitro Diagnostic Risk-Stratification Test for Oral Cancer
The purpose of this study is to verify the discriminatory value of previously identified salivary transcriptome and proteome markers for oral squamous cell cancer in an intended use population of patients with oral lesions…
- Trial name
- NCT01587573
- Testing
- saliva collection prior to clinically driven oral biopsy
- Where
- 5 sites in United States
- Volunteers
- 370 people
- Sponsor
- PeriRx
Lung Biopsy
Effect of Autologous Blood Patch Injection Versus BioSentry Hydrogel Tract Plug in the Reduction of Pneumothorax Risk Following Lung Biopsy Procedures
The purpose of this study is to compare two methods that are currently used at the end of a CT guided lung biopsy to close the hole on the surface of the lung in order to minimize the chance of air leaking out of the hole.
- Trial name
- NCT02224924
- Testing
- ABPI, BioSentry (formerly known as Bio-Seal) hydrogel Tract Plug
- Where
- 2 sites in United States
- Volunteers
- 454 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pancreatic Cyst Fluid
Pancreatic Cyst Fluid Glucose: New Armamentarium in the Diagnosis of Mucinous Pancreatic Cystic Lesion
All participants undergoing radiological imaging and found to have pancreatic cyst of size > 2cm will be subjected to EUS (Endoscopic ultrasound) examination and cystic fluid will be aspirated for analysis, including cystic fluid…
- Trial name
- NCT05962723
- Testing
- EUS
- Volunteers
- 30 people
- Sponsor
- Asian Institute of Gastroenterology, India
Atypical Nevi, Melanoma
Pilot Study Evaluating Sulforaphane in Atypical Nevi-Precursor Lesions
This is a pilot study to see if oral administration of freeze dried, powdered broccoli sprouts have any effect on whether moles end up becoming melanoma.
- Trial name
- NCT01568996
- Testing
- broccoli sprout extract - sulforaphane (BSE-SFN)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- John Kirkwood
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