Clinical trials: Lesion
Primary Progressive Multiple Sclerosis
Effect of Ocrelizumab on Cortical Lesion Accumulation in Patients With PPMS (ORATORIO-Cortical)
The goal of this non-interventional, observational study is to determine whether cortical pathology can be slowed down by use of ocrelizumab.
- Trial name
- ORATORIO-Cort (NCT05974839)
- Testing
- Ocrelizumab
- Where
- United States
- Volunteers
- 732 people
- Sponsor
- State University of New York at Buffalo
Ischemic Stroke
A Phase 3 Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke
This Phase 3 study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke.
- Trial name
- MASTRE-3 (NCT07645586)
- Testing
- LNM-navigated cTBS
- Where
- China
- Volunteers
- 584 people
- Sponsor
- Beijing Tiantan Hospital
Post-operative Air Leaks
Observational Study of TissuePatch SF in Prevention of Air Leaks Following Lung Resection
Post-market, observational study to assess effectiveness of TissuePatch SF in managing/preventing air leaks after lung resection.
- Trial name
- NCT06934486
- Testing
- TissuePatch Sealant Film
- Volunteers
- 250 people
- Sponsor
- C. R. Bard
Inflammatory Bowel Disease
Colon Capsule Endoscopy in Children
The incidence of Inflammatory Bowel Diseases (IBD) is in a continuous progression both in adults as in children. The colonoscopy is considered as the gold standard exam for the diagnosis and the follow-up of the patients…
- Trial name
- VICCOINBODI (NCT02129972)
- Testing
- Colon videocapsule endoscopy (PillCam colon 2)
- Where
- 7 sites in France
- Volunteers
- 52 people
- Sponsor
- Hospices Civils de Lyon
Skin Cancer
DermaSensor Study of Primary Care Physician Use of Elastic-Scattering Spectroscopy (ESS) on Skin Lesions Suggestive of Skin Cancer
The purpose of this study is to evaluate the clinical validity of the proprietary DermaSensor Elastic Scattering Spectroscopy (ESS) device and classifier algorithm to support assessment of skin lesions suggestive of melanoma…
- Trial name
- DERM-SUCCESS (NCT06690086)
- Testing
- Lesion biopsy, DermaSensor Device Use
- Where
- United States
- Volunteers
- 1,028 people
- Sponsor
- DermaSensor, Inc.
Breast Diseases
To Evaluate the Efficacy and Safety of LuminoMark Injection in Patients With Nonpalpable Breast Lesions(Phase 3)
This study is a multicenter, Randomized, Open-label, Parallel, Phase 3 Clinical Trial in 8 weeks for screening, once Investigational product injection, Follow up visit.
- Trial name
- NCT04606329
- Testing
- LuminoMark inj.(Conc. for fluorescence), Charcotrace Inj.
- Where
- South Korea
- Volunteers
- 109 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
White Matter Lesions, Postural Instability Gait Disorders
White Matter Pathology in Parkinson's Disease (PD)
The relationship between WM lesions (WM) and Postural Instability Gait Disorders (PIGD-PD)in Parkinson's disease patients is largely unknown.
- Trial name
- NCT01039831
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Common Warts, Plantar Warts
Salicylic Acid Wart Patch for the Treatment of Common Warts and Plantar Warts
Common and plantar warts are a type of skin lesion caused by infection with the human papilloma virus. The incidence of warts is relatively high, with an estimated few to several per cent of the adult population affected.
- Trial name
- NCT06958237
- Testing
- salicylic acid wart patches
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Langsteiner sp. z o.o.
Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU)
Safety and Preliminary Efficacy of TrophiPatch, an Adipose-Derived Stromal Cell Patch for Chronic Leg Ulcers
This study aims to evaluate the safety and effectiveness of an experimental biological dressing called TrophiPatch, applied to adults with chronic leg ulcers of diabetic or vascular orign.
- Trial name
- RESCUE-PATCH (NCT07048054)
- Testing
- TrophiPatch: allogeneic adipose-derived stromal cell patch
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Nicolò Brembilla
Arteriovenous Fistula
Paclitaxel-Coated Balloon for the Treatment of AVF
To evaluate the safety and efficacy of the Zylox Drug Coated Balloon (DCB) for treatment of subjects presenting with de novo or non-stented restenotic obstructive lesion of native arteriovenous dialysis fistulae (AVF) in the…
- Trial name
- AVF (NCT05088083)
- Testing
- Paclitaxel-Coated Percutaneous Transluminal Angioplasty (PTA) Balloon
- Volunteers
- 143 people
- Sponsor
- Zhejiang Zylox Medical Device Co., Ltd.
Pulmonary Hypertension, Pulmonary Arterial Hypertension
The Qutenza Patch as Treatment for Disabling Treprostinil (Remodulin) Infusion Site Pain
Subcutaneous treprostinil (Remodulin) is effective therapy for pulmonary arterial hypertension, a life threatening disease of the lung blood vessels.
- Trial name
- NCT01260454
- Testing
- Qutenza (8% capsaicin)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Rochester
Tear; Knee, Cartilage, Articular
Clinical Trial for the Regeneration of Cartilage Lesions in the Knee
The purpose of this study is to investigate the efficacy of an engineered cartilage transplant (N-TEC) in comparison to a cell-activated matrix (N-CAM) for the treatment of articular cartilage lesions in the knee.
- Trial name
- NosetoKnee2 (NCT02673905)
- Testing
- Tissue Engineered Product
- Where
- 5 sites in Croatia, Germany and 2 more
- Volunteers
- 108 people
- Sponsor
- University Hospital, Basel, Switzerland
Psoriasis Vulgaris, Inflammation
The Efficacy of Topical Formulation Containing Ciplukan (Physalis Angulata Linn.) on Psoriasis Vulgaris Lesions
Psoriasis vulgaris is a chronic inflammatory skin disease mediated by the immune system, with a complex pathogenesis that requires long-term therapy.
- Trial name
- NCT06887322
- Testing
- Ciplukan, Bethametasone valerate 0,1% cream
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Padjadjaran
Spinal Cord Injury, Acute, Spinal Cord Injury at C4 Level With Complete Lesion
Safety and Exploratory Efficacy of Transplantation Therapy Using PSA-NCAM(+) NPC in AIS-A Level of Sub-acute SCI
This study intends to evaluate the safety and exploratory efficacy of transplantation therapy using neural precursor cells (PSA-NCAM(+) NPC) derived from the human embryonic stem cell line for the treatment of paralysis and other…
- Conditions
- Spinal Cord Injury, Acute, Spinal Cord Injury at C4 Level With Complete Lesion, Spinal Cord Injury at C5-C7 Level With Complete Lesion
- Trial name
- SB-SCI-001 (NCT04812431)
- Testing
- Neural precursor cells derived from human embryonic stem cell line
- Where
- 2 sites in South Korea
- Volunteers
- 5 people
- Sponsor
- S.Biomedics Co., Ltd.
Polyposis
Endocuff for Surveillance of Serrated Polyposis Syndrome
Serrated Polyposis Syndrome (SPS) is a high-risk condition for colorectal cancer (CRC). SPS patients have a cumulative CRC risk of 1.9% in 5 years despite a strict endoscopic surveillance in specialized centers.
- Trial name
- NCT02592603
- Testing
- Endocuff-assisted Colonoscopy
- Where
- Spain
- Volunteers
- 125 people
- Sponsor
- Hospital Clinic of Barcelona
Atherosclerotic Lesions in the Aortorenal Ostium
A Prospective, Multi-center, Single Arm Study Evaluating the Express™ Renal Premounted Stent System in the Treatment of Atherosclerotic Lesions in the Aortorenal Ostium.
The purpose of this study is to demonstrate superior 9-month binary restenosis rate of the Express™ Renal Premounted Stent System as compared to an Objective Performance Criterion representative of PTRA, for atherosclerotic…
- Trial name
- RENAISSANCE (NCT00597142)
- Testing
- Express™ Renal Premounted Stent System
- Where
- 14 sites in United States
- Volunteers
- 100 people
- Sponsor
- Boston Scientific Corporation
Dental Caries
Remineralizing Efficacy of Grape Seed Extract in Management of White Spot Lesion in Post Orthodontic Treated Patients.
This clinical trial will be conducted to compare the efficacy of grape seed extract oil versus sodium fluoride mouth wash in the management of remineralization in adult patients with white spot lesion over six months.
- Trial name
- NCT04357093
- Testing
- Grape seed extract mouthwash, Sodium fluoride mouthwash
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Coronary Artery Disease, Coronary Artery Stenosis
First in Man Study of the DREAMS 2nd Generation Drug Eluting Absorbable Metal Scaffold (BIOSOLVE-II)
BIOSOLVE-II is a prospective, international, multicenter, First in Man study. The purpose of this study is to assess the safety and clinical performance of the drug eluting absorbable metal scaffold (DREAMS 2nd Generation).
- Trial name
- BIOSOLVE-II (NCT01960504)
- Testing
- Percutaneous Coronary Intervention (DREAMS) stenting
- Where
- 13 sites in Belgium, Brazil and 6 more
- Volunteers
- 123 people
- Sponsor
- Biotronik AG
Coronary Artery Disease
Hydroxyapatite Active Pro Healing Clinical Trial Program
The purpose of this first feasibility study is to evaluate the performance of Vesta™ \& VestaCOR™ (Hydroxy-Apetite coated GenX) stent in de novo native coronary artery lesions.
- Trial name
- HApFIM (NCT00474084)
- Testing
- Intravascular Coronary Stent
- Volunteers
- 70 people
- Sponsor
- BioSync Scientific Pvt. Ltd.
Smokers
Oral Mucosal Lesions Among Smokers in an Egyptian Population Study.
This cross-sectional study will assess the prevalence of oral changes among smokers in an Egyptian cohort (patients attending to the hospital of Faculty of Dentistry - Cairo University), aiming that this study can serve as a…
- Trial name
- NCT03299634
- Testing
- printed questionnaire
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- Cairo University
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