Clinical trials: Lesion of Brain
Epilepsy
Pilot Study to Evaluate MR-guided Laser Ablation of Focal Lesions in Patients With Medically Refractory Partial Epilepsy
To investigate whether MR-guided laser induced thermal therapy in patients diagnosed with focal lesional epilepsy using the Visualase Thermal Therapy System is both a feasible and safe minimally invasive technique for control of…
- Trial name
- NCT01703143
- Testing
- Laser ablation
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Mayo Clinic
Cerebral White Matter Lesions
MRI,Gene And Cognitive Performance Study of Patients With Cerebral White Matter Lesions(WMLs)
The purpose of this study is:1)to observe topological organization in brain structural and functional networks in cerebral white matter lesion patients and to evaluate the association between impairment of cognitive function and…
- Trial name
- NCT02276976
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wei Wang
Visual Field Defect, Stroke
Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training
The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual…
- Conditions
- Visual Field Defect, Stroke, Hemianopia, Quadrantanopia
- Trial name
- VIBRANT (NCT07105358)
- Testing
- transcranial random noise stimulation (tRNS), Perceptual learning-based training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Georgetown University
Parkinson's Disease
A Study to Compare the Adhesiveness of 2 Different Rotigotine Patches Used for the Treatment of Parkinson's Disease
The primary objective of the study is to compare the adhesiveness of 2 different patch formulations of Rotigotine using the largest patch size of 40 cm^2, under the assumption that both patch formulations show similar…
- Trial name
- NCT02230904
- Testing
- Rotigotine (Test product PR 2.3.1), Rotigotine (Reference product PR 2.1.1)
- Where
- 11 sites in Germany
- Volunteers
- 57 people
- Sponsor
- UCB BIOSCIENCES GmbH
Motor Skill Acquisition in Healthy Older Adults
Training in Combination With Non-invasive Brain Stimulation
The goal of this study is to investigate the impact of non-invasive brain stimulation on motor skill acquisition in healthy individuals.
- Trial name
- TrainStim (NCT07059533)
- Testing
- Verum
- Where
- Switzerland
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Friedhelm Hummel
Delirium, Fatigue
The Impact of Non-motor Symptom on the Outcome of Stroke Subjects
The most common symptoms of stroke were focal weakness, hemiparesis, speech disturbance, diplopia and ataxia. Beside those symptoms, there are still many symptoms occurring after stroke, which may affect the life quality of…
- Conditions
- Delirium, Fatigue, Depression, Insomnia
- Trial name
- NMCHYIS (NCT06854497)
- Testing
- MMSE (Mini-Mental State Examination),NIHSS (NIH Stroke Scale) and mRS (Mordified Rankin Score), Confusion Assessment Methods (CAM), PSQI Pittsburgh Sleep Quality Index, Respiratory polygraphy
- Where
- Taiwan
- Volunteers
- 1,500 people
- Sponsor
- Chiayi Christian Hospital
Alzheimer's Disease
Compliance and Tolerability of Rivastigmine Transdermal Patch 10 cm² in Patients With Probable Alzheimer's Disease.
This study will evaluate compliance, tolerability, safety, efficacy and caregiver burden of rivastigmine patch 10 cm² treatment in people with Alzheimer's disease (MMSE 10-26) initiating therapy for the first time with a…
- Trial name
- CARE (NCT00731224)
- Testing
- Rivastigmine transdermal patch
- Where
- 40 sites in Australia, Malaysia and 3 more
- Volunteers
- 380 people
- Sponsor
- Novartis Pharmaceuticals
Cerebral Palsy
Impact of Early Intensive Stimulation on Bimanual Function in Infants at High Risk of Unilateral CP (BB-BIM)
The aim of this study is to measure the impact of early bimanual stimulation in babies with clinical signs of underuse of one hand. The observation focuses on the developmental curve of hands use.
- Trial name
- BB-BIM (NCT04899284)
- Testing
- Early Intensive Bimanual Stimulation
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Médico-Chirurgical de Réadaptation des Massues Croix Rouge Française
Lung Carcinoma Metastatic to the Brain
MRI Perfusion on T1 and T2 Brain Lesion(s)
This study therefore aims to assess current treatment recommended by scientific societies [ 6-13 ] , brain MRI with injection of contrast for the diagnosis and monitoring of brain metastases .
- Trial name
- METAPERF (NCT02250755)
- Testing
- MRI T1 T2 sequences
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Parkinson's Disease
Compensatory Mechanisms in Parkinson Disease (PD)
Parkinson's disease is characterized by a large number of non motor, especially neuropsychiatric, signs. Their pathophysiology is complex but the role of dopaminergic and serotoninergic systems dysfunction is suggested by several…
- Trial name
- CompensationPD (NCT02038608)
- Testing
- PET
- Where
- France
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Carotid Artery Stenosis
Balloon Guide Catheter Combined With Filter Protection for Carotid Artery Stenting
This multicenter, randomized, controlled trial evaluates a combined embolic protection strategy during carotid artery stenting (CAS). Carotid artery stenosis is a major cause of stroke.
- Trial name
- ANGEL-BEACON (NCT07247864)
- Testing
- Balloon Guide Catheter, Distal Filter Protection Device
- Where
- China
- Volunteers
- 296 people
- Sponsor
- Beijing Anzhen Hospital
Trauma, Brain, Mass Lesion
Assess the Clinical Effectiveness in AI Prioritising CT Heads
Non-Contrast Computed Tomography (NCCT) of the head is the most common imaging method used to assess patients attending the Emergency Department (ED) with a wide range of significant neurological presentations including trauma…
- Conditions
- Trauma, Brain, Mass Lesion, Skull Fractures, Hemorrhage, Intracranial
- Trial name
- ACCEPT (NCT06027411)
- Testing
- qER (qER EU 2.0)
- Where
- 4 sites in United Kingdom
- Volunteers
- 16,800 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Alzheimer's Dementia
Tolerability of Rivastigmine Before and After Switching From Oral Formulation to Transdermal Patch in Alzheimer's Dementia
This phase IIIb study is intended to implement a consistent treatment way for switching to Exelon transdermal patch from oral formulation of rivastigmine to stress the importance of (1) advantages of transdermal patch over…
- Trial name
- NCT01585272
- Testing
- ENA713
- Where
- 4 sites in Taiwan
- Volunteers
- 121 people
- Sponsor
- Novartis Pharmaceuticals
Parkinson Disease
A Randomized, Open-Label, Crossover Study to Evaluate the Pharmacokinetic Profiles of Rotigotine After a Single Dose of LY03003 (28 mg) Versus After a Week of Daily NEUPRO® Transdermal Patch (4 mg Every 24 Hours) in Healthy Volunteers
This is a randomized, open-label, 2-sequence, 2-treatment cross-over study in healthy adult subjects. Rotigotine PK profiles will be obtained from all subjects after both a single dose of 28 mg LY03003 and 1 week of 4 mg q24h…
- Trial name
- NCT04384666
- Testing
- LY03003 (rotigotine extended release microspheres for intramuscular [IM] injection), Neupro 4 mg / 24 Hr. Transdermal Patch
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Hyperprolactinemia, Endometriosis
Endometriosis Patients Undergoing Quinagolide Treatment
Dopamine agonists, such as quinagolide, are able to act on the VEGFR-2 blocking antibodies, diminishing Vascular Endothelial Growth Factor effect on angiogenesis in human endometriotic lesions.
- Trial name
- NCT00625950
- Testing
- ENDOMETRIAL BIOPSY
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Multiple Sclerosis, Clinically Isolated Syndrome
Evaluation of an Automatic Segmentation Software (Pixyl.Neuro) to Track Lesions in Multiple Sclerosis Patients Via Cerebral MRI
Using an automatic software tool, Pixyl.Neuro, to conduct a retrospective analysis (detection of lesions + segmentation of images + tracking over time) of cerebral MRI images acquired during a prospective study of patients…
- Trial name
- PIXCIS (NCT03438357)
- Testing
- Analysis of cerebral MRI with automatic segmentation software
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Late Infantile Metachromatic Leukodystrophy
Imaging Study of the White Matter Lesions in Children With Metachromatic Leucodystrophy
High-field MRI and diffusion tensor imaging with 3D reconstruction of the myelin tracks, in combination with multivoxel proton spectroscopy, will allow to precise more accurately the evolution of the white matter lesions in…
- Trial name
- HCIT-MLD (NCT01325025)
- Testing
- High-field MRI (3 Teslas)
- Where
- 3 sites in France
- Volunteers
- 29 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Tumor
18F-DOPA-PET in Non-tumoral and Tumoral Brain Lesions
Background: 3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine (FDOPA) positron emission tomography (PET) can identify well low and high grade brain tumors.
- Trial name
- FDOPA (NCT04306484)
- Testing
- FDOPA-TEP
- Where
- France
- Volunteers
- 74 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Intracranial Aneurysm, Wide Neck Aneurysm, Large Neck Aneurysm, Lesion
Clinical Study of Merlin's DiVeRt - Vascular Reconstruction Device and Delivery System
The objective of the proposed investigation is to assess the safety and effectiveness of the Merlin's DiVeRt system for the treatment of intracranial lesions.
- Trial name
- NCT04589585
- Testing
- DiVeRt
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Merlin MD Pte Ltd
Stroke, Acute, Traumatic Brain Injury
Natural Evolution of Muscle Structure and Stiffness Following Brain Lesion
We propose to carry out a single center, prospective, interventional trial to assess the natural evolution of lower limb muscle structure and muscle stiffness of hemiparetic patients following brain damage.
- Trial name
- Navomuss (NCT06718608)
- Testing
- imaging
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain