Clinical trials: Leukocyte Disorders
Chemotherapy-Induced Neutropenia
Study to Evaluate the Safety, Tolerability and PK of EC-18 After Oral Administration in Healthy Volunteers
This study is a Dose block-randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Dose Escalation, Phase I clinical trial to assess the safety, tolerability and pharmacokinetics of single-dose and…
- Trial name
- NCT02532712
- Testing
- EC-18
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Enzychem Lifesciences Corporation
Acute Tonsillitis, Peritonsillar Cellulitis
Microbiology of Severe Acute Tonsillitis, Peritonsillar Cellulitis, and Infectious Mononucleosis
Prospective, observational study of the microbiology of patients referred to a tertiary care center with severe acute tonsillitis, peritonsillar cellulitis, or infectious mononucleosis.
- Conditions
- Acute Tonsillitis, Peritonsillar Cellulitis, Infectious Mononucleosis
- Trial name
- NCT02715037
- Testing
- Throat swabbing
- Where
- Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Tejs Ehlers Klug
Solid Tumors
A Study Using White Blood Cells From Healthy Donors To Treat Solid Cancers
Background \& Rationale: About 75% of US population living today will not die of cancer. There has been a recent report of a colony of cancer-resistant mice developed from a single male mouse that unexpectedly survived challenges…
- Trial name
- NCT00900497
- Testing
- White Blood Cells/Granulocytes
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Dipnarine Maharaj
Asthma
Inflammation Following Mepolizumab and Oral Corticosteroids in Asthma
The aim of the project is to study the persistence of inflammation after addition of an interleukin-5 (IL-5) blocker in severe eosinophilic asthma as a study of untreated pathways in these patients.
- Trial name
- MAPLE (NCT03610685)
- Testing
- Prednisolone
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Infections, Pneumonia
Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)
The Hyper IgE Syndromes (HIES) are primary immunodeficiencies resulting in eczema and recurrent skin and lung infections. Autosomal dominant Hyper IgE syndrome (AD-HIIES; Job's syndrome) is caused by STAT3 mutations, and is a…
- Conditions
- Infections, Pneumonia, Immune System Diseases, STAT3 Transcription Factor
- Trial name
- NCT00006150
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Gene Expression, Gene Expression Profiling
Host Response to Infection by Direct Analysis of Leukocyte Single Cell-type Gene Expression/transcript Abundance, Direct LS-TA
Febrile illness is a common condition, particularly among young patients and it is crucial to have an early triage of patients according to various aetiologies to enable appropriate treatment.
- Conditions
- Gene Expression, Gene Expression Profiling, Infection, Viral Diseases
- Trial name
- NCT06838780
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Multiple Sclerosis
Sunlight-mediated Inter-organ Leukocyte Exchange
Ultraviolet B (UVB) irradiation induces regulatory immune cell types that may transmigrate from the skin to the blood and to the central nervous system and exert regulatory effects.
- Trial name
- SMILE (NCT05627609)
- Testing
- 311 nm narrowband UVB irradiation
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Cancer of Cervix
The Correlation Between the Haplotype of Human Leukocyte Antigen (HLA) and Human Papillomavirus
Cervical cancer is the most frequent neoplasm of women in Taiwan and in the world. It influences about 2,700 women with about 1,000 women dying of cervical cancer each year and in Taiwan.
- Trial name
- NCT00154479
- Where
- Taiwan
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Chronic Granulomatous Disease (CGD), X-Linked Severe Combined Immune Deficiency (XSCID)
Evaluation of Patients With Immune Function Abnormalities
This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation.
- Conditions
- Chronic Granulomatous Disease (CGD), X-Linked Severe Combined Immune Deficiency (XSCID), Leukocyte Adhesion Deficiency 1 (LAD), Graft Versus Host Disease (cGvHD)
- Trial name
- NCT00128973
- Where
- United States
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Intra-bony Pockets, Periodontitis
Biologicals in Management of Intra-Bony Defects
The aim is of this study is to evaluate and compare the effects (clinical and radiological) of different biomaterials on the repair of bone defects around the teeth.
- Trial name
- NCT07292870
- Testing
- Minimally invasive surgical treatment of the intra-bony defects, Use of the xenograft Bio-Oss® Collagen during the surgery, Use of enamel matrix derivative (Emdogain®)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sickle Cell Disease
Blood Collection for Research Related to Certain Diseases Involving Blood Vessels
The collection of human specimens from both patients and healthy volunteers is necessary for the development of laboratory assays to further basic and clinical research studies.
- Trial name
- NCT00047996
- Where
- 2 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Mucin B5 rs (35705950) Gene Polymorphism in Interstitial Lung Diseases
MucinB5 Gene Polymorphism and Leucocytes Telomere Length in Interstitial Lung Diseases
This is an observertional study aimed at Study the association between Mucin B5 rs (35705950) gene polymorphism and Leucocytes telomere length in relation to interstitial lung diseases.
- Trial name
- NCT06498141
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Epstein-Barr Virus Infection
A Study of an Epstein-Barr Virus (EBV) Candidate Vaccine, mRNA-1189, in 10- to 30-Year-Old Healthy Adolescents and Adults
The main objective of Part A of this trial is to evaluate the safety and reactogenicity of mRNA-1189 in 18- to 30-year-old healthy adults, the main objective of Part B is to evaluate the safety and reactogenicity of mRNA-1189 in…
- Trial name
- NCT05164094
- Testing
- mRNA-1189
- Where
- 65 sites in United States
- Volunteers
- 867 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Alveolar Bone Loss
Comparison of Autogenous Bone Graft and Screw Tent-Pole Technique on Atrophic Mandible
The purpose of the present study was to assess the effect of injectable platelet-rich fibrin (i-PRF) enriched with allograft on alveolar bone regeneration when compared with autogenous block bone graft, in the same participants.
- Trial name
- NCT04133090
- Testing
- Autogenous block bone graft, i-PRF enriched allograft material+ screw tent pole technique
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Ege University
Eosinophilic Esophagitis
Comparing Anesthetic Techniques in Children Having Esophagogastroduodenoscopies
The purpose of this research study is to compare the safety and effectiveness of three commonly used techniques for delivering anesthesia during a procedure known as esophagogastroduodenoscopy.
- Trial name
- NCT02038894
- Testing
- Intubated with Sevoflurane (IS), Intubated with Propofol (IP), Zofran - no intubation
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Asthma Persistent, Asthma, Allergic
Identifying Serum Cytokine Profiles of Distinct Inflammatory Phenotypes in Severe Asthma
The aim of this study is to determine and compare serum cytokine levels of six different severe asthma inflammatory phenotypes differentiated by their atopy, peripheral eosinophilia and/or chronic rhinosinusitis and/or nasal…
- Conditions
- Asthma Persistent, Asthma, Allergic, Eosinophilic Asthma, Chronic Rhinosinusitis (Diagnosis)
- Trial name
- NCT03563521
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Pemphigus, Bullous Pemphigoid
Human Leukocyte Antigen Class II (DRB1 and DQB1) Alleles and Haplotypes Frequencies in Patients With Pemphigus Vulgaris Among the Russian Population
Pemphigus is a rare autoimmune life-threatening blistering condition affecting skin and mucous membranes. Pemphigus belongs to a family of polygenic disorders.
- Conditions
- Pemphigus, Bullous Pemphigoid, Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses
- Trial name
- NCT05284929
- Testing
- A single blood sample for HLA typing
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sechenov University
Parkinson Disease
LRRK2 G2385R Leucocyte and Urine Biomarker Study
Given the emerging evidence on LRRK2-related biomarkers, this project will focus on identifying leucocyte and urine biomarkers that are altered by the LRRK2 G2385R variant, and investigating the effects of LRRK2 kinase inhibitor…
- Trial name
- LRRK2 G2385R (NCT04436848)
- Testing
- This is a non-interventional study
- Where
- Malaysia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Eosinophilia, Hypereosinophilic Syndrome
A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression
Eosinophils are a type of white blood cell. Elevated eosinophil levels can damage the heart, nerves, and other organs, in the syndrome known as hypereosinophilic syndrome (HES).
- Trial name
- NCT00091871
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Neutropenia
Biosimilarity Study of Subcutaneous Pegfilgrastim in Healthy Volunteers
This study will compare the pharmacokinetics and pharmacodynamics, after single subcutaneous application, in healthy men, between pegfilgrastim formulation, produced by Megalabs (test product) and Neulastim® (reference product)…
- Trial name
- NCT04873765
- Testing
- Pegfilgastrim Megalabs, Pegfilgastim Amgen
- Where
- Uruguay
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Megalabs