Clinical trials: Leukocytes
Hematologic Diseases
Evaluation, Treatment, and Training for Patients With Blood Disorders
This study is designed to allow the evaluation, follow-up, and medical care of patients with blood disorders not currently participating in a research study being conducted by the Hematology Branch of the National Heart, Lung and…
- Trial name
- NCT00001397
- Where
- United States
- Volunteers
- 1,452 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Melanoma
TNF in Melanoma Patients Treated With Immunotherapy
This trial is a translational proof-of-concept, open-label, prospective cohort study of 60 patients aiming to identify the clinical markers and/or biomarkers associated with therapeutic response to immune checkpoints inhibitors…
- Trial name
- MELANFα (NCT03348891)
- Testing
- Tumor biopsy specimens and blood samples
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- Institut Claudius Regaud
Neutropenia, Febrile, Leukemia
Cefepime vs Ceftazidime as Empirical Therapy for Neutropenic Fever
Empirical antibiotic therapy has been known to reduce the mortality and morbidity rate in neutropenic fever. Until now, ceftazidime was the first line choice of neutropenic fever.
- Conditions
- Neutropenia, Febrile, Leukemia, Pediatric Cancer, Antibiotic Reaction
- Trial name
- NCT04187755
- Testing
- Ceftazidime Injection, Cefepime Injection
- Where
- Indonesia
- Volunteers
- 72 people
- Sponsor
- Universitas Indonesia
Childhood Cancer, Infection
Host RNA Signature in Children With Cancer and Infection
The aim is to investigate if RNA expression signature can discriminate bacterial from viral infection or non-infectious inflammation in children with cancer.
- Conditions
- Childhood Cancer, Infection, Neutropenia, Febrile
- Trial name
- NCT04669418
- Testing
- RNA expression signature
- Where
- 5 sites in Denmark
- Volunteers
- 370 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Diabetes Mellitus, Type 1
Immune Profile in Subjects With New Onset Type 1 Diabetes
It is hypothesized that early changes in the immune system in New Onset Type 1 Diabetes Mellitus (NOT1D) subjects can be detected in immune cells from the inguinal lymph nodes (iLN), which will be distinct from changes observed…
- Trial name
- NCT02801942
- Testing
- Inguinal lymph node fine needle aspirate biopsy, Inguinal lymph node core biopsy, Peripheral blood collection
- Where
- 2 sites in United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bloodstream Infection
Antimicrobial Catheter Securement Dressings for the Prevention of Cvc-related Bloodstream Infections in Cancer Patients
In neutropenic cancer patients, catheter-related bloodstream infections may cause severe infections and even death. To assess the prophylactic effect of a chlorhexidine coated catheter securement dressing on the incidence of…
- Trial name
- COAT (NCT01544686)
- Testing
- 3M™ Tegaderm™ CHG IV and 3M™ Tegaderm™ Advanced IV
- Where
- 5 sites in Germany
- Volunteers
- 630 people
- Sponsor
- University of Cologne
Septic Shock
Study of Platelet Activation in Septic Shock Patients
Some studies have shown that antiplatelets agents could reduce organ dysfunction in septic shock in mice and human models. Platelets are actors in immunity and their activation can be complicated by tissue damage with vascular…
- Trial name
- PASS (NCT02635854)
- Testing
- Septic choc group, Orthopedic surgery group
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital, Toulouse
Stroke, Lymphopenia
Stroke-induced Immunodepression in Neurorehabilitation
The close interconnection between nervous system and the immune system is well known. Brain injuries lead to homeostasis disruption.
- Conditions
- Stroke, Lymphopenia, Immunosuppression
- Trial name
- NeuroLympho (NCT05889169)
- Testing
- Neurorehabilitation
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Eosinophilic Esophagitis
A Study of Detergents in the Pathogenesis of Eosinophilic Esophagitis
The purpose of this research is to determine if detergents in everyday products such as toothpaste make the lining of the esophagus leaky and cause allergic inflammation.
- Trial name
- NCT05482256
- Testing
- Esophageal String Test (EST), Colgate, High Resolution Esophageal Manometry (HREM)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Eosinophilic Esophagitis, Eosinophilic Gastroenteritis
Eosinophilic Gastrointestinal Disorders Registry
The purpose of this study is to learn more about Eosinophilic Gastrointestinal Disorders (EGIDs). With this registry we hope to find out more about the symptoms that patients have during their treatment, the quality of life they…
- Conditions
- Eosinophilic Esophagitis, Eosinophilic Gastroenteritis, Eosinophilic Colitis, Eosinophilic Gastrointestinal Disease
- Trial name
- NCT05199532
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Chronic Granulomatous Disease
Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) Antagonists
Background: Chronic granulomatous disease (CGD) affects the immune system. People with CGD are more likely to get infections. Drugs can help control infections, but these treatments can cause side effects including kidney failure…
- Trial name
- NCT05463133
- Testing
- Sirolimus, Cyclophosphamide, Alemtuzumab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hypereosinophilic Syndrome
Study to Evaluate Safety and Efficacy of Dexpramipexole (KNS-760704) in Subjects With Hypereosinophilic Syndrome
Background: Eosinophils are white blood cells that fight infections. In people with hypereosinophilic syndrome (HES), eosinophil levels are too high and can damage their organs.
- Trial name
- NCT02101138
- Testing
- Dexpramipexole
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Eosinophilic Esophagitis (EoE)
A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis
This study is researching an experimental drug called dupilumab (called "study drug"). The study is focused on children with active eosinophilic esophagitis (EoE; an inflammatory disease of the esophagus) which impacts feeding…
- Trial name
- EoE-TOTs (NCT07112378)
- Testing
- dupilumab
- Where
- 13 sites in United States
- Volunteers
- 20 people
- Sponsor
- Regeneron Pharmaceuticals
Hypereosinophilic Syndrome
Depemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety Trial
This is a 52-week, randomized, placebo-controlled, double-blind, parallel group, multicenter study of depemokimab in adults with uncontrolled HES receiving standard of care (SoC) therapy.
- Trial name
- DESTINY (NCT05334368)
- Testing
- Depemokimab
- Where
- 60 sites in United States, Argentina and 14 more
- Volunteers
- 110 people
- Sponsor
- GlaxoSmithKline
Alveolar Ridge Resorption After Extraction, Alveolar Bone Loss
L-PRF Block vs Composite Graft for Horizontal Ridge Augmentation
Brief SummaryCopy and paste the text below into the Brief Summary text box:The purpose of this randomized controlled clinical trial is to evaluate and compare the clinical, radiographic, and histological outcomes of horizontal…
- Conditions
- Alveolar Ridge Resorption After Extraction, Alveolar Bone Loss, Jaw, Edentulous, Partially, Horizontal Ridge Defect
- Trial name
- NCT07918950
- Testing
- L-PRF Block with DBBM, Autogenous Bone / DBBM Composite Graft
- Where
- United Arab Emirates
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Apparently Healthy People Aged 55 and Over
Gender-specific Associations Between Quality of Life and Leukocyte Telomere Length
Quality of life (QoL) is an important factor for successful aging. Telomere length is an indicator of cellular aging and cumulative biological stress and is thus related to health status and survival.
- Trial name
- NCT03151824
- Testing
- quality of life
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Jung-Ha Kim
Eosinophilic Esophagitis
Targeted Elimination Diet in EoE Patients Following Identification of Trigger Nutrients Using Confocal Laser Endomicroscopy
Using confocal laser endomicroscopy (CLE), gastrointestinal allergic reactions to certain foods in the duodenum will be evaluated on a cellular level.
- Trial name
- CLE-EoE (NCT05695456)
- Testing
- personalized exclusion diet based on CLE, empiric exclusion diet
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Eosinophilic Esophagitis
Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis
This is a randomized, double-blind, placebo-controlled study of oral cromolyn sodium when made into a viscous preparation for the treatment of eosinophilic esophagitis.
- Trial name
- NCT02371941
- Testing
- oral cromolyn sodium
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Tennessee
Stroke Patients Presenting Within 24 Hrs of Onset of Symptoms
Influence of Hydroxyehtyl Starch (HES) on Hemorehology, Coagulation and Elimination Kinetics
The use of HES has been found clinically to improve patients with stroke if administered within a window period by means of hemodilution to improve rehology.
- Trial name
- NCT00255957
- Testing
- HES administration, Hydroxy Ethyl Starch administration to stroke patients
- Volunteers
- 20 people
- Sponsor
- Nizam's Institute of Medical Sciences University, India
Unspecified Adult Solid Tumor, Protocol Specific
Interleukin-2 Plus Activated White Blood Cells in Treating Patients With Cancer That Has Not Responded to Chemotherapy or Radiation Therapy
RATIONALE: Interleukin-2 may stimulate a person's white blood cells to kill tumor cells. Combining white blood cells, which have been activated by a vaccine, with interleukin-2 may kill more cancer cells.
- Trial name
- NCT00019357
- Testing
- aldesleukin, therapeutic autologous lymphocytes, therapeutic tumor infiltrating lymphocytes
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
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