Clinical trials: Leukoderma
Pigmentation Disorders, Vitiligo
Maintenance Treatment of Non Segmental Vitiligo With Tacrolimus Ointment 0.1% Versus Control
Tacrolimus ointment 0.1% has shown promising results for treating vitiligo in many prospective studies. Prospective randomized studies versus placebo are required to confirm the hypothesis that maintenance treatment with two…
- Trial name
- NCT01841008
- Testing
- Protopic
- Where
- 2 sites in France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Vitiligo
Botulinum Toxin Treatment for Localized Vitiligo
Background: New light shed on the cholinergic aspects of vitiligo pathophysiology. It was found that acetylcholine concentration increased with a significantly reduced expression of acetylcholinesterase in vitiliginous patches…
- Trial name
- NCT01051687
- Testing
- Botulinum toxin A
- Where
- Saudi Arabia
- Volunteers
- 10 people
- Sponsor
- King Saud University
Vitiligo
A Study of ATI-50002 Topical Solution for the Treatment of Vitiligo
The main objective of this study is to assess the safety, tolerability and efficacy of ATI-50002 Topical Solution, 0.46% in subjects with non-segmental facial vitiligo.
- Trial name
- NCT03468855
- Testing
- ATI-50002 topical solution
- Where
- 5 sites in United States
- Volunteers
- 34 people
- Sponsor
- Aclaris Therapeutics, Inc.
Vitiligo
Plasma Exeresis Plus NB-UVB Versus NB-UVB Alone for Stable Vitiligo
The goal of this quasi-experimental clinical trial is to compare the effectiveness of plasma exeresis combined with narrowband ultraviolet B (NB-UVB) phototherapy versus NB-UVB monotherapy in patients with stable non-segmental…
- Trial name
- NCT07907744
- Testing
- Plasma Exeresis, Narrowband Ultraviolet B (NB-UVB) Phototherapy
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- University of Faisalabad
Fovea Plana, Albinism
Genetic Analysis and Multimodal Retinal Imaging of Asymptomatic Fovea Plana Cases in the General Population
Albinism is a genetic condition, resulting from mutations in at least 19 known genes responsible for the production of melanin in the skin, hair and eyes. Ophthalmological manifestations are a constant feature of this disease.
- Trial name
- APOGEE (NCT04658381)
- Testing
- Genetic analysis, Ophthalmologic exam
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Albinism, Ocular
Genetic Determinant of Foveolar Hypoplasia in Parents of Albinos Children
Fovea plana could be the phenoyipic translation of a genetic anomaly in one of the genes identified in albinisme
- Trial name
- ALAFOR (NCT03959605)
- Testing
- blood sample for genetic test, Ophtalmological examination
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Vitiligo
Examination Of Vitiligo Skin Samples Before and After UVB Treatment
The keratinocytes of lesional skin of vitiligo compared to normal and perilesional skin will differentially express genes correlating with melanocyte death.
- Trial name
- NCT00177034
- Testing
- Narrow Band UVB Treatment
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mimi Cho, MD
Vitiligo
NB-UVB and PUVA Vitiligo Study
To evaluate if the combination of psoralen plus ultraviolet A and narrowband ultraviolet B is more effective than narrowband ultraviolet B alone in the treatment of vitiligo.
- Trial name
- NCT01732965
- Testing
- Phototherapy, Phototherapy and Photochemotherapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Henry Ford Health System
Metabolism Disorder, Glucose, Metabolism Disorder, Lipid
Correlation of Glucose and Lipid Metabolism Levels With Vitiligo
The goal of this observational study is to compare serum glucose and lipid metabolism levels between health volunteers and vitiligo patients.
- Conditions
- Metabolism Disorder, Glucose, Metabolism Disorder, Lipid, Vitiligo
- Trial name
- NCT05968235
- Testing
- Collecting blood samples
- Where
- China
- Volunteers
- 963 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Vitiligo, NB-UVB
Immunomodulatory Effects of NB-UVB and Steroids in Vitiligo: A Study on CXCL11 and TEMRA Biomarkers
this is a prospective, randomized controlled trial (RCT) investigating the immunological effects of narrowband UVB (NB-UVB) phototherapy-both as monotherapy and in combination with oral mini-pulse (OMP) steroids-in non-segmental…
- Trial name
- NCT06946069
- Testing
- NB-UVB twice weekly, NB-UVB + dexamethasone (2.5-3 mg/week)
- Volunteers
- 40 people
- Sponsor
- Assiut University
Vitiligo - Macular Depigmentation
Comparison of the Efficacy of Micro-holes vs. Laser-assisted Dermabrasion, for Repigmenting in Vitiligo Skin
Principal objective: To compare the efficacy of laser-assisted dermabrasion + autologous epidermal cells suspension grafting versus dermabrasion using micro-needling technique + autologous epidermal cells suspension grafting and…
- Trial name
- Dermabrasion (NCT02660320)
- Testing
- Dermabrasion
- Where
- 3 sites in France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Gingival Hyperpigmentation
Clinical Effectiveness Of Polishing Brush Compared To Ceramic Soft Tissue Trimming Bur In Gingival Depigmentation
Gingival hyperpigmentation, particularly of melanin origin, can pose significant aesthetic concerns, especially among patients with a high smile line.
- Trial name
- NCT07402720
- Testing
- Gingival Depigmentation using polishing brush, Depigmentation using ceramic soft tissue trimming bur
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Atopic Dermatitis, Psoriasis
Determinants of Chronic Inflammatory Skin Disease Trajectories
Although it is well known that the clinical expression and course of chronic inflammatory skin diseases are highly variable, there are insufficient epidemiological data on this, and the factors that determine the manifestation…
- Conditions
- Atopic Dermatitis, Psoriasis, Lichen Planus, Alopecia Areata
- Trial name
- NCT05928169
- Testing
- Topical and systemic drugs
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Vitiligo
Comparitive Study Between Uvb Alone and Uvb With Topical Tacrolimus 0.03% for the Treatment of Vitiligo
Vitiligo is a skin disorder that causes substantial social and psychological distress due to multiple patches of depigmentation.Disease can target at any age, but it appears to affect various parts of body due to loss of melanin.
- Trial name
- NCT05577637
- Testing
- 0.03% tacrolimus twice daily was applied on group A patients with uvb phototherapy thrice daily
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Combined Military Hospital Abbottabad
Vitiligo
Evaluation of Serum and Tissue Cathepsin L in Non-segmental Vitiligo Patients
Introduction Vitiligo is an autoimmune disease of the skin that targets pigment producing melanocytes and results in patches of depigmentation that are visible as white spots (Frisoli et al., 2020) Vitiligo is a relatively common…
- Trial name
- NCT06261073
- Testing
- blood sample and tissue biopsy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sohag University
Poikiloderma of Civatte, Dyschromia
Study of the 532 nm KTP Laser for the Treatment of Poikiloderma of Civatte
This study will evaluate the safety and efficacy of the Excel V 532 nm KTP laser for the treatment of dyschromia of the neck and/or chest (poikiloderma of Civatte).
- Conditions
- Poikiloderma of Civatte, Dyschromia, Pigmentation Disorders, Telangiectasia
- Trial name
- NCT01491620
- Testing
- 532 nm KTP laser
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Cutera Inc.
Vitiligo, Generalized
Gasdermin D Expression in Generalized Vitiligo Patients After Narrow-band Ultraviolet B Therapy
The aim of this study is to: 1. Evaluate the role of tissue Gasdermin D expression using immunehistochemstry techniques in patients with generalized vitiligo and compare it with healthy controls. 2.
- Trial name
- NCT06546059
- Testing
- narrow band ultraviolet-B
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- South Valley University
Vitiligo
Safety and Tolerability Study of Cerdulatinib Gel, 0.37% in Adults With Vitiligo
This is a phase 2a, randomized, double-blind, vehicle-controlled study to assess the safety, tolerability, and systemic exposure of cerdulatinib gel, 0.37% in adults with vitiligo
- Trial name
- NCT04103060
- Testing
- Cerdulatinib 0.37% gel, Vehicle gel
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Dermavant Sciences GmbH
Vitiligo
Contribution of Skin Color in Stabilization of Active Cases of Vitiligo by Narrow Band UVB
Vitiligo is a disease in which autoimmunity plays a major role. Multiple treatment options are available, of which narrow-band UVB is a cornerstone, acting through immunosuppression and repigmentation by stimulating reservoir…
- Trial name
- NCT04030988
- Testing
- Oral dexamethasone minipulse
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Upper Crossed Syndrome, Upper Cross Syndrome
Dynamic Neuromuscular Stabilization Versus Corrective Exercises in Upper Cross Syndrome
The purpose of the study will be to investigate dynamic neuromuscular stabilization versus National American Academy of Sports Medicine (NASM) corrective exercises on pain, functional disability, cranio-vertebral angle, forward…
- Conditions
- Upper Crossed Syndrome, Upper Cross Syndrome, Upper Crossed Syndorme
- Trial name
- DNS/NASM (NCT07698392)
- Testing
- Dynamic neuromuscular stabilization, NASM corrective exercises
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University