Clinical trials: Leukoderma
Vitiligo, Child
Oral Tacrolimus vs Dexamethasone Micro-pulse Therapy in Pediatric Rapidly Progressing Vitiligo: A Multicenter RCT
This clinical study aims to compare the safety and effectiveness of two treatments-oral Tacrolimus capsules and Dexamethasone micro-pulse therapy-in children aged 4-12 years with rapidly progressing vitiligo.
- Conditions
- Vitiligo, Child, Progressive Disease
- Trial name
- NCT06900777
- Testing
- Tacrolimus, Dexamethasone
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Low Vision, Retinitis Pigmentosa
Visual Performance Measures in a Virtual Reality Environment for Assessing Clinical Trial Outcomes in Those With Severely Reduced Vision
Purpose: To validate a newly developed battery of performance-based tests of visual function to be presented using virtual reality.
- Conditions
- Low Vision, Retinitis Pigmentosa, Stargardt Disease 1, Stargardt Disease 3
- Trial name
- NCT04281732
- Testing
- Virtual Reality Headset based tests
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Queen's University, Belfast
Vitiligo Vulgaris, Psoriasis
PALLAS Laser for Skin Diseases
The primary objective of this study is to get clinical experiences with the PALLAS laser in the treatment of skin conditions that respond well to UV light (vitiligo, psoriasis, alopecia areata, atopic dermatitis).
- Conditions
- Vitiligo Vulgaris, Psoriasis, Alopecia Areata, Atopic Dermatitis
- Trial name
- PALLAS-UV (NCT07250997)
- Testing
- UVB laser treatment
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Szeged University
Gastrointestinal Stromal Tumors, Small-cell Lung Cancer
A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit
This open-label clinical trial will evaluate the safety and tolerability of NN3201 in subjects with advanced and/or metastatic solid tumors known to express c-Kit.
- Conditions
- Gastrointestinal Stromal Tumors, Small-cell Lung Cancer, Adenoid Cystic Carcinoma, Uveal Melanoma
- Trial name
- NCT06805825
- Testing
- NN3201
- Where
- 5 sites in United States
- Volunteers
- 67 people
- Sponsor
- Novelty Nobility, Inc.
Vitiligo, Generalized
Catecholamines Level in Vitiligo Patients Before and After Excimer Light
Vitiligo is an acquired cutaneous disorder of pigmentation, with a 1-2% incidence worldwide, without predilection for sex or race.
- Trial name
- NCT04803461
- Testing
- serum and urinary catecholamines
- Volunteers
- 21 people
- Sponsor
- Assiut University
Vitiligo
Deciphering the Vitiligo Transcriptomic Signature Between Repigmented and Non Repigmented Lesions
The purpose of this study is to perform an in-depth analysis of the molecular pathways involved in lesions responding to current treatment and lesions not responding to current treatment
- Trial name
- STRAVI (NCT05927272)
- Testing
- SKIN SAMPLES, BLOOD SAMPLES, narrowband UVB
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Bordeaux
Vitiligo
Assessment of Vitiligo Lesions Using Polarized Dermoscopy, Sub-Ultraviolet Reflectance Dermoscopy, and Ultraviolet Dermoscopy
The goal of this observational study is to learn how different close-up skin imaging methods show vitiligo spots in adults with vitiligo.
- Trial name
- NCT07846969
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul Training and Research Hospital
Vitiligo, Healthy
The Gut and Skin Microbiome in Vitiligo Disease Progression
Investigators plan to perform a pilot study that aims to characterize the microbiome of human vitiligo patients with both active and stable disease and compare this to the microbiome of age and sex matched controls.
- Trial name
- NCT03577327
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Vitiligo
Study of the Role of Innate Lymphoid Cells and Natural Killer Cells in Immune Activation of Vitiligo - INNATE Vitiligo
The cohort included only major patients with non-segmental vitiligo and no other autoimmune or inflammatory associated diseases (except thyroiditis). Control subjects should have no autoimmune or inflammatory diseases.
- Trial name
- INNATEvitiligo (NCT03859518)
- Testing
- blood and skin samples
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Vitiligo
A 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental Vitiligo
This study is to evaluate how safe and effective ritlecitinib is in participants with non-segmental vitiligo (NSV). Ritlecitinib is studied in patients with non-segmental vitiligo.
- Trial name
- Tranquillo LTE (NCT06163326)
- Testing
- Ritlecitinib, Ritlecitinib 100 mg
- Where
- 73 sites in United States, Australia and 11 more
- Volunteers
- 394 people
- Sponsor
- Pfizer
Depigmentation Treatment, Depigmentation
Effect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation
This study aims to assess the clinical effectiveness of Co-enzyme Q10 and Vitamin C, applied individually or in combination after surgical gingival depigmentation.
- Trial name
- Effect of Coe (NCT07677826)
- Testing
- surgical depigmentation, Coenzyme Q10, Vitamin C
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Upper Crossed Syndrome
Effect of Cervicothoracic Mobilization on Upper Crossed Syndrome
PURPOSE: To investigate the effect of cervicothoracic mobilization on Craniovertebral angle (CVA), sagittal shoulder angle (SSA), kyphotic angle and pain intensity level in upper crossed syndrome.
- Trial name
- NCT05665296
- Testing
- cervicothoracic mobilization, CCE
- Volunteers
- 60 people
- Sponsor
- Cairo University
Neck Pain
ELDOA's Effect in Upper Cross Syndrome
The aim of this randomized clinical trial is to find the effects of ELDOA on decreasing pain ,kyphosis , improving range of motion and reducing disability
- Trial name
- NCT06564077
- Testing
- Eldoa technique with conventional therapy, conventional therapy
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Alopecia Areata, Alopecia Totalis
The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic
The study series consists of three studies with the aim to assess the incidence, prevalence, risk factors, comorbidities and management of patients with alopecia areata in Czech Republic based on the patients and registry of a…
- Conditions
- Alopecia Areata, Alopecia Totalis, Alopecia Universalis, Alopecia Areata (& Ophiasis)
- Trial name
- NCT05098600
- Testing
- Exposure of interest
- Where
- Czechia
- Volunteers
- 123 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Vitiligo
The Value of Methotrexate in NCES for Stable Vitiligo
The goal of this clinical trial is to learn if adding a six months course of Methotrexate would improve the results of non cultured epidermal suspension (NCES) in adult patients with acral and resistant vitiligo lesions over the…
- Trial name
- NCT07352293
- Testing
- Non cultured epidermal suspension
- Where
- Egypt
- Volunteers
- 21 people
- Sponsor
- Cairo University
Gingival Pigmentation
Influence of Adjunctive Acids Use on Esthetic Outcomes of Gingival Melanin Depigmentation: A Periodontal-Operative Pilot Randomized Clinical Trial
This pilot randomized clinical trial aims to evaluate the effect of adjunctive acid application on the esthetic outcomes of gingival melanin depigmentation.
- Trial name
- GMDAcidRCT (NCT07708792)
- Testing
- Citric acid
- Volunteers
- 30 people
- Sponsor
- Dijlah University
Gingival Pigmentation, Melanosis
Comparative Evaluation of Microsurgery vs Conventional Surgical Technique of Gingival Depigmentation
Gingiva being the most frequently pigmented tissue of the oral cavity challenges a lot of people with an esthetic concern. Increased production of melanin, a pigment produced by the melanocytes present in the basal and suprabasal…
- Trial name
- NCT05930392
- Testing
- Gingival depigmentation using microsurgery, Conventional surgical depigmentation
- Where
- India
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Acquired Hypomelanosis
Microneedling for Acquired Hypomelanosis
Acquired hypomelanosis is a type of cutaneous melanocytopenic hypomelanosis, denoting the lightening of the skin due to a reduction in the number of epidermal and/or follicular melanocytes secondary to physical…
- Trial name
- NCT04419350
- Testing
- Microneedling
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Vitiligo
Vitiligo Skin Transplantation
In vitiligo, the melanocytes are lost from the skin in certain areas. One treatment for vitiligo takes the melanocytes from areas of normal skin and places them on areas of that same person's body which have lost their color.
- Trial name
- MKTP (NCT00830713)
- Testing
- Melanocyte-keratinocyte transplantation procedure (MKTP)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Henry Ford Health System
Hypopigmented Skin
Dermoscopy of Hypo-pigmented Lesions in Children
Hypo-pigmented skin lesions in children are of great concern in the society. They cause anxiety among children and their parents due to the social stigma attached to these conditions especially in dark skinned children.
- Trial name
- NCT04089475
- Testing
- Dermoscope
- Volunteers
- 150 people
- Sponsor
- Assiut University