Clinical trials: Leukoderma
Vitiligo
Prostaglandin F2-alpha (PGF2α) in Vitiligo
study the cutaneous expression of PGF2α in vitiligo patients and compare it with normal control subjects.
- Trial name
- NCT03755830
- Testing
- Skin biopsy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Atopic Dermatitis, Alopecia Areata
A Longitudinal Observational Study of Patients Undergoing Therapy for IMISC
TARGET-DERM is a longitudinal, observational study of adult and pediatric patients being managed for Atopic Dermatitis and other Immune-Mediated Inflammatory Skin Conditions (IMISC) in usual clinical practice.
- Conditions
- Atopic Dermatitis, Alopecia Areata, Hidradenitis Suppurativa, Vitiligo
- Trial name
- TARGET-DERM (NCT03661866)
- Where
- 62 sites in United States, Canada and 2 more
- Volunteers
- 15,000 people
- Sponsor
- Target PharmaSolutions, Inc.
GIST - Gastrointestinal Stromal Tumor, KIT Gene Mutation
Comparing Regorafenib Combined With Envafolimab to Physician's Choice in Patients With Metastatic Gastrointestinal Stromal Tumors Harboring KIT Exon 17 Mutations Refractory to Standard Treatment
Gastrointestinal stromal tumors (GISTs) are mostly driven by c-kit or PDGFRA mutations, and commonly occur in the stomach and small intestine.
- Trial name
- NCT07559864
- Testing
- physician-selected treatment, Regorafenib + Envafolimab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jian Li
Upper Cross Syndrome
"Effects of Neuromuscular Reeducation Versus Post Facilitation Stretch Technique for Upper Cross Syndrome Among IT Professionals
This study is a randomised control trial and the purpose of this study is to determine the "Effects of Neuromuscular Reeducation Versus Post Facilitation Stretch Technique for Upper Cross Syndrome among IT professionals .
- Trial name
- NCT06648070
- Testing
- Neuromuscular reeducation technique, Post Facilitation Stretch
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Foundation University Islamabad
Vitiligo
Efficacy and Tolerance of the Association of ANIFROLUMAB (300mg) IV Every Four Weeks and Phototherapy Versus Phototherapy in Adults With Progressive Vitiligo
The purpose of this phase 2 study is to evaluate the effect and the safety of the combination of ANIFROLUMAB in combination with phototherapy in adult participants with non-segmental progressive vitiligo
- Trial name
- VITANI (NCT05917561)
- Testing
- Anifrolumab Infusion Product
- Where
- 4 sites in France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Bordeaux
Forward Head Posture, Rounded Shoulder Posture
AI Training Program vs Standard Correction for Forward Head and Rounded Shoulder in Neck Pain
this study will be to evaluate the effectiveness of AI-recommended exercise interventions versus standard corrective exercises in management of non-specific neck pain with forward head and rounded shoulder posture.
- Conditions
- Forward Head Posture, Rounded Shoulder Posture, Upper Cross Syndrome
- Trial name
- AI (NCT07236385)
- Testing
- AI based exercise, standard corrective exercises
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Cairo University
Vitiligo
Repigmentation Patterns Induced by NB-UVB and Their Relationship With Melanocytic Migration in Vitiligo
Vitiligo is the most common acquired depigmented disorder of the skin characterized by destruction of melanocytes resulting in well-circumscribed achromic macules.
- Trial name
- UVBVIT (NCT02625012)
- Volunteers
- 30 people
- Sponsor
- Juan Pablo Castanedo-Cazares
Upper Crossed Syndrome, Postural Dysfunction
Effect of a Comprehensive Corrective Exercise Program With and Without Instrument-Assisted Soft Tissue Mobilization on Cervical Range of Motion, Muscle Strength, Disability, and Postural Alignment in Individuals With Upper-Crossed Syndrome
This study is a double-blind, parallel-group randomized controlled trial designed to evaluate the effectiveness of a Comprehensive Corrective Exercise Program (CCEP) with and without Instrument-Assisted Soft Tissue Mobilization…
- Trial name
- NCT07702604
- Testing
- Instrument-Assisted Soft Tissue Mobilization (IASTM) + Comprehensive Corrective Exercise Program (CCEP), Comprehensive Corrective Exercise Program (CCEP)
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Vitiligo
A Phase III Clinical Study to Evaluate the Efficacy and Safety of MH004 Ointment in Non-segmental Vitiligo
This is a randomized, double-blind, multicenter, placebo-controlled clinical study intended to evaluate the efficacy, safety and population pharmacokinetic profiles of MH004 ointment in eligible participants with NSV.
- Trial name
- NCT07682506
- Testing
- MH004 1.0% Ointment
- Where
- China
- Volunteers
- 405 people
- Sponsor
- Minghui Pharmaceutical (Hangzhou) Ltd
Vitiligo, Nonsegmental Vitiligo
Topical Ruxolitinib Versus Tacrolimus With Excimer Laser for Localized Vitiligo
This randomized comparative study will evaluate the efficacy and safety of topical ruxolitinib 1.5% cream compared with topical tacrolimus 0.1% ointment, each combined with 308-nm excimer laser therapy, in patients aged 12 years…
- Trial name
- NCT07909668
- Testing
- Tacrolimus 0.1% ointment, Ruxolitinib 1.5% cream, 308-nm excimer laser
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
VITILIGO
Epidermal Cell Transplantation in Vitiligo Skin
The effects of treatment of transplantation of harvested autologous epidermal cells on vitiligo lesions followed by narrow-band UVB will be investigated in a randomized controlled study.
- Trial name
- VITICELL (NCT01629979)
- Testing
- Grafting with epidermal cells, UVB treatment
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Upper Cross Syndrome
Comparative Effect of Maitland Mobilization Combined With Kendall Exercises for Pain and Postural Alignment in Adults With Upper Cross Syndrome
This randomized controlled trial aims to compare the effects of Maitland mobilization combined with Kendall exercises versus Kendall exercises alone on pain and postural alignment in adults with Upper Cross Syndrome (UCS).
- Trial name
- NCT07588061
- Testing
- Kendall Exercises combined Maitland Mobilization, Kendall Exercise alone
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Ibadat International University, Islamabad
Vitiligo, Skin Abnormalities
How Does Skin Tone Affect Quantitative Photoacoustic Imaging
Photoacoustic imaging (PAI) is an emerging method which combines light and ultrasound to assess the blood content and oxygenation of the body.
- Trial name
- PAISKINTONE (NCT05554523)
- Testing
- Photoacoustic imaging
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Albinism, Inborn Errors of Metabolism
Oral Pirfenidone for the Pulmonary Fibrosis of Hermansky-Pudlak Syndrome
Hermansky-Pudlak Syndrome (HPS) is an inherited disease that results in decreased pigmentation (oculocutaneous albinism), bleeding problems due to a platelet abnormality (platelet storage pool defect), and storage of an abnormal…
- Conditions
- Albinism, Inborn Errors of Metabolism, Oculocutaneous Albinism, Platelet Storage Pool Deficiency
- Trial name
- NCT00001596
- Testing
- Pirfenidone
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- William Gahl, M.D.
Vitiligo
Oral Mini Pulse Dexamethasone in Pediatric Vitiligo
The goal of this clinical trial is to learn if oral mini pulse (OMP) dexamethasone works to treat active vitiligo in children and also learn about the safety of this drug within this age group the main questions it aims to answer…
- Trial name
- NCT07353801
- Testing
- Dexamethasone (0.1 mg/kg)
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Cairo University
Vitiligo
Virus Early Transcription Factor (VETF) Multicenter Phototherapy Protocol
Background Phototherapy UVB TL01 currently represents the first choice in treatment to induce the repigmentation of vitiligo spots.
- Trial name
- VETF (NCT00525395)
- Testing
- Sequential phototherapy, Continuous phototherapy
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituti Fisioterapici Ospitalieri
Postural; Defect
Effect Of Schroth Method On Balance In Upper Crossed Syndrome
The study will be conducted to investigate the effect of Schroth method on balance in patients with the upper cross syndrome
- Trial name
- UCS (NCT05599204)
- Testing
- schroth exercise, postural correction exercise
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Vitiligo
Comparing Recipient Site Preparation Using Dermabrasion, Dermaroller and Liquid Nitrogen Induced Blister in Non Cultured Epidermal Cell Suspension in Stable Vitiligo
A COMPARATIVE STUDY BETWEEN RECEPIENT SITE PREPARATION USING DERMABRASION, LIQUID NITROGEN INDUCED BLISTER AND DERMAROLLING SYSTEM IN AUTOLOGOUS NON CULTURED EPIDERMAL CELL SUSPENSION PROCEDURE IN STABLE VITILIGO PATIENTS
- Trial name
- NCT03668834
- Testing
- Dermabrasion with NCES, Dermaroller with NCES, Liquid nitrogen induced blister with NCES
- Where
- India
- Volunteers
- 36 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Immune-related Vitiligo-like-Depigmentation
Topical Ruxolitinib Evaluation in Immune-related Vitiligo-like Depigmentation
White spot disease is a common side effect on the skin in the context of cancer treatments with immunotherapies. There is no standard therapy yet for white spot caused by cancer therapies.
- Trial name
- TRuE-VLD (NCT07725432)
- Testing
- Ruxolitinib Topical Cream
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- University of Zurich
Photosensitivity Disorders
Conventional Microneedling vs Microneedling With 5-FU (MMP) for Idiopathic Guttate Hypomelanosis (IGH) Repigmentation
The purpose of this study is to determine whether 5-FU infusion (Microinfusion of Medicine Percutaneously - MMP) is effective for Idiopathic Guttate Hypomelanosis (IGH) repigmentation compared to conventional Microneedling.
- Trial name
- MMP (NCT02904564)
- Testing
- MMP with 5-FU, MMP with Saline infusion
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Clinica Dermatologica Arbache ltda