Clinical trials: Leukoderma
Hepatocellular Carcinoma, Liver Cancer
A Phase 2b Study of Modified Vaccinia Virus to Treat Patients Advanced Liver Cancer Who Failed Sorafenib
This study is to determine whether JX-594 (Pexa-Vec) plus best supportive care is more effective in improving survival than best supportive care in patients with advanced Hepatocellular Carcinoma (HCC) who have failed sorafenib.
- Conditions
- Hepatocellular Carcinoma, Liver Cancer, HCC
- Trial name
- TRAVERSE (NCT01387555)
- Testing
- JX-594 recombinant vaccina GM-CSF, Best Supportive Care
- Where
- 38 sites in United States, Canada and 5 more
- Volunteers
- 129 people
- Sponsor
- Jennerex Biotherapeutics
Upper Crossed Syndrome
Comparison of Brugger's Exercise With and Without Kendall Exercises in Sterno-Symphyseal Syndrome
Sterno-symphyseal syndrome is a natural result of prolonged sitting work, especially with computers .In actual it is the approximation between pubic symphysis and sternum.
- Trial name
- NCT06407700
- Testing
- Brugger's exercise., Kendall Exercise.
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Skin and Connective Tissue Diseases, Skin Diseases
Pilot Study Assessing the Effect of Tildrakizumab in Vitiligo
Vitiligo is a common acquired depigmentation disorder affecting approximately 2% of the world population. The purpose of this pilot study is to evaluate the effect and the safety of Tildrakizumab in adult participants with…
- Conditions
- Skin and Connective Tissue Diseases, Skin Diseases, Pigmentation Disorder, Hypopigmentation
- Trial name
- TILDVIT-1227 (NCT04971200)
- Testing
- Tildrakizumab
- Where
- Australia
- Volunteers
- 12 people
- Sponsor
- Premier Specialists, Australia
Upper Cross Syndrome
Effects of Scapular Stabilization Exercises Combined With Post Facilitation Stretch in Patients With Upper Cross Syndrome: A Randomized Control Trial
Upper Cross Syndrome is characterized by the postural deviation of head , neck , shoulders and altered muscular muscular activation which included weakness of rhomboids , middle and lower trapezius and serratus anterior and…
- Trial name
- NCT06534736
- Testing
- Electrotherapy and physical agents, Post Facilitation Stretch, Scapular Stabilization Exercise
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Vitiligo
Diphenylcyclopropenone (DPCP) as a Depigmenting Therapy in Extensive Vitiligo
The aim of the present work is to evaluate the efficacy and safety of diphenylcyclopropenone (DPCP) as a depigmenting therapy in extensive Vitiligo.
- Trial name
- NCT04775979
- Testing
- diphenylcyclopropenone (DPCP)
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Vitiligo
Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Light in the Treatment of Nonsegmental Vitiligo (NSV)
The purpose of this study is to look at the efficacy of afamelanotide, when combined with narrow-band ultraviolet B (NB-UVB) light, in patients with nonsegmental vitiligo.
- Trial name
- CUV102 (NCT01430195)
- Testing
- Afamelanotide, Narrow-Band UVB Light Treatment
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- Clinuvel Pharmaceuticals Limited
Non-segmental Vitiligo, Segmental Vitiligo
Punchgrafting Techniques for Vitiligo
Rationale: Punch grafting is a safe, simple and widely used technique for in vitiligo. However, no reliable data are available on the effect of punch depth and punch size.
- Conditions
- Non-segmental Vitiligo, Segmental Vitiligo, Piebaldism
- Trial name
- MiniSNIP (NCT01377077)
- Testing
- punchgrafting
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Phototherapy, Vitiligo
Maintenance Therapy of Narrow-band UV-B Therapy in Patients With Vitiligo
Although vitiligo is difficult to cure, recurrences are frequent after treatment, and many patients suffer from concerns about recurrence as well as disease.
- Conditions
- Phototherapy, Vitiligo, Maintenance Therapy, Narrow-band UV-B
- Trial name
- NCT03384342
- Testing
- Narrow-band UV-B therapy
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- The Catholic University of Korea
Vitiligo
Evaluation of Pyroptosis-related Indicators in the Pathogenesis of Vitiligo:Across-sectional Comparative Study
Vitiligo is an acquired pigmentary disorder on skin and/or mucosae, which is characterized by death of melanocytes (MCs), affecting 0.5%-2% of the population worldwide (1).
- Trial name
- NCT06261086
- Testing
- evaluate serum levels pyroptosis-related indicators (GASDM-D, IL 1β & IL-18)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Physiologic Gingival Melanin Pigmentation
Gingival Depigmentation Using a 940 nm Diode Laser Versus Ceramic Bur
This randomized split-mouth clinical trial will compare the effectiveness of a 940 nm GaAlAs diode laser and a ceramic soft tissue trimmer for the treatment of physiologic gingival melanin pigmentation.
- Trial name
- NCT07841119
- Testing
- 940 nm GaAlAs Diode Laser, Ceramic Soft Tissue Trimmer
- Where
- Vietnam
- Volunteers
- 17 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Vitiligo, Atopic Dermatitis
An Observational Study of Patients With Dermatologic Disease
TARGET-DERM+ is an observational research study to conduct a comprehensive review of outcomes for patients with dermatologic disease (DD) and providers who treat these patients.
- Conditions
- Vitiligo, Atopic Dermatitis, Alopecia Areata, Hidradenitis Suppurativa (HS)
- Trial name
- TARGET-DERM+ (NCT07748169)
- Where
- United States
- Volunteers
- 2,000,000 people
- Sponsor
- Target PharmaSolutions, Inc.
Vitiligo, Non-Segmental Vitiligo (NSV)
Evaluation of Crisaborole 2% Versus Tacrolimus 0.1% Each Combined With Excimer Light in the Treatment of Stable Non-segmental Facial Vitiligo: a Prospective Randomized Controlled Study.
The goal of this clinical trial is to learn if topical application of crisaborole 2% ointment can treat stable patches of facial vitiligo in pediatrics and adult patients of both genders.
- Conditions
- Vitiligo, Non-Segmental Vitiligo (NSV), Stable Vitiligo
- Trial name
- NCT07904910
- Testing
- Crisaborole 2% topical ointment, tacrolimus 0.1%, Excimer Light therapy
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Cairo University
Upper Cross Syndrome
Kendall Versus Janda's Approach Along With Diaphragmatic Breathing Exercises in Upper Crossed Syndrome
Upper Crossed Syndrome (UCS) is a postural imbalance in the upper body characterized by shortened and tight muscles in the front and upper back, while weak muscles in the back and neck are stretched and underactive.
- Trial name
- NCT07724574
- Testing
- Kendall exercises, Janda's Approach
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Psoriasis (PsO), Vitiligo Vulgaris
Evaluation of Stigma Toward Patients With Alopecia Areata, Atopic Dermatitis, Vitiligo, and Psoriasis
Primary objective: The primary objective is to evaluate in the general population the difference between emotional reactions associated with facial involvement by four major dermatologic diseases: psoriasis, atopic dermatitis…
- Conditions
- Psoriasis (PsO), Vitiligo Vulgaris, Atopic Dermatitis, Areata Alopecia
- Trial name
- STIGMADERM (NCT06801821)
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Vitiligo
Effects of Combination Therapy With Camouflage in the Repigmentation of Vitiligo
Vitiligo is a common depigmented skin disorder characterized by the white patches of skin and mucous membrane. It can be cosmetically disfiguring and lead to serious psychological problems for patients with vitiligo.
- Trial name
- NCT03973073
- Testing
- CapulinTM, topical applications and NB-UVB
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
Stable Vitiligo
Melanocyte Transplantation for Patients With Stable Vitiligo.
Vitiligo is an acquired skin disease that significantly impacts the quality of life of patients. Medical treatment of vitiligo includes the use of melanocyte transplantation but the results are variable.
- Trial name
- NCT01701648
- Testing
- Laser CO2
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Inherited Ophthalmic Diseases, Hypopigmentation Disorder
National Ophthalmic Genotyping and Phenotyping Network (eyeGENE (Registered Trademark)), Stage 3 - Expansion of DNA and Data Repositories for Rare Inherited Ophthalmic Diseases
Background: The eyeGENE (Registered Trademark) program is a research resource for inherited eye conditions which includes genotypic and phenotypic data, imaging, and a corresponding biobank of DNA samples from people with a…
- Conditions
- Inherited Ophthalmic Diseases, Hypopigmentation Disorder, Corneal Dystrophy, Blue-cone Monochromacy
- Trial name
- NCT06491615
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- National Eye Institute (NEI)
Vitiligo, Secukinumab
Secukinumab in Active Non-segmental Vitiligo
Vitiligo is an acquired autoimmune skin disorder which leads to cutaneous depigmentations. A lot of progress has been made to unravel the pathophysiology of vitiligo.
- Trial name
- NCT05676333
- Testing
- Secukinumab
- Where
- Belgium
- Volunteers
- 8 people
- Sponsor
- University Hospital, Ghent
Vitiligo
Comparative Study of Surgical Treatment of Vitiligo
A comparative study for the surgical treatment of vitiligo in which the same patient will receive in acromic and symmetric lesions of vitiligo dermabrasion with micro needling and on the other side dermabrasion with micro…
- Trial name
- NCT03497208
- Testing
- Microneedling, Cell suspension, Phototherapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Chediak-Higashi Syndrome
Study of Chediak-Higashi Syndrome
Chediak-Higashi syndrome (CHS) is a rare autosomal recessive disorder characterized in its classical form by oculocutaneous albinism, a bleeding diathesis, recurrent infection due to abnormal neutrophil and natural killer cell…
- Trial name
- NCT00005917
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Human Genome Research Institute (NHGRI)