Clinical trials: Leukoderma
Vitiligo
Topical Methotrexate with Fractional CO2 Laser in Treatment of Non Segmental Vitiligo
This prospective, within subject clinical trial aims to evaluate the efficacy of combining fractional CO2 laser with topical methotrexate versus topical methotrexate alone in treating non-segmental vitiligo.
- Trial name
- NCT06877455
- Testing
- Fractional CO2 laser assisted PDT
- Volunteers
- 50 people
- Sponsor
- Assiut University
Vitiligo, Pigmentation
Randomized, Split-body, Single-blinded Clinical Trial of NB-UVB Treatment for Vitiligo
The objective of this study is to assess the effectiveness and safety of narrowband-ultraviolet B (NB-UVB) treatment in adult subjects with vitiligo.
- Conditions
- Vitiligo, Pigmentation, Dyschromia
- Trial name
- NCT02506101
- Testing
- narrow-band ultraviolet B phototherapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
Melanin Hyperpigmentation
Melanin Recurrence in Scalpel and LASER Gingival Depigmentation in Thin and Thick Phenotypes.
This study aimed to compare melanin pigmentation recurrence, pain perception and wound healing between laser and scalpel surgeries in thin and thick gingival phenotypes.Thirty patients (60 sites) were included in this study.
- Trial name
- NCT06886100
- Testing
- Diode laser, Scalpel No 15
- Where
- Yemen
- Volunteers
- 30 people
- Sponsor
- Thamar University
Neck Pain
Effects of MET and Biofeedback Strengthening With and Without Kinesiotaping in Upper Crossed Syndrome
This randomised controlled trial will aim to evaluate the combined effects of Muscle Energy Technique (MET) and biofeedback strengthening, with and without Kinesiotaping (KT), on pain, posture, deep neck flexor strength, and…
- Trial name
- NCT07079319
- Testing
- MET + Biofeedback Strengthening + Kinesiotaping, MET + Biofeedback Strengthening
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Riphah International University
Segmental Vitiligo, Piebaldism
Autologous Cell Suspension Grafting Using ReCell in Vitiligo and Piebaldism Patients
The purpose of this study is to assess the efficacy and safety of ReCell grafting after CO2 laser abrasion with superficial full surface ablation, fractional laser treatment and conventional (deep) full surface CO2 laser…
- Trial name
- NCT02458417
- Testing
- ReCell, Full surface CO2 laser 200 mJ, Full surface CO2 laser 150 mJ
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Netherlands Institute for Pigment Disorders
Upper Cross Syndrome
Effectiveness of Rib Mobilization Combined With Postural Correction Exercises in Individuals With Upper Crossed Syndrome
This randomized controlled trial aims to evaluate the effectiveness of rib mobilization combined with postural correction exercises in reducing pain, improving cervical posture, and enhancing rib and thoracic mobility among…
- Trial name
- NCT07573553
- Testing
- Rib Mobilization and Postural Correction Exercises, Postural Correction Exercises Only
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Riphah International University
Albinism, Albinism, Ocular
Visual Function and Ocular Pigmentation in Albinism
To study the relationship between visual function and ocular (iris, retina/choroidal) pigmentation in patients with albinism and other hypomelanotic disorders.
- Conditions
- Albinism, Albinism, Ocular, Albinism, Oculocutaneous
- Trial name
- NCT00001153
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Eye Institute (NEI)
Gingival Hyperpigmentation, Laser Depigmentation
Effect of Topical Argan Oil on Healing After Laser Depigmentation.
Effect of Argan oil vs placebo on healing after laser depigmentation
- Conditions
- Gingival Hyperpigmentation, Laser Depigmentation, Topical Argan Oil, Postoperative Gingival Healing
- Trial name
- NCT07357883
- Testing
- Laser Depigmentation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ghada Adayil
Vitiligo
Evaluation of Scanoskin for the Assessment of Vitiligo
The aim of this study is to establish whether the use of a special digital camera (SIAscopy) can provide an accurate and reliable measure of vitiligo which is at least equivalent to the current gold standard of planimetry.
- Trial name
- NCT03133871
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Melasma, Lichen Planus Pigmentosus
Efficacy of Red Light in the Treatment of Pigmentary Disorders
Pigmentary disorders such as melasma, lichen planus pigmentosus and vitiligo can significantly affect patients' quality of life. Treatment responses are usually slow and typically have limited efficacy.
- Conditions
- Melasma, Lichen Planus Pigmentosus, Vitiligo
- Trial name
- NCT04308421
- Testing
- Red light
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- University of British Columbia
Hermansky Pudlak Syndrome, Interstitial Lung Disease
Efficacy and Safety of Pirfenidone Treatment in HPS-ILD
This research study will explore the safety and efficacy of the drug, pirfenidone, in patients with a diagnosis of Hermansky-Pudlak Syndrome (HPS) who have an associated interstitial lung disease (ILD) over a planned period of 56…
- Trial name
- PEARL (NCT04193592)
- Testing
- Pirfenidone
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 50 people
- Sponsor
- Jesse Roman
Vitiligo
Assessing the Efficacy of Needling With or Without Corticosteroids in the Repigmentation of Vitiligo
Vitiligo is an autoimmune cutaneous disorder that destroys melanocytes leading to depigmented areas of skin. In the United States, vitiligo affects 1% of patients, causing not only changes in the color of skin, but also…
- Trial name
- NCT02191748
- Testing
- Needling, Triamcinolone
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Rutgers, The State University of New Jersey
Pigmentation, Gingiva
Post Gingival Depigmentation Assessment: Comparison of Surgical Stripping vs (Er,Cr:YSGG) Laser
The appearance and health of the gingiva significantly contribute to an aesthetically pleasing smile. Pink gingiva indicates healthy gums and is generally preferred over dark or mixed colors.
- Trial name
- NCT06075641
- Testing
- Gingival depigmentation
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Hermanski-Pudlak Syndrome, Colitis
Medical Treatment of Colitis in Patients With Hermansky-Pudlak Syndrome
This study will determine if medical treatment of colitis (inflammation of the colon resulting in loose bowel movements, rectal bleeding, and belly pain) that is used for other colitis conditions, such as Crohn's disease and…
- Conditions
- Hermanski-Pudlak Syndrome, Colitis, Cytokines, Lymphocytes
- Trial name
- NCT00514982
- Testing
- Mesalamine, Infliximab, Corticosteroids
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pulmonary Fibrosis, Healthy Volunteers
Analysis of Specimens From Individuals With Pulmonary Fibrosis
The etiology of pulmonary fibrosis is unknown. Analyses of blood, genomic DNA, and specimens procured by bronchoscopy, lung biopsy, lung transplantation, clinically-indicated extra-pulmonary biopsies, or post-mortem examination…
- Conditions
- Pulmonary Fibrosis, Healthy Volunteers, Hermansky-Pudlak Syndrome (HPS)
- Trial name
- NCT00084305
- Where
- United States
- Volunteers
- 315 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Vitiligo
Excimer Lamp Versus Excimer Laser in Vitiligo Treatment
308 nm excimer lamp and 308 nm excimer laser have both provide interesting results in treating vitiligo. They have the same wavelength but the type of emission of the photons is different.
- Trial name
- NCT00696358
- Testing
- 308nm excimer lamp, 308nm excimer laser
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire de Nice
Vitiligo
5-fluorouracil for Treatment of Stable Vitiligo
Vitiligo, a significant dermatologic challenge affecting 0.5 to 2% of the global population. Despite various existing medical approaches, current vitiligo treatments are still far from optimal.
- Trial name
- NCT06209138
- Testing
- 5 fluorouracil, Saline
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Vitiligo
Comparative Study of Techniques in Melanocyte-Keratinocyte Transplantation for the Treatment of Vitiligo
Previous studies have evaluated the transplantation of pigment cells (melanocytes)and skin cells (keratinocytes) for the treatment of vitiligo. This procedure is known as MKTP (Melanocyte Keratinocyte Transplantation Procedure).
- Trial name
- NCT01822379
- Testing
- Melanocyte Keratinocyte transplantation
- Where
- United States
- Sponsor
- Henry Ford Health System
Vitiligo
Efficacy of Upadacitinib After NECS in Vitiligo
The goal of this clinical trial is to investigate the efficacy of upadacitinib after NECS in participants with vitiligo. The main question it aims to answer is: whether the short time use of upadacitinib after NECS will improve…
- Trial name
- NCT06454461
- Testing
- Upadacitinib 15 MG
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jilin University
Vitiligo
Evaluation of Efficacy of Microneedling and Topical Methotrexate Versus Microneedling and Topical 5-flourouracil in Treatment of Vitillgo Patients
Vitiligo is a depigmenting skin disorder, characterized by the selective loss of melanocytes, which in turn leads to loss of pigment in the affected areas of the skin It considerd as autoimmune disease, associated with genetic…
- Trial name
- NCT05467839
- Testing
- derma pen
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University