Clinical trials: Levosimendan
Cardiovascular Risk Factor
Effect Levosimendan Administration on Postoperative NT-proBNP in Cardiac Risk Patients
This is a prospective randomised trial investigating the effect of a preemptive administration of levosimendan on postoperative cardiac NT-proBNP concentrations.
- Trial name
- IMPROVE (NCT04329624)
- Testing
- Levosimendan
- Where
- Austria
- Volunteers
- 230 people
- Sponsor
- Medical University of Vienna
Septic Shock
Effects of Levosimendan on Microcirculation in Septic Shock
The present study was conducted as a prospective, randomized, controlled study to: investigate the effects of a combination of levosimendan and inhaled nitric oxide on systemic hemodynamics and microcirculation in patients with…
- Trial name
- NCT00800306
- Testing
- Levosimendan, dobutamine
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
ST Elevation Myocardial Infarction
Clinical Trial in Patients Who Have Suffered a Heart Attack and Who Have Undergone Catheterization Treated With Levosimendan
The disease under study is acute coronary syndrome with ST segment elevation, defined as patients presenting chest pain of anginal characteristics of more than 20 minutes of duration, with changes in the electrocardiogram…
- Trial name
- LEVOCEST (NCT03699215)
- Testing
- Levosimendan
- Where
- Spain
- Volunteers
- 184 people
- Sponsor
- Hospital Universitario de Canarias
Low Cardiac Output Syndrome
Levosimendan in High Risk Patients Undergoing Cardiac Surgery
Low cardiac output syndrome (LCOs) is a serious complication in critically ill patients or those undergoing major surgery, resulting in multiple organ damage with significant in-hospital and long-term morbidity and mortality, as…
- Trial name
- CHEETAH (NCT00994825)
- Testing
- Levosimendan
- Where
- 18 sites in Brazil, Italy and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Università Vita-Salute San Raffaele
Acute Heart Failure
Levosimendan Pharmacokinetics in Children
Levosimendan is a drug used in patients with heart failure and has several advantages over other heart failure drugs. A lot of research has been done with Levosimendan in Adults, and the way the body handles the drug…
- Trial name
- LevoCorKids (NCT01704131)
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- Leiden University Medical Center
Heart Failure
Effect of Levosimendan on miRNAs Regulation in the Failing Hearts
Chronic heart failure is the terminal stage of various cardiovascular diseases. It is characterized with high fatality rate and high recurrence rate, which brings a heavy economic burden to patients and society.
- Trial name
- NCT04950569
- Testing
- levosimendan
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Tongji Hospital
Myocardial Infarction, Heart Failure
Levosimendan in Acute Heart Failure Following Acute Myocardial Infarction.
The purpose of this study is to determine the safety and efficacy of a 24 hour infusion with levosimendan in patients with acute myocardial infarction and heart failure after acute percutaneous coronary intervention (PCI)…
- Conditions
- Myocardial Infarction, Heart Failure, Cardiogenic Shock
- Trial name
- NCT00324766
- Testing
- levosimendan
- Where
- Norway
- Volunteers
- 61 people
- Sponsor
- Oslo University Hospital
Acute Heart Failure
FranceLEVO - Zimino Registry (FZR)
The French National Authority for Health (Haute Autorité de santé) requested a registry study to obtain post-market surveillance data to describe baseline clinical profiles, management and outcome of patients treated with…
- Trial name
- FZR (NCT04252404)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Arcothova
Heart Failure
Myocardial Hemodynamic Effects of Levosimendan
This study will test the hypothesis that mechanical efficiency as measured by pressure-volume loop assessment should improve during short-term treatment with intravenous levosimendan.
- Trial name
- NCT00585104
- Testing
- levosimendan
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Utah
Diastolic Dysfunction, Left Ventricular Hypertrophy
Effects of Levosimendan in Patients Eligible for Aortic Valve Replacement With Left Ventricular Hypertrophy
This is a clinical, randomised, double-blinded study in which patients eligible for aortic valve replacement are enrolled. Patients receive infusion of either levosimendan or placebo 4 hours prior to surgery and until the end of…
- Trial name
- NCT01188369
- Testing
- levosimendan
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Cardiorenal Syndrome
Levosimendan Versus Dobutamine for Renal Function in Heart Failure
Although inotropes have a favorable effect on central hemodynamics in patients with heart failure, their effect on renal hemodynamics is incompletely defined.
- Trial name
- ELDOR (NCT02133105)
- Testing
- Levosimendan, Dobutamine
- Where
- Sweden
- Volunteers
- 33 people
- Sponsor
- Göteborg University
Cardiac Surgery, Low Ejection Fraction
Impact of Perioperative Levosimendan on Patients Undergoing Cardiac Surgery With Low Ejection Fraction
to compar levosemindan to other cardiac intropic medications that strengthen the heart in diffrent common adult heart surgery with patients with low ejection fraction(weak heart)
- Trial name
- NCT06784570
- Testing
- levosemindan, adrenaline,noreadrenaline,dopamine and doputamine
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Zagazig University
Muscle Weakness Conditions, Weaning Failure
Effects of Levosimendan on Diaphragm Function in Mechanically Ventilated Patients
Levosimendan is a relatively new drug that improves cardiac contractility in patients with heart failure. Its main mechanism of action is enhanced binding of calcium to the myocardial contractile proteins.
- Trial name
- NCT01721434
- Testing
- Levosimendan
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- University Medical Center Nijmegen
Aortic Valve Stenosis, Heart Failure
The Effectiveness and Safety of Levosimendan in Patients With Severe Aortic Stenosis and Heart Failure Undergoing Transcatheter Aortic Valve Replacement
A study to evaluate the effectiveness and safety of levosimendan compared with placebo in subjects with severe aortic stenosis and heart failure undergoing transcatheter aortic valve replacement
- Conditions
- Aortic Valve Stenosis, Heart Failure, Inotropic Agents, Safety Issues
- Trial name
- NCT04573049
- Testing
- Levosimendan
- Where
- China
- Volunteers
- 124 people
- Sponsor
- China National Center for Cardiovascular Diseases
Heart Failure
Repetitive Levosimendan Infusion for Patients With Advanced Chronic Heart Failure
Repetitive levosimendan infusions for patients with advanced chronic heart failure (LeoDOR) A randomised, double-blind, placebo-controlled multicentre study with parallel group design.
- Trial name
- LeoDOR (NCT03437226)
- Testing
- Levosimendan 2.5 MG/ML
- Where
- Austria
- Volunteers
- 264 people
- Sponsor
- Dr. Gerhard Pölzl
Heart Failure, Congestive
Evaluation of Intravenous Levosimendan Efficacy in the Short Term Treatment of Decompensated Chronic Heart Failure.
The purpose of this study is to evaluate the efficacy of a 24-hour infusion of levosimendan compared with placebo in the treatment of decompensated chronic heart failure.
- Trial name
- NCT00048425
- Testing
- Levosimendan
- Where
- 166 sites in United States, Australia and 2 more
- Volunteers
- 600 people
- Sponsor
- Abbott
Coronary Artery Bypass Grafting, Left Ventricular Dysfonction
Preoperative Levosimendan in CABG Patients With Poor LV Function
The investigators want to test the hypothesis that an infusion of levosimendan started prior to CABG surgery can reduce incidence and severity of low cardiac output syndrome in patients with poor LV function (EF 40% or less).
- Trial name
- LICORN (NCT02184819)
- Testing
- levosimendan
- Where
- France
- Volunteers
- 335 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiogenic Shock, Refractory Shock
Levosimendan for Veno-arterial ECMO Weaning
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a temporary mechanical circulatory support that has been increasingly used over the last decade to restore and maintain adequate end-organ perfusion, with data…
- Trial name
- WEANECMO (NCT04323709)
- Testing
- Data collection, Data analysis
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Cardiovascular Diseases
Levosimendan Versus Dobutamine in Cardiopatic Patients Undergoing Major Non Cardiac Surgery
This study wants to investigate the hemodynamic changes in cardiopatic patients undergoing major non cardiac surgery, during and after the continuous infusion of levosimendan or dobutamine.
- Trial name
- NCT02012946
- Testing
- Levosimendan, Dobutamine
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Policlinico Umberto I
Respiratory Muscle Function
Effect of Levosimendan on Respiratory Muscle Function in Healthy Subjects
The purpose of this study is to investigate if levosimendan improves contractile performance of the diaphragm in healthy subjects.
- Trial name
- LSD1 (NCT01101620)
- Testing
- Levosimendan
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center Nijmegen