Clinical trials: Levothyroxine
Levothyroxine, Cardiac Function
Levothyroxine Treatment on Cardiac Function in Children With Subclinical Hypothyroidism
This study aims to evaluate the effect of the treatment with levothyroxine on cardiac function in children with subclinical hypothyroidism.
- Conditions
- Levothyroxine, Cardiac Function, Children, Subclinical Hypothyroidism
- Trial name
- NCT07393165
- Testing
- L-thyroxine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Pregnancy Related, Thyroid Stimulating; Hormone, C
Correlation Between Levothyroxine and Blood Th17/Treg in Pregnant Women With Normal-high TSH and Positive TPOAb
The purpose of this clinical trial is to understand the impact of different doses of levothyroxine on the immune inflammatory response in pregnant women with normal-high TSH and positive TPOAb in the first half of pregnancy.
- Trial name
- NCT06527859
- Testing
- Levothyroxin
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Third Affiliated Hospital of Zhengzhou University
Hypothyroidism, Brain Tumor
Combined Levothyroxine/Liothyronine Supplementation in Hypothyroid Patients With Brain Tumors
Primary Objectives: 1. Assess whether combined treatment with Levothyroxine and Liothyronine improves learning and memory. 2. Explore the relationship between T3 treatment and other domains of cognitive function, quality of life…
- Trial name
- NCT00488644
- Testing
- Levothyroxine, Liothyronine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
Healthy
Bioequivalence Study of Levothyroxine Sodium Tablets 150 mcg
The objective of this study is to establish the bioequivalence of two levothyroxine formulations through the estimation of T4 levels in serum samples after baseline correction, according to Food and Drugs Administration (FDA)…
- Trial name
- NCT03634371
- Testing
- Drug Levothyroxine 150 mcg, Drug Eutirox 150 mcg
- Where
- Colombia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tecnoquimicas
Hypothyroidism
Comparison of Levothyroxine Formulation in Hypothyroid Patients With Enteral Feeding
The purpose of this study is to test a liquid levothyroxine formula and examine if it will lead to improvement in management of thyroid function and if it improves hypothyroid symptoms that patients experience.
- Trial name
- NCT04878614
- Testing
- Levothyroxine Tablet, Levothyroxine Sodium
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Hypothyroidism
Interventional Study to Improve Medication Adherence Using Patient Decision Aid
Background: Although hypothyroidism is easily treated with levothyroxine (LT4) replacement, results from several studies indicate that people receiving LT4 replacement often have under- or over-replaced thyroid function.
- Trial name
- IMPART (NCT06205303)
- Testing
- Patient Decision Aid (Video)
- Where
- Singapore
- Volunteers
- 236 people
- Sponsor
- SingHealth Polyclinics
Healthy
Levothyroxine-sodium Bioequivalence Trial With Oral Single Dose Administration
Levothyroxine-sodium Bioequivalence Trial With Oral Single Dose Administration
- Trial name
- NCT06547242
- Testing
- Levothyroxin
- Where
- Germany
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Berlin-Chemie AG Menarini Group
Keratoconus
The Possible Role of Thyroxine in Keratoconus Development
Keratoconus (KC) is a corneal ectatic disorders, with incidence rate 1 per 50,000 among the population. Hormonal imbalances may be associated with KC as it affects the corneal metabolism.
- Trial name
- NCT03637673
- Testing
- No intervention
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Alexandria University
Hypothyroidism
Long-Term Efficacy and Safety of Once-Weekly Levothyroxine Regimen in Hypothyroid Patients
Hypothyroidism is a prevalent endocrine disorder characterized by insufficient production of thyroid hormones. Traditional treatment involves daily administration of levothyroxine (L-T4), which can be challenging for some…
- Trial name
- NCT07133295
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Sohag University
Hypothyroidism
Thyroxine Titration Study
The aim of the study is to examine the effects of fine titration of thyroxine dosage on symptoms of hypothyroidism, wellbeing and quality of life.
- Trial name
- NCT00111735
- Testing
- Thyroxine
- Where
- Australia
- Volunteers
- 55 people
- Sponsor
- Sir Charles Gairdner Hospital
Hypothyroidism, Hyperthyroidism
NOMOTHETICOS: Nonlinear Modelling of Thyroid Hormones' Effect on Thyrotropin Incretion in Confirmed Open-loop Situation
The NOMOTHETICOS study is a unicentric cross-sectional study for a quantitative analysis of feedback-inhibition in the thyrotropic homeostatic control.
- Trial name
- NOMOTHETICOS (NCT01145040)
- Where
- 3 sites in Germany
- Volunteers
- 138 people
- Sponsor
- Ruhr University of Bochum
Thyroid Carcinoma, Hypothyroidism
The Effect of Coffee on the Absorption of Thyroid Hormone in Patients With Thyroid Carcinoma
The purpose of this study is to evaluate whether taking thyroid hormone medication with beverages other than water, decreases absorption of the medication by the intestine.
- Trial name
- NCT01707056
- Testing
- Black Coffee, Coffee with Milk, Black Tea
- Where
- 3 sites in United States
- Sponsor
- Medstar Health Research Institute
Malignant Neoplasm of Thyroid Stage I, Malignant Neoplasm of Thyroid Stage II
Effect of Metformin on Decrement in Levothyroxin Dose Required for Thyroid Stimulating Hormone (TSH) Suppression in Patients With Differentiated Thyroid Cancer
Differentiated thyroid cancer is the most common neoplasm of endocrine system. After surgery and radioiodine treatment, thyroid stimulating hormone (TSH) suppression is the main goal which is achieved with levothyroxine…
- Trial name
- NCT01341886
- Testing
- Metformin
- Where
- Iran
- Volunteers
- 51 people
- Sponsor
- Mashhad University of Medical Sciences
Melasma, Hyperthyroidism
Comparative Study of mMASI Before and After Hyperthyroid Therapy in Hyperthyroid Subjects With Melasma
Study's objectives are to determine proportion of melasma cases in hyperthyroid patients and to compare severity of melasma before and after medications of three months hyperthyroid therapy using modified melasma area and…
- Trial name
- NCT04346901
- Testing
- Thiamazol
- Where
- Indonesia
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Dr.dr.Irma Bernadette, SpKK (K)
Myocardial Infarction, Hypothyroidism
Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction(ThyroHeart-AMI)
Based on accumulating evidences showing that hypothyroid status is associated with poor prognosis among acute myocardial infarction (AMI) patients, the study is designed to evaluate whether replacement treatment with…
- Trial name
- NCT02512978
- Testing
- Levothyroxine
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Hypothyroidism
Dosing of LT4 in Older Individuals
Our overall goal is to determine the clinical consequences of allowing greater flexibility in LT4 dosing in older individuals who take LT4.
- Trial name
- DOT4 (NCT06073665)
- Testing
- Levothyroxine Sodium
- Where
- United States
- Volunteers
- 228 people
- Sponsor
- University of Pennsylvania
Malignant Neoplasm of Thyroid, Heart Diseases
Thyrotropin Over-suppression and Heart
The investigators evaluated the cardiac effects of Thyroid-stimulating hormone (TSH) over-suppression in women with differentiated thyroid cancer (DTC) frequently encountered during suppression therapy.
- Conditions
- Malignant Neoplasm of Thyroid, Heart Diseases, Thyrotoxicosis on Thyroxine Therapy
- Trial name
- NCT02645786
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Chuncheon Sacred Heart Hospital
Child Development Disorders, Pregnancy
The Effect of Thyroid Hormone Levels in Pregnant Women on the Intelligence Quotient (IQ) of Their Children
This study is designed to test the hypothesis that the level of the thyroid hormone thyroxine (specifically, free thyroxine, FT4) circulating in the blood of pregnant women is the key thyroid-related factor to influence early…
- Conditions
- Child Development Disorders, Pregnancy, Subclinical Hypothyroidism
- Trial name
- NCT00147433
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Healthy
Fasting Study of Levothyroxine Sodium Tablets 300 μg to Levothroid® Tablets 300 μg
The objective of this study was to investigate the bioequivalence of Mylan's levothyroxine sodium 300 μg tablets to Lloyd's Levothroid® 300 μg tablets following a single 600 μg (2 x 300 μg) dose administered in healthy adult…
- Trial name
- NCT00648700
- Testing
- Levothyroxine Sodium Tablets 300 μg, Levothroid® Tablets 300 μg
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Hypothyroidism Primary
The Effect of Dietary Supplements for Pregnant Women on Levothyroxine Absorption
Hypothyroidism is a common disease that is successfully treated with the replacement of thyroid hormones in the form of levothyroxine.
- Trial name
- NCT04988802
- Testing
- Prenatal Nutrients Solgar
- Where
- Croatia
- Volunteers
- 37 people
- Sponsor
- University Hospital Dubrava