Clinical trials: Levothyroxine
Autoimmune Hypothyroidism
LT4/LT3 Combination Therapy Versus LT4 Monotherapy in Patients with Autoimmune Hypothyroidism.
Hypothyroidism is common, affecting 5% of the general population, for which levothyroxine (LT4) monotherapy is the standard treatment.
- Trial name
- T3-4-Hypo (NCT05682482)
- Testing
- LT3 (liothyronine)
- Where
- 19 sites in Netherlands
- Volunteers
- 600 people
- Sponsor
- M. Medici
Energy Supply; Deficiency, Carbohydrate Availability
Endocrinological and Physiological Responses to Short-term Reduced Carbohydrate Availability in Males
Using a randomised crossover design, nine weight-stable men, aged 18 - 40 years old, will be recruited via convenience sampling from the staff and student body of LJMU and local area.
- Trial name
- NCT05551455
- Testing
- Nutritional/dietary intake manipulation ('Normal'), Nutritional/dietary intake manipulation ('Low')
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Hypothyroidism
Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers
GSK markets a drug called levothyroxine or T4 that is used to treat patients with hypothyroidism. Till date, the active drug substance or active pharmaceutical ingredient (API) for levothyroxine tablets marketed in India has been…
- Trial name
- NCT01536678
- Testing
- Levothyroxine
- Where
- India
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Subclinical Hypothyroidism
Discontinuation of Levothyroxine Therapy for Patients With Subclinical Hypothyroidism
The investigators propose the following hypothesis: discontinuation of levothyroxine (LT4) for veterans with subclinical hypothyroidism (SCH) will be feasible, acceptable, and safe and will not negatively affect their Quality of…
- Trial name
- NCT04288115
- Testing
- Levothyroxine
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VA Office of Research and Development
Central Hypothyroidism
Central Hypothyroidism, a Novel Laboratory Measurement
Medical management of central hypothyroidism is controversial due to lack of reference for evaluation of pituitary negative feedback.
- Trial name
- NCT01280292
- Testing
- Eltroxin
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Subclinical Hypothyroidism, Infertility
Levothyroxine Treatment and IVF Outcomes in Women With Subclinical Hypothyroidism: A Target Trial Emulation
Subclinical hypothyroidism (SCH) is defined by elevated thyroid-stimulating hormone (TSH) with normal free thyroxine (fT4) levels.
- Conditions
- Subclinical Hypothyroidism, Infertility, Assisted Reproductive Technology, In Vitro Fertilization (IVF)
- Trial name
- LESI (NCT07257250)
- Where
- 2 sites in Vietnam
- Volunteers
- 900 people
- Sponsor
- Mỹ Đức Hospital
Healthy
A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028)
Levothyroxine (T4) is a man-made thyroid hormone used to treat certain thyroid conditions. After taking levothyroxine, a person's body changes it to triiodothyronine (T3).
- Trial name
- NCT06625814
- Testing
- Levothyroxine, Enlicitide Decanoate
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Hypothyroidism, Thyroid Cancer
Patient-centered Dosage of Levothyroxine
Levothyroxine is the most used thyroid hormone replacement when the thyroid gland is failing. Because dosage adjustment normally takes several months, the investigators have developed a decision support tool (DST) that predicts…
- Conditions
- Hypothyroidism, Thyroid Cancer, Thyroid
- Trial name
- NCT06455371
- Testing
- Decision support tool
- Where
- 3 sites in Norway
- Volunteers
- 240 people
- Sponsor
- University Hospital of North Norway
Pregnancy, Hypothyroidism
Thyroid Hormone Dose Adjustment in Pregnancy
Our aim is to compare the safety and efficacy of 2 different empiric levothyroxine dose adjustment recommendations to be made at the first confirmation of pregnancy in women with a history of hypothyroidism.
- Trial name
- NCT00230802
- Testing
- Anticipatory dose increase of levothyroxine, levothyroxine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Brigham and Women's Hospital
Primary Hypothyroidism.
Desiccated Thyroid Extract and Levothyroxine for Hypothyroidism Treatment
Our hypothesis is that hypothyroid patients on DTE may have a decrease in symptoms, an improvement of cognitive function, and an increase in sense of well-being/ quality of life equivalently compared with L-T4.
- Trial name
- DTE (NCT01739972)
- Testing
- Levothyroxine, Desiccated thyroid extract
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Walter Reed National Military Medical Center
Child Development Disorders, Pregnancy
The Effect of Thyroid Hormone Levels in Pregnant Women on the Intelligence Quotient (IQ) of Their Children
This study is designed to test the hypothesis that the level of the thyroid hormone thyroxine (specifically, free thyroxine, FT4) circulating in the blood of pregnant women is the key thyroid-related factor to influence early…
- Conditions
- Child Development Disorders, Pregnancy, Subclinical Hypothyroidism
- Trial name
- NCT00147433
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Chronic Prostatitis
Non Interventional Study of Levofloxacin in Chronic Prostatitis
Chronic prostatitis is a common disease in men with the following typical symptoms decreasing the ability to work and quality of life: pain, urination disorders, copulatory dysfunction.
- Trial name
- Levolet-R (NCT02711943)
- Testing
- Levofloxacin 500
- Volunteers
- 500 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Hashimoto Disease, Treatment Levothyroxine
Effect of Treatment for Vitamin D Deficiency on Thyroid Function and Autoimmunity in Hashimoto's Thyroiditis.
The objective of this study is to evaluate the effect of vitamin D supplementation on thyroid autoimmunity, thyroid function, and other metabolic and clinical variables associated with the thyroid axis in patients with…
- Conditions
- Hashimoto Disease, Treatment Levothyroxine, Vitamin D Deficiency
- Trial name
- NCT04778865
- Testing
- Vitamin D-correction, Vitamin D-RDA
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad de Valparaiso
Recurrent Goiter
Thyroid Lobectomy With or Without Levothyroxine Treatment Postoperatively
The aim of this study was to compare the prevalence of recurrent nodular goiter in the contralateral thyroid lobe among patients after unilateral thyroid lobectomy for unilateral multinodular goiter receiving versus not receiving…
- Trial name
- NCT00941551
- Testing
- levothyroxine, no levothyroxine
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Jagiellonian University
Hypothyroidism
Long-Term Efficacy and Safety of Once-Weekly Levothyroxine Regimen in Hypothyroid Patients
Hypothyroidism is a prevalent endocrine disorder characterized by insufficient production of thyroid hormones. Traditional treatment involves daily administration of levothyroxine (L-T4), which can be challenging for some…
- Trial name
- NCT07133295
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Sohag University
Schizophrenia, Avolition
A Clinical Trial of Adjunctive Thyroxine for Avolition in Schizophrenia
The goal of this clinical trial is to investigate whether adjunctive thyroxine treatment can ameliorate motivation deficits in adults with schizophrenia experiencing predominant avolition (core negative symptom).
- Trial name
- NCT07011953
- Testing
- Antipsychotics plus Levothyroxine Sodium
- Volunteers
- 90 people
- Sponsor
- Peking University
Congenital Hypothyroidism
Use of Tirosint®-SOL or Tablet Formulations of Levothyroxine in Pediatric Patients With Congenital Hypothyroidism (CH)
This is a multi-center, prospective, parallel-group, open-label, randomized clinical study in one hundred and twenty-six (126) neonates and infants diagnosed with CH.
- Trial name
- NCT05228184
- Testing
- Tirosint®-SOL, Levothyroxine Sodium
- Where
- 10 sites in United States
- Volunteers
- 34 people
- Sponsor
- IBSA Institut Biochimique SA
Pregnancy Complicated by Hyperthyroidism, Hypothyroidism in Pregnancy
Maternal Autoimmune Thyroid Disease and Fetal Thyroxin
The purpose of this trial is to correlate fetal thyroid hormones from fetal cord blood with clinical (maternal antithyroid drug dose and antithyroid antibodies) and ultrasound (US) parameters of fetal thyroid function from…
- Trial name
- NCT01528904
- Where
- Serbia
- Volunteers
- 83 people
- Sponsor
- University of Belgrade
Thyroid Cancer
Quantitative Pharmacology-Based Dose Adjustment Protocol in Postoperative Thyroid Cancer Patients
Through pharmacometric approaches-including modeling, mathematics, and statistics-this work aims to refine the levothyroxine sodium tablet (brand name: Euthyrox) dosing strategy in post-thyroidectomy cancer patients, enabling…
- Trial name
- NCT07752277
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Zhejiang Provincial People's Hospital
Subclinical hypothyroïdism
Effects of Levothyroxine Treatment on Hemodynamic and Renal Functions in Subclinical Hypothyroidism
Renal and cardiovascular effects of subclinical hypothyroidism, defined by a high TSH and normal T4 are less known and the indications for treatment of subclinical hypothyroidism are subject to controversies.
- Trial name
- NCT02186405
- Testing
- LEVOTHYROXINE
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire de Nice