Clinical trials: Lichen
Vulvar Lichen Sclerosus
Dynamic Quadripolar Radiofrequency VS Topical Corticosteroids in Women With Vulvar Lichen Sclerosus
This is a prospective, randomized study in women of reproductive age with vulvar lichen sclerosus. Participants will be randomly assigned by investigators using a computer-generated sequence to receive either combined dynamic…
- Trial name
- NCT07363733
- Testing
- Dynamic Quadripolar Radiofrequency (DQRF), Topical high-potency corticosteroid
- Where
- Russia
- Volunteers
- 68 people
- Sponsor
- Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Oral Lichen Planus, Leptin Levels
Salivary and Serum Leptin Levels in Oral Lichen Planus Patients: A Case-control Study.
This study aims to evaluate the levels of leptin in both saliva and serum samples of patients diagnosed with oral lichen.
- Trial name
- NCT06078579
- Testing
- Leptin
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Cairo University
Lichen Sclerosus, Lichen Sclerosus Et Atrophicus
Nd:Yttrium Aluminum Garnet Laser Treatment for Lichen Sclerosus
This study evaluates the efficacy of Nd:Yttrium Aluminum Garnet Laser (Nd:YAG) Treatment of Lichen sclerosus in comparison with topical corticosteroid treatment.
- Trial name
- NCT03525522
- Testing
- Nd:YAG Laser, Topical corticosteroid Diprosone
- Volunteers
- 40 people
- Sponsor
- Dr Adolf Lukanovič
Oral Lichen Planus
Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treat Oral Lichen Planus
Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease characterized by outbreaks or flares. It affects 0.2-1.9% of the population.
- Trial name
- lichenPlanus (NCT02421770)
- Testing
- Chamaemelum nobile 2%
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad de Murcia
Lichen Planus
Dexamethasone Solution for the Treatment of Oral Lichen Planus
The objective of this single center, 4-week, open label randomized, phase II study is to evaluate and characterize the tolerability and clinical effectiveness of dexamethasone 0.5mg/5ml solution in a mucoadhesive vehicle…
- Trial name
- NCT02850601
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Brigham and Women's Hospital
Oral Lichen Planus, Mucous Membrane Pemphigoid
Dexamethasone Solution and Dexamethasone in Mucolox™
Topical steroid therapy is considered the first line of treatment for Oral Inflammatory Ulcerative Diseases with current treatment regimens requiring multiple application or rinses daily.
- Conditions
- Oral Lichen Planus, Mucous Membrane Pemphigoid, Pemphigus Vulgaris, Chronic Graft-versus-host-disease
- Trial name
- NCT04540133
- Testing
- dexamethasone 0.5mg/5ml solution, dexamethasone 0.5mg/5ml solution in Mucolox™
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Oral Lichen Planus
Evaluation of Efficacy and Safety of add-on Tofacitinib in Patients With Oral Lichen Planus
Many of the patients with oral lichen planus (OLP) either fail to achieve complete remission or experience frequent relapses with conventional topical corticosteroid therapy, which is currently the mainstay of treatment.
- Trial name
- NCT07131813
- Testing
- Tofacitinib 5 mg BID and Triamcinolone ointment
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Lichen Sclerosus of Vulva
Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus
Lichen sclerosus (LS) is a skin condition of the external genitals (vulva) of women. LS causes vulvar itching, pain, and burning.
- Trial name
- NCT03045172
- Testing
- Platelet Rich Plasma
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Center for Vulvovaginal Disorders
Oral Lichen Planus, Periodontal Diseases
Periodontal Initial Treatment Combined With Glucocorticoid Therapy for Erosive Oral Lichen Planus
The purpose of this clinical trial is to understand whether the combination of periodontal initial treatment under local anesthesia and glucocorticoids can improve the effectiveness of treatment for erosive oral lichen planus.
- Trial name
- NCT06498180
- Testing
- Periodontal initial treatment under local anesthesia, Glucocorticoid Therapy, oral hygiene instruction
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Oral Lichen Planus
Molecular & Cellular Characterisation of Oral Lichen Planus
The principal research objective is to provide enhanced understanding of the cellular and molecular events important in the pathogenesis of Oral Lichen Planus to enable improved diagnosis and development of novel treatments for…
- Trial name
- NCT04289233
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Birmingham
Oral Lichen Planus
The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% FAO in the Management of Oral Lichen Planus
This randomized, double-blind clinical trial evaluates the therapeutic effects of curcumin in nanogels compared to 0.1% fluocinolone acetonide oral paste in the management of atrophic-erosive oral lichen planus (OLP).
- Trial name
- NCT06932848
- Testing
- Curcumin in Nanogels, 0.1% Fluocinolone Acetonide Oral Paste
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Oral Lichen Planus
Impact of PDT and Topical Corticosteroids on Taste Perception and Salivary Oxidative Stress Markers in Patients With OLP
Oral lichen planus (OLP) is a long-term inflammatory disease affecting the lining of the mouth. It may cause pain, burning sensations, discomfort, and changes in the appearance of the oral mucosa.
- Trial name
- NCT07536737
- Testing
- 5-Amino Levulinic Acid, Clobetasol Propionate 0.05% Cream
- Where
- Poland
- Volunteers
- 65 people
- Sponsor
- Medical University of Bialystok
Lichen Planus, Oral
Evaluation of Desmoglein-3 Autoantibodies in the Tissues of Oral Lichen Planus and Correlation with Disease Severity
1. evaluate the level of Dsg3 autoantibodies in tissue biopsy of Atrophic/Bullous Erosive (A/BE) OLP (Primary Objective). 2. correlate the severity of the disease with the level of tissue Dsg3 autoantibodies (Secondary Objective).
- Trial name
- NCT06652477
- Testing
- ELISA
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Vulvar Lichen Sclerosus
To Compare Inflammatory Biomarkers Before and After Treatment With Clobetasol or Fractional CO2 Laser, in Women With Histologically Confirmed Vulvar Lichen Sclerosus, Without Prior Corticosteroid Treatment.
The present study is a Clinical trial that compares clobetasol ointment versus Fractional CO2 laser for vulvar lichen sclerosus (VLE) treatment confirmed by histology, with no previous treatment.
- Trial name
- LASER (NCT07240519)
- Testing
- Fractional microablative CO2 Laser
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Oral Cancer, Oral Lichen Planus
Diagnostic Accuracy of Salivary Gamma-synuclein in Oral Malignant and Premalignant Lesions
Synucleins are a family of small, highly conserved proteins found in vertebrates and are specially abundant in neurons particularly in presynaptic terminals (Surguchov et al., 2001).
- Conditions
- Oral Cancer, Oral Lichen Planus, Oral Leukoplakia, Premalignant Lesion
- Trial name
- NCT04732741
- Testing
- Salivary Gamma-synuclein, Incisional biopsy, Conventional visual and tactile examination
- Volunteers
- 69 people
- Sponsor
- Cairo University
Oral Lichen Planus
The Clinical and Biological Effects Of The Use Of Probiotic VSL#3 In Patients With Oral Lichen Planus
Oral Lichen Planus (OLP) is an inflammatory disease of mucosal and skin with unknown etiology. The prevalence rate in England is reported to be between 1-2.4%.
- Trial name
- CABRIO (NCT03052179)
- Testing
- Poly-biotic
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Atopic Dermatitis, Psoriasis
Identification of Cutaneous and Blood Biomarkers Predictive of Response to Systemic Treatments During Chronic Inflammatory Skin Diseases
Chronic inflammatory skin diseases constitute a heterogeneous group of pathologies. They affect the skin but also other organs (joints, lungs, muscles, etc.). Their prognosis and response to treatments is extremely variable.
- Conditions
- Atopic Dermatitis, Psoriasis, Hidradenitis Suppurativa, Lichen Planus
- Trial name
- ImmuneSkinBank (NCT06599411)
- Testing
- Sampling
- Where
- France
- Volunteers
- 830 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lichen Sclerosus
Platelet Rich Plasma Injections for Vulvar Lichen Sclerosus
15 patients with biopsy proven active vulvar lichen sclerosus will be recruited by a clinic specializing in vulvar disorders. This study consists of a 2 week screening period and a 12-week treatment period.
- Trial name
- NCT02794363
- Testing
- Autologous platelet rich plasma
- Volunteers
- 15 people
- Sponsor
- Center for Vulvovaginal Disorders
Lichen Planus
Treatment Of Oral Lichen Planus
This novel project aims to explore an alternative treatment for oral lichen planus (OLP), a challenging condition with limited therapeutic options.
- Trial name
- NCT06327620
- Testing
- Daivobet ointment, topical steroids
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Mansoura University
Oral Lichen Planus
A Comparison of Photodynamic Therapy and Topical Clobetasol in Treatment of Oral Lichen Planus: a Split-Mouth Randomised Controlled Study
Lichen planus is a chronic inflammatory dermatosis. It most often affects the skin and mucous membranes. Sometimes lesions may appear in the area of nails (estimated at 10% of patients) or genital organs and anus.
- Trial name
- NCT06752343
- Testing
- Photodynamic Therapy, Clobetasol
- Where
- Poland
- Volunteers
- 29 people
- Sponsor
- Wroclaw Medical University