Clinical trials: Lichen Planus, Oral
Lichen Planus, Oral
Hydroxychloroquine vs. Clobetasol Rinse to Treat Oral Lichen Planus
This study will compare two treatments for oral lichen planus - hydroxychloroquine (Plaquenil) tablets and clobetasol oral rinse.
- Trial name
- NCT00102557
- Testing
- Hydroxychloroquine
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Oral Lichen Planus
Impact of PDT and Topical Corticosteroids on Taste Perception and Salivary Oxidative Stress Markers in Patients With OLP
Oral lichen planus (OLP) is a long-term inflammatory disease affecting the lining of the mouth. It may cause pain, burning sensations, discomfort, and changes in the appearance of the oral mucosa.
- Trial name
- NCT07536737
- Testing
- 5-Amino Levulinic Acid, Clobetasol Propionate 0.05% Cream
- Where
- Poland
- Volunteers
- 65 people
- Sponsor
- Medical University of Bialystok
Oral Lichen Planus
Micronutrients in Management of Symptomatic Oral Lichen Planus
Treatment of oral lichen planus is challenging. Diverse therapeutic modalities have been suggested, but a permanent cure is not yet available.
- Trial name
- NCT04765267
- Testing
- Zinc sulphate heptahydrate
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Lichen Planus, Oral, Lichen Planus of Vulva
Clinical and Molecular Correlates of Response to First Line Treatment in Lichen Planus
Lichen planus is a common inflammatory (swelling and pain of tissue) disease in the general population that affects mostly the mouth although skin and genital areas can also be affected.
- Trial name
- NCT05330572
- Testing
- No interventions were administered to the patients as a part of this study.
- Where
- 2 sites in United Kingdom
- Volunteers
- 110 people
- Sponsor
- University of Aberdeen
Oral Lichen Planus
Evaluation of Efficacy and Safety of add-on Tofacitinib in Patients With Oral Lichen Planus
Many of the patients with oral lichen planus (OLP) either fail to achieve complete remission or experience frequent relapses with conventional topical corticosteroid therapy, which is currently the mainstay of treatment.
- Trial name
- NCT07131813
- Testing
- Tofacitinib 5 mg BID and Triamcinolone ointment
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Oral Lichen Planus
Evaluating LP-10 in Subjects With OLP
This is a multicenter, dose-ranging study including adult male and female subjects (>= 18 years old) with symptomatic Oral Lichen Planus (OLP).
- Trial name
- NCT06233591
- Testing
- LP-10 (Liposomal Tacrolimus)
- Where
- 7 sites in United States
- Volunteers
- 24 people
- Sponsor
- Lipella Pharmaceuticals, Inc.
Oral Lichen Planus
Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen Planus
60 individuals were subdivided into 2 groups, 30 patients with oral lichen planus, 30 control individuals. Expression of miRNA-138 and cyclin D1 were evaluated in oral mucosa utilizing Quantitative real-time polymerase chain…
- Trial name
- NCT02834520
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Cancer, Oral Leukoplakia
Oral Cancer Screening and Education in Hong Kong
This study will be conducted to obtain data on oral cancer risk factors to generate machine learning models with good predictive accuracy for stratifying individuals with high-oral cancer risk and delineating high-risk and…
- Conditions
- Oral Cancer, Oral Leukoplakia, Oral Submucous Fibrosis, Proliferative Verrucous Leukoplakia
- Trial name
- NCT04487938
- Testing
- No intervention utilised
- Volunteers
- 3,190 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Oral Lichen Planus
Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus
Bromelain, an enzyme extract derived from pineapples, has shown promise due to its anti-inflammatory and wound-healing properties. However, its efficacy in treating oral mucosal ulcers remains unexplored.
- Trial name
- NCT06981767
- Testing
- Topical Bromelain, 0.1% topical triamcinolone acetonide, Combination of Topical Bromelain and Triamcinolone Acetonide in Orabase
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Lichen Planus
Adjunctive Oral Systemic Vitamin E Therapy on Salivary Nitric Oxide Level in Patients With Erosive Oral Lichen Planus
Oral lichen planus (OLP) is a chronic inflammatory disease affecting the skin, mucous membranes,s and rarely scalp and nails. It is a T-cell-mediated autoimmune disease.
- Trial name
- NCT05787925
- Testing
- Topical corticosteroid and Vitamin E, Topical corticosteroid
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Hams Hamed Abdelrahman
Oral Cancer, Oral Lichen Planus
Diagnostic Accuracy of Salivary Gamma-synuclein in Oral Malignant and Premalignant Lesions
Synucleins are a family of small, highly conserved proteins found in vertebrates and are specially abundant in neurons particularly in presynaptic terminals (Surguchov et al., 2001).
- Conditions
- Oral Cancer, Oral Lichen Planus, Oral Leukoplakia, Premalignant Lesion
- Trial name
- NCT04732741
- Testing
- Salivary Gamma-synuclein, Incisional biopsy, Conventional visual and tactile examination
- Volunteers
- 69 people
- Sponsor
- Cairo University
Oral Lichen Planus, Oral Lichen Planus Related Stress
Mucoadhesive Modified-Release Formulations for the Topical Treatment of Symptomatic Oral Lichen Planus
The goal of this clinical trial is to learn if a mucoadhesive patch containing clobetasol alone or in combination with resveratrol can reduce symptoms and improve quality of life in adults with Oral Lichen Planus (OLP).
- Conditions
- Oral Lichen Planus, Oral Lichen Planus Related Stress, Oral Mucosal Disease, Oral Pain
- Trial name
- EMPATIA (NCT07100613)
- Testing
- Clobetasol Patch, Clobetasol + Resveratrol Patch, Clobetasol in Orabase
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Palermo
Lichen Planus, Oral, Lichen Planus, Mucosal
Efficacy and Safety of Baricitinib in Oral Lichen Planus: a Proof-of-Concept Study
The goal of this clinical trial is to learn the effects of baricitinib (the study drug) in patients with Oral Lichen Planus. The main questions it aims to answer are: What is the efficacy of baricitinib in treating moderate to…
- Conditions
- Lichen Planus, Oral, Lichen Planus, Mucosal, Oral Lichen Planus
- Trial name
- NCT06158113
- Testing
- Baricitinib 4 milligram Oral Tablet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of North Carolina, Chapel Hill
Erythroplakia, Fanconi Anemia
Widefield Fluorescence and Reflectance Imaging Systems and Oral Tissue Samples in Monitoring Participants at Risk for Developing Oral Cancer
This clinical trial studies widefield fluorescence and reflectance imaging, fluorescence spectroscopy, and tissue samples in regularly examining (monitoring) participants at risk for developing oral cancer.
- Conditions
- Erythroplakia, Fanconi Anemia, Lichen Planus, Oral Cavity and Lip Precancerous Condition
- Trial name
- NCT00542373
- Testing
- Cytology Specimen Collection Procedure, Diagnostic Microscopy, Diagnostic Procedure
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- M.D. Anderson Cancer Center
Oral Lichen Planus
The Effect of Topical Curcumin Versus Topical Corticosteroid on Management of Oral Lichen Planus Patients
Introduce a new anti-inflammatory and antioxidant paste preparation (curcumin paste) in the management of Oral lichen planus. Assess the efficacy of this preparation on pain, clinical parameter and the level of IL-33 in saliva.
- Trial name
- NCT03877679
- Testing
- Triamcinolone, Turmeric paste
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus
Evaluation of Salivary Level of miR-155 and IL-10 in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid
Thirty patients will be recruited from the outpatient clinic of the faculty of dentistry.fifteen systemically healthy individuals with normal mucosa and fifteen atrophic/erosive oral lichen planus patients.
- Trial name
- NCT03871114
- Testing
- Triamcinolone Acetonide in orabase
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus, Tumor Necrosis Factor-alpha
Efficacy of Aloe Vera Compared to Corticosteroid in Topical Treatment of Oral Lichen Planus and on Salivary Levels of Tumor Necrosis Factor Alpha
Aloe Vera Herbal treatment has been widely used as an anti-inflammatory and antioxidant the objective of this study was to evaluate the clinical efficacy of Aloevera gel compared to corticosteroid gel o for symptomatic oral…
- Trial name
- NCT07792512
- Testing
- aloevera gel, Topical Corticosteroid Creams (Triamcinolone acetonide 0.1% and Hydrocortisone 2.5%)
- Where
- 5 sites in Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Oral Lichen Planus, Oral Cancer
Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions
investigating the level of malondialdehyde (MDA) \& nitric oxide (NO) in saliva in oral premalignant and malignant lesions in order to determine their diagnostic value for the malignant and potentially malignant lesions.
- Conditions
- Oral Lichen Planus, Oral Cancer, Leukoplakia, Oral Keratoses
- Trial name
- NCT04267419
- Testing
- salivary biomarker
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Oral Leukoplakia, Autofluorescence
Identification of Oral Lesions Through an Autofluorescence System
The aim of the study will be to evaluate the efficacy of a tissue autofluorescence detection system as an aid to clinical screening in identifying lesions of the oral mucosa.
- Conditions
- Oral Leukoplakia, Autofluorescence, Secondary Prevention, Keratosis
- Trial name
- NCT05942794
- Testing
- Screening examination
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Federico II University
Oral Lichen Planus
Molecular & Cellular Characterisation of Oral Lichen Planus
The principal research objective is to provide enhanced understanding of the cellular and molecular events important in the pathogenesis of Oral Lichen Planus to enable improved diagnosis and development of novel treatments for…
- Trial name
- NCT04289233
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Birmingham