Clinical trials: Lichen Planus, Oral
Oral Lichen Planus
Efficacy of Topical Rapamycin to Treat Chronic Erosive Oral Lichen
The purpose of this study is to determine wether topical rapamycin is more efficient than topical steroids in the treatment of chronic erosive lichen planus.
- Trial name
- RALIB (NCT01061853)
- Testing
- TOPICAL SIROLIMUS (RAPAMUNE*), TOPICAL BETAMETHASONE 0.05%
- Where
- 9 sites in France
- Volunteers
- 76 people
- Sponsor
- University Hospital, Tours
Oral Lichen Planus, Vitamin D Deficiency
The Role of Vitamin D in Amelioration of Oral Lichen Planus and Its Effect on Salivary IFN-γ Level
The goal of this clinical trial is to compare between the use of vitamin D supplement in conjunction with systemic steroids versus the use of systemic steroids alone in the management of patients with symptomatic Oral Lichen…
- Trial name
- NCT06204796
- Testing
- vitamin D supplement was given as 60,000 IU weekly in conjunction with systemic prednisone, Systemic prednisone
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Fayoum University
Oral Lichen Planus
Dexamethasone to Treat Oral Lichen Planus
This study will evaluate the effectiveness of dexamethasone 0.01% solution in treating pain associated with oral lichen planus, a chronic disease that causes painful ulcers inside the mouth.
- Trial name
- NCT00111072
- Testing
- dexamethasone 0.01% solution
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Oral Lichen Planus
Oral Lichen Planus Treatment
Oral lichen planus (OLP) is a chronic inflammatory and immune-mediated disease affecting the oral mucosa. OLP presents with asymptomatic, lacelike white stripes and/or symptomatic red, ulcerated mucous membranes.
- Trial name
- NCT05127083
- Testing
- Patients will be treated with localized PBM with a diode laser
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Murcia
Oral Lichen Planus
Evaluation of Mucoadhesive Tacrolimus Patch on Caspase-3 Inducing Apoptosis in Oral Lichen Planus
tacrolimus has been widely used as an immunosuppressant. the objective of this study was to evaluate the clinical efficacy of tacrolimus 0.1 % in muco adhesive patch compared to tacrolimus or corticosteroids in paste forms for…
- Trial name
- NCT05139667
- Testing
- Corticosteroid Topical
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Saliva, Oral Lichen Planus
Unveiling the Protein Expression Patterns in Oral Lichen Planus and Leukoplakia Through Comparative Salivary Proteomics
The goal of this observational study is to compare salivary proteome profiles in patients with Oral Lichen Planus (OLP), Oral Leukoplakia (OL), and healthy individuals without oral mucosal disease.
- Conditions
- Saliva, Oral Lichen Planus, Oral Leukoplakia, Proteomics
- Trial name
- NCT07416318
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Lichen Planus, Oral, Low-Level Light Therapy
Photobiomodulation in Oral Lichen Planus
The aim of this study was to compare the efficacy of PBM (660nm) and corticosteroid therapy with clobetasol propionate 0.05% in the treatment of OLP. This is a protocol for a randomized, controlled, double blind clinical trial.
- Trial name
- NCT03320460
- Testing
- Propionate clobetasol gel 0.05%, Photobiomodulation
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Nove de Julho
Erosive and Atrophic Oral Lichen Planus
Cedar Honey in Oral Lichen Planus
The study aimed to evaluate the effect of cedar honey in treatment of erosive and atrophic oral lichen planus ( a common oral problem).
- Trial name
- NCT01974414
- Testing
- orally administered cedar honey
- Where
- Iran
- Volunteers
- 36 people
- Sponsor
- Mashhad University of Medical Sciences
Oral Lichen Planus, Recurrent Aphthous Stomatitis
Improving Prescribing Quality for Oral Mucosal Disorders Using a Pharmacist-Led Model
This study aims to improve how oral mucosal disorders-such as oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, herpes viral infection and oral candidiasis-are treated in dental settings.
- Conditions
- Oral Lichen Planus, Recurrent Aphthous Stomatitis, Burning Mouth Syndrome, Oral Candidiasis
- Trial name
- NCT07721090
- Testing
- Pharmacist-Led Prescribing Optimization and Patient Counselling
- Volunteers
- 336 people
- Sponsor
- University of Fujairah
Oral Lichen Planus
The Efficacy of Topical Sesame Oil Versus Topical Triamcinolone on Oral Lichen Planus and Salivary Level of Oxidative Stress Biomarker [MDA]
use seseme oil and corticosteroid topically for two groups
- Trial name
- (MDA) (NCT03738176)
- Testing
- Sesame Oil, triamcinolone in orabase
- Volunteers
- 40 people
- Sponsor
- Mona Taha Mohammed MD
Oral Lichen Planus, Periodontal Diseases
Periodontal Initial Treatment Combined With Glucocorticoid Therapy for Erosive Oral Lichen Planus
The purpose of this clinical trial is to understand whether the combination of periodontal initial treatment under local anesthesia and glucocorticoids can improve the effectiveness of treatment for erosive oral lichen planus.
- Trial name
- NCT06498180
- Testing
- Periodontal initial treatment under local anesthesia, Glucocorticoid Therapy, oral hygiene instruction
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Oral Lichen Planus
Oral Zinc Supplement as Adjunctive Therapy for Erosive Oral Lichen Planus
Lichen Planus (LP) is a chronic mucocutaneous inflammatory disease and considered as T-cell mediated autoimmune disorder. Zinc is a potent antioxidant micronutrient that contributes to the proper functioning of the antioxidant…
- Trial name
- NCT06042010
- Testing
- Oral zinc supplement, triamcinolone acetonide Oral paste
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Hams Hamed Abdelrahman
Oral Lichen Planus
A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus
Oral lichen planus (OLP) is a common sub-acute, chronic inflammatory mucocutaneous disease.This study was evaluated the comparative efficacy of lycopene and prednisolone for the treatment of oral lichen planus.
- Trial name
- OLP (NCT02587117)
- Testing
- lycopene, Prednisolone
- Volunteers
- 28 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Gingival Diseases, Gingivitis
Acquired Chronic Erosive Gingivitis: Clinical Relevance of Papillary Gingival Biopsy
Chronic erosive gingivitis is a syndrome (CEGS) that combines severe gingival inflammation and gingival erosion. The term "desquamative gingivitis" is often used in the literature to define chronic erosive gingivitis.
- Conditions
- Gingival Diseases, Gingivitis, Autoimmune Diseases, Oral Lichen Planus
- Trial name
- NCT04293718
- Testing
- papillary gum biopsies
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Oral Lichen Planus, Biopsy
Discomfort Following Oral Biopsy Comparing Laser and Punch Biopsy
Oral biopsy is essential for diagnosing mucosal lesions such as oral lichen planus (OLP). Laser surgery offers a minimally invasive alternative to traditional techniques, but thermal effects may impact healing and postoperative…
- Trial name
- OLP_BIOP (NCT07414797)
- Testing
- Laser Biopsy, Punch Biopsy
- Where
- Italy
- Volunteers
- 112 people
- Sponsor
- Catholic University of the Sacred Heart
Oral Lichen Planus
Treatment Modalities of Oral Lichen Planus
Background: Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous autoimmune disease mainly affecting stratum basal of the epithelium. It is very painful and hamper the daily routine of patients e.g.
- Trial name
- OLP (NCT03237533)
- Testing
- Dexamethasone
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- University of Faisalabad
Oral Lichen Planus
Thyme Honey for Management of Oral Lichen Planus
the study aimed to assess the effect of topical application of thyme honey in comparison to 0.1% triamcinolone acetonide oral paste on the relief of pain and clinical improvement in patients with OLP
- Trial name
- NCT06810752
- Testing
- thyme honey, Triamcinolone Acetonide
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- British University In Egypt
Degree of Adherence of Symptomatic OLP Patients to Their Medications
Adherence to Topical and Systemic Medications Among Symptomatic Oral Lichen Planus Patients: A Pilot Randomized Clinical Trial
This trial will assess the effect of adjunctive use of explanatory leaflet or daily text message reminder compared to standard instructions alone in degree of adherence of symptomatic OLP patients to their medications.
- Trial name
- NCT07879300
- Testing
- standard verbal instructions, Explanatory leaflets, text msgs
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Oral Lichen Planus, Oral Cancer
the Oncogenic Potential of Salivary miRNA-93 and miRNA-412-3P in Oral Lichen Planus Patients
Assessment The oncogenic potential of salivary microRNA-93 and microRNA-412-3p in oral lichen planus
- Trial name
- NCT05400057
- Where
- 2 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Moataz Mahmoud
Oral Lichen Planus
Intra-oral Treatment of OLP With Rivelin®-CLO Patches
Participants with symptomatic Oral Lichen Planus lesions will be treated with Rivelin® patches containing either 0, 1, 5, or 20 μg clobetasol per patch. Each participant will apply up to 6 patches twice daily for 4 weeks.
- Trial name
- NCT03592342
- Testing
- Clobetasol Propionate
- Where
- 27 sites in United States, Canada and 4 more
- Volunteers
- 140 people
- Sponsor
- Dermtreat