Clinical trials: Lichen Planus, Oral
Lichen Planus
Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus
The lichen planus is a mucocutaneous disease of unknown etiology with an incidence of 1-2%, that affects in 30-70% of cases either the mucosa of the mouth, or partly in combination with infection of the skin, the oral with his…
- Trial name
- NCT02532166
- Testing
- Esophageal lichen planus
- Where
- 2 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Ruhr University of Bochum
Oral Erosive Lichen Planus
Evaluation of the Efficacy of 0.08% Tacrolimus Nanoencapsulated Aqueous Solution Spray Vs. 0.1% Free Tacrolimus Commercial Ointment in the Treatment of Oral Lichen Planus
The goal of this clinical trial is to assess the efficacy of different formulations of the drug tacrolimus in treating patients with oral lichen planus.
- Trial name
- NCT06591884
- Testing
- Tacrolimus modified-release, tacrolimus ointment 0.1%
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Oral Lichen Planus
Evaluation of Topical Pomegranate Extracts in Management of Oral Lichen Planus (A Randomized Clinical Trial)
This study was conducted to estimate the hypothesis that the Pomegranate Extracts have no role in management of oral lichen planus
- Trial name
- NCT04193748
- Testing
- Topical pomegranate seeds and peel extracts
- Where
- 2 sites in Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Oral Leukoplakia, Oral Lichen Planus
Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy
Abstract Objective: To study the diagnostic efficiency of Rose Bengal with Toluidine blue in detecting the biopsy sites and thus establish an accurate diagnosis in oral premalignant lesions.
- Conditions
- Oral Leukoplakia, Oral Lichen Planus, Premalignant Lesion
- Trial name
- NCT03031899
- Testing
- Biopsy, Rose Bengal, toluidine blue
- Volunteers
- 27 people
- Sponsor
- The Oxford Dental College, Hospital and Research Center, Bangalore, India
Oral Lichen Planus
Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treat Oral Lichen Planus
Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease characterized by outbreaks or flares. It affects 0.2-1.9% of the population.
- Trial name
- lichenPlanus (NCT02421770)
- Testing
- Chamaemelum nobile 2%
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad de Murcia
Lichen Penis Planus
Glutamine With Topical Corticosteroids for Lichen Planus Treatment
Lichen planus (LP) is an inflammatory skin disease of unknown etiology. Glutamine promotes protein and collagen synthesis, imparts immunity, and maintains the alimentary canal mucosa structure.
- Trial name
- NCT04442633
- Testing
- Glutamine Cap/Tab, Miconazole Oral gel, Kenacort in orabase
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Hams Hamed Abdelrahman
Oral Cancer, Oral Lichen Planus
Artificial Intelligence Based Program to Classify Oral Cavity Findings Based on Clinical Image Analysis
This study aims to develop an AI program that can classify oral findings into Normal/variation of normal or an oral disease by clinical photos analysis, aiding in lowering the percentages of false positive and false negative…
- Conditions
- Oral Cancer, Oral Lichen Planus, Fordyce Granule, Leukoplakia
- Trial name
- NCT06325514
- Testing
- Artificial intelligence based program
- Where
- Egypt
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus
The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus
The aim of the present study is to assess the clinical efficacy of topical minocyclin in managing of symptoms associated with oral lichen planus (OLP).
- Trial name
- NCT01083420
- Testing
- Minocycline, Dexamethasone
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Lichen Planus
Adjunctive Oral Systemic Vitamin E Therapy on Salivary Nitric Oxide Level in Patients With Erosive Oral Lichen Planus
Oral lichen planus (OLP) is a chronic inflammatory disease affecting the skin, mucous membranes,s and rarely scalp and nails. It is a T-cell-mediated autoimmune disease.
- Trial name
- NCT05787925
- Testing
- Topical corticosteroid and Vitamin E, Topical corticosteroid
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Hams Hamed Abdelrahman
Lichen Planus, Oral
Evaluation of Desmoglein-3 Autoantibodies in the Tissues of Oral Lichen Planus and Correlation with Disease Severity
1. evaluate the level of Dsg3 autoantibodies in tissue biopsy of Atrophic/Bullous Erosive (A/BE) OLP (Primary Objective). 2. correlate the severity of the disease with the level of tissue Dsg3 autoantibodies (Secondary Objective).
- Trial name
- NCT06652477
- Testing
- ELISA
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Oral Lichen Planus
Based on Metabonomics Dryness Pathogen Type of OLP: a Dynamic Study
Due to the change of life style, the incidence of oral cavity mucous membrane disease increased.In this study，been done a large number of pre-clinical practice and some experimental studies， based on the application of…
- Trial name
- OLP (NCT02332486)
- Testing
- Qingxuan Decoction
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Heilongjiang University of Chinese Medicine
Oral Lichen Planus
Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen Planus
60 individuals were subdivided into 2 groups, 30 patients with oral lichen planus, 30 control individuals. Expression of miRNA-138 and cyclin D1 were evaluated in oral mucosa utilizing Quantitative real-time polymerase chain…
- Trial name
- NCT02834520
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Erosive Oral Lichen Planus, Atrophic Lichen Planus
Treatment Outcomes and Patient Satisfaction of Oral Lichen Planus Treatment
The goal of this clinical trial is to assess Honey in orabase (1:1) for treating patients with OLP and improving their quality of life: The research question aims to answer: Does honey in orabase (1:1) improve or reduce OLP…
- Trial name
- NCT06988527
- Testing
- Honey in orabase 1: 1 paste
- Where
- Saudi Arabia
- Volunteers
- 56 people
- Sponsor
- Dar Al Uloom University
Lichen Planus, Oral, Lichen Planus of Vulva
Clinical and Molecular Correlates of Response to First Line Treatment in Lichen Planus
Lichen planus is a common inflammatory (swelling and pain of tissue) disease in the general population that affects mostly the mouth although skin and genital areas can also be affected.
- Trial name
- NCT05330572
- Testing
- No interventions were administered to the patients as a part of this study.
- Where
- 2 sites in United Kingdom
- Volunteers
- 110 people
- Sponsor
- University of Aberdeen
Oral Lichen Planus
A Randomized, Placebo-controlled, Double-blind Clinical Trial of Curcuminoids in Oral Lichen Planus
The purpose of this study is to determine whether curcuminoids are effective in the treatment of oral lichen planus.
- Trial name
- NCT00226174
- Testing
- Curcuminoids
- Where
- United States
- Sponsor
- University of California, San Francisco
Oral Lichen Planus
Relationship Between Oral Lichen Planus and Autoimmune Thyroid Diseases
On the basis of previous studies, a validation cohort will be established to explore the relationship between oral lichen planus and autoimmune thyroid diseases, and a disease efficacy prediction strategy can be formed.
- Trial name
- NCT05403216
- Testing
- no intervention
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Potentially Malignant Lesions, Oral Lichen Planus
Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions
The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.
- Conditions
- Potentially Malignant Lesions, Oral Lichen Planus, Leukoplakia, Oral
- Trial name
- NCT05730855
- Testing
- Real-time Polymerase Chain Reaction technique
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Oral Lichen Planus
The Effect of Topical Curcumin Versus Topical Corticosteroid on Management of Oral Lichen Planus Patients
Introduce a new anti-inflammatory and antioxidant paste preparation (curcumin paste) in the management of Oral lichen planus. Assess the efficacy of this preparation on pain, clinical parameter and the level of IL-33 in saliva.
- Trial name
- NCT03877679
- Testing
- Triamcinolone, Turmeric paste
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus
Management of Pain in Oral Lichen Planus
Treating Oral Lichen Planus (OLP) is a big challenge for clinicians. Despite numerous existing remedies, to date no effective cure has been found, which is mainly attributed to the lack of understanding of the pathogenesis of the…
- Trial name
- NCT03572959
- Testing
- 0.1 % topical triamcinolone acetonide, SIROIaser
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sherine Adel Nasry
Oral Lichen Planus
Tacrolimus Ointment in Oral Lichen Planus
The purpose of this study is to compare the effectiveness of topical tacrolimus, triamcinolone and placebo in alleviating signs and symptoms of oral lichen planus (OLP).
- Trial name
- NCT01544842
- Testing
- 0.1 % tacrolimus ointment, 0.1 % triamcinolone paste, Orabase paste
- Where
- 2 sites in Finland
- Volunteers
- 28 people
- Sponsor
- University of Oulu