Clinical trials: Lichen Sclerosus
Vulvar Lichen Sclerosus
Dynamic Quadripolar Radiofrequency VS Topical Corticosteroids in Women With Vulvar Lichen Sclerosus
This is a prospective, randomized study in women of reproductive age with vulvar lichen sclerosus. Participants will be randomly assigned by investigators using a computer-generated sequence to receive either combined dynamic…
- Trial name
- NCT07363733
- Testing
- Dynamic Quadripolar Radiofrequency (DQRF), Topical high-potency corticosteroid
- Where
- Russia
- Volunteers
- 68 people
- Sponsor
- Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Lichen Sclerosus, Lichen Sclerosus Et Atrophicus
Nd:Yttrium Aluminum Garnet Laser Treatment for Lichen Sclerosus
This study evaluates the efficacy of Nd:Yttrium Aluminum Garnet Laser (Nd:YAG) Treatment of Lichen sclerosus in comparison with topical corticosteroid treatment.
- Trial name
- NCT03525522
- Testing
- Nd:YAG Laser, Topical corticosteroid Diprosone
- Volunteers
- 40 people
- Sponsor
- Dr Adolf Lukanovič
Lichen Sclerosus of Vulva
Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus
Lichen sclerosus (LS) is a skin condition of the external genitals (vulva) of women. LS causes vulvar itching, pain, and burning.
- Trial name
- NCT03045172
- Testing
- Platelet Rich Plasma
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Center for Vulvovaginal Disorders
Vulvar Lichen Sclerosus
To Compare Inflammatory Biomarkers Before and After Treatment With Clobetasol or Fractional CO2 Laser, in Women With Histologically Confirmed Vulvar Lichen Sclerosus, Without Prior Corticosteroid Treatment.
The present study is a Clinical trial that compares clobetasol ointment versus Fractional CO2 laser for vulvar lichen sclerosus (VLE) treatment confirmed by histology, with no previous treatment.
- Trial name
- LASER (NCT07240519)
- Testing
- Fractional microablative CO2 Laser
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Lichen Sclerosus
Platelet Rich Plasma Injections for Vulvar Lichen Sclerosus
15 patients with biopsy proven active vulvar lichen sclerosus will be recruited by a clinic specializing in vulvar disorders. This study consists of a 2 week screening period and a 12-week treatment period.
- Trial name
- NCT02794363
- Testing
- Autologous platelet rich plasma
- Volunteers
- 15 people
- Sponsor
- Center for Vulvovaginal Disorders
Vulvar Lichen Sclerosus
Topical 0.05% Clobetasol Propionate in Vaseline Versus UVA-1 Phototherapy in Vulvar Lichen Sclerosus
Lichen sclerosus is a rare, chronic cutaneous disorder with a predilection for the genital area. Any age group may be affected, although it is seen more often in postmenopausal women.
- Trial name
- NCT01400022
- Testing
- UVA1 phototherapy, Cortisone
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Ruhr University of Bochum
Vulvar Lichen Sclerosus
Treatment of Vulvar Lichen Sclerosus With Corticosteroid Ointment, Calcineurin Inhibitor Ointment, and Platelet-Rich Plasma (PRP) Therapy.
Vulvar lichen sclerosus (VLS) is a chronic inflammatory skin condition that affects the vulvar area, often causing itching, burning, and pain, and may lead to scarring and narrowing of the vaginal opening.
- Trial name
- VULIS-3T (NCT07240389)
- Testing
- Platelet-Rich Plasma (PRP) Treatment, Clobetasol Propionate 0.05% Cream (Dermovate), Pimecrolimus Cream (Elidel)
- Where
- Poland
- Volunteers
- 45 people
- Sponsor
- Milosz Pietrus
Vulvar Lichen Sclerosus
Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus
This is a randomized trial comparing progesterone with conventional clobetasol propionate in patients with vulvar lichen sclerosus.
- Trial name
- NCT01126255
- Testing
- Clobetasol propionate 0.05%, Progesterone 8%
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Lichen Sclerosus of Vulva
Plasma Rich in Growth Factors (PRGF) for the Treatment of Lichen Sclerosus Atrophicus of the Vulva
Lichen sclerosus is a chronic dermatosis of the skin and semimucous membranes, characterized by the presence of well-defined atrophic white papules or plaques, which appear mainly on the skin of the anogenital region of both…
- Trial name
- PRGF (NCT05364515)
- Testing
- PRGF, Clobetasol Propionate
- Sponsor
- Fundación Eduardo Anitua
Herpes Genitalis, Genital Wart
Safety and Efficacy of Laser Therapy in Gynaecology
The aim of this study is to retrospectively evaluate the effectiveness and safety of Er:YAG laser for treatment of different gynecological indication, e.g.
- Conditions
- Herpes Genitalis, Genital Wart, Lichen Sclerosus, Cervical Intraepithelial Neoplasia
- Trial name
- NCT04073082
- Where
- Slovenia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Juna d.o.o.
Lichen Sclerosus
Laser vs Clobetasol for Lichen Sclerosus
Lichen sclerosus (LS) is a common autoimmune disease of the genital skin. It affects 1/900 women with an age peak in the sixth decade of life and is manifested by chronic inflammation of the genital, perineal, and perianal areas…
- Trial name
- NCT05010421
- Testing
- Clobetasol 0.05% Emollient Top Cream, Non-ablative CO2 Laser
- Where
- Germany
- Volunteers
- 246 people
- Sponsor
- Ruhr University of Bochum
Quality of Life
Low-Level Laser Therapy: an Efficient Supplement to Treatments of Vulvar Lichen Sclerosus to Improve Quality of Life
Objectives: The aim of this study was to investigate whether Low Level Laser therapy (LLLT) can improve the quality of life in women with Lichen Sclerosus (LS) and insufficient topical treatment.
- Trial name
- NCT05060224
- Testing
- EasyLaser: Low Level Laser therapy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kolding Sygehus
Vulvar Lichen Sclerosus
StrataMGT in the Reduction of Vulvar Lichen Sclerosus (LS) Symptoms
This study is designed to evaluate the efficacy and safety of StrataMGT for the management of vulvar lichen sclerosus symptoms.
- Trial name
- LS (NCT06662942)
- Testing
- StrataMGT
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Andrew T. Goldstein, MD
Lichen Sclerosus
A Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Lichen Sclerosus
The purpose of this study is to evaluate the efficacy and safety of Ruxolitinib cream in participants With Lichen Sclerosus. This is randomized, double-blind, vehicle-controlled (DBVC) study with a DBVC period of 12 weeks…
- Trial name
- NCT05593445
- Testing
- Ruxolitinib cream, Vehicle cream
- Where
- 14 sites in United States, Canada
- Volunteers
- 61 people
- Sponsor
- Incyte Corporation
Vulvar Lichen Sclerosus
Tacrolimus Versus Clobetasol Propionate in the Treatment of Vulvar Lichen Sclerosus
Lichen Sclerosus is an inflammatory skin condition affecting mostly the genital area of persons of all ages, gender or race. The most frequent complaint is that of itchiness of the vulva but pain may also occur.
- Trial name
- NCT00757874
- Testing
- Tacrolimus cream, Clobetasol cream
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Deana Funaro
Immune-related Vitiligo-like-Depigmentation
Topical Ruxolitinib Evaluation in Immune-related Vitiligo-like Depigmentation
White spot disease is a common side effect on the skin in the context of cancer treatments with immunotherapies. There is no standard therapy yet for white spot caused by cancer therapies.
- Trial name
- TRuE-VLD (NCT07725432)
- Testing
- Ruxolitinib Topical Cream
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- University of Zurich
Lichen Sclerosus
MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus
Lichen sclerosus (LS) is a skin condition of the external genitals (vulva) of women. LS causes vulvar itching, pain, and burning.
- Trial name
- NCT03665584
- Testing
- FxCO2 Laser
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Center for Vulvovaginal Disorders
Vulvar Lichen Sclerosus
Fractionated CO2 Laser With and Without Clobetasol for Treatment of Vulvar Lichen Sclerosus
This is a randomized placebo-controlled trial design to determine whether combining FxCO2-laser with the traditional therapy of clobetasol propionate 0.05% ointment (combined treatment) as compared to FxCO2-laser and placebo…
- Trial name
- VULVIE (NCT04951206)
- Testing
- Fractionated CO2-laser, Clobetasol Propionate 0.05% Ointment
- Where
- 10 sites in United States
- Volunteers
- 212 people
- Sponsor
- Medstar Health Research Institute
Vulvar Lichen Sclerosus
Characterizing the Microbiome in Postmenopausal Women With Vulvar Lichen Sclerosus
Vulvar lichen sclerosus (LS) is a chronic inflammatory disease, often diagnosed at late stages after scarring has obliterated normal vulvar architecture and severely affected a woman's quality of life.
- Trial name
- NCT05147129
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Texas Southwestern Medical Center
Vulvar Lichen Sclerosus
Methotrexate for Severe Vulvar Lichen Sclerosus
Vulvar lichen sclerosus is a chronic inflammatory skin disease affecting the vulva and genital region, which may cause intense pruritus, pain, burning sensations, and progressive scarring.
- Trial name
- GRAVES-MTX (NCT07352917)
- Testing
- Methotrexate (MTX)
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Clinica Dermatologica Arbache ltda