Clinical trials: Lichen Sclerosus, open to volunteers
Lichen Sclerosus of Vulva
Nemolizumab for LS
Patients ≥ 18 years of age with Lichen sclerosis (LS)
- Trial name
- NCT07704775
- Testing
- Nemolizumab 30 mg
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Texas Southwestern Medical Center
Vulvar Lichen Sclerosus
To Compare Inflammatory Biomarkers Before and After Treatment With Clobetasol or Fractional CO2 Laser, in Women With Histologically Confirmed Vulvar Lichen Sclerosus, Without Prior Corticosteroid Treatment.
The present study is a Clinical trial that compares clobetasol ointment versus Fractional CO2 laser for vulvar lichen sclerosus (VLE) treatment confirmed by histology, with no previous treatment.
- Trial name
- LASER (NCT07240519)
- Testing
- Fractional microablative CO2 Laser
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Lichen Sclerosus Lesion
Laser Treatment for Lichen Sclerosus
Fractional ablative laser treatment for Lichen Sclerosus lesion
- Trial name
- NCT06389071
- Testing
- Fractional 2940 nm Laser
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sciton
Lichen Sclerosus
A 52-Week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream in Adult Participants With Lichen Sclerosus
The main objective of the study is to evaluate the efficacy of twice daily applications of delgocitinib cream compared with cream vehicle in the treatment of adult participants with mild to severe lichen sclerosus (LS).
- Trial name
- DELTA CARE 1 (NCT07335588)
- Testing
- Delgocitinib, Cream Vehicle
- Where
- 33 sites in United States, Canada and 1 more
- Volunteers
- 652 people
- Sponsor
- LEO Pharma
Lichen Sclerosus Lesion
Identification of Genetic Variants Associated With Lichen Sclerosus
Lichen Sclerosus (LS) is a common genital skin condition that severely impacts on daily living. LS occurs worldwide but may be more common in the white population.
- Trial name
- GENITALS (NCT07720830)
- Testing
- No Interventions
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gudula Kirtschig
Vulvar Lichen Sclerosus
Methotrexate for Severe Vulvar Lichen Sclerosus
Vulvar lichen sclerosus is a chronic inflammatory skin disease affecting the vulva and genital region, which may cause intense pruritus, pain, burning sensations, and progressive scarring.
- Trial name
- GRAVES-MTX (NCT07352917)
- Testing
- Methotrexate (MTX)
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Clinica Dermatologica Arbache ltda
Lichen Sclerosus
Male Lichen Sclerosus - Risk Factors, Treatment, and Impact on Quality of Life
This observational study aims to evaluate routine treatment outcomes in men with lichen sclerosus (LS), including a long-term follow-up to assess disease progression and histopathological changes.
- Trial name
- NCT06984263
- Testing
- Circumcision
- Where
- Sweden
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Region Västerbotten
Vulvar Lichen Sclerosus
Dynamic Quadripolar Radiofrequency VS Topical Corticosteroids in Women With Vulvar Lichen Sclerosus
This is a prospective, randomized study in women of reproductive age with vulvar lichen sclerosus. Participants will be randomly assigned by investigators using a computer-generated sequence to receive either combined dynamic…
- Trial name
- NCT07363733
- Testing
- Dynamic Quadripolar Radiofrequency (DQRF), Topical high-potency corticosteroid
- Where
- Russia
- Volunteers
- 68 people
- Sponsor
- Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Atrophic Vaginitis, Vaginal Atrophy
VALOR: Vaginal Atrophy & Long-term Observation of Recovery
Vulvovaginal skin conditions, namely vaginal atrophy, lichen sclerosus, lichen simplex chronicus and lichen planus affecting the female adult population will be treated with a novel gel dressing to test the short- and long-term…
- Conditions
- Atrophic Vaginitis, Vaginal Atrophy, Genitourinary Syndrome of Menopause, Lichen Sclerosus of Vulva
- Trial name
- VALOR (NCT05953090)
- Testing
- 7-0940
- Where
- 14 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Stratpharma AG
Vulvar Lichen Sclerosus, Vulvar Atrophy
Efficacy of Collagendep in Reducing Vulvar Dryness in Patients With Lichen Sclerosus Treated With Fat Grafting
This randomized, interventional study evaluates the efficacy of Collagendep Pink Beauty, an oral nutritional supplement, in reducing vulvar dryness in women with Genital Lichen Sclerosus (VLS) who are undergoing fat grafting…
- Trial name
- Collagendep (NCT07450625)
- Testing
- Autologous Fat Grafting (Lipofilling), Collagendep Pink Beauty
- Volunteers
- 40 people
- Sponsor
- San Gallicano Dermatological Institute IRCCS
Vulvodynia, Dyspareunia
Use of Topical Testosterone and Estrogen vs Estrogen Alone in Vulvodynia: a Randomized Controlled Trial
We are looking to see if patients using both topical testosterone and estrogen will have a greater improvement in pain with vaginal penetration compared to those using topical estrogen alone.
- Conditions
- Vulvodynia, Dyspareunia, Lichen Sclerosus of Vulva
- Trial name
- NCT07260825
- Testing
- Estradiol 0.01% Vag Cream, testosterone 0.1% and estradiol 0.01% vaginal cream
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- TriHealth Inc.
Bacterial Vaginosis, Candidiasis
Vaginal Ecosystem and Network in the United States Study
The central premise of this study is that the intricate balance and diversity of the vaginal microbiome plays a pivotal role in the onset, progression, and severity of various gynecological conditions.
- Conditions
- Bacterial Vaginosis, Candidiasis, Urinary Tract Infections, Genitourinary Syndrome of Menopause
- Trial name
- VENUS (NCT06472765)
- Testing
- Vaginal Swab Collection
- Where
- 21 sites in United States, Canada
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Vaginal Biome Science
Vulvar Lichen Sclerosus
Treatment of Vulvar Lichen Sclerosus With Corticosteroid Ointment, Calcineurin Inhibitor Ointment, and Platelet-Rich Plasma (PRP) Therapy.
Vulvar lichen sclerosus (VLS) is a chronic inflammatory skin condition that affects the vulvar area, often causing itching, burning, and pain, and may lead to scarring and narrowing of the vaginal opening.
- Trial name
- VULIS-3T (NCT07240389)
- Testing
- Platelet-Rich Plasma (PRP) Treatment, Clobetasol Propionate 0.05% Cream (Dermovate), Pimecrolimus Cream (Elidel)
- Where
- Poland
- Volunteers
- 45 people
- Sponsor
- Milosz Pietrus
Vulvar Lichen Sclerosus
StrataMGT in the Reduction of Vulvar Lichen Sclerosus (LS) Symptoms
This study is designed to evaluate the efficacy and safety of StrataMGT for the management of vulvar lichen sclerosus symptoms.
- Trial name
- LS (NCT06662942)
- Testing
- StrataMGT
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Andrew T. Goldstein, MD
Lichen Sclerosus
Comparison of Laser Treatment With Clobetasol Therapy in Patients With Lichen Sclerosus
With this trial the investigators look for the effect of Laser maintenance therapy in patients with vulvar lichen sclerosus compared to the maintenance standard treatment clobetasol propionate.
- Trial name
- NCT06135402
- Testing
- Treatment with Monalisa Glide Laser, Treatment with Clobetasol
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Kantonsspital Winterthur KSW