Clinical trials: Lichen Sclerosus et Atrophicus
Lichen Sclerosus
Clobetasol Versus Pimecrolimus for Vulvar Lichen Sclerosus
Lichen sclerosus (LS) is a skin condition of the external genitals (vulva) of women. LS causes vulvar itching, pain, and burning.
- Trial name
- NCT00393263
- Testing
- pimecrolimus and clobetasol, clobetasol 0.05% cream
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Center for Vulvovaginal Disorders
Vulvar Lichen Sclerosus
Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus
This is a randomized trial comparing progesterone with conventional clobetasol propionate in patients with vulvar lichen sclerosus.
- Trial name
- NCT01126255
- Testing
- Clobetasol propionate 0.05%, Progesterone 8%
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Vulvar Disease, Lichen Sclerosus
Vulvar Mucosal Specialty Clinic Chart Review
This study aims to develop a clinical database of patients presenting with vulvar complaints in order to comprehensively assess the presentation and current trends in management of vulvar disease.
- Conditions
- Vulvar Disease, Lichen Sclerosus, Lichen Planus, Vulvodynia
- Trial name
- NCT02881229
- Where
- United States
- Volunteers
- 719 people
- Sponsor
- Northwestern University
Vulvar Lichen Sclerosus, Vulvar Atrophy
Efficacy of Collagendep in Reducing Vulvar Dryness in Patients With Lichen Sclerosus Treated With Fat Grafting
This randomized, interventional study evaluates the efficacy of Collagendep Pink Beauty, an oral nutritional supplement, in reducing vulvar dryness in women with Genital Lichen Sclerosus (VLS) who are undergoing fat grafting…
- Trial name
- Collagendep (NCT07450625)
- Testing
- Autologous Fat Grafting (Lipofilling), Collagendep Pink Beauty
- Volunteers
- 40 people
- Sponsor
- San Gallicano Dermatological Institute IRCCS
Genitourinary Syndrome of Menopause, Pelvic Floor Dysfunction
Efficacy and Safety of the Neodymium Laser in Treatment of Urogenital Tract Diseases in Women
Study objective: To evaluate the efficacy and safety of the Magic Max neodymium laser in the medical treatment of women with symptoms of genitourinary syndrome of menopausal, vulvar lichen sclerosus and pelvic floor muscle…
- Conditions
- Genitourinary Syndrome of Menopause, Pelvic Floor Dysfunction, Vulvar Lichen Sclerosus
- Trial name
- NCT05251220
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- 1st Federal Budgetary Healthcare Institution Volga District Medical Center
Bacterial Vaginosis, Candidiasis
Vaginal Ecosystem and Network in the United States Study
The central premise of this study is that the intricate balance and diversity of the vaginal microbiome plays a pivotal role in the onset, progression, and severity of various gynecological conditions.
- Conditions
- Bacterial Vaginosis, Candidiasis, Urinary Tract Infections, Genitourinary Syndrome of Menopause
- Trial name
- VENUS (NCT06472765)
- Testing
- Vaginal Swab Collection
- Where
- 21 sites in United States, Canada
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Vaginal Biome Science
Quality of Life
Low-Level Laser Therapy: an Efficient Supplement to Treatments of Vulvar Lichen Sclerosus to Improve Quality of Life
Objectives: The aim of this study was to investigate whether Low Level Laser therapy (LLLT) can improve the quality of life in women with Lichen Sclerosus (LS) and insufficient topical treatment.
- Trial name
- NCT05060224
- Testing
- EasyLaser: Low Level Laser therapy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kolding Sygehus
Immune-related Vitiligo-like-Depigmentation
Topical Ruxolitinib Evaluation in Immune-related Vitiligo-like Depigmentation
White spot disease is a common side effect on the skin in the context of cancer treatments with immunotherapies. There is no standard therapy yet for white spot caused by cancer therapies.
- Trial name
- TRuE-VLD (NCT07725432)
- Testing
- Ruxolitinib Topical Cream
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- University of Zurich
Lichen Sclerosus
Genital Lichen Sclerosus - Epidemiology, Comorbidities and the Role of Vulvar and Penile Microbiome
In genital LSc, three pathological processes are implicated in disease development: inflammation, sclerosis/fibrosis and neoplasia. The role of genital microbiome is still to be investigated and explained.
- Trial name
- NCT05671263
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Region Jönköping County
Lichen Sclerosus, Lichen Sclerosus et Atrophicus
Vulvar Scarring Grading Scale for Lichen Sclerosus
The study aims to validate a vulvar scarring grading scale for lichen sclerosus (LS).
- Trial name
- NCT02880904
- Testing
- Photography
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Lichen Sclerosus Lesion
Identification of Genetic Variants Associated With Lichen Sclerosus
Lichen Sclerosus (LS) is a common genital skin condition that severely impacts on daily living. LS occurs worldwide but may be more common in the white population.
- Trial name
- GENITALS (NCT07720830)
- Testing
- No Interventions
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gudula Kirtschig
Vulvar Lichen Sclerosus
The CO2RE® System for Vulvar Lichen Sclerosus
Subjects with vulvar lichen sclerosus (VLS) will undergo fractional carbon dioxide (CO2) laser treatment to the vulvar area. Subjects will be evaluated for changes in clinical signs and architectural changes associated with VLS…
- Trial name
- NCT04148651
- Testing
- The CO2RE® System
- Where
- 4 sites in United States
- Volunteers
- 14 people
- Sponsor
- Candela Corporation
Vulvar Lichen Sclerosus
Characterizing the Microbiome in Postmenopausal Women With Vulvar Lichen Sclerosus
Vulvar lichen sclerosus (LS) is a chronic inflammatory disease, often diagnosed at late stages after scarring has obliterated normal vulvar architecture and severely affected a woman's quality of life.
- Trial name
- NCT05147129
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Texas Southwestern Medical Center
Vulvar Lichen Sclerosus
A Study to Evaluate Platelet Rich Plasma to Treat Vulvar Lichen Sclerosus
The purposes of this study are to determine the safety and feasibility of autologous platelet-rich plasma for the treatment of vulvar lichen sclerosus, and to determine the efficacy of autologous platelet-rich plasma for the…
- Trial name
- NCT04967170
- Testing
- Autologous Platelet-Rich Plasma (PRP)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Jennifer R. Arthurs
Lichen Sclerosus Et Atrophicus of the Vulva
Effect of Treatment With the Ablative Fractional Carbodioxide Laser in Vulvar Lichen Sclerosis
Aim of this study is to evaluate the therapeutic effect of the laser treatment in vulvar LS, mainly the reduction of existing symptoms.
- Trial name
- NCT04107454
- Testing
- Active microablative fractional CO2 laser designed as SmartXide Touch C60, CO2 laser system for MonaLisa Touch, DEKA, Florence
- Where
- Switzerland
- Volunteers
- 64 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Lichen Sclerosus, Lichen Sclerosus Et Atrophicus
Nd:Yttrium Aluminum Garnet Laser Treatment for Lichen Sclerosus
This study evaluates the efficacy of Nd:Yttrium Aluminum Garnet Laser (Nd:YAG) Treatment of Lichen sclerosus in comparison with topical corticosteroid treatment.
- Trial name
- NCT03525522
- Testing
- Nd:YAG Laser, Topical corticosteroid Diprosone
- Volunteers
- 40 people
- Sponsor
- Dr Adolf Lukanovič
Lichen Sclerosus
Lichen Sclerosus - the Influence on Quality of Life
A randomised controlled trial of Lichen Sclerosus in a period of six months measuring Quality of Life and sexuality among women with Lichen Sclerosus.
- Trial name
- NCT03419377
- Testing
- Standard care and sexological counseling
- Where
- Denmark
- Volunteers
- 158 people
- Sponsor
- Regionshospital Nordjylland
Lichen Sclerosus
A 52-Week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream in Adult Participants With Lichen Sclerosus
The main objective of the study is to evaluate the efficacy of twice daily applications of delgocitinib cream compared with cream vehicle in the treatment of adult participants with mild to severe lichen sclerosus (LS).
- Trial name
- DELTA CARE 1 (NCT07335588)
- Testing
- Delgocitinib, Cream Vehicle
- Where
- 33 sites in United States, Canada and 1 more
- Volunteers
- 652 people
- Sponsor
- LEO Pharma
Lichen Sclerosus
MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus
Lichen sclerosus (LS) is a skin condition of the external genitals (vulva) of women. LS causes vulvar itching, pain, and burning.
- Trial name
- NCT03665584
- Testing
- FxCO2 Laser
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Center for Vulvovaginal Disorders
Vulvar Lichen Sclerosus
Use of Platelet Rich Plasma From Cord Blood vs Placebo in the Treatment of Vulvar Lichen Sclerosus
Vulvar lichen Sclerosus (VLS) is a cutaneous-mucosal dermatosis that causes in the adult female vulvar itching and burning due to scratching abrasions. Dyspareunia is often associated .
- Trial name
- NCT06661382
- Testing
- Infiltrative treatment with CB-PRP
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico