Clinical trials: Ligament Tear Knee
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
Biologic Augmentation With Mesenchymal Stem Cells in Patients Undergoing Anterior Cruciate Ligament Reconstruction
This study will evaluate the efficacy of biologic augmentation of ACL reconstruction with bone marrow derived mesenchymal stem cells as measured by magnetic resonance imaging to detect graft healing and integration.
- Trial name
- BMAC (NCT04650568)
- Testing
- Autologous Bone Marrow Derived Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rush University Medical Center
Anterior Cruciate Ligament Injuries, Atrophy, Muscular
Bilateral Versus Unilateral Strength Training After ACLR
After rehabilitation completion, there remains large deficiencies between the operative (OP) and non-operative (NOP) limbs in lower-limb outcomes (e.g., size, strength, and function) and these deficits can persist for years.
- Conditions
- Anterior Cruciate Ligament Injuries, Atrophy, Muscular, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- BUST (NCT06032247)
- Testing
- Resistance exercise program- UL, Resistance exercise program- BL
- Where
- United States
- Sponsor
- University of Kansas
Rupture of Anterior Cruciate Ligament
Multicenter ACL Revision Study (MARS)
The purpose of this study is to determine the effects of modifiable risk factors on patient-reported quality of life, physical activity levels, and risk of early osteoarthritis following revision anterior cruciate ligament (ACL)…
- Trial name
- MARS (NCT00625885)
- Where
- 49 sites in United States, Canada
- Volunteers
- 1,234 people
- Sponsor
- Vanderbilt University Medical Center
Muscle Atrophy, Proximal, Muscle Atrophy
Ultrasound for Rectus Femoris Measurement
Postoperative protocols for orthopedic procedures on the lower limb often require a period of immobilization to protect the surgical site.
- Conditions
- Muscle Atrophy, Proximal, Muscle Atrophy, ACL Tear, Quadriceps Muscle Atrophy
- Trial name
- NCT04105816
- Testing
- 892.1550 Ultrasonic pulsed doppler imaging system, Thigh circumference measurement
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Robert Westermann
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Tear
Bridge-Enhanced ACL Repair-Safety Study (BEAR Trial)
This study will assess the safety and early efficacy of a newly developed device, bridge-enhanced scaffold (MIACH™,) used to repair a torn anterior cruciate ligament (ACL.) Ten participants will undergo surgery with the new…
- Trial name
- BEAR (NCT02292004)
- Testing
- ACL Repair with MIACH Scaffold, Standard ACL Reconstruction
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Miach Orthopaedics
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
The BEAR III Trial for Bridge-Enhanced ACL (Anterior Cruciate Ligament) Restoration
Bridge-Enhanced ACL Restoration (BEAR) is a new procedure being developed to treat patients with ACL injuries. In the BEAR procedure, an implant is placed between the torn ends of the ACL and the patient's own blood is added to…
- Trial name
- NCT03348995
- Testing
- Bridge-Enhanced ACL Restoration (BEAR)
- Where
- 11 sites in United States
- Volunteers
- 250 people
- Sponsor
- Miach Orthopaedics
Anterior Cruciate Ligament Rupture, Knee Instability
Single and Double Bundle ACL Reconstructions, in Term of Cartilage Damage Due to Remaining Instability After Surgery.
The prevalence of ACL (Anterior Cruciate Ligament) ruptures is relatively high, primarily due to sports and military training injuries.
- Conditions
- Anterior Cruciate Ligament Rupture, Knee Instability, Cartilage Damage
- Trial name
- ACL (NCT04626999)
- Testing
- Single Bundle ACL Reconstruction, Double Bundle ACL Reconstruction
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Universitas Indonesia
Anterior Cruciate Ligament Rupture
Efficacy of Preoperative Re-education on Patients With an Anterior Cruciate Ligament Rupture
Anterior cruciate ligament (ACR) rupture is a common lesion of sportsmen that leads to functional deficits which are difficult to overcome.
- Trial name
- PRELIG (NCT02505659)
- Testing
- Preoperative re-education
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ligament; Laxity, Knee, Rupture of Anterior Cruciate Ligament
Anterior Cruciate Ligament-reconstruction: Quadriceps Tendon or Hamstrings Tendon? A Prospective Trial
The purpose of this study is to determine whether there is a difference in muscle strength after anterior cruciate ligament comparing 2 surgery technics. Using either autograft hamstrings tendon or a autograft quadriceps tendon.
- Trial name
- NCT02173483
- Testing
- Quadriceps graft
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital
Ligament Injury, Ligament Rupture
Knee Functionality Recovery Indicators in Athletes Submitted to Ligamentoplasty of the Anterior Cruciate Ligament
Anterior cruciate ligament (ACL) injuries are recurrent, especially in sports. There is still no consensus on the characterization of functional indicators in this clinical condition, as well as their correlation with measuring…
- Conditions
- Ligament Injury, Ligament Rupture, Ligament Disorders
- Trial name
- NCT06050005
- Testing
- Diagnostic test through functional tests and comparison of scales applied to participants in the pre-surgical and post-surgical period.
- Where
- Portugal
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
ACL - Anterior Cruciate Ligament Rupture, Activation Failure
Activation Failure of Knee Extensors After Anterior Cruciate Ligament Rupture Depending on the Contraction Mode
The primary objective of the study is to evaluate the impact of ACL injury and ACL reconstruction on voluntary activation during maximal voluntary contraction (measured by neurophysiological parameters) according to the…
- Conditions
- ACL - Anterior Cruciate Ligament Rupture, Activation Failure, Contraction Mode
- Trial name
- QUADFAIL (NCT06783062)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- La Tour Hospital
Anterior Cruciate Ligament Injuries
Neuromuscular Rehab for ACL Reconstruction: Knee Function & Brain Plasticity
This study focuses on patients with anterior cruciate ligament (ACL) rupture and reconstruction, aiming to systematically investigate the clinical efficacy and underlying mechanisms of neuromuscular training in restoring knee…
- Trial name
- NCT07243860
- Testing
- Neuromuscular Training, Conventional Rehabilitation
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Anterior Cruciate Ligament Rupture
Anatomic and Biomechanical Investigation on ACL: A Cadaveric Study
The present study was aimed to investigate the kinematics differences between round-tunnel (ROT) and flat-tunnel (FLT) techniques and compare the influence to the anterior root of lateral meniscus (ARLM ) in anterior cruciate…
- Trial name
- NCT04957797
- Testing
- round tunnel, flat tunnel
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Peking University Third Hospital
Osteoarthritis, Knee, Post-traumatic Osteoarthritis
Preventing Injured Knees From osteoArthritis: Severity Outcomes
This study is being done to find out if metformin is effective at reducing pain by delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction.
- Conditions
- Osteoarthritis, Knee, Post-traumatic Osteoarthritis, ACL Tear
- Trial name
- PIKASO (NCT06096259)
- Testing
- Metformin
- Where
- 9 sites in United States
- Volunteers
- 512 people
- Sponsor
- Brigham and Women's Hospital
Rupture of the Anterior Cruciate Ligament With Instability of the Knee Joint
Evaluation of Arthroscopic Reconstruction of the Anterior Cruciate Ligament by One Night Hospital Stay or by Day Surgery: a Randomised, Prospective Clinical Trial
Patients who suffered from a rupture of the Anterior Cruciate Ligament with instability of the knee joint, will be treated with an operative ACL-reconstruction.
- Trial name
- NCT00620477
- Testing
- injection in the knee joint with 20 ml of chirocaine 0.125%, injection in the knee joint with 20 ml of physiological fluid
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University Hospital, Ghent
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
The PreOperative Management of Patients Awaiting Anterior Cruciate Ligament Reconstruction
Patient experiences of the NHS ACL treatment pathway are unknown. This study aims to explore patient experiences of anterior cruciate ligament ruptures at three different time points on the patient pathway: (1) 12 participants up…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Rehabilitation
- Trial name
- POP-ACLR (NCT05529511)
- Testing
- Phase 1 - semi-structured interviews, Phase 2 - consensus meeting
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
External Focus of Attention Posttraumatic Osteoarthritis
Knee injuries, especially those to the ACL, are common among physically active people. These injuries are frequently treated with surgical reconstruction (ACL reconstruction; ACLR).
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Osteo Arthritis Knee
- Trial name
- NCT04922268
- Testing
- Internal focus of attention feedback, External focus of attention feedback
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of North Carolina, Charlotte
Anterior Cruciate Ligament Rupture, Osteoarthritis, Knee
A Cohort Study of Non-surgical Treatment and Exercise Rehabilitation in Patients With Anterior Cruciate Ligament Rupture
This clinical trial compared the prognosis of surgical and non-surgical treatment in patients with complete anterior cruciate ligament rupture
- Trial name
- NCT05403905
- Testing
- non surgical treatment, surgical treatment
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital