Clinical trials: Light
Complication of Personal Oral Hygiene
The Use of Quantitative Light Induced Fluorescence Digital as an Oral Hygiene Evaluation Tool in Orthodontics
During orthodontic treatment bacterial plaque readily accumulates on the teeth. This is because food easily accumulates around the braces and it is more difficult to clean when the braces are in place.
- Trial name
- NCT02545660
- Testing
- QLF Image, White Light Image
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Relapse Remitting Multiple Sclerosis
Early Versus Delayed Start of Ocrevus Zunovo for Relapsing Multiple Sclerosis
This study will compare starting Ocrevus Zunovo soon after an active episode of relapsing multiple sclerosis (MS) with starting it later.
- Trial name
- STAT (NCT07878923)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Oklahoma Medical Research Foundation
Cataract
Blue Light Intraocular Lenses (IOLs) and Photostress
To determine what effect a blue light filtering Intraocular Lens (IOL) has on macular pigment levels.
- Trial name
- NCT00710996
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Non-pressure Chronic Ulcer of Skin, Not Elsewhere Classified
To Study the Effect of Organic Light Emitting Diodes (OLED) on Cultured Fibroblast
Chronic ulcers is a common clinical problem. Diabetes or peripheral vascular occlusion is major reason leading to chronic wound healing.
- Trial name
- NCT01724710
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Chronic Inflammatory Disease
Study of Intravenously Administered Anti-LIGHT Monoclonal Antibody CBS001 in Healthy Volunteers
A Phase 1, first in human (FIH), single-centre, double-blind, randomized, placebo-controlled, dose escalating trial to assess the safety and tolerability, pharmacokinetics (PK), immunogenicity and pharmacodynamics (PD) of CBS001…
- Trial name
- NCT05323110
- Testing
- CBS001
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Capella Bioscience Ltd
Pregnancy
Effects of Light on Melatonin and Contractions in Pregnant Women
Specific Aim: Test the hypothesis that ocular light exposure will suppress melatonin secretion and reduce uterine contractions in women at late term pregnancies. Secondary aim.
- Trial name
- NCT01863446
- Testing
- Lighting1, Lighting2
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Aged, Quality of Life
Improving Sports and Recreation Services in Mashhad for Elderly and Intergenerational Interaction (ESPIRE-M)
This interventional study aims to design strategies to improve service quality and productivity in recreational sports facilities in Mashhad Municipality, focusing on creating an age-friendly city.
- Conditions
- Aged, Quality of Life, Mental Health
- Trial name
- ESPIRE-M (NCT06860126)
- Testing
- Intergenerational Activity Program: This indicates a program that involves activities designed for interaction between older adults and younger participants, Yoga and Mindfulness Sessions, Physical Exercise and Storytelling
- Where
- 2 sites in Iran
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Zinat Ebrahimi
Photophobia, Traumatic Brain Injury
Objectively Diagnose and Monitor Treatment of Light Sensitivity
The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and…
- Conditions
- Photophobia, Traumatic Brain Injury, Migraine
- Trial name
- NCT03694626
- Testing
- Pupillography, Ocular Coherence Tomography (OCT), Wrist-watch sensor device
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Tooth Discoloration, Dentin Sensitivity
Efficacy and Safety Assessment of Experimental Bleaching Agents
Tooth bleaching is widely used to treat the colors of teeth. This study compares the efficiency of two experimental bleaching gels, with and without nanoparticles, and with and without light activation versus two commercial…
- Conditions
- Tooth Discoloration, Dentin Sensitivity, Patient Satisfaction
- Trial name
- NCT06802614
- Testing
- BLEACHING GEL A, 5% NF_TiO2, BLEACHING GEL B
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Healthy Volunteers
An Investigational Study to Assess the Effect of a Light Meal and a High-Fat Meal on the Absorption of BMS-986205 in Healthy Participants
The purpose of this study is to investigate the effect of a light meal and a high-fat meal on the bioavailability (absorption) of of BMS-986205 commercial tablet in healthy participants.
- Trial name
- NCT03312426
- Testing
- BMS-986205
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Smoking, Stress
Physiological Responses in Tobacco Chippers
This study will analyze a series of biological and behavioral markers in different populations of smokers. The study groups will differ in their cigarette consumption and level of nicotine dependence.
- Trial name
- NCT01237834
- Where
- United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Customized Healing Abutment, Dental Implant
A Comparison Between Protemp and Flowable Light Cure Composite Material for Creating Optimal Gingival Emergence Profile Around Implant
The study focuses on the critical role of the gingival emergence profile in the success of dental implants, emphasizing its importance for both peri-implant health and esthetics.
- Conditions
- Customized Healing Abutment, Dental Implant, Composite Resin, Peri-Implant Health
- Trial name
- NCT07196293
- Testing
- Customized Healing Abutment - bulk fill composite, customized healing abutments - Bis acryl composite materials
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Amrita Institute of Medical Sciences & Research Center
Glucose, Circadian Rhythm
Interaction of Melatonin With MTNR1B Genotype on Glucose Control - Study 2
This project aims to test the impact of melatonin and MTNR1B variation on regulation glucose regulation in a highly controlled in-laboratory setting and ex vivo in pancreatic islets.
- Conditions
- Glucose, Circadian Rhythm, Melatonin, Genes
- Trial name
- NCT03464084
- Testing
- melatonin, bright light, dim light
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Fibromyalgia
Effects of Blue-enriched White Light Therapy in Patients with Fibromyalgia
Fibromyalgia is a chronic condition with an unclear etiology. The syndrome includes symptoms such as chronic musculoskeletal pain, cognitive dysfunctions, fatigue, sleep disorders, and circadian rhythm disturbances.
- Trial name
- NCT04504721
- Testing
- light therapy
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Cognitive Change
Transcranial Near-Infrared Light in Healthy Subjects: a Cerebral Blood Flow Study With Diffuse Correlation Spectroscopy
Transcranial Light Therapy involves non-invasive and invisible beams of light that increase energy metabolism in the brain. Transcranial light therapy has been found to promote brain metabolism.
- Trial name
- NIR-Flow (NCT03740152)
- Testing
- Transcranial Light Therapy
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Stress, Psychological
Investigation of Different Relaxation Techniques in Eliciting a Relaxation Response
While the stress response, characterised by an increase in heart rate, blood pressure, and cortisol, has evolved to ensure the survival of the organism in face of danger, chronic stress due to psychological stressors can be…
- Trial name
- NCT03592147
- Testing
- Guided Imagery Relaxation Tape, Music Listening, Relaxation Lighting
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University College, London
Skin Diseases
Single-cell Transcriptome Identification of UV- and Visible-light-induced Genes in Human Melanocytes in Vivo
Medical condition and pathology studied skin pigmentation. Justification / rationale for the study UV are both the physiological stimulus for skin pigmentation and the main etiological factor in melanoma.
- Trial name
- melatrans (NCT05780606)
- Testing
- Exposed to UV
- Where
- France
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Myopia
Daily Low-level Red Light and 0.01% Low-dose Atropine for Myopia Prevention
To compare the preventive effects of daily low-level red-light and 0.01% low-dose atropine eye drops on myopia.
- Trial name
- NCT06727019
- Testing
- low-level red-light, Atropine (0.01%)
- Where
- China
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Colorectal Adenoma
Three Arm Rand Trial of HD Light vs Reveal® Cap vs Endocuff Cap for Detection of Colorectal Adenomas (TRACE)
Protocol Title: Three Arm Prospective Randomized controlled trial of High-Definition White-light colonoscopy versus High-Definition White-light colonoscopy with Reveal® Distal Attachment Cap versus High-Definition White-light…
- Trial name
- TRACE (NCT03952611)
- Testing
- Colonoscopy, distal Cap, Endocuff
- Where
- United States
- Volunteers
- 1,203 people, healthy volunteers welcome
- Sponsor
- Midwest Biomedical Research
Capsaicin, Ultaviolet B Light Burn
A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin
The aim of this project is to study the role of transient receptor potential (TRP-) channel V1 (TRPV1+) fibers in the development of cutaneous inflammation induced by epidermal Ultraviolet-B damage.
- Conditions
- Capsaicin, Ultaviolet B Light Burn, Neuropathic Pain, Lidocaine
- Trial name
- NCT03587220
- Testing
- Capsaicin Topical, Ultraviolet-B (UVB) irradiation, Histamine 1%
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Aalborg University