Clinical trials: Light
Conditions for Lower Back Pain Working Nurse
LED Photobiomodulation Therapy for Non-specific LBP in Working Nurses
Background: Low back pain (LBP) affects approximately 51-57% of hospital nurses and nurses' aides in Europe. New high-risk groups include home- and long-term-care nurses and physiotherapists.
- Trial name
- NCT04424823
- Testing
- LED photobiomodulation
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Sleep
Dose-dependent Impact of Daytime Lighting on Evening Responses to Light
The purpose of this study is to systematically examine the impact of different intensities of daytime light and the subsequent impact that such exposure has on non-image forming responses to light in the evening.
- Trial name
- NCT04882280
- Testing
- Light
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Myopia, Myopia, Progressive
Multicenter RCT: LED Red Light Dose-Response in Myopia Progression Control
The goal of this clinical trial is to verify the effectiveness and safety of non-laser LED red light combined with defocus lens therapy for controlling myopia progression and evaluate the impact of different intervention…
- Trial name
- NCT07330180
- Testing
- Yingtong Vision Rehabilitation Instrument, Hoya DIMS multi-point myopia defocus lens
- Where
- 7 sites in China
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Glaucoma
Altered Non-Visual Photoreception in Patients With Glaucoma: Impacts on Sleep, Alertness, Mood, and Cognition
The goal of this study is to understand how light sensitivity in the eye affects sleep, mood, alertness, and cognition in adults with glaucoma compared to healthy individuals aged 45-75 years.
- Trial name
- EyeQ (NCT07364929)
- Testing
- Full-spectrum light exposure, Standard indoor light exposure (Control)
- Where
- 2 sites in Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Macula Edema, Retinal Vein Occlusion
Near-Infrared Light Photobiomodulation Treatment for Retinal Vein Occlusion Macular Oedema
This pilot study aims to establish that treatment with near infrared light (NIR) reduces cystic macular oedema in patients with a retinal vein occlusion.
- Trial name
- NIRVO (NCT04847869)
- Testing
- Ellex Integre NIR laser
- Where
- Australia
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Hirsutism
Facial Hair Reduction Using Intense Pulsed Light (IPL) & Alexandrite Laser
The purpose of this study is to compare the efficacy of the IPL system 650advance handpiece with the alexandrite laser for the purposes of female facial hair reduction
- Trial name
- NCT01461694
- Testing
- Intense Pulsed Light (IPL), Alexandrite Laser
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Jaundice, Neonatal
Filtered Sunlight Phototherapy to Treat Significant Jaundice: Safety and Efficacy in Neonates
At present, much of sub-Saharan Africa, including Nigeria and other resource-limited countries, are without ready access to CPT, due to factors including the lack of PT devices, which are expensive and require consistent electric…
- Trial name
- FSPT (NCT02612727)
- Testing
- Filtered-sunlight phototherapy, Intensive phototherapy
- Where
- Nigeria
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Post Concussive Symptoms
Chasing Biomarkers in Post-concussion Syndrome
The goal of this study was to investigate the biomarkers, neurofilament light chain, inflammatory markers, calcitonin-gene-related peptide, and metabolites from the kynurenine pathway in patients with severe post-concussive…
- Trial name
- NCT05812742
- Testing
- Early intervention programme, Enhanced usual care
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Human Sleep and Chronobiology
Benefits and Risks of Artificial Light Exposure: Characterisation of Effects on Alertness, Sleep, Cognitive Performance, Mood and Biological Rhythms
The purpose of this project is to study the influence of light on sleep, wakefulness, EEG activity and cognitive performances.
- Trial name
- LumEnColor (NCT05232383)
- Testing
- polychromatic light, red light, green light
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Chronobiology Disorders, Circadian Rhythm Disorders
Light Sensitization Study
Circadian rhythm disorders are a class of sleep disorders characterized by misalignment between the timing of sleep and the timing of rhythms driven by the biological clock.
- Conditions
- Chronobiology Disorders, Circadian Rhythm Disorders, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT01327040
- Testing
- light exposure
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Fatigue
Feasibility of Light Therapy for Fatigue N-of-1 Trials
This Personalized Trial will test the feasibility and effectiveness of employing technology to facilitate remote N-of-1 interventions to research participants with self-identified fatigue.
- Trial name
- NCT04707846
- Testing
- Bright Blue Light Commercial AYO Light Therapy Device, Dim Blue Light Commercial AYO Light Therapy Device
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Presbyopia, Near Vision
Validation of an Activities-of-daily-living Framework at Different Light Conditions
Primary objective of this study is the construction and validation of an experimental environment for the simulation of a variety of near- and intermediate-vision activities of daily living (ADLs) in different combinations of…
- Conditions
- Presbyopia, Near Vision, Reading, Daily Activities
- Trial name
- NCT05005624
- Testing
- ADL performance
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
White Spot Lesion of Tooth
Impact of Lingual Attachment on WSL Development in Clear Aligner Patients: A Randomized Controlled Clinical Trial
White spot lesions (WSLs) are a common esthetic complication during orthodontic treatment. While clear aligners (CAs) generally reduce WSL risk compared to fixed appliances, composite attachments remain plaque-retentive sites.
- Trial name
- NCT07368296
- Testing
- Lingual attachment participants
- Where
- Jordan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Demodex Blepharitis, Meibomian Gland Dysfunction (MGD)
Effectiveness of Low Level Light Therapy and Intense Pulse Light on Mite Count as Adjuntive Therapies in Demodex Blepharitis Using Artificial Intelligent Program (Ai-Demodex)
Primary Objective: To evaluate the efficacy of LLLT, IPL, and IPL + LLLT in re ducing demodex count in patients with Demodex Blepharitis.
- Trial name
- Ai-Demodex (NCT07169461)
- Testing
- The blue MY MASK-E, IPL, Mechanical with pharmacological treatment
- Where
- Thailand
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Hypoxic-Ischemic Encephalopathy
A Study of a Blood Marker in Newborns With Brain Injury Caused by Lack of Oxygen at Birth
Perinatal asphyxia is a significant health problem with an incidence of 1 to 8 per 1,000 live births and can lead to serious morbidity and mortality during the neonatal period.
- Trial name
- NCT07292220
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mustafa Gürkan
Physiological Neonatal Jaundice, Physiological Hyperbilirubinaemia
Comparison of Effects of Fenofibrate Adjuvant Therapy Versus Conventional Phototherapy in Neonatal Jaundice.
Neonatal jaundice has significant importance in neonatal morbidity and mortality world-wide. Though phototherapy has a relentless use in neonatal jaundice, its cumbersome side effects and the physical separation of baby from the…
- Trial name
- NCT06346743
- Testing
- Fenofibrate, Phototherapy
- Where
- Pakistan
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Muhammad Zark
Gastric Cancer, Preneoplastic Condition
BLI for the Diagnosis of Precancerous Conditions
Introduction: Traditionally, White Light Endoscopy (WLE), enhanced by biopsies following the updated Sydney system guidelines, has been the benchmark for diagnosing and classifying gastric preneoplastic conditions.
- Conditions
- Gastric Cancer, Preneoplastic Condition, Early Gastric Cancer
- Trial name
- NCT04768218
- Where
- Portugal
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Instituto Portugues de Oncologia, Francisco Gentil, Porto
Intrinsic Aging of Skin
Two Formulations of ELAPR Compared to Restylane® Vital Light Following Repeat Implants in the Upper Arm Dermis
This is an early phase study comparing two fixed dose of the study compound ELAPR and a Restylane® Vital Light (control), by multiple intradermal injections to a 3cm x 3cm area of the upper arm dermis.
- Trial name
- NCT01466413
- Testing
- Tropoelastin
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Elastagen Pty Ltd
Embryo Development, Blastocyst IVF
Effects of Light vs. Heavy Paraffin Oil on Embryo Culture in IVF: A Prospective Study on Development and Pregnancy Rate
This prospective study aims to compare the effects of light and heavy paraffin oil in embryo culture during in vitro fertilization (IVF).
- Conditions
- Embryo Development, Blastocyst IVF, Pregnancy Rates, IVF
- Trial name
- NCT06838923
- Testing
- Light Paraffin Oil, Heavy Paraffin Oil
- Where
- Vietnam
- Volunteers
- 818 people, healthy volunteers welcome
- Sponsor
- Hung Vuong Hospital
Fibrosis, Skin Scarring
Light Emitting Diode-Red Light (LED-RL) Phototherapy for Skin Scarring Prevention
Skin scarring (fibrosis) is a common complication in the wound healing process and remains a therapeutic challenge. Scar formation often occurs following injury to the skin such as surgery, trauma, and burns.
- Conditions
- Fibrosis, Skin Scarring, Skin Wound, Hypertrophic Scar
- Trial name
- NCT03795116
- Testing
- LED-RL phototherapy, Mock irradiation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- State University of New York - Downstate Medical Center