Clinical trials: Light
Sun Damaged Skin
An Assessment of TLR4 and TOPK/PRPK Signaling in Sun Damaged Human Skin Acutely Exposed to Solar Simulated Light
The purpose of this project is to obtain clinical data, including skin samples, that will help investigators evaluate changes occurring in sun damaged human skin as a result of light that simulates sun exposure (Solar Simulated…
- Trial name
- NCT05398237
- Testing
- Solar Simulated Light (SSL)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Arizona
White Spot Lesion of Tooth
Color Stability of S-PRG Resin-Based Light-Cure Varnish and Prophylaxis Paste on White Spot Lesions
The aim of the study is to evaluate and compare the long-term color stability of two bioactive materials used in the management of white spot lesions: Surface Pre-Reacted Glass (S-PRG) containing resin-based light-cured varnish…
- Trial name
- NCT07126366
- Testing
- S-PRG Barrier coat, S-PRG Prophylaxis paste
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Cairo University
Athlete
Effects of Phototherapy by Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical and Biomechanical of Muscle Performance in Athletes
Light-emitting diode Therapy (LEDT) has been used to improve human muscle performance in experimental models and human researches.
- Trial name
- NCT01770977
- Testing
- Light-emitting diode therapy
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Body Composition
How Does Continued Use of Green Light Therapy Impact Outcomes?
Already using Green Light Therapy? Explore how continued use with twice-weekly 20-minute sessions may continue to support positive changes in body composition.
- Trial name
- NCT07282275
- Testing
- EmeraldLED
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Efforia, Inc
Circumference Reduction
Study of Over-The-Counter Use of Low Level Laser Light Therapy for Body Contouring of the Waist, Hips and Thighs
The purpose of this study is to test the ability of the lay end user to understand the information contained in the User's Guide; to correctly identify patients who are suitably qualified to receive treatment; and to correctly…
- Trial name
- NCT02167867
- Testing
- Lay End Users, Treatment Subject Group
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Erchonia Corporation
Vascular Dysfunction
LED Photobiomodulation Improves Radial Artery Vascular Function in Vitro
LED photobiomodulation therapy (PBMT) is widely recognized for its beneficial effects in several clinical conditions; however, its potential in modulating vascular function is not yet fully established.
- Trial name
- LED (NCT07041697)
- Testing
- Light-emitting diode photobiomodulation therapy
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Neurofilament Light Chain, Glial Fibrillary Acidic Protein
Analysis of NfL and GFAP in Different Dietary Patterns
This observational study aims to investigate the impact of different dietary patterns on brain tissue biomarkers in healthy young adults by measuring blood levels of NfL and GFAP.
- Conditions
- Neurofilament Light Chain, Glial Fibrillary Acidic Protein, GFAP, Vegan Diet
- Trial name
- NCT07312994
- Where
- Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Salzburger Landeskliniken
Healthy Adult Subjects, Healthy Elderly Subjects
Multiple Dose Study Of BIIB118 (PF-05251749) In Healthy Volunteers
This is the first clinical trial to evaluate ascending multiple oral doses in healthy adult and healthy elderly subjects to characterize the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BIIB118
- Trial name
- NCT02691702
- Testing
- BIIB118, Melatonin
- Where
- 2 sites in United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Biogen
Orthodontic Appliances, Low-Level Light Therapy
Photobiomodulation on Molar Verticalization With Mini-implant
The objective of this study will be to evaluate the effect of photobiomodulation on the acceleration of the orthodontic movement of molar verticalization and its effect on pain and inflammation of the periodontal tissues.
- Trial name
- NCT04036539
- Testing
- Placement of the mini-implant and verticalization
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Disease Type and/or Category Not Applicable
Effectiveness of Light for Enhancement of Cognition by Transcranial Repeated Application (ELECTRA)
Aim: Investigate whether transcranial photobiomodulation (tPBM) using near-infrared light exposure to the head, can improve frontal lobe executive function, working memory and overall mood in normal volunteer participants.
- Trial name
- ELECTRA (NCT02817061)
- Testing
- Omnilux
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Stroke, Stroke (CVA) or TIA
The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3)
Stroke is a major cause of death and disability worldwide, frequently resulting in persistent cognitive deficits among survivors.
- Conditions
- Stroke, Stroke (CVA) or TIA, Dementia, Vascular, Cerebrovascular Disorders
- Trial name
- IC3 (NCT05885295)
- Testing
- MRI brain, Blood tests, cognitive assessments
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Muscle Damage
Effect of Low-level Laser Therapy on Exercise-induced Muscle Damage
Introduction: The effects of Low Level Laser Therapy (LLLT) on exercise-induced muscular damage have been studied over the last years.
- Trial name
- NCT02493556
- Testing
- LLLT before muscle damage, LLLT after muscle damage
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Circadian Rhythm
Effects of Light and Exercise on Human Circadian Rhythms and Performance
Both light and exercise are effective countermeasures for space and ground-based crews for circadian phase resetting and alertness levels.
- Trial name
- NCT02747719
- Testing
- Light and exercise
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Keratoconus
Treatment of Keratoconus Using Collagen Cross-Linking
The purpose of this study is to determine the effectiveness of collagen cross-linking in the cornea in halting the progression and possibly partially reversing the effects of keratoconus.
- Trial name
- NCT00841386
- Testing
- Riboflavin-5-phosphate
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
CLL
Heavy Light Chain in Chronic Lymphocytic Leukemia
Recently, a novel assay for detecting heavy/light chain (HLC) ratios has been reported which enables improvement in paraprotein detection and monitoring in multiple myeloma and other plasma-cell dyscrasias.
- Trial name
- NCT02377869
- Testing
- No intervantion
- Where
- Israel
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Fatigue in Multiple Sclerosis, Multiple Sclerosis
Fatigue in Multiple Sclerosis and Its Relationship to Inflammatory and Neurodegenerative Markers of the Disease
The study is focused on several independent quantifiable biomarkers (sNfL, sGFAP, mitochondrial activity, genetics and fatigue tests) to obtain more detailed information about MS and its progression.
- Conditions
- Fatigue in Multiple Sclerosis, Multiple Sclerosis, Neurofilaments Light Chains, GFAP
- Trial name
- MITOFATIGUE (NCT07025122)
- Where
- Slovakia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Martin
Type 2 Diabetes, Obesity
The Aboriginal Youth Mentorship Program
Building on the successes of a communal, relationship based approach to Aboriginal youth mentoring in an after school physical activity program (AYMP), the investigators are evaluating a peer-led approach for diabetes prevention.
- Trial name
- AYMP (NCT01820377)
- Testing
- Aboriginal Youth Mentorship Program
- Where
- Canada
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Colon Cancer
Linked Color Imaging/Magnifying Blue Laser Imaging vs. White Light for Adenomas and Serrated Lesions in Proximal Colon
Linked color imaging (LCI) and magnifying blue laser imaging (BLI) are two new imaging systems used in endoscopy which are recently developed. BLI was developed to compensate for the limitations of NBI.
- Trial name
- NCT02724397
- Testing
- LCI/BLI then white endoscopy, White endoscopy and then LCI/BLI
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Healthy Subjects, Moderate to Severe Keratoconjunctivitis Sicca (KCS)
Three Dimension Tomography of Eye Structures by White Light Imaging Device
The purpose of this study is to investigate the ability of an imaging device, developed by AdOM Advanced Optical Technologies Ltd. ("AdOM").
- Conditions
- Healthy Subjects, Moderate to Severe Keratoconjunctivitis Sicca (KCS), Dry Eye Syndrome (DES)
- Trial name
- 3D-WLT (NCT02424266)
- Testing
- None invasive imaging of the tear film (AdOM)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Hemolytic Disease of Newborn, Neonatal Hyperbilirubinemia
Safe Threshold to Discontinue Phototherapy in Hemolytic Disease of Newborn
We hypothesized that adopting a lower rather than a higher threshold for phototherapy discontinuation will be associated with reduced rates of rebound hyperbilirubinemia in term and late preterm neonates with hemolytic disease of…
- Trial name
- NCT04218318
- Testing
- phototherapy
- Where
- Saudi Arabia
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Saudi Arabia