Clinical trials: Limb Amputation
Upper Limb Amputation at the Wrist
A Bidirectional MyoKinetic Implanted Interface for Natural Control of Artificial Limbs
This is a European project that it will develop an innovative robotic hand prosthesis, whose movements can be controlled in a natural and intuitive way.
- Trial name
- MYKY (NCT06176482)
- Testing
- Magnetic markers implantation
- Where
- Italy
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Lower Limb Amputation
Walking Strategies in Usual Locomotion of Lower Limb Amputees
Amputation is a life-altering event with an immediate and obvious effect on daily life activities and quality of life. Asymmetrical movements of the lower limbs and compensatory strategies during walking are associated with an…
- Trial name
- STRAAL (NCT05420623)
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- FondationbHopale
Amputation of Upper Limb
Virtual Reality Prosthetic Training and Rehabilitation
The proposed project is to develop an effective prosthetic training and rehabilitation regimen, with the use of virtual reality, to return patients to the highest level of independence and functioning possible.
- Trial name
- NCT02666859
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Amputation, Neuroma Amputation
Effect of Prophylactic TMR and RPNI on Neuroma and Phantom Limb Pain
The purpose of this study is to analyze the efficacy of novel interventions in post-amputation surgical care (specifically Targeted Muscle Reinnervation and Regenerative Peripheral Nerve Interface) on post-amputation pain and…
- Conditions
- Amputation, Neuroma Amputation, Phantom Limb Pain, Residual Limbs
- Trial name
- NCT05344261
- Testing
- Targeted Muscle Re-innervation, Regenerative Peripheral Nerve Interface, Standard Post-Amputation Surgical Care
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Lower Limb Amputation Above Knee (Injury)
Decoding Motion Planning Using Cortical Potentials
The team will investigate the user's intention to move by using cortical activity during a sit to stand movement performance in people with a transfemoral amputation and able-bodied individuals.
- Trial name
- NCT04325516
- Testing
- Daily activities
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Lower Limb Amputation, Older Adults
Study of WiiFit to Enhance Walking in Older Adult Amputees
WiiNWALK is a 4 week physical activity, with the intervention of a WiiFit, targeted to improve walking capacity in individuals with either a unilateral below-knee or above-knee amputation.
- Trial name
- WiiNWalk (NCT01942798)
- Testing
- Nintendo Wii, Wii Big Brain Academy Degree program
- Where
- 5 sites in Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Upper Limb Amputation Below Elbow (Injury)
Myoelectric SoftHand Pro to Improve Prosthetic Function for People With Below-elbow Amputations: A Feasibility Study
A study to investigate the hypothesis that a Pisa/IIT Robotic SoftHand Pro converted to a prosthetic terminal device will enhance the performance of people with limb loss in a wider range of daily living tasks than allowed by…
- Trial name
- SoftHand (NCT02274532)
- Testing
- SoftHand
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Karen L. Andrews, M.D.
Traumatic Amputation of Lower Extremity
A Comparison of External Mechanical Work Between Different Prosthetic Feet
Recent dysvascular and diabetic amputees as well as older, long-term traumatic amputees are at risk of functional decline, joint degeneration, skin breakdown and further limb loss due to the forces placed on the contralateral…
- Trial name
- SEW (NCT01340807)
- Testing
- Specialized Functional Prosthetic Training
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Miami VA Healthcare System
Surgical Wound, Wound Heal
Evaluating the Outcomes for Incisional Application of Negative Pressure for Nontraumatic Amputations
The purpose of this study is to evaluate how well subjects heal after surgery who receive standard dressings or incisional negative pressure wound therapy for non-traumatic amputation sites.
- Conditions
- Surgical Wound, Wound Heal, Amputation
- Trial name
- NCT03250442
- Testing
- PrevenaTM Device, Standard Dry Dressing
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Amputation
Using a Psychosocial Transitional Group to Improve Adaptation, Coping and Mental Health Outcomes Following Limb Loss
People with limb loss receiving inpatient rehabilitation are at greater risk for depression and anxiety, social isolation, and generally have poor quality of life.
- Trial name
- NCT05082870
- Testing
- Supportive-expressive group therapy (SEGT)
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Low Back Pain
The Impact of Unilateral Lower Limb Amputation on Spinal Loads
The prevalence of low back pain among persons with unilateral lower limb amputation is significantly higher than the rate experienced by the general public.
- Trial name
- NCT02897973
- Testing
- Activity of daily living
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Phantom Limb, Motor Activity
The Effects of Targeted Phantom Motor Execution on Phantom Limb Control
Lower limb amputations account for more than 85% of all amputations. In Canada, it has been reported that transtibial amputation (TTA) is the most common level of amputation.
- Conditions
- Phantom Limb, Motor Activity, Amputation Stump, Amputation
- Trial name
- NCT05247827
- Testing
- Targeted phantom limb motor execution (exercise)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Diabetes Mellitus, Leg Injuries
Prosthetic Components and Stability in Amputee Gait
The biomechanics of changing direction while walking has been largely neglected despite its relevancy to functional mobility. In addition, an increased risk of injury can be associated with turning due to a decrease in stability.
- Conditions
- Diabetes Mellitus, Leg Injuries, Traumatic Amputation
- Trial name
- NCT00167778
- Testing
- Transverse plane rotation adaptor pylon, Rigid pylon
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Amputation
Enhanced Auto-Diagnostic Adaptive Precision Trainer for Myoelectric Prosthetic Users
The eADAPT training consists of a variety of mobile games played on a mobile app (phone or tablet). A band is worn on the residual limb. Participants use muscle activation to send signals to execute certain movements in the game.
- Trial name
- eADAPT (NCT04238533)
- Testing
- eADAPT training, Conventional training
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Amputation, Amputation; Traumatic, Leg, Lower
Clinical Outcomes With Passive MPKs vs. Powered Prosthetic Knees
The goal of this proposed project is to gather community-based data from the K4-level Transfemoral Amputee (TFA) population to aid in evidence-based prescription of powered prosthetic knees (i.e., choosing the right device to…
- Conditions
- Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User
- Trial name
- NCT05267639
- Testing
- Power Knee
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Liberating Technologies, Inc.
Neuropathic Pain, Amputation, Traumatic
Reiki for the Management of Neuropathic Pain
This is a prospective, randomized, double-blind, placebo-controlled, repeated measures study with intention-to-treat that involves exposure to Reiki therapy or a placebo control intervention for a total of six treatments, three…
- Trial name
- Reiki4Pain (NCT02328703)
- Testing
- Reiki Therapy
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Fort Belvoir Community Hospital
Amputation, Traumatic
Human Upper Extremity (Hand and Forearm) Allotransplantation
Overall Goal To establish hand transplantation as a safe and effective reconstructive strategy for the treatment of upper extremity amputations.
- Trial name
- NCT00722280
- Testing
- Hand Transplantation
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Amputation, Elderly
Falls in Older Persons With Limb Loss
Lower limb prosthesis users are known to be at a substantially increased fall risk compared to able-bodied individuals. The interaction between increased fall risk, reduced balance confidence and high prevalence of a fear of…
- Trial name
- FOPLL (NCT03670004)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Amputation
Massage on Pain Levels, Range of Motion, and Muscle Strength in Unilateral Lower Limb Amputees
The purpose of this graduate research study is to explore the therapeutic benefits of Myofascial Release massage on lower limb amputees with pain levels, range of motion, and muscle strength.
- Trial name
- NCT03389334
- Testing
- massage
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Amputation
Investigation of Embodiment for Upper Limb Amputees
Today, prosthetic hands are numb. They provide no tactile or proprioceptive sensory information back to the user. The lack of sensory feedback has been shown to reduce the utility of a prosthesis by half.
- Trial name
- NISRL (NCT04578327)
- Testing
- Prosthetic hand, Peripheral Nerve Interface
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Office of Research and Development