Clinical trials: Limb Amputation
Amputation
Upper Limb Loss Perturbation Response
Recent investigations have suggested that persons with upper limb loss experience a high prevalence of falls with a quarter of reported falls resulting from a trip.
- Trial name
- NCT04274218
- Testing
- Perturbation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Amputation, Traumatic Amputation of Lower Extremity
Sitting Balance in Lower Limb Amputees
The aim of this study is to compare the sitting and standing postural stability of transfemoral individuals with healthy individuals with similar demographic characteristics.
- Trial name
- NCT05597696
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Lower Limb Amputation
Evaluation of a Novel Transfemoral Prosthetic Socket System
The purpose of the study is to evaluate residual limb circulation and skin health associated with the use of a novel prosthetic transfemoral socket system.
- Trial name
- NCT01846845
- Testing
- Conventional Prosthetic Transfemoral Socket System, Novel Prosthetic transfemoral socket system
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Ohio Willow Wood
Elevated Metabolic Cost
The Effect of Gait Training Using Virtual Reality and Real-Time Feedback on Physiological and Functional Gait Performance in Persons With a Traumatic Lower Extremity Amputation
To assess the carryover effect of an innovative new gait training program on physiological and functional gait performance in persons with a traumatic lower extremity amputation.
- Trial name
- VRVO2 (NCT01225432)
- Testing
- Gait Training
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Amputation, Amputation; Traumatic, Leg, Lower
Socket Cooling Effectiveness Take Home Study
The comfort and fit of the residual limb within a prosthetic socket are of primary concern for many amputees. The residual limb is typically covered by non-breathable and non- thermally conductive materials that can create a warm…
- Conditions
- Amputation, Amputation; Traumatic, Leg, Lower, Amputation Stump, Limb; Absence, Congenital, Lower
- Trial name
- NCT04484805
- Testing
- ICE Condition
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Liberating Technologies, Inc.
Upper Limb Amputation, Healthy Subjects
Microneurography and Intraneural Microstimulation for Upper Limb Sensory Investigation in Healthy and Amputee Subjects
The goal of this experimental study is to investigate the somatosensory system through intraneural recording and stimulation of the median nerve in healthy volunteers and participants with upper-limb amputation.
- Trial name
- MICROAMP (NCT07691957)
- Testing
- Microneurography, Intraneural Microstimulation
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Amputation, Traumatic
Sonographic Evaluation Of Nerve Thickness In Traumatic Lower-Limb Amputees
Lower limb amputation (LLA) commonly affects young and active people who have long life expectancy. It is a major surgery causing many functional deficiencies which can reduce overall health quality and physical condition of the…
- Trial name
- NCT04602793
- Testing
- ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Prosthesis User, Amputation
Robot-assisted Exercise in Patients With Amputation Using Myoelectric Prosthesis
The aim of this study was to investigate the effect of a robot-assisted biofeedback exercise program on grip strength, movement speed, coordination, functional status, depressive status, and quality of life in patients with a…
- Trial name
- NCT04030585
- Testing
- Robot, Home exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Unilateral Amputation of the Lower Limb
Virtual Reality Applied to the Evaluation and Rehabilitation of Locomotion - Study of Tolerance in the Lower Limb Amputee
The adaptability of the locomotor activity allows to face all the modifications of the immediate environment met in the daily activities.
- Trial name
- REVA (NCT05635799)
- Testing
- Analysis of walking on flat ground, Hospital Anxiety Disorder Questionnaire, Analysis of walking on slopes
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Traumatic Amputation of Upper Limb, Level Unspecified
Development of a Simulation Tool for Upper Extremity Prostheses
Amputees often choose not to wear prostheses due to marginal performance or may settle for a prosthesis that offers only cosmetic improvement, but lacks function.
- Trial name
- NCT01622530
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Amputation, Amputation; Traumatic, Hand
Dexterous Partial Hand Prosthesis Outcomes
Liberating Technologies, Inc. (LTI) has developed a dexterous prosthetic fingertip that will be fit onto an i-Digits™ partial hand prosthesis and allow for an additional fine grasp.
- Conditions
- Amputation, Amputation; Traumatic, Hand, Limb; Absence, Congenital, Upper, Prosthesis User
- Trial name
- NCT05038566
- Testing
- Pointdexter
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Liberating Technologies, Inc.
Stroke, Parkinson Disease
Wearable Airbag Technology to Mitigate Falls in Individuals With High Fall Risk
The purpose of this study is to evaluate the feasibility and efficacy of a smart airbag system that detects and mitigates fall-related impact in individuals with high fall risk.
- Conditions
- Stroke, Parkinson Disease, Lower Limb Amputation Knee, Fall Injury
- Trial name
- NCT05076565
- Testing
- Airbag Belt Fall Protection System
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Amputation
Comparison of Gait Characteristics in Individuals With Above and Below Knee Limb Loss
Twelve individuals with above knee limb loss, 12 individuals with below knee limb loss,15 healthy individuals will be participants of the study.
- Trial name
- NCT02988310
- Testing
- No intervention
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Lower Limb Amputation
Study of Locomotor Expectations for Ascending/Descending Slope and Stairs in Patients With Limb Amputations
Patients with lower limb amputations are equipped with prostheses that can be mechanical and/or electronic. These prostheses can be mono-articular (only the ankle) or bi-articular (knee and ankle for example).
- Trial name
- JCE (NCT04030650)
- Testing
- Functional analyses, 3D analysis of walking and balance
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Amputation
Quantification of Motor Compensation Following Biomechanical, Proprioceptive and Physiological Alterations Post-lower Limb Amputation.
Lower limb amputation causes segmental loss that alters locomotor organization. The human body, designed to function in a multisegmental manner, must adapt to this new configuration where segments are missing, depending on the…
- Trial name
- QAMPA (NCT06780943)
- Testing
- Biomechanics, Physiological, Proprioceptive
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Traumatic Amputation of Lower Extremity
Effects of Wearing a Powered Ankle-Foot Prosthesis on Amputee Walking
Amputees wearing a conventional prosthesis require 20-30% more metabolic energy to walk at the same speeds as non-amputees and this discrepancy is more apparent at faster walking speeds.
- Trial name
- NCT00869947
- Testing
- Powered ankle-foot prosthesis, No device
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Gait, Balance
Gait Stability of People With Lower-limb Amputations
The purpose of this study is to evaluate whether there are quantifiable differences in walking stability, as measured by the acceleration of the trunk or the variation in step length, between people with unilateral below-knee…
- Trial name
- NCT00915109
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kim Parker
Amputation
AMI Construction in Lower Extremity Residual Limbs
This study will involve the development of a novel approach to lower extremity residual limb surgical revision that offers the promise of augmenting volitional motor control, restore proprioception and reverse atrophy
- Trial name
- NCT04063592
- Testing
- Residual limb revision
- Where
- 3 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Limb Amputation
Content Validation of a Questionnaire on Sports Activities in Children With Limb Amputation
The VESAQ study aims to validate the content of a questionnaire designed to assess sports participation in children with limb amputation.
- Trial name
- VESAQ (NCT07782645)
- Testing
- Three-Round Delphi Process
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hopitaux de Saint-Maurice
Lower Limb Amputation, Slip Perturbations
Pilot Study on the Evaluation of the Functionality, Safety and Reliability of New Tripping Devices for Lower Limbs.
The study aims to identify prognostic biomarkers of fall risk in patients with lower limb amputation
- Conditions
- Lower Limb Amputation, Slip Perturbations, Fall Risk
- Trial name
- MOTU++ pedane (NCT06883942)
- Testing
- prosthetic group performs the entire protocol with their own prosthesis, Experimental Group
- Where
- Italy
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS