Clinical trials: Limb Deformities
Syndactyly
Comparison of Scar Formation in Syndactyly Release Surgery With Full Thickness Skin Graft Versus Skin Graft Substitute
Syndactyly is the most common hand abnormality in children. During development, two or more fingers do not separate in the usual way and remain connected by skin. Surgery is needed to separate the fingers.
- Trial name
- NCT03107546
- Testing
- Hyalomatrix, Skin graft
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Gillette Children's Specialty Healthcare
Flatfoot, Flexible
The Effect of Foot Core Exercises or Foot Orthotics in Symptomatic Flexible Flatfoot
The overall goal of this study is to evaluate the effect of a foot strengthening program (focused on the intrinsic foot muscles) on ankle and foot joint kinematics and kinetics (rearfoot, midfoot, and forefoot) in patients with…
- Trial name
- NCT05840965
- Testing
- Foot muscle strengthening, Foot orthotics
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Flatfoot
Evaluation of the Role of Local Steroid Injection in Treatment of Idiopathic Spasmodic Flat Foot in Adolescent Patients
Population: adolescent patients aged from 10 to 16 years Interventions: 1. Examination under general anaesthesia if the deformity corrected spontaneously 2. local injection of steroid in sinus tarsi 3.
- Trial name
- NCT05381558
- Testing
- Triamcinolone Injection
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Exercise, Flatfoot
Short Foot Exercises With Respiratuar Exercises
Pes planus is a common foot problem since childhood, which may include loss of height of the medial longitudinal arch, which is the most important arch supporting the foot, valgus of the hindfoot, and abduction of the midfoot…
- Trial name
- NCT05128526
- Testing
- exercise, respiratory
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Hypochondroplasia
An Interventional Study of Infigratinib in Children With Hypochondroplasia
ACCEL2/3 is a Phase 2/3 study. The purpose of the Phase 2 portion of the study (ACCEL2/3) is to evaluate the efficacy and safety of infigratinib in children with hypochondroplasia (HCH) receiving infigratinib at one of two doses…
- Trial name
- HCH (NCT06873035)
- Testing
- infigratinib 0.128 mg/kg/day, infigratinib 0.25 mg/kg/day
- Where
- 24 sites in United States, Australia and 8 more
- Volunteers
- 24 people
- Sponsor
- QED Therapeutics, a BridgeBio company
Limb-girdle Muscular Dystrophy, Becker Muscular Dystrophy
Weekly Steroids in Muscular Dystrophy
The purpose of this study is to evaluate the safety and efficacy of oral weekly glucocorticoid steroids in patients with Becker Muscular Dystrophy (BMD), an inherited disorder in which patients experience weakness of the legs and…
- Trial name
- WSiMD (NCT04054375)
- Testing
- Prednisone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Gout Flare
The Effects of Limb Elevation During Gout Flare Episodes
The goal of this open-label randomized controlled trial is to explore the benefit of limb elevation in inpatient gout flare episodes, compared with standard treatment The main questions are; Is limb elevation able to reduce pain…
- Trial name
- NCT06207045
- Testing
- limb elevation
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Thammasat University
Lower Limbs Deformities, Gait
The Effect of Lower Limb Deformities (LLD) on Children's Gait and on Energy Expenditure
Lower Limb Deformities (LLDF) is a rather common infirmity among children. LLDF may result from various conditions such as trauma, tumors, infection, and dysplasia, congenital and metabolic abnormalities.
- Conditions
- Lower Limbs Deformities, Gait, Energy Expenditure
- Trial name
- LLD (NCT01255241)
- Where
- 2 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Rambam Health Care Campus
Achondroplasia
Study of Infigratinib in Children With Achondroplasia
This is a Phase 2, multicenter, open-label, dose-escalation and dose-expansion study to evaluate the safety, tolerability, and efficacy of infigratinib, a fibroblast growth factor receptor (FGFR) 1-3-selective tyrosine kinase…
- Trial name
- NCT04265651
- Testing
- Infigratinib 0.016 mg/kg, Infigratinib 0.032 mg/kg, Infigratinib 0.064 mg/kg
- Where
- 19 sites in United States, Australia and 4 more
- Volunteers
- 84 people
- Sponsor
- QED Therapeutics, a BridgeBio company
Flatfoot
Comparison of Two Different Insole Types in Painful Flexible Flatfoot
The purpose of this study is to compare computer aided design/computer aided manufacturing (CAD/CAM) and semi-custom insole types on pain, quality of life and physical performance and also to decide whether they are necessary in…
- Trial name
- NCT02706327
- Testing
- CAD/CAM Insole, Semi-custom Insole, Control
- Volunteers
- 67 people
- Sponsor
- Eastern Mediterranean University
User of an Upper Limb Assistance Device, User Experience
Impact Study on Users of Upper Limb Assistive Devices
This impact study of upper limb (UL) assistance devices is part of the Exploratory PEPR O2R "Robotic assistance for human movements." The integrated project PI3 "ASSISTMOV," composed of a multidisciplinary team in engineering and…
- Conditions
- User of an Upper Limb Assistance Device, User Experience, Post-stroke, Spinal Cord Injury
- Trial name
- AMUSE (NCT07429188)
- Testing
- interviews and questionnaires
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Association APPROCHE
Fracture, Lengthening; Leg
Pediatric Orthopaedic Implant Safety & Efficacy
Implant devices are important tools - their use is essential across a number of orthopaedic indications, including hip conditions, trauma and limb deformity.
- Conditions
- Fracture, Lengthening; Leg, Orthopedic Disorder, Deformity of Limb
- Trial name
- Global POISE (NCT05361980)
- Testing
- Pediatric orthopaedic implant
- Where
- Canada
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia