Clinical trials: Limb Salvage, active
Stroke, Chronic Stroke Patients
RESPARK - Brain Q for Chronic Stroke
This trial tests a promising new intervention to promote post-stroke neural reorganization and functional recovery. The Q Therapeutic (BQ 3.0) is a wearable medical system that produces and delivers non-invasive…
- Conditions
- Stroke, Chronic Stroke Patients, Cerebrovascular Accident (CVA)
- Trial name
- NCT07095920
- Testing
- Device: Q Therapeutic System (BQ 3.0) - Active
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Stroke
Cranial Nerve Neuromodulation to Improve Arm Function and Brain Plasticity in Stroke
Following a stroke, persistent residual muscle weakness in the upper limb (UL) drastically impacts the individuals' quality of life and level of independence.
- Trial name
- CN-NINM (NCT06386510)
- Testing
- Strength training, Cranial nerve non-invasive neuromodulation
- Where
- 3 sites in Canada
- Volunteers
- 74 people
- Sponsor
- Université de Sherbrooke
Stroke, Upper Extremity Paresis
Virtual Reality Training Dose for Arm Recovery After Stroke: Clinical and Blood Biomarker Responses
The goal of this clinical trial is to learn whether adding virtual reality (VR) training to conventional rehabilitation improves arm movement in adults who had a stroke 6 to 24 months earlier, and whether VR training 5 days a…
- Trial name
- NCT07919301
- Testing
- Neuroforma virtual reality training, Conventional rehabilitation program, Home exercise program
- Volunteers
- 72 people
- Sponsor
- Kutahya Health Sciences University
Stroke (CVA) or Transient Ischemic Attack
Comparative Effects of Sensory Augmentation and Neuromodulation on Enhancing Motor Recovery Among Stroke Survivors
This study aims to evaluate the effectiveness of two rehabilitation techniques-Sensory Augmentation (using mirror therapy) and Neuromodulation (using transcranial direct current stimulation, tDCS)-in improving motor recovery…
- Trial name
- NCT07266662
- Testing
- Sensory Augmentation, Neuromodulation, Combination of Sensory Augmentation and Neuromodulation
- Where
- 2 sites in Pakistan
- Volunteers
- 36 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Stroke, Neurological Diseases or Conditions
Development and Efficacy of a Novel, Cost-Effective Gait Training Device Utilized at Home for Stroke Survivors
This pilot, parallel-group randomized controlled trial will evaluate the feasibility, safety, usability, and preliminary efficacy of the Rise\&Walk InHome (RWH), a novel robotic gait training device designed for home use after…
- Conditions
- Stroke, Neurological Diseases or Conditions, Hemiparesis;Poststroke/CVA, Gait Disorders, Neurologic
- Trial name
- NCT07250425
- Testing
- Rise&Walk InHome by Healing Innovations
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Healing Innovations
Spinal Cord Injuries (SCI)
Combined rTMS and tSCS for Upper Limb Recovery in Cervical SCI
This clinical trial investigates whether combining cortical and spinal neuromodulation can improve upper limb motor recovery in adults with chronic incomplete cervical spinal cord injury (SCI).
- Trial name
- NCT07586644
- Testing
- Transcranial Magnetic Stimulation, Transcutaneous Spinal Cord Stimulation
- Where
- Singapore
- Volunteers
- 24 people
- Sponsor
- National University Hospital, Singapore
Critical Limb Ischemia (CLI)
Comprehensive Limb Evaluation and Arterial Revascularization With Toe Pressure Optimization Registry
To address the heterogeneity of practices, better understand the outcomes of cricital limb theatening ischemia (CLTI) patients after endovascular interventions, and recognize effective endovascular options for infrapopliteal…
- Trial name
- CLEAR TOE (NCT07014072)
- Testing
- intensive toe pressure evaluation, data collection
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bordeaux
Functional Recovery, Upper Extremity Vascularized Composite Allotransplantation
Upper Extremity Vascularized Composite Allotransplantation: A Study Evaluating Safety, Functional Outcomes, and Patient-Reported Psychosocial Outcomes
The primary objective of this study is to evaluate the 5-year (60-month) allograft survival rate of upper extremity vascularized composite allotransplantation performed under the standardized CONSORT clinical protocol.
- Trial name
- NCT07810790
- Testing
- Upper Extremity Vascularized Composite Allotransplantation (VCA)
- Where
- 9 sites in United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Stroke Rehabilitation, Stroke
Substrates for Post-Stroke Arm Rehabilitation
Difficulty moving the arm is very common and a major cause of disability after stroke. Although rehabilitation therapies (i.e., occupational and physical therapy) are the most common treatments used to improve arm motor function…
- Conditions
- Stroke Rehabilitation, Stroke, Neurorecovery
- Trial name
- SPARk (NCT06998485)
- Testing
- Arm Basis Training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Wrist Injury, Hand and Upper Limb Trauma
Cortical Changes After Upper Limb Immobilization Measured by Electroencephalography
This study aims to investigate how temporary immobilization of the upper limb after injury affects brain activity and functional recovery.
- Conditions
- Wrist Injury, Hand and Upper Limb Trauma, Muskuloskeletal Diseases
- Trial name
- EEG (NCT07428304)
- Testing
- Orthopedic Immobilization, Standard Rehabilitation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- University of Malaga
Pain Management, Perioperative Analgesia
From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma
To compare the effectiveness of continuous regional anaesthesia with standard pain management strategies for the treatment of acute pain in patients with war-related lower limb trauma.
- Conditions
- Pain Management, Perioperative Analgesia, War-Related Injuries
- Trial name
- CRA-WAR-LIMB S (NCT07474506)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Acute Ischemic Stroke
Temporal Interference Stimulation for Upper-Limb Motor Recovery in Early Subacute Stroke
This study aims to test whether transcranial temporal interference stimulation (tTIs) can improve upper limb motor function in patients in the early subacute stage after acute ischemic stroke.
- Trial name
- TIMES (NCT07896629)
- Testing
- Transcranial Temporal Interference Stimulation (tTIs)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Critical Limb Ischemia, Malnutrition
Nutrition in Patient With Critical Limb Ischemia
A prospective pilot study examining nutritional supplements among vascular surgery patients with Critical Limb Ischemia (CLI). CLI patients have a high rate of malnutrition and has the potential to benefit greatly from…
- Conditions
- Critical Limb Ischemia, Malnutrition, Nutritional Supplements
- Trial name
- NutriVasc (NCT03529019)
- Testing
- Ensure Surgery Immunonutrition Shake, Ensure Enlive Advanced Nutrition Shake
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston Medical Center
Subcortical Lesions, Stroke
Neuroplastic Changes Due to an Exercise Intervention That Aid in Lower Limb Recovery After Subcortical Stroke
This study aims to develop imaging-based biomarkers to assess which chronic stroke participant with lower extremity disability may respond or resist high intensity interval training (HIIT).
- Trial name
- NCT07663292
- Testing
- HIIT intervention
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Emory University
Stroke With Hemiparesis
Home-based Graded Repetitive Arm Supplementary Program for Quality of Life and Functional Upper Limb Recovery
In post-stroke rehabilitation of the affected upper limb, increasing treatment intensity has been shown to lead to better outcomes compared to conventional approaches with fewer hours of therapy per day and week.
- Trial name
- REC-HOMEGRASP (NCT07146789)
- Testing
- occupational therapy combined with HomeGRASP program, occupational therapy
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Postoperative Recovery, Total Knee Arthroplasty
Nutrition and Swelling
This study is looking at whether taking a nutritional supplement before and after knee replacement surgery affects normal recovery.
- Trial name
- NCT07899762
- Testing
- Xcelerated Recovery Nutritional Supplement
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Muscle Loss
Branched Chained Amino Acid Supplement in Patients Undergoing Lower Limb Bone Cancer Curettage for Bone Metastasis
Postoperative muscle loss is common in patients with bone metastases undergoing lower limb bone cancer curettage, affecting both limb skeletal muscles and potentially swallowing-related muscles.
- Trial name
- NCT06604910
- Testing
- branched chained amino acid
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Stroke
Interaction Between the Brain Hemispheres - Key to Motor Recovery After Stroke
Rationale: Acute stroke leaves many patients with functional deficits, of which upper extremity motor impairment is one of the most disabling.
- Trial name
- InterAct (NCT06381388)
- Testing
- cTBS
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jord Vink
Stroke, Upper Extremity Paresis
Rhythmic Initiation vs Isometric Training for Arm Recovery After Stroke
Stroke is a leading cause of long-term disability worldwide. Many stroke survivors experience persistent weakness, loss of motor control, and poor coordination in their upper limb, which limits their ability to perform daily…
- Trial name
- RIITSTROKE (NCT07598435)
- Testing
- Rhythmic Initiation (PNF technique), Isometric Resistance Training
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- University of Faisalabad
Traumatic Brain Injury, Upper Extremity
Transcutaneous Auricular Vagus Nerve Stimulation to Improve Upper Extremity Recovery After Traumatic Brain Injury
Upper extremity weakness, impaired coordination, reduced dexterity, and limited arm and hand use may continue after TBI. Repetitive, task-specific rehabilitation may improve function, but recovery can remain incomplete.
- Trial name
- taVNS (NCT07867015)
- Testing
- taVNS, FTP
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Craig Hospital