Clinical trials: Limbal Stem Cell Deficiency
Stem Cell Transplantation
Studying Corneal Epithelial Stability Following Limbal Stem Cell Transplantation in Cases of Limbal Stem Cell Deficiency
Integrity of the corneal epithelium is the function of intact limbal stem cells. The reduction in the population of LSCs and their dysfunction result in abnormal corneal epithelialization and invasion of the corneal surface by…
- Trial name
- NCT05494671
- Testing
- conjunctival limbal autologous transplant
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Cairo University
Limbal Stem Cell Deficiency
Autologous Cultured Corneal Epithelium (CECA) for the Treatment of Limbal Stem Cell Deficiency
The study " Autologous cultured corneal epithelium (CECA) for the treatment of corneal lesions associated with limbal stem cell deficiency" is the first clinical trial of this product manufactured at the LOEX laboratory.
- Trial name
- CECA (NCT01756365)
- Testing
- Surgical transplantation of ACCE
- Where
- 4 sites in Canada
- Volunteers
- 54 people
- Sponsor
- CHU de Quebec-Universite Laval
Limbus Corneae, Limbus Corneae Insufficiency Syndrome
Safety Evaluation of LSCD101 Transplantation for Limbal Stem Cell Deficiency
Clinical Study Objective: To evaluate the tolerability and safety after transplantation of LSCD101 in patients with intractable limbal stem cell deficiency Study Method: Subjects who finally meet the inclusion/exclusion criteria…
- Trial name
- NCT04773431
- Testing
- LSCD101 (Cultured Autologous Limbal Epithelial Cell Sheet) transplantation
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- CliPS Co., Ltd
Limbal Stem Cell Deficiency (LSCD)
BRM421 Ophthalmic Solution in Patients With Limbal Stem Cell Deficiency
The goal of this program is to provide patients with Limbal Stem Cell Deficiency access to the BRM421 eye drops. Participants will: Use BRM421 two times a day for at least 12 weeks Visit the clinic monthly for checkups and tests
- Trial name
- NCT07422389
- Testing
- BRM421 Ophthalmic Solution, 0.06%
- Where
- United States
- Sponsor
- BRIM Biotechnology Inc.
Limbal Stem Cell Deficiency
Corneal Epithelial Autograft for LSCD
The purpose of the study is to explore whether femtosecond laser-assisted corneal epithelial autograft is more effective than limbal conjunctival autograft for ocular surface reconstruction in patients with limbal stem cell…
- Trial name
- NCT03217487
- Testing
- Corneal epithelial autograft, Limbal conjunctival autograft, Femtosecond laser
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chunxiao Wang
Limbal Stem Cell Deficiency Due to Ocular Burn
Follow-up Study After ACLSCT for Restoration of Corneal Epithelium in Patients With LSCD Due to Ocular Burns
This is a multinational, multicentre, prospective, non-pharmacological follow-up study of the clinical trial HOLOCORE. All patients transplanted with Holoclar in the HOLOCORE clinical trial who consent to participate will be…
- Trial name
- HOLOCORE-FU (NCT03288844)
- Testing
- Ophthalmologic examinations, Digital pictures, QoL Questionnaires
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- Holostem s.r.l.
Limbal Stem-cell Deficiency
Cultivated Limbal Epithelial Transplantation (CLET) for Limbal Stem Cell Deficiency (LSCD)
CLET is a published treatment for the management of corneal failure due to extensive LSCD. Due to our previous studies on this novel treatment, the regulatory agency of Spain "Agencia Española de Medicamentos y Productos…
- Trial name
- CLET-4-LSCD (NCT03884569)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Total Bilateral Limbal Cell Deficiency
Cultured Autologous Oral Mucosa Epithelial Sheet for the Treatment of Bilateral Limbal Stem Cell Deficiency
Some severe ocular burns or other rare ocular pathologies can be associated with a total loss of corneal epithelial stem cells (i.e.
- Trial name
- FEMJA (NCT03949881)
- Testing
- FEMJA transplatation
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Eye Diseases
Collection of Ocular Surface Impressions Cytology of the Living Eye From Patients With Dry Eyes or Limbal Stem Cell Deficiency.
In order to develop innovative biomarkers for the diagnosis of two ocular surface pathologies, Dry Syndrome (DS) and Limbic Stem Cell Deficiency (LSCD), human cells from the ocular surface will be collected in order to test these…
- Trial name
- ESSO (NCT06255301)
- Testing
- EYEPRIM
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Limbal Stem Cells Deficiency
Efficacy and Safety of Autologous Cultivated Limbal Stem Cells Transplantation (ACLSCT) for Restoration of Corneal Epithelium in Patients With Limbal Stem Cell Deficiency
The purpose of this trial is to confirm the efficacy of Holoclar at one year after the first treatment in patients suffering from moderate to severe LSCD (Limbal Stem Cell Deficiency) secondary to ocular burns.
- Trial name
- HOLOCORE (NCT02577861)
- Testing
- Biopsy from donor eye, Implant of Holoclar, Ophtalmologic examination
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Holostem s.r.l.
Limbal Stem Cells Deficiency
A Clinical Study on Co-transplantation of Autologous Limbal Stem Cells and Corneal Stromal Stem Cells to Repair Corneal Injury
This study aims to: 1) verify the feasibility of treating limbal stem cell deficiency (LSCD) caused by chemical injury with autologous limbal stem cell transplantation combined with corneal stromal stem cell transplantation; 2)…
- Trial name
- NCT06700655
- Testing
- Cornea limbal stem cell transplantation group, Corneal transplantation, Cornea limbal stem cell transplantation combined corneal stromal stem cell group
- Volunteers
- 60 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Neurotrophic Keratopathy, Exposure Keratopathy
Clinical Predictors of Visual Outcome in Patients Affected With Ocular Surface Diseases
This retrospective-prospective study aims to identify the diagnostic parameters most predictive of BSCVA in patients with OSD. Clinical, structural, and biochemical data will be collected from standard-of-care examinations and…
- Conditions
- Neurotrophic Keratopathy, Exposure Keratopathy, Limbal Stem Cell Deficiency (LSCD), Cornea Abnormality
- Trial name
- OSD (NCT07694817)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS San Raffaele
Limbal Stem-cell Deficiency
Transplantation of Autologous Oral Mucosal Epithelial Sheets for Limbal Stem-cell Deficiency
The study purpose is to evaluate the efficacy and safety of cultivated oral mucosal epithelial sheet transplantation as a novel therapy for limbal stem cell deficiency, for which no effective approaches has thus far been…
- Trial name
- NCT02415218
- Testing
- Mucosal cell sheet transplantation
- Where
- Thailand
- Volunteers
- 6 people
- Sponsor
- Siriraj Hospital
Limbal Stem Cell Deficiency (LSCD)
The Improvement of Limbal Stem Cell Deficiency (LSCD) in Unilateral Stem Cell Damage by Amniotic Membrane Extract Eye Drop (AMEED)
Corneal epithelial cells and limbal stem cells (LSC) are located in the limbus basal epithelium that are necessary for repair of corneal.
- Trial name
- NCT02649621
- Testing
- Amniotic Membrane Extract Eye Drop (AMEED)
- Volunteers
- 10 people
- Sponsor
- Royan Institute
Limbal Stem Cell Deficiency
Allogeneic ABCB5-positive Limbal Stem Cells for Treatment of LSCD
The aim of this clinical trial is to investigate the efficacy (by monitoring neovascularization and epithelial defects) of up to four doses of the investigational medicinal product (IMP) LSC2 topically administered on the target…
- Trial name
- NCT03549299
- Testing
- LSC2
- Where
- 5 sites in United States, Germany
- Volunteers
- 16 people
- Sponsor
- RHEACELL GmbH & Co. KG
Limbal Stem Cell Deficiency
Implementation of a Protocol for the Transdifferentiation of Buccal Mucosal Epithelium Into Corneal Epithelium
Objectives The transparent surface of the eye, called the cornea, plays a crucial role in transmitting light to the retina and in protecting the eye.
- Trial name
- TransBuCor (NCT06265298)
- Testing
- Conjunctival reconstruction
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Montpellier
Limbal Stem-cell Deficiency
The Effects of Allogeneic SLET
To investigate the effect of allogeneic SLET and re-epithelialization after allogeneic SLET.
- Trial name
- NCT04021134
- Where
- 2 sites in Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Limbal Stem Cell Deficiency
Corneal Epithelial Allograft From Living-related Donor for LSCD
The purpose of the study is to explore whether femtosecond laser-assisted corneal epithelial allograft from living-related donor is more effective than limbal conjunctival allograft from living-related donor for ocular surface…
- Trial name
- NCT03217435
- Testing
- Corneal epithelial allograft, Limbal conjunctival allograft, Femtosecond laser
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chunxiao Wang
Limbal Stem-cell Deficiency
Stem Cell Therapy for Limbal Stem Cell Deficiency
This phase I study will collect preliminary information on the activity and safety of cLSC. We will investigate the ability to manufacture and transplant cLSC onto the cornea successfully at the time of surgery (feasibility), and…
- Trial name
- NCT03957954
- Testing
- cLSC, Scleral contact lens (SCL)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Limbal Stem Cell Deficiency
Transplantation of Autologous Oral Mucosal Epithelial Stem Cell Sheet for Treating Limbal Stem Cell Deficiency Disease
The aim of this trials investigates the therapeutic effects of application autologous oral mucosal epithelial cell sheets in the treatment of limbal stem cell deficiency disease.
- Trial name
- NCT03015779
- Testing
- cultured autologous oral mucosal epithelial cell sheet
- Volunteers
- 7 people
- Sponsor
- He Eye Hospital