Clinical trials: Limbic Encephalitis
Limbic Encephalitis With LGI1 Antibodies
Antibody-mediated LGI1 Encephalitis: Symptoms, Biomarkers, and Mechanisms of the Chronic Phase of the Disease
The encephalitis mediated by antibodies against Leucine-rich, glioma inactivated 1 protein (anti-LGI1 encephalitis) predominantly affects men (M:F, 6:4) and mostly older than 60 years.
- Trial name
- NCT06515106
- Testing
- Remote cognitive rehabilitation program
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Epilepsy
Interest Balance Auto-immune Population in Patients With Focal Epilepsy of Unknown Cause, Not Structural, Not Genetics, Newly Diagnosed
The knowledge of encephalitis associated with antibodies targeting intracellular antigens, and neuronal surface antibody syndromes has expanded considerably in recent times.
- Trial name
- IBADEPIF (NCT02885207)
- Testing
- Focal epilepsy of unknown cause
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Epilepsy, Cryptogenic, Epilepsy, Partial
IVIG Treatment for Refractory Immune-Related Adult Epilepsy
The purpose of the initial screening study is to find out if immune problems are an unrecognized cause of epilepsy in some patients.
- Conditions
- Epilepsy, Cryptogenic, Epilepsy, Partial, Seizure Disorder, Autoimmune Diseases, Nervous System
- Trial name
- NCT01545518
- Testing
- IVIG
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Autoimmune Encephalitis Associated With Anti-CAPR2 Antibodies
Brain MRI Longitudinal Volumetric Characteristics Associated With Outcomes of CASPR2-Limbic Encephalitis
Anti-CASPR2 limbic encephalitis (CASPR2-LE) is a rare neurological disorder primarily affecting males over the age of 50. It is mediated by an autoimmune antibody response in the central nervous system (CNS) against the cellular…
- Trial name
- C2-MRI (NCT06245447)
- Testing
- Retrospective evaluation of specific brain MRI features
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Hospices Civils de Lyon
Autoimmune Encephalitis, LGI1 Encephalitis
Relapse and Functional Outcomes in Anti-LGI1 Encephalitis
This study focuses on a rare brain disease called anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis. In this condition, the body's immune system mistakenly attacks a protein in the brain, which can cause problems with…
- Conditions
- Autoimmune Encephalitis, LGI1 Encephalitis, Limbic Encephalitis
- Trial name
- NCT07722286
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Shen Chun-Hong
Auto-immune Encephalitis, Epilepsy
Antibodies Causing Epilepsy Syndromes: The ACES Study.
The Antibodies Causing Epilepsy Syndromes (ACES) Study is a observational cohort study focusing on detection of auto-immune epilepsy in patients with epilepsy of unknown origin.
- Trial name
- ACES (NCT02802475)
- Testing
- vena punction
- Where
- 8 sites in Netherlands
- Volunteers
- 582 people
- Sponsor
- Erasmus Medical Center