Clinical trials: Limping
Intermittent Claudication
Safety, Efficacy, and Pharmacokinetics (PK) Study of Trans Sodium Crocetinate (TSC) in Patients With Intermittent Claudication
The purpose of this study is to evaluate the safety and pharmacokinetics of multiple, once-daily, intravenous doses of trans sodium crocetinate (TSC).
- Trial name
- NCT00725881
- Testing
- Trans sodium crocetinate (TSC), 0.9% normal saline
- Where
- 7 sites in United States
- Volunteers
- 48 people
- Sponsor
- Diffusion Pharmaceuticals Inc
Peripheral Arterial Disease, Claudication
VISIBILITY™ Iliac Study
The VISIBILITY Iliac study is a prospective, multi-center, non-randomized study confirming the safety and effectiveness of stenting using the Visi-Pro™ Balloon Expandable Stent System for the treatment of stenotic, restenotic or…
- Trial name
- NCT01402700
- Testing
- Visi-Pro™ Balloon Expandable Stent System
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Medtronic Endovascular
Intermittent Claudication, Peripheral Arterial Disease
Using KomPas+ in the Treatment of Patients With Intermittent Claudication
Intermittent claudication is the most common symptom of peripheral arterial disease (PAD). The recommended therapy is supervised exercise therapy combined with lifestyle counselling, provided by a physiotherapist.
- Trial name
- NCT05232474
- Testing
- KomPas+, KomPas
- Where
- Netherlands
- Volunteers
- 2,271 people
- Sponsor
- Radboud University Medical Center
Peripheral Artery Disease (PAD), Ischemia
The Chocolate Touch Study
The Chocolate Touch study is a randomized, multi-center, prospective, adaptive study, designed to show sufficient safety and effectiveness of the Chocolate Touch™ for use in superficial femoral or popliteal arteries with the…
- Conditions
- Peripheral Artery Disease (PAD), Ischemia, Intermittent Claudication
- Trial name
- NCT02924857
- Testing
- Chocolate Touch, Lutonix Drug Coated Balloon
- Where
- 20 sites in United States, Austria and 2 more
- Volunteers
- 333 people
- Sponsor
- TriReme Medical, LLC
Peripheral Vascular Disease
Shockwave Therapy in Lower Limb Intermittent Calf Claudication
Peripheral arterial disease is a common condition affecting approximately 64% of 56-77 year olds. This condition restricts bloody supply to calf muscles.
- Trial name
- ESWT (NCT02652078)
- Testing
- Extracorporeal shockwave therapy
- Where
- United Kingdom
- Volunteers
- 138 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Type 2 Diabetes, Peripheral Vascular Disorder Due to Diabetes Mellitus
Efficacy and Safety of Liraglutide in Type 2 Diabetes With Lower Extremity Arterial Disease
Diabetic lower extremity arterial disease ( DLEAD ), is a common complication of type 2 diabetes. However, DLEAD remains less studied than other diabetic vascular complications; and only few randomised controlled trials (RCTs)…
- Trial name
- NCT04146155
- Testing
- Liraglutide+standard-of-care treatment, standard-of-care treatment
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Peripheral Artery Disease
VIRTUOSE : Efficiency of Sildenafil on the Absolute Claudication Distance of Peripheral Arterial Disease Patients With Intermittent Claudication.
Peripheral Arterial Disease (PAD) is a highly debilitating disease that affects 202 million people around the world and about 7 million people in France. Morbi-mortality from cardiovascular events is increased in this population.
- Trial name
- VIRTUOSE (NCT03686306)
- Testing
- Sildenafil
- Where
- 11 sites in France
- Volunteers
- 106 people
- Sponsor
- Rennes University Hospital
Sleep Apnea
Obstructive Sleep Apnoea in Patients With Intermittent Claudication
The main aim of this study is to determine how common undiagnosed obstructive sleep apnoea is in individuals with intermittent claudication.
- Trial name
- WITH-SAS (NCT01801592)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Angers
Spinal Stenosis, Spinal Stenosis Lumbar
Decompression vs Physical Training for the Treatment of Lumbar Spinal Stenosis
Lumbar spinal stenosis (LSS) is characterized by low back and leg pain, walking disturbances and sometimes instability, impaired balance and numbness of the lower limbs.
- Conditions
- Spinal Stenosis, Spinal Stenosis Lumbar, Degeneration Lumbar Spine, Degeneration Spine
- Trial name
- UppSten (NCT03495661)
- Testing
- Decompression
- Where
- Sweden
- Volunteers
- 156 people
- Sponsor
- Uppsala University
Lumbar Spinal Stenosis
EFFECTS OF EXERCISE AND EXERCISE COUNSELLING IN PATIENTS WITH LUMBAR SPINAL STENOSIS
Lumbar spinal stenosis is a condition in which narrowing of the spinal canal can cause pain, neurogenic claudication, reduced walking ability, and limitations in daily activities.
- Trial name
- NCT07861334
- Testing
- Individualized Multimodal Exercise and Exercise-Counselling Program
- Where
- Slovenia
- Volunteers
- 87 people
- Sponsor
- University Medical Centre Ljubljana
Arterial Occlusive Disease, Intermittent Claudication
Safety and Efficacy of Express LD to Treat Stenosed or Occlusive Atherosclerotic Disease in Iliac Arteries
To obtain additional data on safety and efficacy of the Express stent implantation in the treatment of stenosed or occlusive atherosclerotic disease (de novo or restenotic lesions) in the iliac arteries (common or external).
- Conditions
- Arterial Occlusive Disease, Intermittent Claudication, Atherosclerotic Disease, Thrombosis
- Trial name
- MELODIE (NCT00352222)
- Testing
- stent implantation
- Where
- 10 sites in Belgium, Canada and 3 more
- Volunteers
- 150 people
- Sponsor
- Boston Scientific Corporation
Peripheral Arterial Disease, Endothelial Dysfunction
Effects of Combined Aerobic and Resistance Training in Patients With Intermittent Claudication
Exercise training improves walking capacity and regional perfusion in patients with Intermittent Claudication (IC). Endothelial Progenitor Cells (EPCs) and Endothelial Microparticles (EMPs) could play an important role in this…
- Trial name
- NCT04302571
- Testing
- combined aerobic and resistance physical activity
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Peripheral Artery Disease, Claudication, Intermittent
Lactate Increase in Peripheral Artery Disease
To our knowledge, the measurement of the transcutaneous oxygen pressure during walking is the only continuous method that estimates the importance of ischemia, bilaterally and segment of limb by segment of limb.
- Trial name
- STELLA (NCT03266861)
- Testing
- Exercise oximetry
- Where
- France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Angers
Intermittent Claudication
Home-based vs. Supervised Exercise for People With Claudication
The purpose of this study is to examine the effects of a home-based exercise rehabilitation program compared to a supervised exercise program on intermittent claudication (leg pain or discomfort) and ambulatory function.
- Trial name
- NCT00618670
- Testing
- Walking Exercise, Control--Resistance Training
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- University of Oklahoma
Superficial Femoral Artery Lesions, Atherosclerosis of Femoral Artery
480 Biomedical Bioresorbable Scaffold System in the Treatment of de Novo Superficial Femoral Artery (SFA) Lesions
This is an initial evaluation of the 480 Biomedical Bioresorbable Scaffold System for the treatment of subjects with de novo native superficial femoral artery lesions.
- Trial name
- STANCE (NCT01403077)
- Testing
- 480 Biomedical Bioresorbable Scaffold System
- Where
- 6 sites in Australia, Austria and 2 more
- Volunteers
- 46 people
- Sponsor
- 480 Biomedical
Peripheral Arterial Disease, Intermittent Claudication
Telehealth Exercise Training in Peripheral Arterial Disease - TEXT-PAD
Peripheral arterial disease is a common, under-treated and under-researched issue. The vast majority of these patients often have multiple issues which can be improved with targeted behavioural change interventions.
- Conditions
- Peripheral Arterial Disease, Intermittent Claudication, Behavior, Health, Exercise Intervention
- Trial name
- NCT05260567
- Testing
- Exercise and Lifestyle Change
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Northumbria University
Peripheral Vascular Diseases, Intermittent Claudication
PROVIDENCE-1: Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients
The objective of this study is to determine whether rifalazil can significantly increase peak walking time (PWT) in patients with peripheral arterial disease (PAD).
- Trial name
- NCT00251849
- Testing
- Rifalazil
- Where
- 48 sites in United States, Brazil and 1 more
- Volunteers
- 274 people
- Sponsor
- ActivBiotics
Spinal Disease, Spinal Radiculopathy
This Study is to Determine if Degenerative Spinal Pain and Disorders Cause the Levels of Substance P to Change in a Patients Saliva, Blood and/or Cerebrospinal Fluid.
The objective of this pilot study is to determine if degenerative spinal disorders such as acute radiculopathy, myelopathy, stenosis, or disc and facet disease cause detectable alterations in Substance P levels in saliva, serum…
- Conditions
- Spinal Disease, Spinal Radiculopathy, Myelopathy, Neurogenic Claudication
- Trial name
- Substance P (NCT01458938)
- Testing
- treatment plan
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Carolina Neurosurgery & Spine Associates
Intermittent Claudication, Peripheral Vascular Diseases
Evaluating Two Exercise Training Programs to Reduce Leg Pain in People With Peripheral Arterial Disease (The EXERT Study)
Peripheral arterial disease (PAD) is a disorder that affects more than 8 million people in the United States. As a result of decreased blood flow to the legs, people with PAD may experience leg pain and difficulty with walking.
- Trial name
- EXERT (NCT00895635)
- Testing
- Treadmill Exercise Training, Arm Ergometry Exercise Training, Usual Care
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Minnesota
Diabetes Mellitus, Claudication, Intermittent
Additional Hyperbaric Oxygen After Lower Extremity Amputation
This study evaluates the effect of additional hyperbaric oxygen therapy after lower extremity amputation. The patients will be randomized after amputation to either a treatment group receiving hyperbaric oxygen therapy, or…
- Conditions
- Diabetes Mellitus, Claudication, Intermittent, Critical Limb Ischemia, Osteomyelitis
- Trial name
- AHOLEA (NCT03594344)
- Testing
- Hyperbaric oxygen therapy
- Where
- 2 sites in Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital