Clinical trials: Linezolid
Infections, Bacterial
A Single Center Four Part Study in Healthy Adult Subjects to Evaluate: the Safety, Tolerability and Pharmacokinetics of a Single Oral Dose and Repeat Escalating Oral Doses of GSK945237; the Effect of Linezolid on Hematology Safety Parameters; and the Effects of GSK945237 and Moxifloxacin on QTc.
GSK945237 belongs to the Bacterial Type II Topoisomerase Inhibitor (BTI) class of antibiotics. GSK945237 has demonstrated in vitro and in vivo activity against Gram positive [including methicillin resistant Staphylococcus aureus…
- Trial name
- NCT01039610
- Testing
- GSK945237, Linezolid, Moxifloxacin
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hip Prosthetic Joint Infection
Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection
The purpose of this study is to evaluate the efficacy of oral linezolid-rifampin combination therapy (over 4 or 6 weeks) versus the standard of care in the treatment of Gram-positive prosthetic hip joint infection with a…
- Trial name
- LIZ-BONE (NCT01757236)
- Testing
- VANCOMYCIN, CEFTRIAXONE, CLINDAMYCIN
- Where
- 9 sites in France, Italy and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Gram Positive Infection
Effect of Linezolid on Ex Vivo Neutrophil and Monocyte Function in Healthy Males
Results from previous studies have been inconclusive and the effect of linezolid on cytokines remains unclear. This study is designed to evaluate the effect of linezolid on the functionality of white blood cells (neutrophils and…
- Trial name
- NCT01544673
- Testing
- linezolid
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Tuberculosis
Safety, Tolerability, Pharmacokinetics And Measurement Of Whole Blood Activity (WBA) Of PNU-100480 After Multiple Oral Doses In Healthy Adult Volunteers
The purpose of this study is to assess the safety, tolerability and pharmacokinetics of multiple doses of PNU-100480 given for 14 or 28 days.
- Trial name
- NCT00990990
- Testing
- PNU-100480, Linezolid
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Sequella, Inc.
Neurosurgery
Study of Antibiotics in Cerebrospinal Fluid Following Intravenous Injection
Three different antibiotics are used to prevent infection in case of neurosurgery - this study examines to which extent the antibiotics penetrate from the blood to the cerebrospinal fluid (surrounding the brain).
- Trial name
- NCT00925093
- Testing
- Vancomycin, Teicoplanin, Linezolid
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Renal Failure, Impaired Renal Function
Linezolid Pharmacokinetics In Patients With Impaired Renal Function (PPT6)
Renal failure patients were treated with linezolid (LZD) for proven or suspected infections by multiresistant Gram-positive cocci.
- Trial name
- LZDPPT6 (NCT02087566)
- Testing
- 600 mg linezolid
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Bacterial Infections
A Study To Assess The Effect Of Linezolid On QTc Interval
The FDA has asked Pfizer to assess the risk of linezolid on QT interval (obtained from ECG readings) which could predispose patients to ventricular arrhythmias. This study is conducted to satisfy this requirement.
- Trial name
- NCT00795145
- Testing
- Linezolid 900 mg, Linezolid 1200 mg, Linezolid 600 mg
- Where
- Singapore
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Linezolid in Healthy Volunteers
Linezolid is the first synthetic antibiotic of oxazolidinone group that can inhibit bacterial protein synthesis. Previous studies have found that linezolid was an effective treatment for multidrug-resistant (MDR) and extensively…
- Trial name
- NCT03841721
- Testing
- Linezolid oral tablet 300 mg/day for 5 day
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Burns
Evaluation Of Linezolid Pk Profile In Burns Patients
Evaluation of linezolid pk profile in burns patients
- Trial name
- NCT00255996
- Testing
- linezolid
- Where
- 3 sites in France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Sepsis
The Effects of Linezolid and Vancomycin on Inflammation and Cellular Signaling Vents
We will determine if linezolid inhibits cellular activation and production of pro-inflammatory cytokines, providing mechanistic rationale for its clinical efficacy and the justification for further investigations in S.
- Trial name
- NCT00811980
- Testing
- Linezolid or Vancomycin
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Utah
Healthy Volunteers
Bioequivalence Study Comparing Linezolid 600 Mg Oral Suspension With 600 Mg Tablet In Chinese Healthy Male Subjects
The purpose of this study is to estimate the bioequivalence comparing Linezolid 600 MG Oral Suspension with 600 MG tablet in Chinese healthy male subjects. This study data will be used to support Linezolid OS NDA in China.
- Trial name
- NCT01055769
- Testing
- Linezolid
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pfizer