Clinical trials: Lipemia
Homozygous Familial Hypercholesterolemia
A Study of Inclisiran in Participants With Homozygous Familial Hypercholesterolemia (HoFH)
This study was a Phase III,A two-part (double-blind placebo-controlled/open-label) multicenter study to evaluate safety, tolerability, and efficacy of inclisiran in subjects with homozygous familial hypercholesterolemia (HoFH).
- Trial name
- ORION-5 (NCT03851705)
- Testing
- Inclisiran Sodium for injection
- Where
- 13 sites in Hong Kong, Israel and 6 more
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Hypercholesterolemia
TACTICS (Targeting Adherence to Cholesterol-lowering Therapy to Improve Control Study)
Background: This is a randomized controlled trial (RCT) of two novel behavioral interventions to enhance treatment adherence and improve low-density lipoprotein cholesterol (LDL) in diabetes.
- Trial name
- TACTICS (NCT01043354)
- Testing
- stage-matched intervention, framing effects intervention
- Where
- United States
- Volunteers
- 247 people
- Sponsor
- Narrows Institute for Biomedical Research
Hyperlipidemias
Effect of Probucol and/or Cilostazol on Mean IMT in Patients With Coronary Heart dIsease
The purpose of this study is to evaluate the additional effect of probucol or concomitant administration of cilostazol and probucol on mean carotid artery intima-media thickness (mean IMT) at year 1, 2, and 3.
- Trial name
- IMPACTonIMT (NCT01291641)
- Testing
- HMG-CoA Reductase Inhibitor, Probucol, Cilostazol
- Where
- 5 sites in South Korea
- Volunteers
- 342 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease, Bypass Graft Stenosis
Impact of Cholesterol Level on Long-term Coronary Bypass Graft Patency
This single-centre cross-sectional study aims to ascertain the impact of dyslipidemia on long-term graft patency after coronary artery bypass grafting (CABG).
- Conditions
- Coronary Artery Disease, Bypass Graft Stenosis, Dyslipidemias, Bypass Graft Occlusion
- Trial name
- NCT05393882
- Testing
- Computed tomography coronary angiogram
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Sedentary Behavior, Hypertriglyceridemia
Interrupting Prolonged Sitting With Periodic Interval Exercise: Effect on Postprandial Lipemia
Investigating the effects of interrupting various lengths of prolonged sitting with bike sprints on post prandial lipemia the next day.
- Trial name
- NCT04241081
- Testing
- Interrupting Prolonged Sitting with Periodic Interval Exercise: Effect on Postprandial Lipemia
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Diabetes Mellitus Type 2, Dyslipidemia
Omentectomy for the Treatment of Diabetes Mellitus Type 2
The purpose of this study is to determine whether laparoscopic removal of the omentum (thin layer of fat inside the abdomen) will significantly improve insulin resistance in patients with non-insulin dependent type 2 diabetes…
- Conditions
- Diabetes Mellitus Type 2, Dyslipidemia, Hypercholesterolemia, Obesity
- Trial name
- NCT00270439
- Testing
- removal of omentum
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University
Venous Thromboembolism, Hypercholesterolemia
Statins to Reduce D-dimer Levels in Patients With Venous Thrombosis
Elevated levels of D-dimer, a marker of procoagulant state, have been identified as a marker of an increased risk of recurrent VTE.
- Trial name
- NCT00437892
- Testing
- atorvastatin, diet
- Where
- 3 sites in Italy
- Volunteers
- 10 people
- Sponsor
- Università degli Studi dell'Insubria
Hypercholesterolaemia
An 8-Week Dose-Finding Study to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia
Primary Objective: To evaluate the effect of alirocumab on low-density lipoprotein cholesterol (LDL-C) levels after 8 weeks of treatment in heterozygous familial hypercholesterolemia (heFH) participants aged of 8 to 17 years…
- Trial name
- ODYSSEY KIDS (NCT02890992)
- Testing
- alirocumab SAR236553 (REGN727), statins, ezetimibe
- Where
- 16 sites in United States, Canada and 8 more
- Volunteers
- 42 people
- Sponsor
- Sanofi
Hypercholesterolemia, Familial, Clinical Decision Support
Clinical Decision Support for Familial Hypercholesterolemia
A cluster randomized study in the primary care setting to evaluate a computer-based clinical decision support system to aid in the identification and management of patients with FH.
- Trial name
- CDS-FH (NCT03989167)
- Testing
- Clinical decision support
- Where
- Sweden
- Volunteers
- 472,029 people
- Sponsor
- University Hospital, Linkoeping
Familial Hypercholesterolemia
Child-Parent Familial Hypercholesterolemia Screening
Child-parent screening for familial hypercholesterolemia has been proposed to identify children and their parent who are carrier of mutations and with high risk for inherited premature coronary artery disease.
- Trial name
- NCT04529967
- Testing
- no interventions
- Where
- 6 sites in China
- Volunteers
- 15,000 people
- Sponsor
- Children's Hospital of Fudan University
Diabetes Mellitus, Type 2, Hypercholesterolemia
Dapagliflozin and Cholesterol Metabolism in Type 2 Diabetes (DM2)
Objective: To investigate the effect of 5 weeks dapagliflozin 10 mg once daily treatment on glucose and lipid fluxes in patients with type 2 diabetes. Study design: Single center single arm (mechanistic) intervention trial.
- Trial name
- DICE (NCT03074630)
- Testing
- Dapagliflozin, Rosuvastatin
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Amsterdam UMC, location VUmc
Hypercholesterolemia, Cardiovascular Diseases
Effect of Canned Beans of Multiple Varieties in Daily Amounts of 1 Cup and 1/2 Cup on Serum LDL Cholesterol and Other Cardiovascular Disease Risk Biomarkers in Adults With Elevated LDL Cholesterol
The Bean Study will examine the effects of consuming two daily amounts of canned beans of multiple varieties on fasting serum cholesterol profile in adults with elevated LDL cholesterol.
- Trial name
- NCT03830970
- Testing
- Canned beans of multiple varieties, White Rice
- Where
- 2 sites in Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Coronary Artery Disease, Non-Obstructive Coronary Atherosclerosis
VIsualization of Coronary Artery Disease for Modification of RISK Factors
The VICAD-RISK study assesses if visualization of coronary CT angiography (CTA) images in participants with non-obstructive coronary artery disease will improve LDL lowering, reduce reporting of side effects by cholesterol…
- Trial name
- VICAD-RISK (NCT06413641)
- Testing
- Follow up at general practice, Consultation, Visualization of CTA images
- Where
- 5 sites in Denmark
- Volunteers
- 273 people
- Sponsor
- Aarhus University Hospital
Postprandial Lipemia, Gastric Emptying
The Almond Yogurt Study
The goal of this clinical trial is to explore how almond food structure influences gastric emptying rates when consumed by healthy adult women as part of a standardized breakfast meal.
- Conditions
- Postprandial Lipemia, Gastric Emptying, Satiety Response
- Trial name
- AYS (NCT07065461)
- Testing
- 115 g serving of yogurt with 60 g almonds
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Hyperlipidemias
Effects Of Walnut-Enriched Diet On Blood Lipids And Glucose Profiles In Hyperlipidemic Subjects
Walnuts have been shown to reduce serum lipids in hyperlipidemic individuals with a well-controlled feeding trials. Current study have been determined the effects of daily walnut consumption on serum lipids, fasting glucose and…
- Trial name
- NCT03680027
- Testing
- Walnut-enriched Group
- Volunteers
- 37 people
- Sponsor
- Eastern Mediterranean University
Type 2 Diabetes, Hyperlipidemia
Using Learning Teams for Reflective Adaptation for Diabetes and Depression
The study will randomize 54 primary care practices to two intervention and a comparison groups. Both interventions will involve an on-site Improvement Facilitator who will assist the practice in forming an Improvement Team, using…
- Conditions
- Type 2 Diabetes, Hyperlipidemia, Hypertension, Depression
- Trial name
- ULTRA-DM/MDD (NCT00414986)
- Testing
- Standard CQI intervention, Chronic Care Improvement (CCI) Intervention, Self-directed practice comparison
- Where
- United States
- Volunteers
- 1,565 people
- Sponsor
- University of Colorado, Denver
Cardiovascular Diseases, Heart Diseases
Genetics of Low Density Lipoprotein Subclasses in Hypercholesterolemia
To perform genetic studies of low density lipoprotein (LDL) subclasses in 160 families in whom the probands had metabolically defined hypercholesterolemia.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypercholesterolemia
- Trial name
- NCT00005203
- Sponsor
- University of Washington
Familial Hypercholesterolemia
Familial Hypercolerstremia as Risk Factor in Stemi Patient Who Underwent Ppci
Famulial hypercolerstremia as risk factor
- Trial name
- NCT03900169
- Testing
- Genetic
- Where
- Egypt
- Volunteers
- 2 people
- Sponsor
- Assiut University
High Triglycerides
Study of the Efficacy and Safety of NST-1024 Versus Placebo in Subjects With Hypertriglyceridemia
This is a Phase IIa,multicentre proof of concept study consisting of 2 study periods to study Treatment with NST-1024 as an adjunct to diet to reduce triglyceride (TG) levels in subjects with TG levels of ≥500 mg/dL and ≤2000…
- Trial name
- NCT05889156
- Testing
- NST-1024
- Where
- 31 sites in United States
- Volunteers
- 50 people
- Sponsor
- NorthSea Therapeutics B.V.
Dyslipidemia, Healthy Volunteers
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TAP311 in Healthy Subjects and Dyslipidemic Patients
This study will assess the safety, tolerability, and effect of TAP311 on blood lipids in healthy subjects and in patients who have dyslipidemia.
- Trial name
- NCT01487460
- Testing
- TAP311
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.