Clinical trials: Lipid Disorders
Hypercholesterolemia
Screening for Hypercholesterolemia in Children Using Dried Blood Spot
Purpose: Heterozygous Familial Hypercholesterolemia (HeFH) is a common genetic disease responsible for premature atherosclerosis.
- Trial name
- CHOLESPOT (NCT05191355)
- Testing
- blood test
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Body Fat Disorder
CoolSculpting of the Distal Thigh Study
Evaluate the safety and efficacy of the ZELTIQ CoolSculpting System using a small area applicator for non-invasive subcutaneous fat reduction in the distal thigh.
- Trial name
- DST (NCT02335749)
- Testing
- The ZELTIQ System
- Where
- 4 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Lipid Profile
Hypoglycemic Potential of Garcinia Cambogia (Garcinia Gummi-gutta (L.) N.Robson) Rind Powder Among Pre-diebetic Obese Patients
Garcinia cambogia, rich in hydroxycitric acid (HCA), has been suggested to promote weight loss and improve metabolic parameters. Evidence regarding its efficacy in pre-diabetic obese adults remains limited.
- Trial name
- NCT07419074
- Testing
- Garcinia cambogia rind powder
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Small Fiber Neuropathy, Fabry Disease
Assessment of Small Fiber Neuropathy in Rare Diseases Using Sudoscan
Sudoscan™ (Impeto Medical, Paris France) uses electrochemical skin conductance as a novel noninvasive method to detect sudomotor dysfunction.
- Conditions
- Small Fiber Neuropathy, Fabry Disease, Ehlers Danlos Syndrome, Mitochondrial Disease
- Trial name
- NCT02985710
- Testing
- Sudoscan, Skin biopsy, QSART
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Sleep Disturbance, Fatigue Syndrome, Chronic
Bao Yuan Tang Extract and Galactooligosaccharides for Sleep Regulation
Certain classical formulas in traditional Chinese medicine and dietary prebiotics have demonstrated beneficial effects on various aspects of suboptimal health status in previous studies.
- Conditions
- Sleep Disturbance, Fatigue Syndrome, Chronic, Endocrine Disorder, Glucose Metabolism Disorder
- Trial name
- NCT07774897
- Testing
- Combination product (Bao Yuan Tang full-component extract 2.0g and galactooligosaccharides 2.0g), Galactooligosaccharides 2.0g
- Where
- 6 sites in China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Metabolic Syndrome
Effectiveness of Pulse-Based Foods Combined With Exercise for Improving Components of the Metabolic Syndrome
The investigators specific objective is to determine the effectiveness of a pulse-based diet combined with an exercise training program for reducing the risk of metabolic syndrome in older adults.
- Trial name
- NCT00800033
- Testing
- Aerobic exercise training, pulse based diet
- Where
- Canada
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Abdominal Obesity, Postprandial Lipemia
Alternating Energy Intake and Blood Fat Content After a Meal
Increasing evidence suggests that meal timing affects metabolic health. For example, intermittent fasting (IF) may have positive effects on plasma glucose and lipid levels, insulin sensitivity, and blood pressure.
- Conditions
- Abdominal Obesity, Postprandial Lipemia, Lipid Metabolism, Glucose Metabolism
- Trial name
- NCT04894526
- Testing
- Alternating Energy Intake, Regular Energy Intake
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Carotid Atherosclerosis, Cerebrovascular Accident
Potential Risk Factors for Stroke
Early studies have shown that the immune system may play a role in the development of strokes. Conditions such as high blood pressure, high cholesterol, diabetes, and old age can activate the immune system and increase the risk…
- Conditions
- Carotid Atherosclerosis, Cerebrovascular Accident, Diabetes Mellitus, Hypercholesterolemia
- Trial name
- NCT00001368
- Testing
- cytokine and leukocyte activation profile
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Insulin Resistance, Obesity
The Effects of Orange Juice on Insulin Sensitivity and Plasma Lipids
The aim of this study is primarily to investigate the ability of antioxidants found in orange juice (OJ) to increase the body's sensitivity to the hormone insulin.
- Trial name
- NCT01201603
- Testing
- orange juice
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Cardiovascular Risk Factors, Insulin Resistance
Pilot Validation of the STELA Preventive Medicine Platform to Reduce Modifiable Health Risk Factors in Adults (CPM-STELA)
This study evaluates a comprehensive digital health platform called STELA, developed at the Center for Preventive Medicine (CPM) of AGEL Hospital Trinec-Podlesi in Czechia.
- Conditions
- Cardiovascular Risk Factors, Insulin Resistance, Obesity, Dyslipidemias
- Trial name
- CPM-STELA (NCT07551960)
- Testing
- STELA Digital Preventive Medicine Platform, Comprehensive Preventive Health Assessment
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Pancreatic Cancer
Analyzing Childhood Recall Antigens in Patients With Pancreatic Cancer
The investigator is developing an immune therapy against pancreatic cancer. Immune cells, known as "T cells with tumor killing capacity", are involved in this immune therapy.
- Trial name
- NCT03848182
- Testing
- Gemcitabine, TT vaccine booster
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Overweight, Elevated Cholesterol
Observational Study of Lyzme5 Impact on Cholesterol and Body Weight in Man
This observational placebo-controlled pilot study is intended to document whether or not Lyzme5, an over-the-counter (OTC) proprietary nutritional supplement product can positively impact, (a) weight and, (b) cholesterol levels…
- Trial name
- Lyzme5 (NCT01634646)
- Testing
- Lyzme5
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Jeff Golini
Hypercholesterolemia
Statin Interchange by Pharmacist Collaborative Practice Agreement (CPA)
A group of ~ 225 patients were switched from atorvastatin to an equivalent statin either by their physicians usual management or by an collaborative pharmacist coordinated process.
- Trial name
- NCT01222182
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Lipid Overnutrition, Constitutional Thinness
Adaptation of Lipid and Energy Metabolism During a Lipid Overnutrition in Constitutional Thinness
For a given food intake, fat and energy metabolism in adipose tissue and muscle adapt to nutrient intakes. This adaptation to nutrition may be impaired in susceptible individuals or in obese patients by promoting weight gain…
- Trial name
- Surnutrition (NCT01224561)
- Testing
- Lipid overnutrition
- Where
- 3 sites in France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Metabolic Syndrome (MetS), Metabolic Syndrome Risk Factors
Effects and Mechanisms of Dietary Carbohydrate Intake and Quality on Glucose and Lipid Metabolism
This study aimed to explore the effects of quantity and quality of dietary carbohydrate intakes on glucose and lipid levels and metabolism, as well as gut microbiota by a randomized crossover controlled intervention trial.
- Trial name
- NCT07533513
- Testing
- Diet
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Dyslipidaemia
Study of the Electrocardiographic Effects of TA-8995
A study in healthy males and females to see if a high single dose of TA-8995 has an effect on the ECG QTcF interval.
- Trial name
- NCT02241759
- Testing
- TA-8995, Moxifloxacin
- Where
- United Kingdom
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Xention Ltd
Cardiovascular Risk Factor, Insulin Resistance
Chronic Cardiovascular Risk Outpatient Management in South Asians Using Digital Health Technology
This platform will enable investigation the cardiovascular risk reduction and the increase in participant engagement in their heart-healthy goals, through the use of virtual care/telemedicine with a digital platform that connects…
- Conditions
- Cardiovascular Risk Factor, Insulin Resistance, PreDiabetes, Diabetes
- Trial name
- HealthPals (NCT03167996)
- Testing
- Use of HealthPals (Telemedicine supported by digital health platform)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Stanford University
Metabolic Syndrome
The Impact of Exercise Methods on Human Body Functions and Metabolism
The objective of this study is to compare the effects of 8 months of yoga and walking exercise training on weight-related body fat and metabolic biomarkers in women.
- Trial name
- EXMET-BW&Y (NCT06523790)
- Testing
- Yoga, Brisk walking
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Zhoukou Normal University
Metabolic Syndrome
Acute Effects of Oral Carbohydrate and Fat Loads on Systemic Microvascular Endothelial Function in Healthy Individuals.
The present study was designed to evaluate vascular endothelial dysfunction resulting from the oral ingestion of high loads of sugar and fat meals in healthy individuals.
- Trial name
- NCT03515460
- Testing
- sugar oral load, fat oral load, sugar and fat oral load
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Metabolism, Fatty Liver
Growth Hormone During Fasting.Signaltransduktion in Muscle and Adipose Tissue and Changes in Intrahepatic Lipid Content
The purpose of this study is to examine the effects of growth hormone during fasting in healthy lean men.
- Trial name
- NCT00476879
- Testing
- Somatropin and pegvisomant
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
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