Clinical trials: Lipids
Hypertriglyceridemia, Diabetes Mellitus
Effect of Changing Diet on Fasting and Post Fat Load Lipoproteins
The study examines the effect of two diets on fasting and post fat load lipoproteins of subjects with type 2 diabetes with moderate hypertriglyceridemia.
- Trial name
- NCT00593424
- Testing
- Low Fat/High Carbohydrate, High Monounsaturated Fat/Low Carbohydrate
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Arkansas
Coronary Artery Disease, Diabetes Mellitus, Type 2
CArdioMetabolism and Atherosclerotic PlaqUe progreSsion
Systematic metabolic diseases are closely related to prevalence and progression of atherosclerosis. This prospective cohort consecutively enrolls patients with coronary artery disease compliacted with metabolic abnormalities such…
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Dyslipidemias, Obesity
- Trial name
- CAMPUS (NCT05117424)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Ruijin Hospital
Cardiovascular Diseases, Oxidative Stress
Effects of Prolonged Delivery of Nitric Oxide Gas on Plasma Reduction-Oxidation Reactions in Cardiac Surgical Patients
This study is an ancillary (add-on) study to the clinical trial entitled "Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction", which has Clinical Trials.gov identifier NCT02836899.
- Conditions
- Cardiovascular Diseases, Oxidative Stress, Endothelial Dysfunction
- Trial name
- NCT04022161
- Testing
- Nitrogen Gas for Inhalation, Blood withdrawal, Nitric Oxide
- Where
- 2 sites in United States, United Kingdom
- Sponsor
- Massachusetts General Hospital
Critical Illness
ICULIP, Influence of Two Lipid Emulsions in the Nosocomial Infection in Critical Patients
This study aims to analyse the effect of two total parenteral nutrition diets with lipid emulsions of different compositions on the incidence of nosocomial infection in critical patients.
- Trial name
- ICULIP (NCT00396461)
- Testing
- MCT/LCT (1:1), MCT/LCT/omega-3 (5:4:1)
- Where
- 22 sites in Spain
- Volunteers
- 212 people
- Sponsor
- B. Braun Medical SA
Fabry Disease
Treatment Protocol of Replagal for Patients With Fabry Disease
The study will evaluate the safety and efficacy of Replagal® (agalsidase alfa) at a dose of 0.2 mg/kg infused intravenously (IV) over 40 minutes, every other week.
- Trial name
- NCT01031173
- Testing
- agalsidase alfa
- Where
- 25 sites in United States
- Sponsor
- Shire
GM1 Gangliosidosis
A Safety and Efficacy Study of LYS-GM101 Gene Therapy in Patients With GM1 Gangliosidosis
LYS-GM101 is a gene therapy for GM1 gangliosidosis intended to deliver a functional copy of the GLB1 gene to the central nervous system.
- Trial name
- NCT04273269
- Testing
- LYS-GM101
- Where
- 3 sites in United States, France and 1 more
- Volunteers
- 5 people
- Sponsor
- LYSOGENE
Hypercholesterolaemia
Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in Patients With Heterozygous Familial Hypercholesterolemia (ODYSSEY HIGH FH)
Alirocumab (SAR236553/REGN727) is a fully human monoclonal antibody that binds PCSK9 (proprotein convertase subtilisin/kexin type 9).
- Trial name
- NCT01617655
- Testing
- Alirocumab, Lipid Modifying Therapy (LMT)
- Where
- 35 sites in United States, Canada and 3 more
- Volunteers
- 107 people
- Sponsor
- Sanofi
Dyslipidemias, Hypertension
Efficacy and Safety of Atorvastatin + Perindopril Fixed-Dose Combination S05167 in Adult Patients With Arterial Hypertension and Dyslipidemia
The purpose of this study is to demonstrate the superiority of atorvastatin/perindopril fixed dose combination (FDC) S05167 as compared to atorvastatin reference drug alone or perindopril drug alone on systolic blood pressure…
- Trial name
- NCT04591808
- Testing
- Atorvastatin/Perindopril, Atorvastatin, Perindopril
- Where
- 43 sites in Georgia, Russia and 1 more
- Volunteers
- 146 people
- Sponsor
- Institut de Recherches Internationales Servier
Fabry's Disease
Analysis of the Nervous System in Patients With Fabry's Disease
Fabry's disease a genetic disorder (X-linked recessive) due to the absence of the enzyme ceramidetrihexosidase. The disease is characterized by abnormal collections of glycolipids in cells (histiocytes) within blood vessel walls…
- Trial name
- NCT00001491
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hypercholesterolemia
A Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of AG2304T and AG2304R
A Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of AG2304T and AG2304R in Patients with Primary Hypercholesterolemia
- Trial name
- NCT06717360
- Testing
- AG2304T, AG2304R
- Where
- South Korea
- Volunteers
- 158 people
- Sponsor
- Ahn-Gook Pharmaceuticals Co.,Ltd
Fabry Disease
Replagal Enzyme Replacement Therapy for Adults With Fabry Disease
This study will determine the safety and effectiveness of the drug Replagal for treating people with Fabry disease, an inherited metabolic disorder.
- Trial name
- NCT00097890
- Testing
- Replagal (Agalsidase Alfa), Replagal
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hypertriglyceridemia
An Efficacy and Safety Study of Omacor® in Taiwanese Hypertriglyceridemic Patients
1. Evaluation of the efficacy of Omacor® in Taiwanese hypertriglyceridemia patients 2. Evaluation of the safety of Omacor® in Taiwanese hypertriglyceridemia patients
- Trial name
- NCT01725646
- Testing
- Omacor®
- Where
- 4 sites in Taiwan
- Volunteers
- 253 people
- Sponsor
- Excelsior
Metabolic Syndrome
Assessment of Therapeutic Potential of Stigma Maydis (Cornsilk) on Metabolic Syndrome
Over the past two decades, there has been an increase in the number of people with nutrition related maladies due to changes in their dietary habits and lifestyle.
- Trial name
- cornsilk (NCT06240273)
- Testing
- Corn silk powder
- Volunteers
- 50 people
- Sponsor
- University of Veterinary and Animal Sciences, Lahore - Pakistan
Late-infantile Neuronal Ceroid Lipofuscinosis Type 2 (CLN2)
A Retrospective, Natural History Study in Children With CLN2
This is a multi center, retrospective, chart review study to document the evolution of ocular disease progression in pediatric patients with CLN2.
- Trial name
- NCT04480476
- Sponsor
- REGENXBIO Inc.
Familial Hypercholesterolemia
EAS Familial Hypercholesterolaemia Studies Collaboration
Familial hypercholesterolaemia (FH) is a common genetic disorder resulting in marked elevations in low-density lipoprotein cholesterol (LDL-C).
- Trial name
- FHSC (NCT04272697)
- Where
- United Kingdom
- Volunteers
- 75,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Mixed Hyperlipidemia
Comparison of the Efficacy and Safety of AtorVastatin mOnotherapy vs. Combination Atorvastatin/Fenofibric Acid
The purpose of this study is to compare combination atorvastatin/fenofibric acid 10/135mg with atorvastatin 20mg monotherapy in the mixed hyperlipidemia who were not at lipid goals with atorvastatin 10mg monotherapy.
- Trial name
- AVOCADO (NCT01974297)
- Testing
- Atorvastatin 10mg, fenofibric acid 135mg, atorvastatin 20mg
- Where
- South Korea
- Volunteers
- 194 people
- Sponsor
- Sang Hak Lee
Hypercholesterolemia
Comparison of Simvastatin Versus Simvastatin/Ezetimibe on Small Dense Low -Density Lipoprotein (LDL)
Both simvastatin 40 mg and simvastatin/ezetimibe 10/10 mg result in low-density lipoprotein cholesterol (LDL-C) reductions of approximately the same magnitude.
- Trial name
- NCT00932620
- Testing
- SIMVASTATIN 40 mg, SIMVASTATIN/EZETIMIBE 10/10 mg
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Ioannina
Inflammation
Beef Burger Versus a Vegetarian Burger
The purpose of this graduate student research study is to compare the rise of serum lipids, glucose, and hs-CRP levels after consumption of a beef burger versus a vegetarian burger in healthy adults between the ages of 21 and 55
- Trial name
- NCT04034160
- Testing
- vegetarian burger, beef burger
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Type 2 Diabetes Mellitus
The HOME Trial: Hyperinsulinaemia: the Outcome of Its Metabolic Effects, a Randomized Controlled Trial
The HOME-trial is a prospective, randomized controlled trial. The purpose of this study is to investigate the effects of metformin HCL in patients with type 2 diabetes mellitus intensively treated with insulin on the quality of…
- Trial name
- NCT00375388
- Testing
- Metformin on top of intensive insulin therapy
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Bethesda General Hospital, Hoogeveen
Hypercholesterolemia
A Safety Study of BMS-852927 in Subjects With Hypercholesterolemia
The purpose of this study is to evaluate the safety of BMS-852927 after 28 days of dosing in patients with high cholesterol.
- Trial name
- NCT01651273
- Testing
- BMS-852927
- Where
- 8 sites in Canada, Germany
- Volunteers
- 97 people
- Sponsor
- Bristol-Myers Squibb