Clinical trials: Lipohypertrophy
Diabetic Retinopathy, HIV
Diabetic Retinopathy in HIV Subjects Treated With EGRIFTA®
To show the non-inferiority of EGRIFTA® vs. placebo in the development or progression of Diabetic Retinopathy in HIV-infected subjects with concomitant abdominal lipohypertrophy and Type 2 diabetes mellitus (T2DM).
- Trial name
- NCT01591902
- Testing
- Tesamorelin
- Where
- 24 sites in United States
- Volunteers
- 129 people
- Sponsor
- Theratechnologies
Diabetes Mellitus, Lipohypertrophy
Dynamics of Insulin Absorption in Subclinical Lipohypertrophy Using the Euglycemic Clamp Technique
This study will use the euglycemic clamp technique to evaluate insulin absorption when insulin is administered subcutaneously in an area of subclinical lipohypertrophy vs an area of normal tissue.
- Trial name
- NCT03229850
- Testing
- Insulin lispro
- Where
- Canada
- Sponsor
- Graydon Meneilly
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
The Role of Proper Insulin Injection Technique in the Treatment of Diabetes Mellitus
This is a prospective, post-marketing, single-arm clinical investigation on the effects of optimal insulin injection technique, in conjunction with the use of disposable Becton Dickinson (BD) Micro-Fine Plus 32G pen needles, by…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Lipohypertrophy
- Trial name
- NCT04120974
- Testing
- Optimal insulin injection
- Where
- 4 sites in Russia
- Volunteers
- 90 people
- Sponsor
- Becton, Dickinson and Company
Type 1 Diabetes Mellitus, Lipohypertrophy
Innovative Insulin Injection Sites Map to Minimize Lipohypertrophy Risk
Background: Patients on long-term insulin therapy frequently develop a condition called lipohypertrophy (LH), which involves the accumulation of abnormal fatty tissue at insulin injection sites.
- Trial name
- NCT07561086
- Testing
- Insulin Injection Site Mapping Tool
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Helwan University
Diabetes Mellitus
Practices Made by Patients to Avoid Insulin Injection Pain
Abstract Objective: This study was conducted to determine the knowledge levels of DM patients about the disease and insulin use, and their practices to avoid insulin injection pain.
- Trial name
- NCT05566912
- Testing
- filling out a survey
- Where
- Turkey (Türkiye)
- Volunteers
- 399 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Diabetes, Lipohypertrophy
Ultrasound Detection and Characterization of Subclinical Hypertrophy in Diabetes
This is a pilot study to enroll 100 people to assess the incidence of lipohypertrophy as detected with ultrasound and its impact on glycemic variability.
- Trial name
- NCT02348099
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Human Immunodeficiency Virus, Lipohypertrophy
Evaluation of Raltegravir Plus Maraviroc Therapy in Controlled HIV Patients Presenting With Lipohypertrophy
Evaluation of antiretroviral therapy combining Raltegravir and Maraviroc in patients with virological success, presenting with clinical lipohypertrophy.
- Trial name
- ROCnRAL (NCT01420523)
- Testing
- Raltegravir-Maraviroc
- Where
- France
- Volunteers
- 48 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infections
HIV Acquired Lipodystrophy (HAL) Classification, Measurement and Fat Response to Thiazolidinedione (TZD) (Pioglitazone)
This study is being done to better understand why people with HIV who have taken drugs for HIV begin to show abnormal changes in fat loss or fat gain in their bodies. This condition is called lipodystrophy.
- Trial name
- HAL (NCT01023620)
- Testing
- Pioglitazone, Observation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Texas Southwestern Medical Center
Lipohypertrophy, Type 1 Diabetes Mellitus
Ultrasound Classification and Grading of Lipohypertrophy and Its Impact on Glucose Variability in Type 1 Diabetes
This study will use ultrasound to characterise lipohypertrophy(LH) and assess the impact of LH on glucose variability in adults with type 1 diabetes.
- Trial name
- TITANIC (NCT03669770)
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- King's College London
Insulin Injections and Lipohypertrophy
Treating Diabetic Lipohypertrophy With Intensive Education Versus Standard Care
The investigators intend to assess the impact of optimized injection technique on the evolution of clinical parameters in insulin-treated patients with diabetes (DM) who have clinical lipohypertrophy (LH) in a controlled…
- Trial name
- NCT02271594
- Testing
- Intensive Training on Best Insulin Injection Technique, Standard education on injection technique
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Becton, Dickinson and Company
Type 1 Diabetes
Four-Week SkinSiteStudy in Type 1 Diabetes
Using insulin pumps and sensors to monitor blood glucose has become standard of care for children with diabetes. The continous infusion of insulin in the subcutaneous tissue leads to increased risk of lipohypertrophy that might…
- Trial name
- SSS-4WK (NCT06177054)
- Testing
- Rotation guided by ultrasound
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Steno Diabetes Center Copenhagen
HIV, HIV-Infections
The Visceral Adiposity Measurement and Observation Study
The Visceral Adiposity Measurement and Observation Study
- Conditions
- HIV, HIV-Infections, HIV-1-infection, HIV I Infection
- Trial name
- VAMOS (NCT05383456)
- Testing
- Diagnostic Test, HIV Anti-retroviral Background Therapy
- Where
- 8 sites in United States
- Volunteers
- 196 people
- Sponsor
- Theratechnologies
Diabetes Mellitus, Lipohypertrophy
The Use of Ultrasound Detection of Lipohypertrophy to Improve Glycemic Control
Lipohypertrophy is swelling of the fatty tissue located below the skin ("subcutaneous tissue") where many patients with diabetes inject their insulin.
- Trial name
- NCT05377268
- Testing
- LH Protocol
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Insulin Resistance, Lipohypertrophy
De-tensioning Patch, in Subjects With Type 1 Diabetes and Lipohypertrophy
This is a single-center, single-cohort, open, repeated-application study. Baseline assessments will include a Hyperinsulinemic clamp after injection of 0.15 U/kg body weight of insulin lispro in the target LH lesion, as well as a…
- Trial name
- NCT06025513
- Testing
- Embrace Patch
- Where
- Germany
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Neodyne Biosciences, Inc.
Diabetes Mellitus, Lipohypertrophy
Glucose Variability in Subclinical Hypertrophy
Evaluation of insulin absorption at sites affected by clinically apparent lipohypertrophy through short-term continuous glucose monitoring has shown inconsistent results and it is yet unknown how or if subclinical lipohypertrophy…
- Trial name
- NCT02748434
- Testing
- Lipohypertrophy, Normal Subcutaneous Tissue
- Where
- 2 sites in Canada
- Volunteers
- 9 people
- Sponsor
- University of British Columbia
HIV
Long-term Observational Study in HIV Subjects Exposed to EGRIFTA®
The purpose of this observational, 10-year, prospective cohort study is to assess the potential safety concerns of long-term exposure to EGRIFTA® in HIV-infected subjects with abdominal lipohypertrophy compared with a similar…
- Trial name
- NCT01579695
- Testing
- Tesamorelin for injection
- Where
- 31 sites in United States
- Volunteers
- 391 people
- Sponsor
- Theratechnologies
HIV/AIDS, Lipohypertrophy
Effects of Semaglutide in HIV-Associated Lipohypertrophy
This is a randomized, double-blinded, placebo-controlled trial designed to assess the effect of the GLP-1 receptor agonist, semaglutide, on visceral and ectopic fat, insulin resistance, inflammation markers, and the downstream…
- Conditions
- HIV/AIDS, Lipohypertrophy, Obesity
- Trial name
- NCT04019197
- Testing
- Semaglutide Injectable Product
- Where
- 2 sites in United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
HIV Infections, Lipodystrophy
Observational Study of Changes in Fat Distribution and Blood Metabolites in HIV Infected Adults
The purpose of this study is to collect data on the body's breakdown of sugar and fat in HIV infected adults. Data from this study will make clearer the roles of HIV infection and anti-HIV drugs in the development of diabetes…
- Conditions
- HIV Infections, Lipodystrophy, Diabetes, Hyperlipidemia
- Trial name
- NCT00331448
- Volunteers
- 1,483 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Lipohypertrophy
Lipohypertrophy Monitoring Study
The investigators intend to audit the impact of optimal injection technique education delivered through a multimodal tailored approach augmented with a digital 'tailorable' patient learning platform on clinical parameters and…
- Conditions
- Diabetes Mellitus, Lipohypertrophy, Hypoglycemia
- Trial name
- LiMo (NCT04659330)
- Testing
- Online education (BdandMe) for injection technique, 4mm needles
- Where
- Belgium
- Volunteers
- 171 people
- Sponsor
- University Hospital, Antwerp
Diabetes, Diabetes Mellitus, Type 1
Impact of Two Medtronic Infusion Sets on Lipohypertrophy in Type 1 Diabetes (T1DM) Patients Thought to Have LH
This is an observational study using ultrasound (US) and palpation to assess the impact of infusion sets on lipohypertrophy (LH) in an infusion set crossover study.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Lipohypertrophy
- Trial name
- NCT06074965
- Testing
- Medtronic Extended Infusion Set
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Azienda Ospedaliera San Camillo Forlanini