Clinical trials: Lipolysis
Moderate or Severe Submental Fullness
Evaluate the Efficacy and Safety of Polyene Phosphatidylcholine Injection (AYP-101) for the Reduction of Submental Fat
Phase 2 trial to evaluate the safety and potential efficacy of three concentration of polyene phosphatidylcholine injection (AYP-101) compared to placebo for the reduction of submental fat.
- Trial name
- AYP-101 (NCT03982225)
- Testing
- Polyene phosphatidylcholine injection
- Where
- 4 sites in South Korea
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- AMIpharm Co., Ltd.
Obesity
The Role of Atrial Natriuretic Peptide in the Lipolytic Process: Effect of Obesity and Exercise
In the developing countries, obesity prevalence is on a dramatic rise. Obesity is related to co-morbidities and as a result, obesity significantly shortens life expectancy and lowers quality of life.
- Trial name
- BALO (NCT02418728)
- Testing
- subcutaneous adipose tissue microdialysis under local beta/alpha blockade
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Body Fat Disorder
Tissue Optimization on Cryolipolysis Procedures for Fat Layer Reduction
Evaluate the effects of tissue optimization before and during cryolipolysis procedures on the outcome of non-invasive fat reduction using the ZELTIQ System.
- Trial name
- TOPS (NCT01728857)
- Testing
- The Zeltiq System
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Postmenopause
Acute Metabolic Effects of Estradiol
Estradiol promotes and maintains the typical female phenotype characterized by subcutaneous fat accumulation. There is evidence to suggest that this effect relies on the ability of estradiol to increase the amount of…
- Trial name
- NCT00435175
- Testing
- estradiol
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity, Healthy
IL-6 Regulation of Substrate Metabolism and Influence of Obesity
The aim of the study is to investigate the effects of blocking IL-6 signaling with tocilizumab on lipid, glucose and protein metabolism during rest and exercise in healthy and obese humans.
- Trial name
- NCT03967691
- Testing
- Tocilizumab infusion, Saline 0.9%
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Dyslipidemias
Effect of Niacin on Transport of HDL and Relationship to Atherogenic Lipoproteins and Lipolysis
This study looks at whether niacin improves reverse cholesterol transport (RCT) in healthy volunteers. 3H-Cholesterol will be used to measure RCT by analyzing changes in the tracer activity in total plasma, lipoproteins, red…
- Trial name
- ENTHRALL (NCT01250990)
- Testing
- Niacin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Fat Reduction
Non-Invasive Reduction of Abdominal Fat
This study is being performed to reduce unwanted abdominal fat using a new applicator for the Zeltiq System.
- Trial name
- JUNO (NCT01101997)
- Testing
- The Zeltiq System
- Where
- 5 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Body Fat Disorder
Pilot Study of CoolTXT for Non-Invasive Fat Reduction
This study is being performed to reduce unwanted fat, in various body areas, using a new applicator and control unit for Zeltiq.
- Trial name
- NCT01517646
- Testing
- The Zeltiq System
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Fat Disorder
Non-invasive Lipolysis and Improvement of Muscle Tone in Inner Thighs
This study will evaluate the clinical efficacy and safety of the BTL-899 device for changes in subcutaneous fat tissue and muscle tissue of inner thighs. The study is a prospective multi-center open-label single-arm study.
- Trial name
- NCT04596228
- Testing
- BTL-899
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Body Fat Disorder
Pilot Study on the Submental Area
The purpose of this study is to evaluate the safety and feasibility of cryolipolysis for non-invasive reduction of submental fat.
- Trial name
- NCT01859091
- Testing
- The Zeltiq System
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Obesity
Calcium and Lipid Metabolism
We hope to determine if supplementing the diet of women who habitually consume low levels of calcium, with 1500 mg of calcium a day for three months will increase fat oxidation and decrease fat storage.
- Trial name
- NCT00686192
- Testing
- Calcium Carbonate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Postmenopause
AFTER: Altering Fat Through Estrogen and Raloxifene
The purpose of this study is to determine whether estrogens specifically promote a reduction in fat from abdominal regions during weight loss and/or prevent the accumulation of abdominal fat during weight gain.
- Trial name
- NCT00149604
- Testing
- conjugated estrogens, Raloxifene, exercise plus mild caloric restriction for weight loss
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Subcutaneous Fat
Effects of Ultrasound Cavitation Focused on Located Adiposity
The aim of this study is to evaluate the effect of cavitation ultrasound focused on localized adiposity and its effects associated with stereodynamic lymphatic drainage.
- Trial name
- NCT02539043
- Testing
- LIPOFOCUS
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Healthy Volunteers
Thyroid and Fat Tissue Metabolism
This study will use a technique called microperfusion to examine how thyroid hormones are involved in fat metabolism. The thyroid gland produces two kinds of hormones: T3 and T4.
- Trial name
- NCT00312715
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity
Insulin Regulation of Lipolysis and Lipolysis Proteins
These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which…
- Trial name
- NCT03866408
- Testing
- Immediate weight loss, Pioglitazone, Deferred weight loss
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Improvement of Abdomen Appearance
Clinical Evaluation of the BTL-899 Device for Non-invasive Lipolysis on Human Fat Tissue
The subjects will be enrolled and assigned to a single study group. They will be required to complete two treatment visits and come for a biopsy procedure.
- Trial name
- NCT03923855
- Testing
- BTL-899
- Where
- Bulgaria
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Weight Change, Body, Weight Loss
Study of Human Adipose Tissue (LOSHAT)
The investigators will study the influence of initial fat cell size/number and adipose function (in particular lipolysis) on weight development over very long time periods (years).
- Conditions
- Weight Change, Body, Weight Loss, Weight Gain, Lipolysis
- Trial name
- LOSHAT (NCT03675464)
- Where
- Sweden
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Body Fat Disorder
Outer Thigh Study With Varied Treatment Parameters
The purpose of this study is to compare the performance of the Zeltiq CoolSculpting System using various treatment parameters for non-invasive reduction of subcutaneous fat in the lateral thighs.
- Trial name
- NCT02081209
- Testing
- The Zeltiq CoolSculpting System
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Fat Disorder
SlimShape Device for Abdominal Fat and Circumference Reduction
Prospective, one-arm, baseline-controlled, clinical study for the evaluation of the SlimShape device for non-invasive abdominal fat and circumference reduction.
- Trial name
- NCT02999763
- Testing
- SlimShape
- Where
- 4 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Syneron Medical
Body Fat Disorder
CoolSculpting of the Flank With Alternate Treatment Parameters
The purpose of this study is to evaluate the safety and efficacy of non-invasive subcutaneous fat layer reduction with an alternative treatment parameter.
- Trial name
- NCT02081196
- Testing
- The Zeltiq CoolSculpting System
- Where
- 3 sites in United States, Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics