Clinical trials: Lipolysis
Type 2 Diabetes
SGLT2i, Ketoacidosis, Volume Contraction, and Insulinopenia
To examine the 2-HIT hypothesis that the SGLT2i-induced stimulation of EGP, lipolysis, and ketone production requires the combination of volume depletion plus insulinopenia in T2D individuals.
- Trial name
- NCT07053306
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Body Fat Disorder
CoolSculpting of the Flank With Alternate Treatment Parameters
The purpose of this study is to evaluate the safety and efficacy of non-invasive subcutaneous fat layer reduction with an alternative treatment parameter.
- Trial name
- NCT02081196
- Testing
- The Zeltiq CoolSculpting System
- Where
- 3 sites in United States, Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Body Fat Disorder
Non-Invasive Reduction of Fat in the Flanks of Patients With Sharp Body Curvature
The purpose of this study is to evaluate the safety and efficacy of the ZELTIQ System and the CoolCurve+ applicator for non-invasive fat reduction in flanks for a patient population with sharp body curvature.
- Trial name
- NCT01600638
- Testing
- The Zeltiq System
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Cancer, Cachexia
TuLip : Role of the Tumor Environment in Cancer-related Fat Loss
Cancer cachexia is defined as a weight loss of more than 5% over the last 6 months, a loss of body fat and muscle atrophy. It is found in 80% of patients with advanced cancer.
- Conditions
- Cancer, Cachexia, Adipose Tissue
- Trial name
- TuLip (NCT05128318)
- Testing
- Nissen Fundoplication, cholecystectomy
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- Université Catholique de Louvain
Obesity, Healthy Volunteers
Fat Metabolism and Melanocortin 3 Receptors in African Americans
Background: Melanocortin receptors are proteins in the body that help send messages between body systems. One such receptor, the melanocortin 3 receptor (MC3R), is important for regulating body weight.
- Trial name
- NCT01851421
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Ultrasound Lipolysis, Cryolipolysis
Ultrasound Lipolysis Versus Cryolipolysis On Lipid Profile Levels In Centrally Obese Middle Aged Men
The study compares the effects of ultrasound lipolysis and cryo lipolysis on cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, body mass index, skin thickness, waist circumference, and waist hip ratio…
- Conditions
- Ultrasound Lipolysis, Cryolipolysis, Lipid Profile, Central Obesity
- Trial name
- NCT06658639
- Testing
- Ultrasound lipolysis, Cryolipolysis, Low Caloric Diet
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University
Obesity
Nighttime Protein Intake on Overnight Lipolysis and Morning Fat Oxidation in Obese Men
Single macronutrients will be consumed before sleep by obese men. Overnight lipolysis will be measured with the microdialysis technique by measuring glycerol concentration and blood flow in abdominal adipose tissue.
- Trial name
- NCT02211391
- Testing
- Casein Protein
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Florida State University
Insulin Sensitivity
Effect of Physiologic Hyperglucogonemia on Adipocyte Metabolism
Purpose/Objectives: To investigate the effect of hyperglucagonemia on insulin action, particularly on adipose tissue. Research Design/Plan: Normal glucose tolerant subjects will be studied.
- Trial name
- Glucagon (NCT04300049)
- Testing
- Glucagon Infusion, Saline
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Metabolic Disease
Effect of Aerobic Exercise Associated With Abdominal Laser Therapy
The purpose of the present study was to evaluate the effects of one session of aerobic exercise associated with low level laser therapy in lipolytic activity, lipid profile and inflammatory markers (C-reactive protein - CRP).
- Trial name
- NCT03462537
- Testing
- Low level laser therapy, Aerobic Exercise, Low level laser therapy without power
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Escola Superior de Tecnologia da Saúde do Porto
Metabolic Syndrome
Metabolic Actions of Omega-3 Fatty Acids
The metabolic syndrome raises the risk of heart disease and is currently at epidemic proportions in the U.S. It consists of 3 of the following components: central obesity, high triglycerides, low HDL, abnormal blood pressure and…
- Trial name
- NCT01896414
- Testing
- EPA (marine fatty acids)
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Whole Body Catabolisme Induced by Glucocorticoids
Glucocorticoid Induced Whole Body Catabolisme
The main purpose of the trial is to advance our knowledge on the possible mechanism underlying the catabolic effects of long-term treatment with glucocorticoid.
- Trial name
- NCT01762540
- Testing
- Glucocorticoids, Calcium Supplement
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity
Effect of Nicotinic Acid on Adipose Tissue Inflammation in Obese Subjects
Our working hypothesis postulates that lipolysis is a determinant of inflammation in adipose tissue (AT). Inhibition of lipolysis, e.g.
- Trial name
- ANITA (NCT01083329)
- Testing
- training, nicotinic acid
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Toulouse
Obesity
Regional Lipolysis Insulin Regulation
Adults who gain most of their excess weight in the abdominal area typically do not respond to insulin in the same way as lean adults.
- Trial name
- NCT06392854
- Testing
- Insulin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy, Obesity
Fat Tissue Microperfusion to Measure Leptin Secretion and Its Relations With Fat Breakdown in Humans
Leptin is a hormone that acts in the body as a chemical messenger. It is produced in fat cells and is believed to regulate body weight in humans. Leptin decreases appetite and influences the energy balance of the body.
- Trial name
- NCT00001722
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Obesity, Diabetes
Endocrine Regulation of Lipolysis in Obesity and Diabetes
Adipose tissue (AT) dysfunction is a commonly observed feature of metabolic dysfunction in obesity and diabetes. An important characteristic when examining AT function is the capacity to break down stored lipids (i.e.
- Trial name
- ERLO (NCT02598544)
- Testing
- adipose tissue sampling
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Hasselt University
LIPOLYSIS
Evaluation of the Safety and Efficacy of REBORN System for Lipolysis Treatment
The Lightfective ReBorn System is intended for non-invasive lipolysis of the flanks in individuals with a Body Mass Index (BMI) of 30 or less. The device is intended to affect the appearance of visible fat bulges in the flanks.
- Trial name
- NCT05507528
- Testing
- reborn treatment
- Where
- 3 sites in United States, Israel
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Lightfective Ltd
Fat Burn
Effect of BTL-899 Device for Non-invasive Lipolysis on Human Upper Arms
This study will evaluate the clinical safety and the performance of the BTL-899 device during the treatment of upper arms.
- Trial name
- NCT04643275
- Testing
- BTL-899
- Where
- Bulgaria
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Healthy
Peripheral Effects of Endotoxin on Insulin Resistance
The aim of the study is to isolate the direct effects of endotoxin on glucose, lipid and protein metabolism. Eight healthy volunteers are enrolled.
- Trial name
- NCT00929136
- Testing
- USP endotoxin
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Improvement of Abdomen Appearance
Effect of the BTL-899 Therapy for Non-invasive Lipolysis and Circumference Reduction of Abdomen
The study is a prospective open-label single-arm study that includes three treatment procedures and four follow-up visits.
- Trial name
- NCT03270150
- Testing
- BTL-899
- Where
- Bulgaria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Lipolysis
RF and PEMF Following Liposuction
The Venus Legacy LB2 Body applicator is intended for circumference reduction treatment by reducing fat cell size and enhancing collagen synthesis as the result of thermal and non-thermal collagen stimulation.
- Trial name
- NCT03588702
- Testing
- RF and PEMF treatment
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Venus Concept