Clinical trials: Lipolysis, active
Type 2 Diabetes
SGLTi, Hepatic Glucose Production and Ketogenesis
In this study, we will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D) and…
- Trial name
- NCT05960656
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Obesity
Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation
Adults who gain most of their excess weight in the abdominal area typically do not respond to factors that "turn on" fat cells the same way as people who don't have excessive weight.
- Trial name
- NCT06416969
- Testing
- Somatostatin, Epinephrine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hyperlactatemia, Metabolic Syndrome (MetS)
Role of Elevated Lactate Levels on Lipid and Carbohydrate Metabolism.
The purpose of this study is to investigate whether the elevated circulating lactate levels of individuals with metabolic syndrome are responsible for their reduced lipolysis and glucose tolerance.
- Conditions
- Hyperlactatemia, Metabolic Syndrome (MetS), Lipolysis, Exercise
- Trial name
- LACTMET (NCT07426172)
- Testing
- hyperlactacidemia, Saline (0.9%, sterile, for infusion)
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ricardo Mora
Type 2 Diabetes
SGLT2i, Ketoacidosis, Volume Contraction, and Insulinopenia
To examine the 2-HIT hypothesis that the SGLT2i-induced stimulation of EGP, lipolysis, and ketone production requires the combination of volume depletion plus insulinopenia in T2D individuals.
- Trial name
- NCT07053306
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Thigh Cellulite
Pilot Study of Naringenin Beta Carotene Cream for Local Fat Reduction (SCULPT)
this study tests the hypothesis that naringenin, beta carotene and menthol cream when applied to one thigh and a placebo cream to the other twice a day will result in greater loss of girth, smoother appearance of the skin and a…
- Trial name
- SCULPT (NCT07862920)
- Testing
- Thigh Reduction Cream
- Volunteers
- 10 people
- Sponsor
- Frank Greenway
Insulin Resistance, Obesity & Overweight
Effects of Ketone Bodies on Insulin Sensitivity
KETO-SENSE is a clinical research study investigating how ketone bodies affect energy metabolism and insulin sensitivity in humans.
- Conditions
- Insulin Resistance, Obesity & Overweight, Energy Metabolism, Ketone Body Metabolism
- Trial name
- KETO-SENSE (NCT07359625)
- Testing
- Growth Hormone, Human, Oral ketone supplement (KetoAid®, KE4)
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Excessive Weight Gain
A Study of Niacin Regulation
Adults who gain most of their excess weight in the abdominal area typically do not respond to things that "turn off" fat cells the same way as lean people.
- Trial name
- NCT06175403
- Testing
- Niacin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Type 2 Diabetes
SGLT2i, Pioglitazone, and Ketone Production in T2D
To examine whether the empagliflozin-induced stimulation of EGP, lipolysis, and ketone production in T2D individuals can be blocked by pioglitazone (which has direct hepatic and adipose tissue effects).
- Trial name
- NCT07053319
- Testing
- Empagliflozin 25 MG, Empagliflozin 25 mg/d plus Pioglitazone (15/30 mg/d)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Obesity
Regional Lipolysis Insulin Regulation
Adults who gain most of their excess weight in the abdominal area typically do not respond to insulin in the same way as lean adults.
- Trial name
- NCT06392854
- Testing
- Insulin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Insulin Receptor Mutation, Partial Lipodystrophy
Study of Growth Hormone Inhibition Using Pegvisomant in Severe Insulin Resistance
Background: Lipodystrophy (LD) syndromes are a group of rare disorders that affect how a person s body can store and use fat tissue. Many people with LDs become severely insulin resistant.
- Trial name
- NCT05470504
- Testing
- Pegvisomant
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity
Insulin Regulation of Lipolysis and Lipolysis Proteins
These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which…
- Trial name
- NCT03866408
- Testing
- Immediate weight loss, Pioglitazone, Deferred weight loss
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Type1diabetes
SGLT2i, Pioglitazone, and Ketone Production in T1D
Participants are being asked to be in a research study. Scientists do research to answer important questions which might help change or improve treatment of participants disease in the future.
- Trial name
- NCT07056699
- Testing
- Dapagliflozin 10mg Tab, Pioglitazone 15 MG and 30mg
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Type 2 Diabetes
SGLT2i, Hepatic Glucose Production, and SNS
In this study, PI will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D)…
- Trial name
- NCT07053293
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Obesity, Morbid
Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis
It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss.
- Trial name
- NCT03868592
- Testing
- Gastric sleeve/bariatric surgery
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic