Clinical trials: Liposomal Bupivacaine
Pain, Postoperative, Pharmacokinetics
Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy
The purpose of this study is to assess pharmacokinetics of liposomal bupivacaine (Exparel) after multilevel intercostal injections of this local anesthetic for pain control during and after thoracoscopic surgeries.
- Trial name
- NCT03737292
- Testing
- Exparel, Bupivacaine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Milton S. Hershey Medical Center
Acute Pain, Orthopaedic Surgery
Effect of Liposomal Bupivacaine on Rebound Pain After Peripheral Nerve Block in Orthopedic Surgery.
This study will prospectively compare the preventive effect of liposomal bupivacaine combined with plain bupivacaine versus plain bupivacaine alone on rebound pain after nerve block in patients undergoing orthopedic extremity…
- Trial name
- NCT07606911
- Testing
- liposomal bupivacaine, Normal Saline
- Where
- China
- Volunteers
- 668 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Gynecologic Surgical Procedures
Rectus Sheath Block for Analgesia After Gynecological Laparotomy
Thirty subjects undergoing laparotomy for Gynecologic oncology surgery will be prospectively enrolled and will receive a bilateral rectus sheath block (RSB) under ultrasound guidance using 133 mg liposomal bupivacaine and 20 ml…
- Trial name
- NCT06575699
- Testing
- Rectus sheath block, Thoracic Epidural Analgesia, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Duke University
Ovarian Cancer, Fibroids
Pilot Study of Liposomal Bupivacaine Redosing in Patients Undergoing Major Gynecologic Procedures
The purpose of this research study is to find out which type of transversus abdomens plane (TAP) and block (bupivacaine, liposomal bupivacaine or liposomal bupivacaine with re-dosing at 48-60 hours) improves your pain control and…
- Conditions
- Ovarian Cancer, Fibroids, Uterine Cancer
- Trial name
- NCT04849858
- Testing
- Bupivacaine, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of California, Irvine
Pain
Exparel Infiltration in Anterior Cruciate Ligament Reconstruction
This is a randomized, single blinded, standard of care controlled clinical trial. All adult patients over sixteen desiring anterior cruciate ligament reconstruction will be eligible.
- Trial name
- NCT02606448
- Testing
- Liposomal bupivacaine, Femoral nerve block, Ropivacaine
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Male Infertility
Post-operative Pain Control of Testicular Sperm Extraction Using Liposomal Bupivacaine
The study is a drug trial comparing the post-operative pain control provided by liposomal bupivacaine (a local anesthetic) against standard bupivacaine (a different formulation of the local anesthetic) for men undergoing…
- Trial name
- NCT03802864
- Testing
- Liposomal Bupivacaine, Standard Bupivacaine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Weill Medical College of Cornell University
Ankle Fracture
Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF)
This study is a randomized controlled trial assessing pain control in ankle fractures repaired with open reduction and internal fixation.
- Trial name
- NCT02480621
- Testing
- Liposomal Bupivacaine with Bupivacaine
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Jamaica Hospital Medical Center
Knee Arthropathy, Knee Arthritis
Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total Knee Replacement
The purpose of this study was to investigate the effect of bupivacaine liposomes on postoperative pain in TKA ( total knee replacement ) patients.The main questions answered are: 1.
- Trial name
- NCT06653621
- Testing
- Bupivacaine liposome, Nerve block mode : adductor block, Bupivacaine
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Huazhong University of Science and Technology
Rotator Cuff Tear, Postoperative Pain
Interscalene Block With and Without Liposomal Bupivacaine in Shoulder Surgery
The purpose of this study is to examine the difference in perioperative pain after shoulder surgery with a standard bupivacaine nerve block compared to liposomal bupivacaine enhanced nerve block alone in TSA and ARCR.
- Trial name
- NCT03728946
- Testing
- Liposomal Bupivacaine
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Orthopaedic & Neurosurgery Specialists
Pain, Postoperative
Intraoperative Liposomal Bupivacaine vs. Bupivacaine for Total Hip Replacement Pain Management
The purpose of this study is to compare two medications currently injected intra-operatively to help decrease pain after surgery in patients undergoing a primary total hip replacement (THR).
- Trial name
- NCT03001453
- Testing
- Liposomal Bupivacaine, 0.25% Bupivacaine with epinephrine, Saline
- Where
- 2 sites in United States
- Volunteers
- 107 people
- Sponsor
- American Hip Institute
Osteoarthritis, Total Knee Arthroplasty
Effectiveness of Intraoperative Exparel for Postoperative Pain Control in Total Knee Arthroplasty
Does the use of periarticular Exparel in total knee arthroplasty prove to more effectively manage post operative pain control than another local analgesic, Ropivacaine, when both are used as part of a multimodal pain management…
- Conditions
- Osteoarthritis, Total Knee Arthroplasty, Pain Management
- Trial name
- NCT02808728
- Testing
- Pain Cocktail with Exparel, Pain Cocktail with Ropivacaine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- DeClaire LaMacchia Orthopaedic Institute
Postoperative Pain
TAP Block With Plain Bupivacaine Versus Wound Infiltration With Exparel for Postoperative Pain Management
In this randomized, controlled, observer-blinded study we plan to evaluate pain relief after ultrasound-guided transversus abdominis plane (TAP) block using bupivacaine and wound infiltration using liposomal bupivacaine in…
- Trial name
- NCT02074709
- Testing
- Plain bupivacaine, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Urinary Incontinence, Stress
Trial Liposomal Bupivacaine Following Retropubic Suburethral Sling for Stress Urinary Incontinence
The purpose of the study is to determine if the administration of liposomal bupivacaine at the completion of a suburethral sling procedure will result in decreased postoperative pain compared to no injection.
- Trial name
- NCT02296099
- Testing
- liposomal bupivacaine
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- TriHealth Inc.
Rotator Cuff Tears
Liposomal Bupivacaine in Shoulder Arthroscopy
Background: The research study is being conducted to see if using the liposomal Bupivacaine for the Interscalene block will improve the patient pain control and the whole patient's experience 48 hours after surgery when compared…
- Trial name
- NCT04461028
- Testing
- Liposomal bupivacaine, Bupivacaine with Dexamethasone Solution
- Where
- United States
- Sponsor
- University of Pennsylvania
Tonsillectomy, Tonsillitis
EXPAREL® for Pain After Tonsillectomy
The purpose of this study is to determine whether liposomal bupivacaine (long acting injectable anesthetic) provides greater post operative pain relief compared to the standard post operative pain regiment for tonsillectomy…
- Conditions
- Tonsillectomy, Tonsillitis, Post-operative Pain
- Trial name
- NCT02444533
- Testing
- Liposomal Bupivacaine
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Renal Calculi, Postoperative Pain
Efficacy of Liposomal Bupivacaine for Pain Control After Percutaneous Nephrostolithotomy
Percutaneous nephrostolithotomy (PCNL) is a common endoscopic procedure performed for upper urinary tract calculus disease. Despite being minimally invasive, it is associated with significant postoperative pain, often…
- Trial name
- NCT03043027
- Testing
- liposomal bupivicaine, Bupivacaine, Saline Solution
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Colorectal Surgery, TAP Blocks
TAP Block Catheters vs Liposomal Bupivacaine for Pain Control After Colorectal Surgery
This is a prospective randomized study designed to compare the pain control from a single shot of liposomal bupivacaine (Exparel) against transversus abominus plane (TAP) catheters with ropivicaine bolus in patients undergoing…
- Trial name
- NCT03080142
- Testing
- Exparel, Ropivacaine
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of California, Davis
Liposomal Bupivacaine, Microvascular Decompression
Effect of Local Infiltration of Liposomal Bupivacaine on Postoperative Analgesia in Patients With Craniotomy Microvascular Decompression
Background: Approximately 60-84% of patients undergoing craniotomy experience moderate to severe pain within 48 hours postoperatively, with posterior fossa craniotomy patients experiencing more severe pain.
- Trial name
- NCT07245290
- Testing
- liposomal bupivacaine local infiltration, normal operation
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Postoperative Acute Pain, Lumbar Degenerative Diseases
Liposomal Bupivacaine for Pain After Lumbar Fusion
Spine surgery often causes severe postoperative pain. Currently, our hospital routinely uses ropivacaine for local infiltration analgesia (lasting 6-8 hours).
- Trial name
- NCT07171125
- Testing
- Liposomal bupivacaine (local infiltration), ropivacaine (local infiltration)
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Min Li
Total Knee Anthroplasty, Nerve Block
Liposomal Bupivacaine Versus Ropivacaine With Perineural Dexamethasone or Dexmedetomidine as Adjuncts for Adductor Canal Block Combined With IPACK Block in Total Knee Arthroplasty
Effective postoperative pain management remains a cornerstone of enhanced recovery protocols following total knee arthroplasty (TKA).
- Conditions
- Total Knee Anthroplasty, Nerve Block, Ropivacaine, Liposomal Bupivacaine
- Trial name
- NCT07509866
- Testing
- Liposomal bupivacaine (LB), Ropivacaine with Perineural Dexamethasone, Ropivacaine with Perineural Dexmedetomidine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Huazhong University of Science and Technology