Clinical trials: Liposomal Bupivacaine
Herpes Zoster Pain, Neuralgia, Postherpetic
High-Voltage Long-Duration Pulsed Radiofrequency Combined With Liposomal Bupivacaine Subcutaneous Block for Herpes Zoster-Associated Neuralgia
Research Objectives Background and Significance: Zoster-associated neuralgia (ZAN) refers to neuropathic pain experienced by herpes zoster (HZ) patients before, during, and after rash resolution, characterized by paroxysmal…
- Trial name
- NCT06959147
- Testing
- High-Voltage Long-Duration Pulsed Radiofrequency plus Liposomal Bupivacaine group, High-Voltage Long-Duration Pulsed Radiofrequency
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shirong Tan
Coronary Artery Disease, Coronary Artery Stenoses
Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride
The aim of this study is to evaluate the analgesic efficacy and safety of wound infiltration with liposomal bupivacaine (LB) in patients undergoing cardiac surgery with sternotomy and cardiopulmonary bypass (CPB) and compare it…
- Conditions
- Coronary Artery Disease, Coronary Artery Stenoses, Valve Regurgitation, Mitral, Valve Regurgitation, Tricuspid
- Trial name
- NCT03270514
- Testing
- Exparel Injectable Product, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kathirvel Subramaniam
Postoperative Local Analgesia
A Study on the Bioequivalence of Bupivacaine Liposome Injection in Humans
This study aims to investigate the pharmacokinetics of bupivacaine liposomal injection (test preparation) in healthy subjects. The manufactured liposomal bupivacaine injection (EXPAREL®) was used as the reference formulation to…
- Trial name
- NCT07279155
- Testing
- Bupivacaine Liposome Injection T preparation, Bupivacaine Liposome Injection R preparation
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Postoperative Pain, Postoperative Nausea and Vomiting
Surgical Site Infiltration of Exparel vs TAP Block With Exparel in Patients Undergoing Laparotomy Via Midline Incision
This is a randomized-controlled prospective study to be conducted at Danbury Hospital and Norwalk Hospital to compare postoperative opioid consumption and pain scores of patients with suspected or known gynecologic malignancies…
- Conditions
- Postoperative Pain, Postoperative Nausea and Vomiting, Opioid Use
- Trial name
- NCT03870685
- Testing
- TAP Block, Surgical Site Infiltration, Exparel
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Danbury Hospital
Lung Cancer (Diagnosis)
Combination Versus Alone Liposomal Bupivacaine Blocks in Minimally Invasive Thoracic Surgery-1
The goal of this clinical trial is to assess how the location of local anesthetic medication affects pain control capabilities in adult patients undergoing thoracic(chest)-only minimally invasive surgery.
- Trial name
- CALMS-1 (NCT07254650)
- Testing
- Arm 1 "LipoB-I": Liposomal Bupivacaine via Multi-Level Intercostal Nerve Block, Arm 2 "LipoB-S": Liposomal Bupivacaine via Serratus Anterior Plane Block, Arm 3 "LipoB-C": Liposomal Bupivacaine Administered via Combination Block
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Pain, Postoperative, Opioid Use
Liposomal Bupivacaine After Cesarean Delivery
The aim of this study is to determine if local wound infiltration with liposomal bupivacaine at the time of cesarean delivery can decrease opioid use and provide adequate post-operative pain control.
- Trial name
- NCT03907813
- Testing
- Exparel, Saline infiltration
- Where
- United States
- Sponsor
- Wright State University
Bowel Disease
Bilateral TAP and RS Blocks Using Liposomal Bupivacaine/Bupivacaine vs. Regular Bupivacaine in Laparoscopic Colectomy
This study will be a single center, prospective triple blinded randomized controlled study, comparing the use of liposomal bupivacaine (Exparel) to regular bupivacaine with adjuncts in bilateral mid-abdominal transverse abdominis…
- Trial name
- TAPLIP (NCT05224089)
- Testing
- Liposomal Bupivicaine/Bupivacaine Admixture, Bupivacaine HCL
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Hartford Hospital
Intertrochanteric Fractures, Hip Fractures
Liposomal Bupivacaine Fascia Iliaca Block for Perioperative Sleep Quality in Elderly Patients With Intertrochanteric Fracture
Older adults with hip fracture often experience severe pain before and after surgery. This pain can cause anxiety and poor sleep, and may increase the risk of postoperative delirium (sudden confusion after surgery).
- Conditions
- Intertrochanteric Fractures, Hip Fractures, Sleep Disturbance, Postoperative Delirium
- Trial name
- NCT07892859
- Testing
- Liposomal Bupivicaine, Saline Solution (NaCl 0,9%)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Li Xiaoyuan
Pain, Postoperative
Efficacy of Liposomal Bupivacaine Versus 0.25% Bupivacaine for Laparoscopic Urologic Surgery
A prospective, randomized comparison of bupivacaine to liposomal bupivacaine given by local injection at all the wound sites in patients undergoing robotic-assisted or laparoscopic urologic surgeries in an effort to determine…
- Trial name
- NCT02222129
- Testing
- Bupivacaine, liposomal bupivacaine
- Where
- 2 sites in United States
- Volunteers
- 206 people
- Sponsor
- Knight, Richard, M.D.
Shoulder Pain, Postoperative Pain
Interscalene Single Shot With Plain Bupivacaine Versus Liposomal Bupivacaine for Arthroscopic Shoulder Surgery
The investigators will be comparing pain scores and opioid use in patients receiving interscalene peripheral blocks with plain bupivacaine versus those receiving liposomal bupivacaine.
- Trial name
- NCT03638960
- Testing
- Bupivacaine liposome, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Southern California
Pain
Early Post-Operative Pain Control Following Wrist Operations
The purpose of this study is to demonstrate improved pain control and outcomes in wrist operations with the use of a long-acting local anesthetic, EXPAREL, when compared to the use of the standard local anesthetic, Marcaine.
- Trial name
- NCT02052180
- Testing
- Exparel, Marcaine (Control)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Tennessee
Post Operative Pain, Quality of Recovery After Mastectomy
Quality of Recovery From Mastectomy With and Without PECS Blocks
This is a prospective observational study. Investigators want to understand post-operative recovery for patients undergoing mastectomy at NorthShore University HealthSystem.
- Trial name
- NCT05795413
- Testing
- Mastectomy with PECS blocks, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Postoperative Pain, Breast Reconstruction
Effectiveness of Exparel TAP Block in Breast Free Flap Reconstruction
Transversus Abdominis Plane (TAP) block is a useful tool in pain management after abdominal surgery. It is a regional nerve block that targets T6-L1 thoracolumbar nerves running in the plane between internal oblique and…
- Trial name
- NCT04777591
- Testing
- Liposomal bupivacaine TAP block, Bupivacain
- Where
- 2 sites in United States
- Volunteers
- 117 people
- Sponsor
- University of Virginia
Clavicle Fracture
Does Liposomal Bupivacaine Provide Improved Pain Management for ORIF of Midshaft Clavicle Fractures?
To determine whether liposomal bupivacaine wound infiltration decreases pain scores and narcotic use when compared to bupivacaine alone after open reduction internal fixation of midshaft clavicle fractures.
- Trial name
- NCT03020563
- Testing
- Liposomal Bupivacaine, Bupivacaine
- Where
- United States
- Sponsor
- University of Minnesota
Postoperative Pain, Surgery
Exparel Use in Bilateral TAP Blocks for Postoperative Pain Control
To determine if Exparel (Liposomal Bupivacaine, an FDA approved drug) use in ultrasound guided Transversus Abdominis Plane (TAP) blocks may reduce opioid requirement use postoperatively, reduce pain scores postoperatively, reduce…
- Conditions
- Postoperative Pain, Surgery, Anesthesia, Local
- Trial name
- NCT03878888
- Testing
- Exparel 266 MG Per 20 ML Injection
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital, Pennsylvania
Median Sternotomy
Liposomal Bupivacaine and Bupivacaine for TTMPB in Median Sternotomy
In light of the ongoing controversy surrounding the efficacy of bupivacaine liposomes, our study was designed to investigate, for the first time, the differential postoperative analgesic effects between bupivacaine liposomes…
- Trial name
- NCT06646172
- Testing
- Transverse thoracic muscle plane block (TTMPB) using liposomal bupivacaine and bupivacaine mixture, Transverse thoracic muscle plane block (TTMPB) using bupivacaine hydrochloride
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Tongji Hospital
Pain
Impact of Liposomal Bupivacaine Administered Following Placement of a Transobturator Suburethral Sling
Liposomal bupivacaine or placebo will be administered at the end of a transobturator midurethral sling to determine if there is a difference in a patient's perceived postoperative pain.
- Trial name
- NCT02591888
- Testing
- Liposomal bupivacaine
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Rhinoplasty, Pain Management
Efficacy of Liposomal Bupivacaine Post Septorhinoplasty
The objective of this study is to determine if there is a difference in post-operative pain after septorhinoplasty when long-acting liposomal bupivacaine is used for local anesthesia compared to other standard local anesthetic…
- Trial name
- NCT05964868
- Testing
- Liposomal Bupivacaine, 0.25% bupivacaine with 1:200,000 epinephrine
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Jessyka Lighthall
Shoulder Pain
Liposomal Bupivacaine vs Dexamethasone ISB
In this study, patients receiving shoulder arthroscopy will receive an interscalene block for pain management containing either liposomal bupivacaine and standard bupivacaine or standard bupivacaine and dexamethasone.
- Trial name
- NCT04047446
- Testing
- Exparel 133 MG Per 10 ML Injection, Dexamethasone
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Hospital for Special Surgery, New York
Laparoscopic Surgery, Gynecologic Oncology Patient
The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology
Laparoscopic surgery, characterized by minimal invasiveness, rapid recovery, and shorter hospital stays, has been widely adopted in Gynecologic Oncology.
- Conditions
- Laparoscopic Surgery, Gynecologic Oncology Patient, Liposomal Bupivacaine, Transversus Abdominis Plane Block
- Trial name
- NCT07458295
- Testing
- Bupivacaine hydrochloride, Liposomal bupivacaine plus bupivacaine
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Beijing Tiantan Hospital