Clinical trials: Liver Ablation
Hepatocellular Carcinoma, Hepatitis C
HCV Related Hepatocellular Carcinoma Recurrence After Directly Acting Antivirals: A Randomized Controlled Trial
Data regarding hepatocellular carcinoma (HCC) recurrence after directly acting antivirals (DAAs) given for hepatitis C virus treatment are contradictory.
- Conditions
- Hepatocellular Carcinoma, Hepatitis C, Neoplasm Recurrence, Treatment Complication
- Trial name
- RCT (NCT04653818)
- Testing
- Velpatasvir/Sofosbuvir
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Alexandria University
Hepatocellular Carcinoma, Ablation
Plan for Microwave Thermal Field
Develop an intelligent system based on contrast-enhanced ultrasound and clinical information to help doctors automatically obtain ablation parameters (ablation needle number, ablation needle type, ablation time,ablation power)…
- Trial name
- NCT05270642
- Testing
- Microwave Thermal guided by Plan for Microwave Thermal Field system
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Chinese PLA General Hospital
Liver Tumor
Treat-and-resect Study of Echo Decorrelation Imaging-controlled Radiofrequency Ablation in Liver Tumors
This study will comprise the first pilot clinical trial of 3D, ultrasound-based thermal ablation control using echo decorrelation imaging, directly testing the capability of this approach to ensure reliable tumor treatment.
- Trial name
- NCT05211388
- Testing
- RFA controlled using echo decorrelation imaging, RFA controlled using standard manufacturer-specified algorithms
- Where
- United States
- Sponsor
- University of Cincinnati
Focal Liver Lesions, Ultrasonics
Utility of Ultrasound Imaging for Diagnosis of Focal Liver Lesions: A Radiomics Analysis
Ultrasound (US) as first-line imaging technology in detecting focal liver lesions,also plays a crucial role in evaluating image and guiding ablation which is the main treatment for liver lesions.
- Conditions
- Focal Liver Lesions, Ultrasonics, Intelligent Diagnosis, Ablation
- Trial name
- NCT03871140
- Testing
- diagnosis
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Liver Neoplasms
Tislelizumab Plus TKI as Adjuvant Therapy Versus Active Surveillance in Patients With HCC
Background: Ablation is important radical treatment in hepatocellular carcinoma (HCC). However, the 5-year recurrence rate of HCC after ablation is up to 80%.
- Trial name
- NCT06059885
- Testing
- Tislelizumab plus tyrosine kinase inhibitor
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing 302 Hospital
Secondary Malignant Neoplasm of Liver
A Trial on SBRT Versus MWA for Inoperable Colorectal Liver Metastases (CLM)
The trial is designed to perform a rigorous evaluation of efficacy and tolerability of SBRT by means of a randomised, controlled trial in patients affected by inoperable colorectal liver metastases. The chosen comparator is MWA.
- Trial name
- NCT02820194
- Testing
- Stereotactic Body Radiation Therapy, Microwave Ablation
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Istituto Clinico Humanitas
Colon Cancer Liver Metastasis
Phase 2 Study of Thermodox as Adjuvant Therapy With Thermal Ablation (RFA) in Treatment of Metastatic Colorectal Cancer(mCRC)
The purpose of this study is to determine the safety and efficacy of Thermodox, a thermally sensitive liposomal doxorubicin, in combination with thermal ablation in the treatment of hepatic colorectal liver metastases (CRLM).
- Trial name
- ABLATE (NCT01464593)
- Testing
- Lyso-Thermosensitive Liposomal Doxorubicin, 5% Dextrose Solution, ThermoDox
- Where
- 4 sites in United States
- Volunteers
- 2 people
- Sponsor
- Imunon
Liver Cancer, Metastatic Cancer
Cryosurgery in Treating Patients With Liver Cancer or Liver Metastases
RATIONALE: Cryosurgery kills cancer cells by freezing them during surgery. PURPOSE: Phase I/II trial to study the effectiveness of cryosurgery in treating patients with unresectable primary liver cancer or liver metastases.
- Trial name
- NCT00002655
- Testing
- cryosurgery
- Where
- United States
- Sponsor
- University of Colorado, Denver
Hepatocellular Carcinoma
Pretreatment MRI Predicting Outcome After Radio-frequency Ablation of HCC
HCC is classified as keratin (K) 19 positive or K19 negative. K19 is a biliary/hepatic progenitor cell (HPC) marker only expressed in a subset of HCC with poor prognosis and high risk of early recurrence after treatment…
- Trial name
- NCT02051283
- Testing
- RFA
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Colorectal Cancer
Treatment of Unresectable Colorectal Metastases by Radiofrequency Ablation Combined or Not With Resection, With or Without Neoadjuvant Chemotherapy.
The hypothesis is that radiofrequency ablation combined or not with resection may allow a local control (the liver) in patients suffering from unresectable colorectal liver metastases.
- Trial name
- ARF2003 (NCT00210106)
- Testing
- Ablathermy
- Where
- 12 sites in France
- Volunteers
- 52 people
- Sponsor
- Institut Bergonié
Primary Liver Cancer, Radiofrequency Ablation
RFA or Surgical Resection Combined With Neo-MASCT for Primary HCC: a Phase II Trial
RAMEC is a phase II, multi-center, randomized trial with a safety test. There will be a safety test to establish the safety and tolerability of Neo-MASCT treatment and assess the immune response to the treatment.The randomized…
- Conditions
- Primary Liver Cancer, Radiofrequency Ablation, Immunotherapy, Hepatectomy
- Trial name
- RAMEC (NCT03067493)
- Testing
- Neo-MASCT
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Sun Yat-sen University
Liver Metastases, Hepatic Metastases
Therapeutic Efficacy and Safety of Ultrasound-Guided Microwave Ablation for Hepatic Metastatic Nodules
The liver is one of the most common organs where cancer cells spread (metastasize) from other parts of the body, especially from gastrointestinal cancers such as colorectal cancer.
- Conditions
- Liver Metastases, Hepatic Metastases, Secondary Malignant Neoplasm of Liver, Colorectal Cancer Metastatic
- Trial name
- NCT07871253
- Testing
- Ultrasound-Guided Microwave Ablation
- Volunteers
- 30 people
- Sponsor
- Assiut University
Thermoablation, Chronic Liver Disease
Comparison of Response and Recurrence Rates Following Percutaneous Microwave Coagulation Therapy Versus Percutaneous Radiofrequency Ablation
To date, the majority of studies that have evaluated the efficacy of microwave ablation (MWA) in the treatment of hepatocellular carcinoma (HCC) lesions in cirrhotic patients and compared its efficacy with that of percutaneous…
- Conditions
- Thermoablation, Chronic Liver Disease, Hepatocellular Carcinoma
- Trial name
- Thermoablation (NCT02859753)
- Testing
- Percutaneous Radiofrequency Ablation, Percutaneous Microwave Ablation
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Hepatocellular Carcinoma, Obesity
Central Obesity and Hepatocellular Carcinoma
Recurrence and metastases after microwave ablation(MWA) of hepatocellular carcinoma(HCC) are the major factors that influence the survival.
- Conditions
- Hepatocellular Carcinoma, Obesity, Microwave Ablation
- Trial name
- NCT03082378
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Hepatocellular Carcinoma, Liver Neoplasms
Enhanced Radiofrequency Ablation for Recurrent HCC Post-TACE Using Twin Internally Cooled-Perfusion Electrodes
This single-center, prospective study evaluates the therapeutic outcomes of saline-augmented bipolar radiofrequency ablation (RFA) with twin internally cooled-perfusion (TICP) electrodes for treating recurrent hepatocellular…
- Trial name
- ERFA (NCT07192172)
- Testing
- Bipolar radiofrequency ablation using twin internally cooled perfusion electrodes
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Hepatocellular Carcinoma
Trial of Ablation of Small Hepatocellular Carcinomas in Patients of Cirrhosis
The purpose of this study is to assess the efficacy of Radiofrequency ablation (RFA) and percutaneous acetic acid ablation (PAI) in the management of small hepatocellular carcinoma (HCC) in patients of cirrhosis of liver.
- Trial name
- NCT01438437
- Testing
- PAI, RFA
- Where
- India
- Volunteers
- 54 people
- Sponsor
- All India Institute of Medical Sciences
Liver Neoplasms
Single-probe Microwave Ablation (MWA) of Metastatic Liver Cancer
Microwave ablation (MWA) is the most recent development in the field of local ablative therapies. The aim of this study was to evaluate the variability and reproducibility of single-probe MWA versus radiofrequency ablation (RFA)…
- Trial name
- LiverMWA1 (NCT00922181)
- Testing
- Microwave ablation, Radiofrequency ablation
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- University Hospital, Gasthuisberg
Liver Cancer, Liver Metastases
Prospective Cohort Study on Thermal Ablation of Malignant Liver Tumors
The endpoint of this study is to develop and validate algorithms, using artificial intelligence and machine learning, to optimize patient selection, treatment planning, treatment evaluation and outcome prediction in patients…
- Conditions
- Liver Cancer, Liver Metastases, Liver Metastasis Colon Cancer, Hepatocellular Carcinoma
- Trial name
- A-IMAGIO (NCT06179602)
- Where
- Netherlands
- Volunteers
- 1,500 people
- Sponsor
- Leiden University Medical Center
Liver Cancer, Ciprofol
Ciprofol Sedation in Patients Undergoing Liver Cancer Percutaneous Radiofrequency Ablation
Efficacy and Safety of Ciprofol Sedation in Patients Undergoing Liver Cancer Percutaneous Radiofrequency Ablation
- Trial name
- NCT06178926
- Testing
- Propofol, Ciprofol
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhejiang Cancer Hospital
Solid Tumor Including Thyroid, Bone, Liver, Pancreas
Eastern Ablation Registry for Solid Tumor (EAST)
Local tumor ablation is among the major anti-tumor modalities worldwide. Given the number of changes that have taken place in the field of tumor ablation in the past 10 years, it is our intention to ensure that this highly…
- Trial name
- EAST (NCT03362749)
- Testing
- RFA, MWA, cryo and IRE
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital