Clinical trials: Liver Biopsy
MASLD, T2DM (Type 2 Diabetes Mellitus)
Non-Invasive MASLD Diagnosis & T2D Remission Biomarkers
The goal of this observational study is to prospectively develop and validate a non-invasive scoring system based on metabolic markers, proteomic, and transcriptomic profiles to accurately screen, diagnose, stage, and monitor…
- Conditions
- MASLD, T2DM (Type 2 Diabetes Mellitus), Non-alcoholic Fatty Liver Disease (NAFLD), Obesity
- Trial name
- ENSURE-MASLD (NCT07172997)
- Testing
- Bariatric Surgery
- Where
- 2 sites in Bahrain
- Volunteers
- 163 people
- Sponsor
- Royal College of Surgeons in Ireland - Medical University of Bahrain
Living Donor Liver Transplantation
Steatosis Assessment Pre-LDLT
There is a major shortage of donor livers in the Netherlands. Living donor liver transplantation (LDLT) is a good solution to this shortage. Donor screening is extensive to minimalize risks for donors and recipients.
- Trial name
- SILDLT (NCT07015723)
- Testing
- Living liver donors
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- Erasmus Medical Center
Liver Cancer, Biliary Tract Cancer
Early-stage Detection of LIver, Biliary TRAct and PancReatic Cancers
LIBRARY is a prospective, multi-center, observational study aimed at detecting early liver, biliary tract, and pancreatic cancers by combining assays of cell-free DNA (cfDNA) methylation, serum protein, and microRNA.
- Conditions
- Liver Cancer, Biliary Tract Cancer, Pancreatic Cancer
- Trial name
- NCT06139042
- Testing
- Blood drawing
- Where
- China
- Volunteers
- 1,608 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
HEPATITIS B CHRONIC, Hepatitis B Chronic Infection
Bepirovirsen Liver Biopsy Study
Bepirovirsen Liver Biopsy study is a single centre open label phase II study to examine the antiviral and immunological effects of bepirovirsen in CHB patients both treated and untreated with HBsAg<1000 IU/ml
- Trial name
- GSK Biopsy (NCT07696520)
- Testing
- Bepirovirsen, Liver biopsy, Optional Liver biopsy
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- National University Health System, Singapore
Non-alcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis
Endoscopic Ultrasound(EUS)-Guided TRUCUT Biopsy (EUS-TCB) of Suspected Nonalcoholic Fatty Liver Disease(NAFLD.)
Endoscopic Ultrasound involves the placement of a small flexible camera through the mouth and into the stomach to image various parts of the body.
- Trial name
- NAFLD (NCT00586313)
- Testing
- Tru-cut biopsy, Tru-cut
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Indiana University
Liver Disease
Comparing Pain in Patients Undergoing Percutaneous Versus Transjugular Techniques of Liver Biopsy
Background: In a liver biopsy, a small piece of liver is removed. A percutaneous liver biopsy (PLB) is done through a needle on the right side of your belly.
- Trial name
- NCT02311348
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hepatitis C, Chronic
Viral Kinetics and Liver Gene Expression in Response to Ribavirin and Peginterferon Therapy of Chronic Hepatitis C
Up to 120 patients with chronic hepatitis C will be enrolled in a study of viral kinetics and liver gene expression before and during combination therapy with peginterferon and ribavirin.
- Trial name
- NCT00718172
- Testing
- Liver Biopsy, Peginterferon & Ribavirin for Hepatitis C, Pre-treatment Ribavirin
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cancer of Digestive System, Ovarian Cancer
Feasibility Study for Robotic Endomicroscopy to Better Define Resection Strategies (PERSEE)
This study aims at demonstrating the feasibility of probe-based confocal laser endomicroscopy (pCLE) and needle-based confocal laser endomicroscopy (nCLE).
- Trial name
- PERSEE (NCT02312167)
- Testing
- confocal laser endomicroscopy
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut Mutualiste Montsouris
Non-alcoholic Steatohepatitis
Study of Liver Fibrosis Stage Assessment by Fibroblast Activation Protein Imaging in Patients With Biopsy for Suspected or Proven Nonalcoholic Steatohepatitis
Non-alcoholic fatty liver disease (NAFLD), estimated to be 17% prevalent in France, can lead to non-alcoholic steatohepatitis (NASH), which in turn can progress to fibrosis, the ultimate stage of which is cirrhosis, a major cause…
- Trial name
- HEFITEP (NCT06160271)
- Testing
- PET scan of 68Ga-FAPI
- Volunteers
- 72 people
- Sponsor
- Central Hospital, Nancy, France
Diagnoses Diseases, Ultrasound Therapy; Complications
19 Versus 22-Gauge Needle for EUS-LB
Chronic liver disorders (CLD) are a major cause of morbidity and mortality for individuals in the US. Though serologic analysis will often lead to a conclusive diagnosis, liver biopsy remains an important method for helping to…
- Conditions
- Diagnoses Diseases, Ultrasound Therapy; Complications, Liver Diseases
- Trial name
- EUSLB1922 (NCT02967991)
- Testing
- EUS-guided liver biopsy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Obesity, Non-Alcoholic Steatohepatitis
EUS Guided Core Liver Biopsy and IGB Placement for the Diagnosis and Management of NASH and Obesity
This study is designed to investigate the impact of weight loss achieved with the IGB on NASH with early fibrosis in a select cohort of patients with obesity preselected to have a high pre-test probability of having NASH with…
- Trial name
- NCT02880189
- Testing
- Orbera Intragastric Balloon, Endoscopic Ultrasound Guided Core Liver Biopsy
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Obesity, Obesity, Morbid
Prevalence of Steatosis and Steatohepatitis in Patients Undergoing Bariatric Surgery; a Biopsy-based Study
To study the prevalence of steatosis, steatohepatitis, and their associated risk factors in obese patients undergoing bariatric surgery.
- Conditions
- Obesity, Obesity, Morbid, Bariatric Surgery Candidate, Steatosis of Liver
- Trial name
- NCT06499675
- Testing
- sleeve gastrectomy, Liver Biopsy
- Where
- Egypt
- Volunteers
- 272 people
- Sponsor
- Egyptian Liver Hospital
Liver Biopsy
Identification of Liver Tumours Using BIP - Biopsy System
This clinical device investigation is conducted by performing liver biopsies using the BIP - Biopsy Tool. The aim is to assess the feasibility of bioimpedance spectroscopy based biopsy tool guidance method and test how well BIP…
- Trial name
- NCT02620228
- Testing
- BIP Biopsy System
- Where
- Finland
- Volunteers
- 26 people
- Sponsor
- Injeq Ltd
Liver Fibrosis, Cirrhosis
Endosonographic Shear Wave Elastography to Assess Liver and Splenic Fibrosis
The study is being done to collect information on the effectiveness of endosonographic elastography (a technique which uses sound waves) to measure the stiffness of the liver and spleen.
- Trial name
- EUS SWE liver (NCT06867731)
- Testing
- Endosonographic Elastography, Endosonographic shear wave elastography
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Providence Medical Research Center
HIV Infections, Hepatitis C
Comparing Single Photon Emission Computed Tomography (SPECT) and Liver Biopsy to Evaluate the Liver in Patients With HIV and Hepatitis C Virus
The purpose of this study is to find if the Single Photon Emission Computed Tomography (SPECT) scan is as effective as a liver biopsy (using a special needle to remove tissue from the liver) in examining liver damage in patients…
- Trial name
- NCT00006643
- Where
- 11 sites in United States
- Volunteers
- 44 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Liver Biopsy, Lung Biopsy
Novel Guidance Device for Image Fusion and Needle Guidance in Lung, Liver or Kidney Biopsy
This study investigates whether a new image fusion technology can reduce patient radiation dose from CTs and/or procedure time during biopsies of lung, liver or kidney.
- Conditions
- Liver Biopsy, Lung Biopsy, Kidney Biopsy
- Trial name
- NCT04039529
- Testing
- SCENERGY-guided Biopsy
- Where
- United States
- Sponsor
- Clear Guide Medical
Wilson Disease
Copper Concentration & Histopathologic Changes in Liver Biopsy in Participants With Wilson Disease Treated With ALXN1840
The main objective of the study is to evaluate the change in liver copper (Cu) concentration following 48 weeks of treatment with ALXN1840 in adult participants with Wilson Disease (WD) who have been previously treated for at…
- Trial name
- NCT04422431
- Testing
- Bis-Choline Tetrathiomolybdate
- Where
- 12 sites in United States, Canada and 6 more
- Volunteers
- 31 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
NASH
A Multiple Ascending Dose Study of Pegozafermin in Participants With Biopsy Confirmed Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) and at High Risk of NASH
Part 1: This is a multi-center evaluation of pegozafermin (administered weekly or every other week) in a randomized, double-blind, placebo-controlled study administered for 12 weeks in participants with NASH and NAFLD at high…
- Trial name
- NCT04048135
- Testing
- Pegozafermin
- Where
- 26 sites in United States, Puerto Rico
- Volunteers
- 101 people
- Sponsor
- 89bio, Inc.
Hepatic Disease, Renal Disease
Assess Safety and Performance of the Kronos Electrocautery Device for Electrocautery Procedures Following Coaxial Biopsy Procedures
The primary objective for this study is to assess safety and performance of the Kronos Electrocautery Device for electrocautery procedures following coaxial biopsy procedures on areas that include, but are not limited to, liver…
- Trial name
- NCT05593211
- Testing
- Kronos Electrocautery Device
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Single Pass Inc
Pancreatic Cancer, Liver Metastases
A Study of Pancreatic Cancer in Xenografts From Liver Metastases
This is a feasibility study to perform image-guided liver biopsies in 25 patients who have pancreatic cancer with liver metastasis (cancer in the pancreas that has spread to the liver).
- Conditions
- Pancreatic Cancer, Liver Metastases, Tumor Tissue Biopsy, Blood Samples
- Trial name
- NCT01774643
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- University Health Network, Toronto