Clinical trials: Liver Disease
Chronic Hepatitis C Infection
A Study to Evaluate the Safety and Effect of the Experimental Drugs ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 in Subjects With Chronic Hepatitis C
The purpose of this study is to evaluate the safety and antiviral activity of ABT-450/ritonavir/ABT-267 (ABT-450/r/ABT-267; ABT-450 also known as paritaprevir; ABT-267 also known as ombitasvir) and ABT-333 (also known as…
- Trial name
- PEARL-II (NCT01674725)
- Testing
- ABT-450/r/ABT-267, ABT-333, Ribavirin
- Volunteers
- 187 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Hepatocellular Carcinoma
Immune Cells as a New Biomarker of Response in Patients Treated by Immunotherapy for Advanced Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Treatment options for advanced HCC remain very limited.
- Trial name
- IMMUNOCELL (NCT05044676)
- Testing
- patients with hepatocellular carcinoma
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatitis C, Chronic
A Study to Assess the Effectiveness, Safety, and Pharmacokinetics of TMC435 in Combination With Peginterferon Alfa-2a and Ribavirin in Hepatitis-C Infected Patients
The purpose of this study is to evaluate effectiveness, safety and pharmacokinetics (Explores what the body does to the medication) of TMC435350 in combination with Peginterferon Alfa-2a and Ribavirin in genotype 1 hepatitis C…
- Trial name
- DRAGON (NCT00996476)
- Testing
- TMC435, PegIFNα-2a, RBV
- Where
- 19 sites in Japan
- Volunteers
- 92 people
- Sponsor
- Janssen Pharmaceutical K.K.
Colorectal Cancer, Gastric Cancer
Study of BO-112 With Pembrolizumab for Colorectal or Gastric/GEJ Cancer With Liver Metastasis
This is an open, single arm, multicenter phase 2 trial in which BO-112 will be administered intratumorally in combination with intravenous pembrolizumab in patients with liver metastasis from colorectal, gastric or…
- Conditions
- Colorectal Cancer, Gastric Cancer, Oesophageal Cancer
- Trial name
- NCT04508140
- Testing
- Hepatic Biopsy, BO-112 with pembrolizumab
- Where
- 12 sites in Belgium, Italy and 1 more
- Volunteers
- 18 people
- Sponsor
- Highlight Therapeutics
Non-Alcoholic Fatty Liver Disease, Hepatitis B
A Prospective Study of HBV Immunity and HBV Vaccination in Patients With NAFLD in Canada
(1) Due to missed childhood vaccination programs, the majority of adult patients with NAFLD in Canada do not have immunity to hepatitis B.
- Conditions
- Non-Alcoholic Fatty Liver Disease, Hepatitis B, Vaccine Reaction
- Trial name
- NCT02985450
- Testing
- Engerix-B
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- University of Calgary
Thrombocytopenia, Hepatitis B
Observation Study of Prednisone and Cyclosporine in Treatment of Thrombocytopenia in Hepatitis B Cirrhosis
To compare the safety and efficacy of 12 months of low dose prednisone with low dose cyclosporine combined with entecavir in patients with thrombocytopenia associated with HBV-related cirrhosis.
- Conditions
- Thrombocytopenia, Hepatitis B, Cirrhosis
- Trial name
- NCT01987791
- Volunteers
- 15 people
- Sponsor
- Peking University People's Hospital
Obesity, Morbid, Liver Fibrosis
Performances Evaluation of New FibroScan Probes Dedicated to Morbidly Obese Patients
Non-Alcoholic Fatty Liver is a common clinical and histological condition associated with metabolic syndrome in patients with and without excess body weight.
- Trial name
- NCT03872024
- Testing
- For the first 60 patients: 3 XXL probe prototypes of the FibroScan 630 Research Model, From patient 61 to patient 120: 1 XXL probe prototype of the FibroScan 630 Research Model
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Echosens
Hepatocerebral Encephalopathy, Portal-Systemic Encephalopathy
Lactulose for the Prevention of Hepatic Encephalopathy in Cirrhotic Patients With Upper Gastrointestinal Hemorrhage
To evaluate the role of lactulose in prevention of clinically overt hepatic encephalopathy (HE) in the setting of acute upper gastrointestinal bleeding in cirrhotic patients
- Conditions
- Hepatocerebral Encephalopathy, Portal-Systemic Encephalopathy, Encephalopathy, Hepatic, Encephalopathy, Hepatocerebral
- Trial name
- NCT00553423
- Testing
- Lactulose
- Where
- 2 sites in Pakistan
- Volunteers
- 128 people
- Sponsor
- Aga Khan University
Cholesterol; Lipidosis
Liver Adiposity Effects on Pediatric Statin
Single center, open-label, prospective investigation to quantify the effects hepatocellular fat has on hepatic statin transport and response in children and adolescents in obese and non-obese children and adolescents 8-21 years…
- Trial name
- NCT04903223
- Testing
- Rosuvastatin 10mg
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Hepatitis B, Hepatitis, Viral, Human
Interruption of Maternal-to-Infant Transmission of Hepatitis B by Means of Hepatitis B Immune Globulin
To evaluate whether hepatitis B immune globulin with a high level of antibody against the hepatitis B antigen would be capable of interrupting maternal-fetal transmission of hepatitis B virus, the single most important route of…
- Conditions
- Hepatitis B, Hepatitis, Viral, Human, Liver Diseases
- Trial name
- NCT00000580
- Testing
- immunoglobulins, intravenous
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Liver Fibrosis Due to NASH
Simtuzumab (SIM, GS-6624) in the Treatment of Cirrhosis Due to NASH
The primary objective of this study is to evaluate the safety and efficacy of SIM (formerly referred to as GS-6624) in adults with compensated cirrhosis due to Non-Alcoholic Steatohepatitis (NASH).
- Trial name
- NASH (NCT01672879)
- Testing
- SIM
- Where
- 59 sites in United States, Canada and 6 more
- Volunteers
- 259 people
- Sponsor
- Gilead Sciences
Liver Cirrhosis
Can Aspirin Reduce the Risk of HCC in Cirrhosis: The AspiRe HCC Trial
This clinical trial is testing whether taking a low dose aspirin tablet (100 mg) once a day can help prevent liver cancer (hepatocellular carcinoma, HCC) in people who have cirrhosis, which is severe scarring of the liver.
- Trial name
- AspiRe HCC (NCT07529262)
- Testing
- Low-dose aspirin
- Volunteers
- 890 people
- Sponsor
- Curtin University
Alpha 1-Antitrypsin Deficiency
Safety Study of Alfalastin (Human Alpha-1 Antitrypsin) Administered at Home
The purpose of this study is to collect safety data on ALFALASTIN® infusions performed at home or in out-of hospital locations.
- Trial name
- NCT01676688
- Volunteers
- 17 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Hepatocellular Carcinoma
Study of Sorafenib and Gemcitabine in Advanced Hepatocellular Carcinoma (HCC)
For the majority of patients, metastatic HCC is incurable and patients should be considered candidates for clinical trials when appropriate.
- Trial name
- HCC (NCT00844688)
- Testing
- sorafenib, Gemcitabine
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Combined Military Hospital, Pakistan
Hepatitis C, Chronic
A Study to Evaluate the Safety and Effect of Co-administration of ABT-450 With Ritonavir (ABT-450/r) and ABT-267 in Adults With Chronic Hepatitis C Virus Infection
The purpose of this study is to evaluate the safety and efficacy of co-administration of ABT-450 (also known as paritaprevir) with ritonavir (ABT-450/r) and ABT-267 (also known as ombitasvir) in adults with chronic hepatitis C…
- Trial name
- PEARL-I (NCT01685203)
- Testing
- ABT-450/r, ABT-267, Ribavirin (RBV)
- Volunteers
- 316 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Clinically Significant Portal Hypertension
The Impact of Carvedilol Posology on Clinically Significant Portal Hypertension
Carvedilol has emerged as the preferred non-selective β-blocker (NSBB) for treating portal hypertension. However, there is still a debate in dosing regimen, specially regarding dose interval, with a potential lower bioavalability…
- Trial name
- NCT06015373
- Testing
- supress the night dose of carvedilol
- Where
- Portugal
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar De São João, E.P.E.
Total Parenteral Nutrition-induced Cholestasis
Fish Oil for Patients With Liver Disease Due to Parenteral Nutrition
Patients who are not able to eat normally for a longer time require parenteral nutrition, i.e. they receive liquids and nutrients directly into their veins. This can have many long-term side effects, including liver problems.
- Trial name
- NCT01565278
- Testing
- Soybean oil (Standard treatment), Soybean oil + Fish oil
- Where
- 4 sites in Canada
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Johane Allard
Non-Alcoholic Fatty Liver Disease, Obesity
Bariatric Surgery on NASH
The study investigates non-alcoholic fatty liver disease from serial liver biopsies collected from participants referred for assessment of bariatric surgery, RYGB or SG.
- Trial name
- NCT04043585
- Where
- Denmark
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Cancer of Pancreas, Cancer of Stomach
Wet Heparinized Suction for Abdominal Cancer
The purpose of this research is to compare the amount and quality of tissue obtained by EUS-FNB when the device is flushed with an anticoagulant or "blood thinner" vs.
- Conditions
- Cancer of Pancreas, Cancer of Stomach, Cancer of Esophagus, Cancer of Liver
- Trial name
- EUS Heparin (NCT05041335)
- Testing
- wet heparinzed suction, Microsieve, No heparin flush
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Chronic Hepatitis C
A Single Ascending Dose Study of BMS-791325 in HCV Infected Subjects
The primary purpose of this study is to evaluate the safety profile and tolerability of single oral doses of BMS-791325 in subjects with chronic hepatitis C infection
- Trial name
- NCT00664625
- Testing
- BMS-791325
- Where
- 6 sites in United States, Argentina
- Volunteers
- 24 people
- Sponsor
- Bristol-Myers Squibb